{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:40:58Z","timestamp":1776109258679,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The relationship between vitamin D deficiency and sensitivity to thyroid hormones was unclear. We aimed to explore the association of 25-hydroxyvitamin D (25(OH)D) levels with thyroid hormone sensitivity in euthyroid adults. A total of 3143 subjects were included. The serum 25(OH)D, free thyroxine (FT3), free thyrotropin (FT4), thyroid-stimulating hormone (TSH), and other clinical variables were measured. Vitamin D deficiency was defined as 25(OH)D &lt; 20 ng\/mL. Thyroid feedback quantile-based index (TFQI), parametric thyroid feedback quantile-based index (PTFQI), thyroid-stimulating hormone index (TSHI), thyrotrophic thyroxine resistance index (TT4RI), and FT3\/FT4 were calculated to assess thyroid hormone sensitivity. Results showed that 58.8% of the participants had vitamin D deficiency. They had significantly higher levels of triglyceride, insulin, FT3, FT4, TSH, TFQI, PTFQI, TSHI, and TT4RI and lower levels of high-density lipoprotein cholesterol than those with sufficient vitamin D (all p &lt; 0.05). Logistic regression analysis showed that the risk of impaired sensitivity to thyroid hormones evaluated by TFIQ, PTFQI, TSHI, and TT4RI increased by 68% (OR: 1.68; 95%CI: 1.45\u20131.95; and p &lt; 0.001), 70% (OR: 1.70; 95%CI: 1.46\u20131.97; and p &lt; 0.001), 66% (OR: 1.66; 95%CI: 1.43\u20131.92; and p &lt; 0.001), and 50% (OR: 1.50; 95%CI: 1.30\u20131.74; and p &lt; 0.001), respectively, in participants with vitamin D deficiency compared with those with sufficient vitamin D after adjusting for multiple confounders. In conclusion, in euthyroid populations, vitamin D deficiency was associated with impaired sensitivity to thyroid hormones.<\/jats:p>","DOI":"10.3390\/nu15173697","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:23:40Z","timestamp":1692872620000},"page":"3697","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vitamin D Deficiency Is Associated with Impaired Sensitivity to Thyroid Hormones in Euthyroid Adults"],"prefix":"10.3390","volume":"15","author":[{"given":"Liyuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Examination Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingru","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"An","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.beem.2011.06.007","article-title":"Worldwide vitamin D status","volume":"25","author":"Lips","year":"2011","journal-title":"Best Pract. 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