{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:42:53Z","timestamp":1788414173326,"version":"build-2803163510"},"reference-count":50,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T00:00:00Z","timestamp":1692489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 University Funding","doi-asserted-by":"publisher","award":["UFF 89\/441-176"],"award-info":[{"award-number":["UFF 89\/441-176"]}],"id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin","award":["UFF 89\/441-176"],"award-info":[{"award-number":["UFF 89\/441-176"]}]},{"name":"the German Research Foundation (DFG)","award":["UFF 89\/441-176"],"award-info":[{"award-number":["UFF 89\/441-176"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Human genetic studies have associated Neuronatin gene variants with anorexia nervosa (AN) and obesity. Studies on the expression of the Neuronatin gene product, a proteolipid, are lacking. We investigated the relationship between circulating Neuronatin, body mass index (BMI), body composition (BC), physical activity (PA), and psychometric outcomes in patients with AN, normal weight, and obesity. Plasma Neuronatin was measured by ELISA in (1) 79 subjects of five BMI categories (AN\/BMI &lt; 17.5 kg\/m2; normal weight\/BMI 18.5\u201325 kg\/m2; obesity\/BMI 30\u201340 kg\/m2; obesity\/BMI 40\u201350 kg\/m2; obesity\/BMI &gt; 50 kg\/m2) with assessment of BC (bioimpedance analysis; BIA); (2) 49 women with AN (BMI 14.5 \u00b1 1.8 kg\/m2) with measurements of BC (BIA) and PA (accelerometry); (3) 79 women with obesity (BMI 48.8 \u00b1 7.8 kg\/m2) with measurements of anxiety (GAD-7), stress (PSQ-20), depression (PHQ-9) and eating behavior (EDI-2). Overall, a positive correlation was found between Neuronatin and BMI (p = 0.006) as well as total fat mass (FM; p = 0.036). In AN, Neuronatin did not correlate with BMI, FM, or PA (p &gt; 0.05); no correlations were found between Neuronatin and psychometric outcomes in obesity (p &gt; 0.05). The findings suggest an FM-dependent peripheral Neuronatin expression. The decreased Neuronatin expression in AN provides evidence that Neuronatin is implicated in the pathogenesis of eating disorders.<\/jats:p>","DOI":"10.3390\/nu15163657","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:46:56Z","timestamp":1692582416000},"page":"3657","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Circulating Neuronatin Levels Are Positively Associated with BMI and Body Fat Mass but Not with Psychological Parameters"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6178-0870","authenticated-orcid":false,"given":"Amelie","family":"Rudolph","sequence":"first","affiliation":[{"name":"Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Stengel","sequence":"additional","affiliation":[{"name":"Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 12203 Berlin, Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy, University Hospital T\u00fcbingen, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-3521","authenticated-orcid":false,"given":"Maria","family":"Suhs","sequence":"additional","affiliation":[{"name":"Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5621-3561","authenticated-orcid":false,"given":"Selina","family":"Schaper","sequence":"additional","affiliation":[{"name":"Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"W\u00f6lk","sequence":"additional","affiliation":[{"name":"Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Rose","sequence":"additional","affiliation":[{"name":"Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 12203 Berlin, Germany"},{"name":"Quantitative Health Sciences, Outcomes Measurement Science, University of Massachusetts Medical School, Worcester, MA 01655, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4002-3552","authenticated-orcid":false,"given":"Tobias","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Center for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, 12203 Berlin, Germany"},{"name":"Department of Psychosomatic Medicine, DRK Kliniken Berlin Wiegmann Klinik, 14050 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.mam.2012.06.009","article-title":"The role of imprinted genes in humans","volume":"34","author":"Ishida","year":"2013","journal-title":"Mol. 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