{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:54:44Z","timestamp":1790456084910,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Project for Medical Research and Health Sciences","award":["2023KY644"],"award-info":[{"award-number":["2023KY644"]}]},{"name":"Zhejiang Provincial Project for Medical Research and Health Sciences","award":["GF20H240001"],"award-info":[{"award-number":["GF20H240001"]}]},{"name":"Zhejiang Provincial Project for Medical Research and Health Sciences","award":["TGY23H240001"],"award-info":[{"award-number":["TGY23H240001"]}]},{"name":"Zhejiang Provincial Project for Fundamental Research on Public Welfare","award":["2023KY644"],"award-info":[{"award-number":["2023KY644"]}]},{"name":"Zhejiang Provincial Project for Fundamental Research on Public Welfare","award":["GF20H240001"],"award-info":[{"award-number":["GF20H240001"]}]},{"name":"Zhejiang Provincial Project for Fundamental Research on Public Welfare","award":["TGY23H240001"],"award-info":[{"award-number":["TGY23H240001"]}]},{"name":"Zhejiang Provincial Project for Fundamental Research on Public Welfare","award":["2023KY644"],"award-info":[{"award-number":["2023KY644"]}]},{"name":"Zhejiang Provincial Project for Fundamental Research on Public Welfare","award":["GF20H240001"],"award-info":[{"award-number":["GF20H240001"]}]},{"name":"Zhejiang Provincial Project for Fundamental Research on Public Welfare","award":["TGY23H240001"],"award-info":[{"award-number":["TGY23H240001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iodine deficiency during pregnancy is a widespread public health concern, but indicators and methods for assessing iodine nutritional status are lacking. Serum iodine concentration (SIC) is an important iodine metabolism biomarker and can, to some extent, predict the risk of thyroid diseases, making it a potential biomarker for assessing individual iodine nutrition levels. Our study aimed to analyze the relationship between SIC and thyroid function in a cohort of mild iodine deficient pregnant women in China in order to explore the potential of SIC as a biomarker of individual iodine status in pregnancy. A total of 1540 early pregnant women (gestation &lt; 10 weeks) aged 18 to 45 years old were included in the final study from a Zhejiang multicenter population-based mother and child cohort. Repeated measures of SIC, urinary iodine concentration (UIC), and thyroid function were taken at approximately 10, 17, and 32 weeks of gestation. The SIC was statistically correlated with all thyroid function indexes in the first trimester, and a very strong positive correlation with FT4 over three trimesters (r = 0.449, 0.550, and 0.544, respectively). Pregnant women with an SIC &lt; 72.4 \u00b5g\/L were at a higher risk of hypothyroxinemia (adjusted OR = 8.911, 95% CI = 5.141\u201315.447) and iodine deficiency (adjusted OR = 1.244, 95% CI = 1.031\u20131.502), while those with an SIC &gt; 93.9 \u00b5g\/L were at a higher risk of thyrotoxicosis (adjusted OR = 11.064, 95% CI = 6.324\u201319.357) and excessive iodine (adjusted OR = 11.064, 95% CI = 6.324\u201319.357). In contrast, the UIC was not correlated with thyroid diseases (p &gt; 0.05). These findings indicate that the SIC is a potential biomarker for assessing individual iodine nutrition and thyroid dysfunction in pregnant women.<\/jats:p>","DOI":"10.3390\/nu15163555","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T10:33:23Z","timestamp":1691750003000},"page":"3555","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Serum Iodine as a Potential Individual Iodine Status Biomarker: A Cohort Study of Mild Iodine Deficient Pregnant Women in China"],"prefix":"10.3390","volume":"15","author":[{"given":"Xueqing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeng","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-1434","authenticated-orcid":false,"given":"Lizhi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingluan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-3613","authenticated-orcid":false,"given":"Zhijian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou 310051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000442078","article-title":"The Importance of Adequate Iodine during Pregnancy and Infancy","volume":"115","author":"Zimmermann","year":"2016","journal-title":"World Rev. Nutr. Diet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/thy.2016.0457","article-title":"2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum","volume":"27","author":"Alexander","year":"2017","journal-title":"Thyroid"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1210\/er.2009-0011","article-title":"Iodine deficiency","volume":"30","author":"Zimmermann","year":"2009","journal-title":"Endocr. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S2213-8587(15)00263-6","article-title":"Iodine deficiency in pregnant women in Europe","volume":"3","author":"Zimmermann","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1017\/S1368980016003232","article-title":"Urinary iodine concentration identifies pregnant women as iodine deficient yet school-aged children as iodine sufficient in rural Niger","volume":"20","author":"Hess","year":"2017","journal-title":"Public Health Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12011-018-1257-6","article-title":"A Comparison of Iodine Status in Children and Pregnant Women After a Policy Change in the Iodized Salt Standard in Shanghai, China","volume":"185","author":"Wang","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S2414-6447(19)30076-4","article-title":"Iodized salt consumption and iodine deficiency status in China: A cross-sectional study","volume":"1","author":"Fan","year":"2017","journal-title":"Global Health J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1017\/S1368980007361004","article-title":"Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old: Conclusions and recommendations of the Technical Consultation","volume":"10","author":"Andersson","year":"2007","journal-title":"Public Health Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1753-4887.2012.00528.x","article-title":"Assessment of iodine nutrition in populations: Past, present, and future","volume":"70","author":"Zimmermann","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/jn\/134.7.1673","article-title":"Assessing iodine status and monitoring progress of iodized salt