{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:45:22Z","timestamp":1790898322815,"version":"4.1.0"},"reference-count":157,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["143325"],"award-info":[{"award-number":["143325"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Despite the growing recognition of the obesity crisis, its rates continue to rise. The current first-line therapies, such as dietary changes, energy restriction, and physical activity, are typically met with poor adherence. Novel nutritional interventions can address the root causes of obesity, including mitochondrial dysfunction, and facilitate weight loss. Objective: The objective of this study was to investigate the effects of a multi-ingredient nutritional supplement designed to facilitate mitochondrial function and metabolic health outcomes over a 12 wk period. Methods: Fifty-five overweight and\/or obese participants (age (mean \u00b1 SEM): 26 \u00b1 1; body mass index (BMI) (kg\/m2): 30.5 \u00b1 0.6) completed this double-blind, placebo-controlled clinical trial. Participants were randomized to 12 wks of daily consumption of multi-ingredient supplement (MIS; n = 28; containing 50 mg forskolin, 500 mg green coffee bean extract, 500 mg green tea extract, 500 mg beet root extract, 400 mg \u03b1-lipoic acid, 200 IU vitamin E, and 200 mg CoQ10) or control placebo (PLA, n = 27; containing microcrystalline cellulose) matched in appearance. The co-primary outcomes were bodyweight and fat mass (kg) changes. The secondary outcomes included other body composition measures, plasma markers of obesity, fatty liver disease biomarkers, resting energy metabolism, blood pressure, physical performance, and quality of life. The post-intervention differences between MIS and PLA were examined via ANCOVA which was adjusted for the respective pre-intervention variables. Results: After adjustment for pre-intervention data, there was a significant difference in weight (p &lt; 0.001) and fat mass (p &lt; 0.001) post-intervention between the PLA and MIS treatment arms. Post-intervention weight and fat mass were significantly lower in MIS. Significant post-intervention differences corrected for baseline were found in markers of clinical biochemistry (AST, p = 0.017; ALT, p = 0.008), molecular metabolism (GDF15, p = 0.028), and extracellular vesicle-associated miRNA species miR-122 and miR-34a in MIS (p &lt; 0.05). Conclusions: Following the 12 wks of MIS supplementation, weight and body composition significantly improved, concomitant with improvements in molecular markers of liver health and metabolism.<\/jats:p>","DOI":"10.3390\/nu15173693","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:23:40Z","timestamp":1692872620000},"page":"3693","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial"],"prefix":"10.3390","volume":"15","author":[{"given":"Joshua P.","family":"Nederveen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Health Sciences, McMaster University Medical Center (MUMC), Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Mastrolonardo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Health Sciences, McMaster University Medical Center (MUMC), Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Xhuti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Health Sciences, McMaster University Medical Center (MUMC), Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Di Carlo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Health Sciences, McMaster University Medical Center (MUMC), Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Manta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Health Sciences, McMaster University Medical Center (MUMC), Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Fuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Health Sciences, McMaster University Medical Center (MUMC), Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-3746","authenticated-orcid":false,"given":"Mark A.","family":"Tarnopolsky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Health Sciences, McMaster University Medical Center (MUMC), Hamilton, ON L8N 3Z5, Canada"},{"name":"Exerkine Corporation, McMaster University Medical Center (MUMC), Hamilton, ON L8N 3Z5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.metabol.2018.09.005","article-title":"The epidemiology of obesity","volume":"92","author":"Chooi","year":"2019","journal-title":"Metabolism"},{"key":"ref_2","unstructured":"Hales, C.M., Carroll, M.D., Fryar, C.D., and Ogden, C.L. (2017). Prevalence of Obesity and Severe Obesity among Adults: United States, 2017\u20132018 Key Findings Data from the National Health and Nutrition Examination Survey, Centers for Disease Control and Prevention."