{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:35:15Z","timestamp":1793298915802,"version":"4.5.0"},"reference-count":162,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NASR","award":["PN 23.16.01.03\/2022"],"award-info":[{"award-number":["PN 23.16.01.03\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Psoriasis, an autoimmune chronic inflammatory skin condition, has a high incidence in the general population, reaching 2\u20134%. Its pathogenesis involves an interplay of genetic factors, immune disturbances, and environmental factors. Within the environmental factors that aid the appearance of this autoimmune skin disease, the Western lifestyle and overall diet play important roles in the steady growth in psoriasis prevalence. Furthermore, psoriasis is associated with comorbidities such as psoriatic arthritis, cardiovascular disease, metabolic syndrome, and obesity. Accumulating evidence suggests that obesity is an important risk factor for psoriasis. Moreover, obesity aggravates established psoriasis, and a reduction in the body mass index can improve the clinical outcomes of psoriasis and increase the efficacy of standard psoriasis therapies. The possible connection between this autoimmune disease and obesity relies on the fact that white adipose tissue is an essential endocrine organ that secretes an array of immune mediators and inflammatory and metabolic factors with pro-inflammatory action. Thus, immune-mediated mechanisms in both psoriasis and obesity conditions are common factors. This paper describes the factors that link obesity with skin autoimmune disease and highlights the importance of the stimulatory or regulatory effects of nutrients and food in psoriasis and the possible improvement of psoriasis through nutritional strategies.<\/jats:p>","DOI":"10.3390\/nu15163528","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T10:52:40Z","timestamp":1691664760000},"page":"3528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Insights into Nutritional Strategies in Psoriasis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2870-5497","authenticated-orcid":false,"given":"Carolina","family":"Constantin","sequence":"first","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"},{"name":"Pathology Department, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5163-4378","authenticated-orcid":false,"given":"Mihaela","family":"Surcel","sequence":"additional","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9339-2805","authenticated-orcid":false,"given":"Monica","family":"Neagu","sequence":"additional","affiliation":[{"name":"Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania"},{"name":"Pathology Department, Colentina Clinical Hospital, 020125 Bucharest, Romania"},{"name":"Doctoral School, Faculty of Biology, University of Bucharest, 050107 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jaad.2013.11.013","article-title":"Psoriasis prevalence among adults in the United States","volume":"70","author":"Rachakonda","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2133.2001.144s58033.x","article-title":"The impact of psoriasis on quality of life","volume":"144","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.disamonth.2018.06.001","article-title":"Biologics for the primary care physician: Review and treatment of psoriasis","volume":"65","author":"Schadler","year":"2018","journal-title":"Dis. Mon."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/01.ASW.0000550592.08674.43","article-title":"Diagnosis and Management of Cutaneous Psoriasis: A Review","volume":"32","author":"Brandon","year":"2019","journal-title":"Adv. Ski. Wound Care"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Salgado-Boquete, L., Carrascosa, J.M., Llamas-Velasco, M., Ruiz-Villaverde, R., de la Cueva, P., and Belinch\u00f3n, I. (2021). A New Classification of the Severity of Psoriasis: What\u2019s Moderate Psoriasis?. Life, 11.","DOI":"10.3390\/life11070627"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Budu-Aggrey, A., Brumpton, B., Tyrrell, J., Watkins, S., Modalsli, E.H., Celis-Morales, C., Ferguson, L.D., Vie, G.\u00c5., Palmer, T., and Fritsche, L.G. (2019). Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. PLoS Med., 16.","DOI":"10.1371\/journal.pmed.1002739"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1021\/acs.jproteome.0c00646","article-title":"Effect of Very-Low-Calorie Ketogenic Diet on Psoriasis Patients: A Nuclear Magnetic Resonance-Based Metabolomic Study","volume":"20","author":"Castaldo","year":"2021","journal-title":"J. Proteome Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/10408398.2020.1818053","article-title":"Very low-calorie ketogenic diet (VLCKD) in patients with psoriasis and obesity: An update for dermatologists and nutritionists","volume":"62","author":"Barrea","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.3389\/fimmu.2019.01807","article-title":"Psoriasis: Obesity and Fatty Acids","volume":"10","author":"Kunz","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e001486","DOI":"10.1136\/rmdopen-2020-001486","article-title":"Impact of baseline body mass index on the efficacy and safety of tofacitinib in patients with psoriatic