{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:15:41Z","timestamp":1790705741259,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior-Brasil (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Hypovitaminosis D is a public health problem due to its implications for various diseases. Vitamin D has numerous functions, such as modulating the metabolism of cellular tissues, and it is expressed through the vitamin D receptor (VDR) gene that may influence gene expression modulation, which plays an important role in vitamin D metabolism. Objective: To evaluate the effect of the genotypes of BsmI single nucleotide polymorphism (SNP) of the VDR gene on VDR, SOD2, and CYP24A1 gene expression in individuals with low serum vitamin D levels. Methods: This was a cross-sectional analytical study. After signing the informed consent form, individuals were invited to participate and answered a structured questionnaire with identification data. Blood was collected for biochemical analysis, and vitamin D was measured by chemiluminescence; BsmI polymorphism was determined using real-time polymerase chain reaction (PCR) assays with TaqMan allelic discrimination, and gene expression was conducted by qRT-PCR using QuantiFast SYBR\u00ae Green PCR Master Mix. Data were analyzed using the SPSS 20.0 software, and differences were considered significant at p &lt; 0.05. Results: 98 individuals with vitamin D \u2264 20 ng\/dL were evaluated, and the BsmI SNP of the VDR gene showed CYP24A1 overexpression and low SOD2 expression. Conclusion: BsmI SNP of the VDR gene can modulate the expression of the genes evaluated without interfering with serum levels.<\/jats:p>","DOI":"10.3390\/nu15163565","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T10:40:31Z","timestamp":1692009631000},"page":"3565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["VDR, SOD-2, and CYP24A1 Gene Expression in Different Genotypes of BsmI SNP of the Vitamin D Receptor Gene in Individuals with Hypovitaminosis"],"prefix":"10.3390","volume":"15","author":[{"given":"Vanessa Rosa","family":"Retamoso","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biochemistry, Federal University of Pampa e Campus Uruguaiana, BR 472-Km 592-Mailbox 118, Uruuguaiana 97508-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-7047","authenticated-orcid":false,"given":"Fernanda","family":"Barbisan","sequence":"additional","affiliation":[{"name":"Pharmacy Department and Post Graduation in Gerontology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziele Meira","family":"Moro","sequence":"additional","affiliation":[{"name":"Pharmacy Department and Post Graduation in Gerontology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Maurer","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biochemistry, Federal University of Pampa e Campus Uruguaiana, BR 472-Km 592-Mailbox 118, Uruuguaiana 97508-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Vasquez","family":"Rubio","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biochemistry, Federal University of Pampa e Campus Uruguaiana, BR 472-Km 592-Mailbox 118, Uruuguaiana 97508-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren Flores Viera","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Physiotherapy Course, Federal University of Pampa e Campus Uruguaiana, BR 472-Km 592-Mailbox 118, Uruguaiana 97508-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyana Berro","family":"Feij\u00f3o","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biochemistry, Federal University of Pampa e Campus Uruguaiana, BR 472-Km 592-Mailbox 118, Uruuguaiana 97508-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5578-4656","authenticated-orcid":false,"given":"Matias Nunes","family":"Frizzo","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Northwest Regional University (Unijui), R. do Com\u00e9rcio, 3000-Universit\u00e1rio, Iju\u00ed 98700-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3008-6899","authenticated-orcid":false,"given":"Ivana Beatrice","family":"M\u00e2nica da Cruz","sequence":"additional","affiliation":[{"name":"Pharmacy Department and Post Graduation in Gerontology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanusa","family":"Manfredini","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biochemistry, Federal University of Pampa e Campus Uruguaiana, BR 472-Km 592-Mailbox 118, Uruuguaiana 97508-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Let\u00edcia Vargas","family":"Barcelos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biochemistry, Federal University of Pampa e Campus Uruguaiana, BR 472-Km 592-Mailbox 118, Uruuguaiana 97508-000, RS, Brazil"},{"name":"Nutrition Course, Federal University of Pampa, Campus Itaqui, Road Luiz Joaquim de S\u00e1 Brito, Itaqui 97650-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline da Costa Escobar","family":"Piccoli","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biochemistry, Federal University of Pampa e Campus Uruguaiana, BR 472-Km 592-Mailbox 118, Uruuguaiana 97508-000, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1007\/s11033-019-05088-9","article-title":"The effects of serum levels, and alterations in the genes of binding protein and receptor of vitamin D on gastric c\u00e2ncer","volume":"46","author":"Durak","year":"2019","journal-title":"Mol. 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