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1016\/S0140-6736(14)61744-X","article-title":"Patchy progress on obesity prevention: Emerging examples, entrenched barriers, and new thinking","volume":"385","author":"Roberto","year":"2015","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(16)30054-X","article-title":"Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants","volume":"387","author":"Bentham","year":"2016","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Afshin","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.24095\/hpcdp.35.7.02","article-title":"Trends and projections of obesity among Canadians","volume":"35","author":"Bancej","year":"2015","journal-title":"Health Promot. Chronic Dis. Prev. Can."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1001\/jama.2016.6458","article-title":"Trends in obesity among adults in the United States, 2005 to 2014","volume":"315","author":"Flegal","year":"2016","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1001\/jama.1995.03520300035033","article-title":"Weight, weight change, and coronary heart disease in women. Risk within the \u201cnormal\u201d weight range","volume":"273","author":"Willett","year":"1995","journal-title":"JAMA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1056\/NEJM199509143331101","article-title":"Body Weight and Mortality among Women","volume":"333","author":"Manson","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3102\/00346543066004543","article-title":"Self-Efficacy Beliefs in Academic Settings","volume":"66","author":"Pajares","year":"1996","journal-title":"Rev. Educ. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults","volume":"348","author":"Calle","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/S0140-6736(05)67663-5","article-title":"Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: A case-control study","volume":"366","author":"Yusuf","year":"2005","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.pop.2009.04.005","article-title":"Obesity and Cancer","volume":"36","author":"Brawer","year":"2009","journal-title":"Prim. Care Clin. Off. Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.metabol.2014.09.012","article-title":"From farm to fat cell: Why aren\u2019t we all fat?","volume":"64","author":"Bray","year":"2015","journal-title":"Metabolism"},{"key":"ref_16","first-page":"7","article-title":"Physical Activity of Canadian Adults:Accelerometer Results from the 2007 to 2009 Canadian Health Measures Survey","volume":"22","author":"Colley","year":"2011","journal-title":"Health Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1746-1561.1989.tb04689.x","article-title":"Perceived barriers to exercise among adolescents","volume":"59","author":"Tappe","year":"1989","journal-title":"J. Sch. Health"},{"key":"ref_18","first-page":"CD007145","article-title":"Diet or exercise, or both, for preventing excessive weight gain in pregnancy","volume":"2015","author":"Muktabhant","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_19","first-page":"fdw038","article-title":"Perceived barriers towards healthy eating and their association with fruit and vegetable consumption","volume":"39","author":"Ludbrook","year":"2016","journal-title":"J. Public Health"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e330","DOI":"10.1016\/j.orcp.2013.05.004","article-title":"Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer","volume":"7","author":"Matsuda","year":"2013","journal-title":"Obes. Res. Clin. Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s13105-012-0154-2","article-title":"Oxidative stress and inflammation interactions in human obesity","volume":"68","author":"Ryan","year":"2012","journal-title":"J. Physiol. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1002\/oby.21654","article-title":"Reactive Oxygen Species and Oxidative Stress in Obesity\u2014Recent Findings and Empirical Approaches","volume":"24","author":"McMurray","year":"2016","journal-title":"Obesity"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.14336\/AD.2014.0305","article-title":"Metabolic syndrome, aging and involvement of oxidative stress","volume":"6","author":"Bonomini","year":"2015","journal-title":"Aging Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1074\/jbc.M411863200","article-title":"The hyperglycemia-induced inflammatory response in adipocytes: The role of reactive oxygen species","volume":"280","author":"Lin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"E295","DOI":"10.1152\/ajpendo.00044.2003","article-title":"Increased glucose uptake promotes oxidative stress and PKC-\u03b4 activation in adipocytes of obese, insulin-resistant mice","volume":"285","author":"Talior","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.3389\/fphys.2014.00352","article-title":"Reactive oxygen species at the crossroads of inflammasome and inflammation","volume":"5","author":"Harijith","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1210\/jc.2007-0955","article-title":"Low-grade inflammation, obesity, and insulin resistance in adolescents","volume":"92","author":"Herder","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1600-065X.2012.01151.x","article-title":"The inflammation highway: Metabolism accelerates inflammatory traffic in obesity","volume":"249","author":"Johnson","year":"2012","journal-title":"Immunol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12263-017-0577-z","article-title":"Role