arthritis","volume":"7","author":"Giles","year":"2021","journal-title":"RMD Open"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"155217","DOI":"10.1016\/j.metabol.2022.155217","article-title":"A 2022 update on the epidemiology of obesity and a call to action: As its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on","volume":"133","author":"Boutari","year":"2022","journal-title":"Metabolism"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Barros, G., Duran, P., Vera, I., and Berm\u00fadez, V. (2022). Exploring the Links between Obesity and Psoriasis: A Comprehensive Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147499"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1038\/nutd.2012.26","article-title":"The association between psoriasis and obesity: A systematic review and meta-analysis of observational studies","volume":"2","author":"Armstrong","year":"2012","journal-title":"Nutr. Diabetes"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s40744-020-00215-6","article-title":"Obesity and Psoriatic Arthritis: A Narrative Review","volume":"7","author":"Kumthekar","year":"2020","journal-title":"Rheumatol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2147\/CCID.S411636","article-title":"A Comparison of Clinical Characteristics in Overweight\/Obese and Normal Weight Patients with Psoriasis Vulgaris: A Bicentric Retrospective Observational Study","volume":"16","author":"Li","year":"2023","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/nbu.12580","article-title":"Approaches to nutrition intervention in plaque psoriasis, a multi-system inflammatory disease-The Diet and Psoriasis Project (DIEPP)","volume":"47","author":"Zanesco","year":"2022","journal-title":"Nutr. Bull."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Blake, T., Gullick, N.J., Hutchinson, C.E., and Barber, T.M. (2020). Psoriatic disease and body composition: A systematic review and narrative synthesis. PLoS ONE., 15.","DOI":"10.1101\/2020.05.18.20104802"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/09546634.2016.1254326","article-title":"Bioelectrical impedance analysis to define an excess of body fat: Evaluation in patients with psoriasis","volume":"28","author":"Galluzzo","year":"2017","journal-title":"J. Dermatol. Treat."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kanda, N., Hoashi, T., and Saeki, H. (2020). Nutrition and Psoriasis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21155405"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: Mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/obr.12646","article-title":"Causes and mechanisms of adipocyte enlargement and adipose expansion","volume":"19","author":"Haczeyni","year":"2018","journal-title":"Obes. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"100064","DOI":"10.1016\/j.xjidi.2021.100064","article-title":"Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity","volume":"2","author":"Guo","year":"2021","journal-title":"JID Innov."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.3389\/fimmu.2018.01668","article-title":"Psoriasis, Cardiovascular Events, and Biologics: Lights and Shadows","volume":"9","author":"Caiazzo","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","article-title":"Adipose tissue inflammation and metabolic dysfunction in obesity","volume":"320","author":"Kawai","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Clemente-Su\u00e1rez, V.J., Redondo-Fl\u00f3rez, L., Beltr\u00e1n-Velasco, A.I., Mart\u00edn-Rodr\u00edguez, A., Mart\u00ednez-Guardado, I., Navarro-Jim\u00e9nez, E., Laborde-C\u00e1rdenas, C.C., and Tornero-Aguilera, J.F. (2023). The Role of Adipokines in Health and Disease. Biomedicines, 11.","DOI":"10.3390\/biomedicines11051290"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.5114\/ada.2019.89503","article-title":"Analysis of serum chemerin concentrations in psoriatic patients in relation to metabolic abnormalities","volume":"36","author":"Gerkowicz","year":"2019","journal-title":"Postepy. Dermatol. Alergol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/DMSO.S281186","article-title":"Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products","volume":"14","author":"Jakab","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.clindermatol.2017.09.005","article-title":"Psoriasis and the metabolic syndrome","volume":"36","author":"Gisondi","year":"2018","journal-title":"Clin. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/1346-8138.12121","article-title":"Adiponectin levels in patients with psoriasis: A meta-analysis","volume":"40","author":"Zhu","year":"2013","journal-title":"J. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jaci.2005.02.023","article-title":"Adipose tissue, adipokines, and inflammation","volume":"115","author":"Fantuzzi","year":"2005","journal-title":"J. Allergy. Clin. