{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:12:57Z","timestamp":1790611977112,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD)\u2014a new definition for non-alcoholic fatty liver disease\u2014reflects the impact of metabolic abnormalities on liver function. We assessed the diagnostic accuracy of biomarker-based scores for prediction of MAFLD in apparently healthy children. Methods: This study included 144 children aged 9\u201311. MAFLD was recognized in 14 girls and 29 boys. Anthropometric indices, glycemia, insulin resistance, lipid profile, enzymes (ALT, AST, GGT, ALP), CRP, N-terminal propeptide of type I procollagen (P1NP) and collagen type I C-telopeptide (CTX-1) levels were measured. Fatty liver and hepatic steatosis index (FLI, HSI) and potential indicators of liver fibrogenesis: P1NP\/ALP, P1NP\/ALPxALT, P1NP\/ALPxCRP were calculated. Results: P1NP\/ALPxALT and P1NP\/ALPxCRP were significantly higher in subjects with MAFLD. FLI was a good, significant predictor of MAFLD occurrence, regardless of sex. In boys, P1NP\/ALPxCRP was a comparable predictor as CRP (OR 1.14 vs. 1.17; p &lt; 0.001). P1NP\/ALPxCRP had better discrimination capability in boys (AUC = 0.79; p &lt; 0.001). However, the use of this algorithm did not improve discriminatory power in comparison to CRP (AUC = 0.81; p &lt; 0.001), but gave a better sensitivity for MAFLD prediction (86% vs. 59%). Conclusions: We suggest that P1NP\/ALPXCRP is a reliable tool for MAFLD prediction in routine pediatric practice.<\/jats:p>","DOI":"10.3390\/nu15163667","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:46:22Z","timestamp":1692665182000},"page":"3667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic Performance of Biomarker-Based Scores as Predictors of Metabolic Dysfunction-Associated Fatty Liver Disease Risk in Healthy Children"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-0325","authenticated-orcid":false,"given":"Katarzyna","family":"Bergmann","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5295-2236","authenticated-orcid":false,"given":"Anna","family":"Stefanska","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Krintus","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Szternel","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech J.","family":"Bilinski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, KoMed Poddebice Health Center, 99-200 Poddebice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemyslaw T.","family":"Paradowski","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences, Division of Orthopaedics, Sunderby Research Unit, Ume\u00e5 University, 971 80 Lule\u00e5, Sweden"},{"name":"Clinical Epidemiology Unit, Orthopedics, Department of Clinical Sciences Lund, Lund University, 223 62 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-7073","authenticated-orcid":false,"given":"Grazyna","family":"Sypniewska","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S2468-1253(21)00183-7","article-title":"Defining Paediatric Metabolic (Dysfunction)-Associated Fatty Liver Disease: An International Expert Consensus Statement","volume":"6","author":"Eslam","year":"2021","journal-title":"Lancet Gastroenterol. 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