of microRNAs in obesity and obesity-related diseases","volume":"12","author":"Iacomino","year":"2017","journal-title":"Genes Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41574-019-0260-0","article-title":"The clinical potential of circulating microRNAs in obesity","volume":"15","author":"Ji","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Landrier, J.F., Derghal, A., and Mounien, L. (2019). MicroRNAs in Obesity and Related Metabolic Disorders. Cells, 8.","DOI":"10.3390\/cells8080859"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"27066","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Siljander","year":"2015","journal-title":"J. Extracell. Vesicles"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3389\/fcell.2021.651996","article-title":"Exosomes and Obesity-Related Insulin Resistance","volume":"9","author":"Lei","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Kim, A., Shah, A., and Nakamura, T. (2018). Extracellular Vesicles: A Potential Novel Regulator of Obesity and Its Associated Complications. Children, 5.","DOI":"10.3390\/children5110152"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.mito.2011.03.122","article-title":"Coenzyme Q10: A novel therapeutic approach for Fibromyalgia? Case series with 5 patients","volume":"11","author":"Cordero","year":"2011","journal-title":"Mitochondrion"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1002\/fsn3.1492","article-title":"The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials","volume":"8","author":"Sangsefidi","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000046879","article-title":"Vitamin E Regulation of Mitochondrial Superoxide Generation","volume":"10","author":"Chow","year":"2001","journal-title":"Neurosignals"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/oby.21135","article-title":"Vitamin E reduces adipose tissue fibrosis, inflammation, and oxidative stress and improves metabolic profile in obesity","volume":"23","author":"Sevillano","year":"2015","journal-title":"Obesity"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/iub.2008","article-title":"Vitamin E: Regulatory Redox Interactions","volume":"71","author":"Miyazawa","year":"2019","journal-title":"IUBMB Life"},{"key":"ref_40","first-page":"139","article-title":"Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise","volume":"60","author":"Szygula","year":"2009","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.clnu.2009.01.017","article-title":"Alpha-lipoic acid modifies oxidative stress parameters in sickle cell trait subjects and sickle cell patients","volume":"28","author":"Martins","year":"2009","journal-title":"Clin. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cmet.2011.01.004","article-title":"Dietary inorganic nitrate improves mitochondrial efficiency in humans","volume":"13","author":"Larsen","year":"2011","journal-title":"Cell Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.3390\/nu7042801","article-title":"The potential benefits of red beetroot supplementation in health and disease","volume":"7","author":"Clifford","year":"2015","journal-title":"Nutrients"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1017\/jns.2014.7","article-title":"Effects of a beetroot juice with high neobetanin content on the early-phase insulin response in healthy volunteers","volume":"3","author":"Brandt","year":"2014","journal-title":"J. Nutr. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10487","DOI":"10.1021\/jf8017172","article-title":"In vitro digestion of betalainic foods. Stability and bioaccessibility of betaxanthins and betacyanins and antioxidative potential of food digesta","volume":"56","author":"Tesoriere","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/oby.2005.162","article-title":"Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men","volume":"13","author":"Godard","year":"2005","journal-title":"Obes. Res."},{"key":"ref_47","first-page":"109","article-title":"Forskolin as an activator of cyclic AMP accumulation and lipolysis in rat adipocytes","volume":"22","author":"Litosch","year":"1982","journal-title":"Mol. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1177\/147323000703500620","article-title":"The Effect of Chlorogenic Acid Enriched Coffee on Glucose Absorption in Healthy Volunteers and Its Effect on Body Mass When Used Long-term in Overweight and Obese People","volume":"35","author":"Thom","year":"2007","journal-title":"J. Int. Med. Res."},{"key":"ref_49","first-page":"482704","article-title":"Consumption of Green Coffee Reduces Blood Pressure and Body Composition by Influencing 11 \u03b2-HSD1 Enzyme Activity in Healthy Individuals: A Pilot Crossover Study Using Green and Black Coffee","volume":"2014","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/ejcn.2014.143","article-title":"The anti-obesity effects of green tea in human intervention and basic molecular studies","volume":"68","author":"Huang","year":"2014","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41367-019-0007-3","article-title":"Nutritionist and obesity: Brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements","volume":"9","author":"Barrea","year":"2019","journal-title":"Int. J. Obes. Suppl."