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2012.08.036","article-title":"Functional and structural features of adipokine family","volume":"61","author":"Raucci","year":"2013","journal-title":"Cytokine"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"S\u0142uczanowska-G\u0142abowska, S., Staniszewska, M., Marchlewicz, M., Duchnik, E., \u0141uczkowska, K., Safranow, K., Machali\u0144ski, B., and Pawlik, A. (2023). Adiponectin, Leptin and Resistin in Patients with Psoriasis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12020663"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1590\/abd1806-4841.20197716","article-title":"Psoriasis in obesity: Comparison of serum levels of leptin and adiponectin in obese subjects\u2014Cases and controls","volume":"94","author":"Bavoso","year":"2019","journal-title":"An. Bras. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12944-019-1115-3","article-title":"New insights into different adipokines in linking the pathophysiology of obesity and psoriasis","volume":"18","author":"Kong","year":"2019","journal-title":"Lipids Health Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3889\/seejim.2023.6024","article-title":"Systemic Circulating Leptin\u2014Aiding New Dimension of Immune-Related Skin Carcinogenesis and Lipid Metabolism","volume":"6","author":"Neagu","year":"2023","journal-title":"SEE J. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12944-020-01391-8","article-title":"The role of leptin in selected skin diseases","volume":"19","author":"Dopytalska","year":"2020","journal-title":"Lipids Health Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1159\/000481882","article-title":"Serum Leptin, Resistin, and Adiponectin Concentrations in Psoriasis: A Meta-Analysis of Observational Studies","volume":"233","author":"Kyriakou","year":"2017","journal-title":"Dermatology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4062\/biomolther.2020.054","article-title":"The Role of Leptin in the Association between Obesity and Psoriasis","volume":"29","author":"Hwang","year":"2021","journal-title":"Biomol. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1111\/febs.15322","article-title":"Resistin in metabolism, inflammation, and disease","volume":"287","author":"Tripathi","year":"2020","journal-title":"FEBS J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1084\/jem.20172094","article-title":"Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I\u2013driven CD8+ T cell response","volume":"215","author":"Stockenhuber","year":"2018","journal-title":"J. Exp. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s13679-020-00380-3","article-title":"Deciphering the Association between Psoriasis and Obesity: Current Evidence and Treatment Considerations","volume":"9","author":"Paroutoglou","year":"2020","journal-title":"Curr. Obes. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.yexmp.2013.07.009","article-title":"Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver","volume":"95","author":"Krautbauer","year":"2013","journal-title":"Exp. Mol. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1080\/1744666X.2016.1201423","article-title":"Crosstalk between skin inflammation and adipose tissue-derived products: Pathogenic evidence linking psoriasis to increased adiposity","volume":"12","author":"Chiricozzi","year":"2016","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.tem.2010.08.001","article-title":"Chemerin: At the crossroads of inflammation and obesity","volume":"21","author":"Ernst","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Buechler, C., Feder, S., Haberl, E.M., and Aslanidis, C. (2019). Chemerin Isoforms and Activity in Obesity. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051128"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1530\/JOE-18-0174","article-title":"Chemerin: A multifaceted adipokine involved in metabolic disorders","volume":"238","author":"Helfer","year":"2018","journal-title":"J. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Antal, D., Alimohammadi, S., Bai, P., Sz\u00f6ll\u0151si, A.G., and Sz\u00e1nt\u00f3, M. (2022). Antigen-Presenting Cells in Psoriasis. Life, 12.","DOI":"10.3390\/life12020234"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1084\/jem.20080129","article-title":"Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment","volume":"206","author":"Albanesi","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11596-023-2721-x","article-title":"Chemerin Exacerbates Psoriasis by Stimulating Keratinocyte Proliferation and Cytokine Production","volume":"43","author":"Kong","year":"2023","journal-title":"Curr. Med. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Bremner, J.D., Moazzami, K., Wittbrodt, M.T., Nye, J.A., Lima, B.B., Gillespie, C.F., Rapaport, M.H., Pearce, B.D., Shah, A.J., and Vaccarino, V. (2020). Diet, Stress and Mental Health. Nutrients, 12.","DOI":"10.3390\/nu12082428"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"adv00609","DOI":"10.2340\/actadv.v101.565","article-title":"Common Fundamentals of Psoriasis and Depression","volume":"101","author":"Krefting","year":"2021","journal-title":"Acta Derm. Venereol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"589726","DOI":"10.3389\/fmicb.2020.589726","article-title":"Skin and Gut Microbiome in Psoriasis: Gaining Insight into the Pathophysiology of It and Finding Novel Therapeutic Strategies","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sikora, M., Stec, A., Chrabaszcz, M., Knot, A., Waskiel-Burnat, A., Rakowska, A., Olszewska, M., and Rudnicka, L. (2020). Gut Microbiome in Psoriasis: An Updated Review. Pathogens, 