programs","volume":"134","author":"Zimmermann","year":"2004","journal-title":"J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1089\/thy.2014.0052","article-title":"Thyroglobulin as a biomarker of iodine deficiency: A review","volume":"24","author":"Ma","year":"2014","journal-title":"Thyroid"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/00365513.2018.1512150","article-title":"Validation of a simple inductively coupled plasma mass spectrometry method for detecting urine and serum iodine and evaluation of iodine status of pregnant women in Beijing","volume":"78","author":"Yu","year":"2018","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jtemb.2014.05.002","article-title":"Characterization of a rapid and reliable method for iodide biomonitoring in serum and urine based on ion chromatography-ICP-mass spectrometry","volume":"29","author":"Michalke","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cca.2019.11.038","article-title":"Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population","volume":"502","author":"Yu","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/jn\/nxy325","article-title":"Serum Iodine Is Correlated with Iodine Intake and Thyroid Function in School-Age Children from a Sufficient-to-Excessive Iodine Intake Area","volume":"149","author":"Cui","year":"2019","journal-title":"J. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1111\/cen.13421","article-title":"The application of serum iodine in assessing individual iodine status","volume":"87","author":"Jin","year":"2017","journal-title":"Clin. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/cen.13945","article-title":"Serum iodine concentration in pregnant women and its association with urinary iodine concentration and thyroid function","volume":"90","author":"Pan","year":"2019","journal-title":"Clin. Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.3945\/jn.111.144071","article-title":"Ten repeat collections for urinary iodine from spot samples or 24-h samples are needed to reliably estimate individual iodine status in women","volume":"141","author":"Konig","year":"2011","journal-title":"J. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1210\/jc.2015-3519","article-title":"The Urine Iodine to Creatinine as an Optimal Index of Iodine During Pregnancy in an Iodine Adequate Area in China","volume":"101","author":"Li","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/cen.13282","article-title":"Urinary iodine excretion (UIE) estimated by iodine\/creatinine ratio from spot urine in Chinese school-age children","volume":"86","author":"Chen","year":"2017","journal-title":"Clin. Endocrinol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e22407","DOI":"10.1002\/jcla.22407","article-title":"Validation of daily urinary creatinine excretion measurement by muscle-creatinine equivalence","volume":"32","author":"Iacone","year":"2018","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1373\/clinchem.2017.282517","article-title":"Biological Variation of Creatinine, Cystatin C, and eGFR over 24 Hours","volume":"64","author":"Hilderink","year":"2018","journal-title":"Clin. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jchromb.2014.05.022","article-title":"Determination of total iodine in serum and urine samples by ion chromatography with pulsed amperometric detection\u2014Studies on analyte loss, optimization of sample preparation procedures, and validation of analytical method","volume":"962","author":"Blazewicz","year":"2014","journal-title":"J. Chromatogr. B"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJM199908193410801","article-title":"Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child","volume":"341","author":"Haddow","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"668S","DOI":"10.3945\/ajcn.2008.26811C","article-title":"Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: A review","volume":"89","author":"Zimmermann","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1530\/EJE-16-0354","article-title":"Management of endocrine disease: Isolated maternal hypothyroxinemia during pregnancy: Knowns and unknowns","volume":"176","author":"Dosiou","year":"2017","journal-title":"Eur. J. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1184747","DOI":"10.3389\/fendo.2023.1184747","article-title":"Urinary iodine concentration and its associations with thyroid function in pregnant women of Shanghai","volume":"14","author":"Wu","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000365145","article-title":"Challenges in the evaluation of urinary iodine status in pregnancy: The importance of iodine supplement intake and time of sampling","volume":"3","author":"Andersen","year":"2014","journal-title":"Eur. Thyroid J."},{"key":"ref_29","first-page":"B5074","article-title":"Iodine status in pregnant and breastfeeding women: A Danish regional investigation","volume":"62","author":"Andersen","year":"2015","journal-title":"Dan. Med. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1365-2265.2007.02928.x","article-title":"Assessment of intertrimester and seasonal variations of urinary iodine concentration during pregnancy in an iodine-replete area","volume":"67","author":"Ainy","year":"2007","journal-title":"Clin. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1017\/S1368980007360989","article-title":"Iodine nutrition of pregnant and lactating women in Hong Kong, where intake is of borderline sufficiency","volume":"10","author":"Kung","year":"2007","journal-title":"Public Health Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4158\/EP.8.1.23","article-title":"Thyroid size and iodine intake in iodine-repleted pregnant women in Isfahan, Iran","volume":"8","author":"Rezvanian","year":"2002","journal-title":"Endocr. Pract."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.endonu.2012.03.012","article-title":"Changes in iodine nutrition status in schoolchildren from the Basque Country","volume":"59","author":"Arrizabalaga","year":"2012","journal-title":"Endocrinol. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/16\/3555\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:31:52Z","timestamp":1760128312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/16\/3555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,11]]},"references-count":33,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["nu15163555"],"URL":"https:\/\/doi.org\/10.3390\/nu15163555","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,11]]}}}