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Nederveen, J.P., Manta, K., Bujak, A.L., Simone, A.C., Fuda, M.R., Nilsson, M.I., Hettinga, B.P., Hughes, M.C., Perry, C.G.R., and Tarnopolsky, M.A. (2021). A Novel Multi-Ingredient Supplement Activates a Browning Program in White Adipose Tissue and Mitigates Weight Gain in High-Fat Diet-Fed Mice. Nutrients, 13.","DOI":"10.3390\/nu13113726"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/ajcn\/68.4.899","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: Executive summary","volume":"68","author":"Becker","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1467-789X.2011.00952.x","article-title":"Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: Systematic review and meta-analysis","volume":"13","author":"Ashwell","year":"2012","journal-title":"Obes. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/eurheartj\/ehm026","article-title":"Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: Meta-regression analysis of prospective studies","volume":"28","author":"Merchant","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bmj.305.6846.160","article-title":"Validating the SF-36 health survey questionnaire: New outcome measure for primary care","volume":"305","author":"Brazier","year":"1992","journal-title":"Br. Med. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0197-2456(02)00242-8","article-title":"The method of minimization for allocation to clinical trials: A review","volume":"23","author":"Scott","year":"2002","journal-title":"Control. Clin. Trials"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1136\/bmj.330.7495.843","article-title":"Treatment allocation by minimisation","volume":"330","author":"Altman","year":"2005","journal-title":"BMJ"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1139\/H11-009","article-title":"New Canadian physical activity guidelines","volume":"36","author":"Tremblay","year":"2011","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ejcn.2009.139","article-title":"Body fat distribution and noncommunicable diseases in populations: Overview of the 2008 WHO Expert Consultation on Waist Circumference and Waist-Hip Ratio","volume":"64","author":"Nishida","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1385\/JCD:6:2:75","article-title":"Clinical applications of body composition measurements using DXA","volume":"6","author":"Albanese","year":"2003","journal-title":"J. Clin. Densitom."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1152\/jappl.1997.83.2.623","article-title":"In vivo validation of whole body composition estimates from dual-energy X-ray absorptiometry","volume":"83","author":"Prior","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4103\/2230-8210.109659","article-title":"Dual energy X-ray absorptiometry: Pitfalls in measurement and interpretation of bone mineral density","volume":"17","author":"Garg","year":"2013","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1590\/S0004-28032010000200009","article-title":"Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals","volume":"47","author":"Salgado","year":"2010","journal-title":"Arq. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1949.sp004363","article-title":"New methods for calculating metabolic rate with special reference to protein metabolism","volume":"109","author":"Weir","year":"1949","journal-title":"J. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0026-0495(88)90110-2","article-title":"The theoretical bases of indirect calorimetry: A review","volume":"37","author":"Ferrannini","year":"1988","journal-title":"Metabolism"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/ajcn\/51.2.241","article-title":"A new predictive equation for resting energy expenditure in healthy individuals","volume":"51","author":"Mifflin","year":"1990","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/ajcn\/88.4.959","article-title":"Validity of predictive equations for resting energy expenditure in US and Dutch overweight and obese class I and II adults aged 18\u201365 y","volume":"88","author":"Weijs","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/S0002-8223(03)00982-9","article-title":"Validation of several established equations for resting metabolic rate in obese and nonobese people","volume":"103","author":"Frankenfield","year":"2003","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"205031211667172","DOI":"10.1177\/2050312116671725","article-title":"SF-36 total score as a single measure of health-related quality of life: Scoping review","volume":"4","author":"Lins","year":"2016","journal-title":"SAGE Open Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3109\/07853890109002089","article-title":"The RAND-36 measure of health-related quality of life","volume":"33","author":"Hays","year":"2001","journal-title":"Ann. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med. Care"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1477-7525-4-43","article-title":"Health-related quality of life following a clinical weight loss intervention among overweight and obese adults: Intervention and 24 month follow-up effects","volume":"4","author":"Blissmer","year":"2006","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"412379","DOI":"10.1155\/2013\/412379","article-title":"Effectiveness of green tea in a randomized human cohort: Relevance to diabetes and its complications","volume":"2013","author":"Toolsee","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/obr.12406","article-title":"A systematic review and meta-analysis on the effects of exercise training versus hypocaloric diet: Distinct effects on body weight and visceral adipose tissue","volume":"17","author":"Verheggen","year":"2016","journal-title":"Obes. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Elobeid, M.A., Padilla, M.A., McVie, T., Thomas, O., Brock, D.W., Musser, B., Lu, K., Coffey, C.S., Desmond, R.A., and St-Onge, M.P. (2009). Missing data in randomized clinical trials for weight loss: Scope of the problem, state of the field, and performance of statistical methods. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006624"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"The Emerging Risk Factors Collaboration, Wormser, D., Kaptoge, S., Di Angelantonio, E., Wood, A.M., Pennells, L., Thompson, A., Sarwar, N., Kizer, J.R., and Lawlor, D.A. (2011). Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: Collaborative analysis of 58 prospective studies. Lancet, 377, 1085\u20131095.","DOI":"10.1016\/S0140-6736(11)60105-0"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0140-6736(09)60318-4","article-title":"Body-mass index and cause-specific mortality in 900,000 adults: Collaborative analyses of 57 prospective studies","volume":"373","author":"MacMahon","year":"2009","journal-title":"Lancet"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/s41366-022-01165-5","article-title":"Body fat and risk of all-cause mortality: A systematic review and dose-response meta-analysis of prospective cohort studies","volume":"46","author":"Jayedi","year":"2022","journal-title":"Int. J. Obes."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1016\/j.jacc.2013.11.004","article-title":"2013 AHA\/ACC\/TOS guideline for the management of overweight and obesity in adults: A report of the American college of cardiology\/American heart association task force on practice guidelines and the obesity society","volume":"63","author":"Jensen","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/sj.ijo.0803483","article-title":"Changes in fat-free mass during significant weight loss: A systematic review","volume":"31","author":"Chaston","year":"2007","journal-title":"Int. J. Obes."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2337\/dc14-1630","article-title":"Weight management in type 2 diabetes: Current and emerging approaches to treatment","volume":"38","author":"Scheen","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S2213-8587(17)30013-X","article-title":"Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): A double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial","volume":"5","author":"Sorli","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2147\/DMSO.S184437","article-title":"Canagliflozin review\u2014Safety and efficacy profile in patients with T2DM","volume":"12","author":"Jakher","year":"2019","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00125-019-05065-8","article-title":"Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: A substudy of the SUSTAIN 8 randomised controlled clinical trial","volume":"63","author":"McCrimmon","year":"2020","journal-title":"Diabetologia"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJMoa2032183","article-title":"Once-Weekly Semaglutide in Adults with Overweight or Obesity","volume":"384","author":"Wilding","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/1573399816666200705210006","article-title":"Effects of Antidiabetic Drugs on Muscle Mass in Type 2 Diabetes Mellitus","volume":"17","author":"Ida","year":"2020","journal-title":"Curr. Diabetes Rev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/jcsm.12434","article-title":"Amelioration of muscle wasting by glucagon-like peptide-1 receptor agonist in muscle atrophy","volume":"10","author":"Hong","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"92","DOI":"10.7326\/0003-4819-133-2-200007180-00008","article-title":"Reduction in Obesity and Related Comorbid Conditions after Diet-Induced Weight Loss or Exercise-Induced Weight Loss in Men","volume":"133","author":"Ross","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/ajcn\/84.3.475","article-title":"The underappreciated role of muscle in health and disease","volume":"84","author":"Wolfe","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1038\/oby.2009.224","article-title":"Relationship between body fat