9.","DOI":"10.3390\/pathogens9060463"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Vetrani, C., Di Nisio, A., Paschou, S.A., Barrea, L., Muscogiuri, G., Graziadio, C., Savastano, S., and Colao, A. (2022). On Behalf of the Obesity Programs of Nutrition Education Research and Assessment Opera Group. From Gut Microbiota through Low-Grade Inflammation to Obesity: Key Players and Potential Targets. Nutrients, 14.","DOI":"10.3390\/nu14102103"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41430-020-0607-6","article-title":"Profile of the gut microbiota of adults with obesity: A systematic review","volume":"74","author":"Crovesy","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Stojanov, S., Berlec, A., and \u0160trukelj, B. (2020). The Influence of Probiotics on the Firmicutes\/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111715"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Thye, A.Y.-K., Bah, Y.-R., Law, J.W.-F., Tan, L.T.-H., He, Y.-W., Wong, S.-H., Thurairajasingam, S., Chan, K.-G., Lee, L.-H., and Letchumanan, V. (2022). Gut\u2013Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10051037"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2213112","DOI":"10.1080\/20002297.2023.2213112","article-title":"The interplay between oral microbiota, gut microbiota and systematic diseases","volume":"15","author":"Tan","year":"2023","journal-title":"J. Oral Microbiol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Al Bander, Z., Nitert, M.D., Mousa, A., and Naderpoor, N. (2020). The Gut Microbiota and Inflammation: An Overview. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17207618"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10753-021-01559-z","article-title":"Role of Inflammatory Cytokines, Growth Factors and Adipokines in Adipogenesis and Insulin Resistance","volume":"45","author":"Prince","year":"2022","journal-title":"Inflammation"},{"key":"ref_61","first-page":"S25","article-title":"The Role of the Gut Microbiome in Psoriasis: From Pathogens to Pathology","volume":"15","author":"Wilchowski","year":"2022","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s13555-020-00466-9","article-title":"Gut\u2013Brain\u2013Skin Axis in Psoriasis: A Review","volume":"11","author":"Chen","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_63","first-page":"1030","article-title":"Phenotypic changes of lymphocyte populations in psoriasiform dermatitis animal model","volume":"17","author":"Surcel","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1002\/eji.201343801","article-title":"TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis","volume":"43","author":"Flutter","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8424","DOI":"10.1038\/ncomms9424","article-title":"Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis","volume":"6","author":"Zanvit","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jcmgh.2018.09.010","article-title":"Toll-Like Receptor 7 Agonist\u2013Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells","volume":"7","author":"Kiyohara","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fmicb.2019.00236","article-title":"Crucial Role of Microbiota in Experimental Psoriasis Revealed by a Gnotobiotic Mouse Model","volume":"10","author":"Stehlikova","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.steroids.2015.04.006","article-title":"On the role of skin in the regulation of local and systemic steroidogenic activities","volume":"103","author":"Slominski","year":"2015","journal-title":"Steroids"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"C1757","DOI":"10.1152\/ajpcell.00147.2022","article-title":"Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides","volume":"323","author":"Slominski","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11265","DOI":"10.1038\/s41598-021-90480-4","article-title":"Abnormal composition of microbiota in the gut and skin of imiquimod-treated mice","volume":"11","author":"Hashimoto","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/bs.ai.2020.02.002","article-title":"Friend or foe? Lactobacillus in the context of autoimmune disease","volume":"146","author":"Fine","year":"2020","journal-title":"Adv. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Z\u00e1kostelsk\u00e1, Z., M\u00e1lkov\u00e1, J., Klime\u0161ov\u00e1, K., Rossmann, P., Hornov\u00e1, M., Novos\u00e1dov\u00e1, I., Stehl\u00edkov\u00e1, Z., Kostov\u010d\u00edk, M., Hudcovic, T., and \u0160tep\u00e1nkov\u00e1, R. (2016). Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0159539"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/2049-2618-1-31","article-title":"Community differentiation of the cutaneous microbiota in psoriasis","volume":"1","author":"Alekseyenko","year":"2013","journal-title":"Microbiome"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.2147\/JIR.S337031","article-title":"Gut and Cutaneous Microbiome Featuring Abundance of Lactobacillus reuteri Protected Against Psoriasis-Like Inflammation in Mice","volume":"14","author":"Chen","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jid.2021.06.019","article-title":"Mouse Models of Psoriasis: A Comprehensive Review","volume":"142","author":"Gangwar","year":"2022","journal-title":"J. Investig. Dermatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jaci.2020.04.034","article-title":"Animal models of psoriasis\u2014Highlights and drawbacks","volume":"147","author":"Manzke","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"109897","DOI":"10.1016\/j.intimp.2023.109897","article-title":"The Experimental Animal Models in Psoriasis Research: A Comprehensive Review","volume":"117","author":"Parab","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jid.2019.06.132","article-title":"E-Cadherin is Dispensable to Maintain Langerhans Cells in the Epidermis","volume":"140","author":"Brand","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jaci.2019.09.025","article-title":"Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation","volume":"145","author":"Cibrian","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/exd.14061","article-title":"Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis","volume":"29","author":"Kiss","year":"2020","journal-title":"Exp. Dermatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/eji.201948349","article-title":"S1PR4-dependent CCL2 production promotes macrophage recruitment in a murine psoriasis model","volume":"50","author":"Schuster","year":"2020","journal-title":"Eur. J. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1111\/bph.15077","article-title":"B1 and B2 kinin receptor blockade improves psoriasis-like disease","volume":"177","author":"Soley","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"eaax1686","DOI":"10.1126\/sciimmunol.aax1686","article-title":"Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine","volume":"5","author":"Hovhannisyan","year":"2020","journal-title":"Sci. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"107054","DOI":"10.1016\/j.vascn.2021.107054","article-title":"Optimization of psoriasis mouse models","volume":"108","author":"Karamani","year":"2021","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"625617","DOI":"10.3389\/fimmu.2021.625617","article-title":"Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4","volume":"12","author":"Pietrobon","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1172\/JCI133159","article-title":"KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease","volume":"130","author":"Billi","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1084\/jem.20060244","article-title":"IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2\u2013dependent mechanisms with implications for psoriasis pathogenesis","volume":"203","author":"Chan","year":"2006","journal-title":"J. Exp. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.immuni.2018.05.012","article-title":"Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A","volume":"49","author":"Wang","year":"2018","journal-title":"Immunity"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/jid.2013.404","article-title":"IL-6 Regulates Neutrophil Microabscess Formation in IL-17A-Driven Psoriasiform Lesions","volume":"134","author":"Croxford","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1161\/ATVBAHA.114.304108","article-title":"Interleukin 17 Drives Vascular Inflammation, Endothelial Dysfunction, and Arterial Hypertension in Psoriasis-Like Skin Disease","volume":"34","author":"Karbach","year":"2014","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ajhg.2012.03.013","article-title":"Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis","volume":"90","author":"Jordan","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/j.jid.2018.03.1525","article-title":"CARD14 Gain-of-Function Mutation Alone Is Sufficient to Drive IL-23\/IL-17\u2013Mediated Psoriasiform Skin Inflammation In Vivo","volume":"138","author":"Mellett","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"589","DOI":"10.15252\/emmm.201607027","article-title":"RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease","volume":"9","author":"Zhu","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.immuni.2007.05.024","article-title":"Crosstalk between Keratinocytes and Adaptive Immune Cells in an I\u03baB\u03b1 Protein-Mediated Inflammatory Disease of the Skin","volume":"27","author":"Rebholz","year":"2007","journal-title":"Immunity"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jid.2019.01.006","article-title":"Imiquimod-Induced Psoriasis in Mice Depends on the IL-17 Signaling of Keratinocytes","volume":"139","author":"Moos","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1177\/1535370221993424","article-title":"Inhibition of phospholipases suppresses progression of psoriasis through modulation of inflammation","volume":"246","author":"Gao","year":"2021","journal-title":"Exp. Biol. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/bjd.19057","article-title":"Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-\u03baB p65 subunit and promotes inflammation in keratinocytes","volume":"184","author":"Yang","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2040622320987348","DOI":"10.1177\/2040622320987348","article-title":"EZH2 is involved in psoriasis progression by impairing miR-125a-5p inhibition of SFMBT1 and leading to inhibition of the TGF\u03b2\/SMAD pathway","volume":"12","author":"Qu","year":"2021","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.jid.2020.01.020","article-title":"Short-Term Exposure to a Western Diet Induces Psoriasiform Dermatitis by Promoting Accumulation of IL-17A\u2013Producing \u03b3\u03b4 T Cells","volume":"140","author":"Shi","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"108537","DOI":"10.1016\/j.clim.2020.108537","article-title":"The cutaneous and intestinal microbiome in psoriatic disease","volume":"218","author":"Le","year":"2020","journal-title":"Clin. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/exd.14016","article-title":"Targeting the gut-skin axis\u2014Probiotics as new tools for skin disorder management?","volume":"28","author":"Antal","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41422-020-0332-7","article-title":"Interaction between microbiota and immunity in health and disease","volume":"30","author":"Zheng","year":"2020","journal-title":"Cell Res."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Toor, D., Wsson, M.K., Kumar, P., Karthikeyan, G., Kaushik, N.K., Goel, C., Singh, S., Kumar, A., and Prakash, H. (2019). Dysbiosis disrupts gut immune homeostasis and promotes gastric diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20102432"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12328-017-0813-5","article-title":"Gut microbiota in the pathogenesis of inflammatory bowel disease","volume":"11","author":"Nishida","year":"2018","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/bjd.18245","article-title":"Management of psoriasis as a systemic disease: What is the evidence?","volume":"182","author":"Korman","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Surcel, M., Munteanu, A., Isvoranu, G., Ibram, A., Caruntu, C., Constantin, C., and Neagu, M. (2021). Unconventional Therapy with IgY in a Psoriatic Mouse Model Targeting Gut Microbiome. J. Pers. Med., 11.","DOI":"10.3390\/jpm11090841"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.metabol.2019.07.001","article-title":"Metabolic syndrome is associated with an increased risk of psoriasis: A nationwide population-based study","volume":"99","author":"Kim","year":"2019","journal-title":"Metabolism"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/ecco-jcc\/jjz152","article-title":"Global prevalence and bidirectional association between psoriasis and inflammatory bowel disease\u2014A systematic review and meta-analysis","volume":"14","author":"Alinaghi","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/bies.201600008","article-title":"The gut-skin axis in health and disease: A paradigm with therapeutic implications","volume":"38","author":"Monteleone","year":"2016","journal-title":"Bioessays"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1001\/jamadermatol.2014.5585","article-title":"Identification of bacterial DNA in the peripheral blood of patients with active psoriasis","volume":"151","author":"Such","year":"2015","journal-title":"JAMA Dermatol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1515\/cclm-2019-0657","article-title":"Gut microbiome investigation in celiac disease: From methods to its pathogenetic role","volume":"58","author":"Sacchetti","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Ellis, S.R., Nguyen, M., Vaughn, A.R., Notay, M., Burney, W.A., Sandhu, S., and Sivamani, R.K. (2019). The skin and gut microbiome and its role in common dermatologic conditions. Microorganisms, 7.","DOI":"10.3390\/microorganisms7110550"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nri3738","article-title":"Regional specialization within the intestinal immune system","volume":"14","author":"Mowat","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.chom.2015.04.004","article-title":"Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life","volume":"17","author":"Roswall","year":"2015","journal-title":"Cell Host Microbe"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/imr.12556","article-title":"The nutrition-gut microbiome-physiology axis and allergic diseases","volume":"278","author":"McKenzie","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Lee, J.K.-F., Hern Tan, L.T., Ramadas, A., Ab Mutalib, N.-S., and Lee, L.-H. (2020). Exploring the Role of Gut Bacteria in Health and Disease in Preterm Neonates. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17196963"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Lau, A.W.Y., Tan, L.T.-H., Ab Mutalib, N.-S., Wong, S.H., Letchumanan, V., and Lee, L.-H. (2021). The chemistry of gut microbiome in health and diseases. Prog. Microbes Mol. Biol., 4.","DOI":"10.36877\/pmmb.a0000175"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1038\/s41380-020-0652-5","article-title":"Depression phenotype identified by using single nucleotide exact amplicon sequence variants of the human gut microbiome","volume":"26","author":"Stevens","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s13679-019-00352-2","article-title":"Understanding the role of the gut microbiome and microbial metabolites in obesity and obesity-associated metabolic disorders: Current evidence and perspectives","volume":"8","author":"Vallianou","year":"2019","journal-title":"Curr. Obes. Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s40168-018-0558-5","article-title":"Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris","volume":"6","author":"Gallo","year":"2018","journal-title":"Microbiome"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Gloster, H., Gebauer, L., and Mistur, R. (2016). Absolute Dermatology Review, Springer.","DOI":"10.1007\/978-3-319-03218-4"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4168\/aair.2020.12.1.137","article-title":"Antibiotics-Induced Dysbiosis of Intestinal Microbiota Aggravates Atopic Dermatitis in Mice by Altered Short-Chain Fatty Acids","volume":"12","author":"Kim","year":"2020","journal-title":"Allergy, Asthma Immunol. Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/jdv.15951","article-title":"The gut microbiome alterations in allergic and inflammatory skin diseases\u2014An update","volume":"34","author":"Gerkowicz","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_124","first-page":"249","article-title":"The potential impact of gut microbiota on your health:Current status and future challenges","volume":"34","author":"Sirisinha","year":"2016","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3389\/fmicb.2015.01085","article-title":"Regulation of lung immunity and host defense by the intestinal microbiota","volume":"6","author":"Samuelson","year":"2015","journal-title":"Front. Microbiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3920\/BM2012.0066","article-title":"Bifidobacterium fermented milk and galacto-oligosaccharides lead to improved skin health by decreasing phenols production by gut microbiota","volume":"5","author":"Miyazaki","year":"2014","journal-title":"Benef. Microbes"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2019.08.002","article-title":"Pursuing Human-Relevant Gut Microbiota-Immune Interactions","volume":"51","author":"Spencer","year":"2019","journal-title":"Immunity"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1016\/j.febslet.2014.03.019","article-title":"Relationship between gut microbiota and development of T cell associated disease","volume":"588","author":"Kosiewicz","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/art.39259","article-title":"Microbiome in Inflammatory Arthritis and Human Rheumatic Diseases","volume":"68","author":"Scher","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Georgescu, S.-R., Tampa, M., Caruntu, C., Sarbu, M.-I., Mitran, C.-I., Mitran, M.-I., Matei, C., Constantin, C., and Neagu, M. (2019). Advances in Understanding the Immunological Pathways in Psoriasis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030739"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4161\/gmic.24373","article-title":"Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis","volume":"4","author":"Robertson","year":"2013","journal-title":"Gut Microbes"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev-physiol-030212-183744","article-title":"Paneth Cells: Maestros of the Small Intestinal Crypts","volume":"75","author":"Clevers","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn\u2019s disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn\u2019s disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/B978-0-12-381300-8.00006-X","article-title":"GALT: Organization and dynamics leading to IgA synthesis","volume":"107","author":"Suzuki","year":"2010","journal-title":"Adv. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/bjd.17745","article-title":"Evaluation of subclinical gut inflammation using faecal calprotectin levels and colonic mucosal biopsy in patients with psoriasis and psoriatic arthritis","volume":"181","author":"Adarsh","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2147\/PTT.S85194","article-title":"Psoriasis and inflammatory bowel disease: Links and risks","volume":"6","author":"Bassukas","year":"2016","journal-title":"Psoriasis: Targets Ther."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fcimb.2019.00007","article-title":"Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris","volume":"9","author":"Visser","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2096995","DOI":"10.1080\/19490976.2022.2096995","article-title":"Impact of gut microbiome on skin health: Gut-Skin axis observed through the lenses of therapeutics and skin diseases","volume":"14","author":"Mahmud","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2147\/PTT.S328581","article-title":"Dietary Intervention and Supplements in the Management of Psoriasis: Current Perspectives","volume":"12","author":"Chung","year":"2022","journal-title":"Psoriasis"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Pona, A., Haidari, W., Kolli, S.S., and Feldman, S.R. (2019). Diet and psoriasis. Dermatol. Online J., 25.","DOI":"10.5070\/D3252042883"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1001\/archdermatol.2010.92","article-title":"Diet and Weight Loss as a Treatment for Psoriasis","volume":"146","author":"Gelfand","year":"2010","journal-title":"Arch. Dermatol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15761\/JTS.1000193","article-title":"Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid","volume":"3","author":"Aronson","year":"2017","journal-title":"J. Transl. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s40257-014-0069-5","article-title":"Bilirubin levels and their association with carotid intima media thickness and high-sensitivity Creactive protein in patients with psoriasis vulgaris","volume":"15","author":"Balta","year":"2014","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/j.1365-2133.2010.09984.x","article-title":"How stress gets under the skin: Cortisol and stress reactivity in psoriasis","volume":"163","author":"Evers","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2340\/00015555-1824","article-title":"Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis","volume":"94","author":"Jensen","year":"2014","journal-title":"Acta Derm Venereol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1111\/ijd.14523","article-title":"Adherence to the Mediterranean diet is independently associated with psoriasis risk, severity, and quality of life: A cross-sectional observational study","volume":"58","author":"Korovesi","year":"2019","journal-title":"Int J Dermatol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Passali, M., Josefsen, K., Frederiksen, J.L., and Antvorskov, J.C. (2020). Current evidence on the efficacy of gluten-free diets in multiple sclerosis, psoriasis, type 1 diabetes and autoimmune thyroid diseases. Nutrients, 12.","DOI":"10.3390\/nu12082316"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.jaad.2019.08.007","article-title":"Gluten intake and risk of psoriasis, psoriatic arthritis, and atopic dermatitis among United States women","volume":"82","author":"Drucker","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jaad.2014.03.017","article-title":"Diet and psoriasis, part II: Celiac disease and role of a gluten-free diet","volume":"71","author":"Bhatia","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1046\/j.1365-2133.2000.03240.x","article-title":"Psoriasis patients with antibodies to gliadin can be improved by a gluten-free diet","volume":"142","author":"Hagforsen","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/00015550310015022","article-title":"Gluten-free diet in psoriasis patients with antibodies to gliadin results in decreased expression of tissue transglutaminase and fewer Ki67 + cells in the dermis","volume":"83","author":"Ahs","year":"2003","journal-title":"Acta Derm Venereol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1365-2133.2006.07725.x","article-title":"Palmoplantar pustulosis and gluten sensitivity: A study of serum antibodies against gliadin and tissue transglutaminase, the duodenal mucosa and effects of gluten-free diet","volume":"156","author":"Lundin","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2147\/JMDH.S122256","article-title":"Prevalence of antigliadin IgA antibodies in psoriasis vulgaris and response of seropositive patients to a gluten-free diet","volume":"11","author":"Kolchak","year":"2018","journal-title":"J. Multidiscip. Healthc."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jaad.2014.03.016","article-title":"Diet and psoriasis, part III: Role of nutritional supplements","volume":"71","author":"Millsop","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e066452","DOI":"10.1136\/bmj-2021-066452","article-title":"Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial","volume":"376","author":"Hahn","year":"2022","journal-title":"BMJ"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"599433","DOI":"10.3389\/fphar.2020.599433","article-title":"Chinese Herbal Medicine for Psoriasis: Evidence From 11 High-Quality Randomized Controlled Trials","volume":"11","author":"Luo","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2623085","DOI":"10.1155\/2018\/2623085","article-title":"Efficacy and safety of Tripterygium wilfordii Hook F on psoriasis vulgaris: A systematic review and meta-analysis of randomized controlled trials","volume":"2018","author":"Lv","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1046\/j.1087-0024.2003.09102.x","article-title":"Psoriasis Is Common, Carries a Substantial Burden Even When Not Extensive, and Is Associated with Widespread Treatment Dissatisfaction","volume":"9","author":"Stern","year":"2004","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jaad.2004.04.014","article-title":"Determinants of quality of life in patients with psoriasis: A study from the US population","volume":"51","author":"Gelfand","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jaad.2012.08.015","article-title":"Psoriasis and metabolic syndrome: A systematic review and meta-analysis of observational studies","volume":"68","author":"Armstrong","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1001\/jamadermatol.2017.2103","article-title":"Psoriasis","volume":"153","author":"Armstrong","year":"2017","journal-title":"JAMA Dermatol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/16\/3528\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:30:51Z","timestamp":1760128251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/16\/3528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,10]]},"references-count":162,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["nu15163528"],"URL":"https:\/\/doi.org\/10.3390\/nu15163528","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,10]]}}}