mass and free fatty acid kinetics in men and women","volume":"17","author":"Mittendorfer","year":"2009","journal-title":"Obesity"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1096\/fj.201700158RR","article-title":"Pronounced energy restriction with elevated protein intake results in no change in proteolysis and reductions in skeletal muscle protein synthesis that are mitigated by resistance exercise","volume":"32","author":"Hector","year":"2018","journal-title":"FASEB J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1139\/apnm-2013-0433","article-title":"Effects of short-term energy deficit on muscle protein breakdown and intramuscular proteolysis in normal-weight young adults","volume":"39","author":"Carbone","year":"2014","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3945\/an.116.014506","article-title":"Preserving healthy muscle during weight loss","volume":"8","author":"Cava","year":"2017","journal-title":"Adv. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1093\/jn\/130.10.2409","article-title":"Effects of tea consumption nutrition health","volume":"130","author":"Yang","year":"2000","journal-title":"J. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1078\/0944-7113-00078","article-title":"Recent findings of green tea extract AR25 (exolise) and its activity for the treatment of obesity","volume":"9","author":"Chantre","year":"2002","journal-title":"Phytomedicine"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/ajcn\/81.1.122","article-title":"Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men","volume":"81","author":"Nagao","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/oby.2007.176","article-title":"A green tea extract high in catechins reduces body fat and cardiovascular risks in humans","volume":"15","author":"Nagao","year":"2007","journal-title":"Obesity"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"599","DOI":"10.5650\/jos.50.599","article-title":"Anti-obesity Effects of Tea Catechins in Humans","volume":"50","author":"Hase","year":"2001","journal-title":"J. Oleo Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/oby.2009.256","article-title":"Effects of catechin enriched green tea on body composition","volume":"18","author":"Wang","year":"2010","journal-title":"Obesity"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/sj.ijo.0801101","article-title":"Green tea and thermogenesis: Interactions between catechin-polyphenols, caffeine and sympathetic activity","volume":"24","author":"Dulloo","year":"2000","journal-title":"Int. J. Obes."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/ajcn\/70.6.1040","article-title":"Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans","volume":"70","author":"Dulloo","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BA20050064","article-title":"Novel inhibitors of fatty-acid synthase from green tea (Camellia sinensis Xihu Longjing) with high activity and a new reacting site","volume":"43","author":"Zhang","year":"2006","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1079\/BJN20051580","article-title":"Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females","volume":"94","author":"Diepvens","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1550-2783-2-2-54","article-title":"Effects of Coleus Forskohlii Supplementation on Body Composition and Hematological Profiles in Mildly Overweight Women","volume":"2","author":"Henderson","year":"2005","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/ptr.5583","article-title":"A Review of Natural Stimulant and Non-stimulant Thermogenic Agents","volume":"30","author":"Stohs","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/0974-8490.122916","article-title":"Effect of Coleus forskohliiextract on cafeteria diet-induced obesity in rats","volume":"6","author":"Shivaprasad","year":"2014","journal-title":"Pharmacogn. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"9508","DOI":"10.3390\/nu7115483","article-title":"Coleus forskohlii extract supplementation in conjunction with a hypocaloric diet reduces the risk factors of metabolic syndrome in overweight and obese subjects: A randomized controlled trial","volume":"7","author":"Loftus","year":"2015","journal-title":"Nutrients"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1021\/jf011702q","article-title":"Effect of roasting on the antioxidant activity of coffee brews","volume":"50","author":"Ames","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1006\/abbi.1996.9874","article-title":"Chlorogenic acid and hydroxynitrobenzaldehyde: New inhibitors of hepatic glucose 6-phosphatase","volume":"339","author":"Arion","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Shimoda, H., Seki, E., and Aitani, M. (2006). Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement. Altern. Med., 6.","DOI":"10.1186\/1472-6882-6-9"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/mus.20688","article-title":"Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders","volume":"35","author":"Rodriguez","year":"2007","journal-title":"Muscle Nerve"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.freeradbiomed.2007.03.024","article-title":"Vitamin E, antioxidant and nothing more","volume":"43","author":"Traber","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Alcala, M., Calderon-Dominguez, M., Serra, D., Herrero, L., Ramos, M.P., and Viana, M. (2017). Short-term vitamin E treatment impairs reactive oxygen species signaling required for adipose tissue expansion, resulting in fatty liver and insulin resistance in obese mice. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186579"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"840","DOI":"10.2174\/138161210790883589","article-title":"\u03b1-Lipoic Acid Supplementation: A Tool for Obesity Therapy?","volume":"16","author":"Carbonelli","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Salehi, B., Berkay Y\u0131lmaz, Y., Antika, G., Boyunegmez Tumer, T., Fawzi Mahomoodally, M., Lobine, D., Akram, M., Riaz, M., Capanoglu, E., and Sharopov, F. (2019). Insights on the use of \u03b1-lipoic acid for therapeutic purposes. Biomolecules, 9.","DOI":"10.3390\/biom9080356"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.bbagen.2009.07.026","article-title":"Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential","volume":"1790","author":"Shay","year":"2009","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.jnutbio.2011.12.004","article-title":"Plasma total antioxidant capacity is associated with dietary intake and plasma level of antioxidants in postmenopausal women","volume":"23","author":"Wang","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/10715760600617843","article-title":"Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics","volume":"40","author":"Bhagavan","year":"2006","journal-title":"Free Radic. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease\u2014Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref_123","first-page":"817","article-title":"The past and present of serum aminotransferases and the future of liver injury biomarkers","volume":"15","author":"McGill","year":"2016","journal-title":"EXCLI J."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1038\/s41598-021-86216-z","article-title":"Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population","volume":"11","author":"Ali","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1053\/gast.2003.50004","article-title":"Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States","volume":"124","author":"Ruhl","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41430-022-01111-8","article-title":"Effect of intensive weight-loss intervention on metabolic, ultrasound and anthropometric parameters among patients with obesity and non-alcoholic fatty liver disease: An RCT","volume":"76","author":"Arora","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/ajcn\/87.5.1141","article-title":"Effect of a dietary-induced weight loss on liver enzymes in obese subjects","volume":"87","author":"Gasteyger","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41574-021-00529-7","article-title":"GDF15: Emerging biology and therapeutic applications for obesity and cardiometabolic disease","volume":"17","author":"Wang","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/liv.13587","article-title":"Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease","volume":"38","author":"Koo","year":"2018","journal-title":"Liver Int."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41387-022-00187-2","article-title":"Growth differentiation factor 15 (GDF15) is associated with non-alcoholic fatty liver disease (NAFLD) in youth with overweight or obesity","volume":"12","author":"Galuppo","year":"2022","journal-title":"Nutr. Diabetes"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41586-019-1911-y","article-title":"GDF15 mediates the effects of metformin on body weight and energy balance","volume":"578","author":"Coll","year":"2020","journal-title":"Nature"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/s42255-019-0146-4","article-title":"Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss","volume":"1","author":"Day","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-023-06249-4","article-title":"GDF15 promotes weight loss by enhancing energy expenditure in muscle","volume":"619","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.molmet.2017.12.016","article-title":"Exercise increases circulating GDF15 in humans","volume":"9","author":"Kleinert","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.2147\/DMSO.S302033","article-title":"Increased serum GDF15 related to improvement in metabolism by lifestyle intervention among young overweight and obese adults","volume":"14","author":"Cai","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes. Targets Ther."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1152\/physiol.00045.2018","article-title":"Extracellular Vesicles: Exosomes and Microvesicles, Integrators of Homeostasis","volume":"34","author":"Stahl","year":"2019","journal-title":"Physiology"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.3389\/fphys.2020.604274","article-title":"Extracellular Vesicles and Exosomes: Insights From Exercise Science","volume":"11","author":"Nederveen","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1083\/jcb.201703206","article-title":"Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling","volume":"217","author":"Verweij","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"563816","DOI":"10.3389\/fendo.2020.563816","article-title":"The Impact of Adipose Tissue\u2013Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer","volume":"11","author":"Heyn","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.taap.2012.04.018","article-title":"Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet","volume":"262","author":"Tryndyak","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cca.2013.05.021","article-title":"Associations between circulating microRNAs (miR-21, miR-34a, miR-122 and miR-451) and non-alcoholic fatty liver","volume":"424","author":"Yamada","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1530\/EJE-14-0867","article-title":"Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults","volume":"172","author":"Wang","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Povero, D., Eguchi, A., Li, H., Johnson, C.D., Papouchado, B.G., Wree, A., Messer, K., and Feldstein, A.E. (2014). Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113651"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1007\/s00535-016-1178-0","article-title":"A micro-RNA expression signature for human NAFLD progression","volume":"51","author":"Guo","year":"2016","journal-title":"J. Gastroenterol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e000096","DOI":"10.1136\/bmjgast-2016-000096","article-title":"Circulating miRNA in patients with non-alcoholic fatty liver disease and coronary artery disease","volume":"3","author":"Mehta","year":"2016","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.alit.2019.05.012","article-title":"Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study","volume":"69","author":"Sunadome","year":"2020","journal-title":"Allergol. Int."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.diabres.2006.02.001","article-title":"The association of total and differential white blood cell count with metabolic syndrome in type 2 diabetic patients","volume":"73","author":"Shim","year":"2006","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10157-012-0719-y","article-title":"Clinical features and long-term renal outcomes of Japanese patients with obesity-related glomerulopathy","volume":"17","author":"Tsuboi","year":"2013","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1046\/j.1523-1755.2001.0590041498.x","article-title":"Obesity-related glomerulopathy: An emerging epidemic","volume":"59","author":"Kambham","year":"2001","journal-title":"Kidney Int."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/aje\/kwr384","article-title":"Mortality prediction by surrogates of body composition: An examination of the obesity paradox in hemodialysis patients using composite ranking score analysis","volume":"175","author":"Streja","year":"2012","journal-title":"Am. J. Epidemiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1053\/j.ajkd.2008.03.003","article-title":"Overweight, Obesity, and the Development of Stage 3 CKD: The Framingham Heart Study","volume":"52","author":"Foster","year":"2008","journal-title":"Am. J. Kidney Dis."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"E38","DOI":"10.1161\/HYP.0000000000000202","article-title":"Weight-Loss Strategies for Prevention and Treatment of Hypertension: A Scientific Statement from the American Heart Association","volume":"78","author":"Hall","year":"2021","journal-title":"Hypertension"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/MNH.0000000000000212","article-title":"The dual roles of obesity in chronic kidney disease: A review of the current literature","volume":"25","author":"Rhee","year":"2016","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Stefansson, V.T.N., Schei, J., Jenssen, T.G., Melsom, T., and Eriksen, B.O. (2016). Central obesity associates with renal hyperfiltration in the non-diabetic general population: A cross-sectional study. BMC Nephrol., 17.","DOI":"10.1186\/s12882-016-0386-4"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1038\/ki.1996.265","article-title":"The hyperfiltration theory: A paradigm shift in nephrology","volume":"49","author":"Brenner","year":"1996","journal-title":"Kidney Int."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1097\/01.ASN.0000068462.38661.89","article-title":"The effects of weight loss on renal function in patients with severe obesity","volume":"14","author":"Chagnac","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1210\/jc.2008-2508","article-title":"Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution","volume":"94","author":"Gerchman","year":"2009","journal-title":"J. Clin. Endocrinol. 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