{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:58:54Z","timestamp":1776790734139,"version":"3.51.2"},"reference-count":67,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Long COVID is a recognized post-viral syndrome characterized by neurological, somatic and neuropsychiatric symptoms that might last for long time after SARS-CoV-2 infection. An ever-growing number of patients come to the observation of General Practitioners complaining of mild or moderate symptoms after the resolution of the acute infection. Nine General Practitioners from the Rome area (Italy) performed a retrospective analysis in order to evaluate the role of the supplementation with Palmitoylethanolamide co-ultramicronized with Luteolin (PEALUT) on neurologic and clinical symptoms reported by their patients after COVID-19 resolution. Supplementation with PEALUT helped to improve all patient-reported symptoms, especially pain, anxiety and depression, fatigue, brain fog, anosmia and dysgeusia, leading to an overall improvement in patients\u2019 health status. To our knowledge these are the first data presented on Long COVID patients collected in a territorial setting. Despite their preliminary nature, these results highlight the pathogenetic role of \u201cnon-resolving\u201d neuroinflammation in Long COVID development and consequently the importance of its control in the resolution of the pathology and put the focus on the General Practitioner as the primary figure for early detection and management of Long COVID syndrome in a real-life setting. Future randomized, controlled, perspective clinical trials are needed to confirm this preliminary observation.<\/jats:p>","DOI":"10.3390\/nu15173701","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:23:40Z","timestamp":1692872620000},"page":"3701","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["What Is the Role of Palmitoylethanolamide Co-Ultramicronized with Luteolin on the Symptomatology Reported by Patients Suffering from Long COVID? A Retrospective Analysis Performed by a Group of General Practitioners in a Real-Life Setting"],"prefix":"10.3390","volume":"15","author":[{"given":"Maurizio","family":"Pirro","sequence":"first","affiliation":[{"name":"Azienda Sanitaria Locale (ASL), Sistema Sanitario Regionale, 00012 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana","family":"Ferri","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Locale (ASL), Sistema Sanitario Regionale, 00012 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licia","family":"Piccioni","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Locale (ASL), Sistema Sanitario Regionale, 00012 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Bellucci","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Locale (ASL), Sistema Sanitario Regionale, 00012 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Bartolucci","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Locale (ASL), Sistema Sanitario Regionale, 00012 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Russo","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Locale (ASL), Sistema Sanitario Regionale, 00012 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Piga","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Locale (ASL), Sistema Sanitario Regionale, 00012 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola Lucia","family":"Ciaramaglia","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Locale (ASL), Sistema Sanitario Regionale, 00012 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Lucangeli","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Locale (ASL), Sistema Sanitario Regionale, 00012 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Russo","sequence":"additional","affiliation":[{"name":"Institute of Anaesthesiology and Reanimation, Catholic University of Sacred Heart, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-3690","authenticated-orcid":false,"given":"Salvatore","family":"Cuzzocrea","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8438-3480","authenticated-orcid":false,"given":"Maurizio","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Institute of Anaesthesiology and Reanimation, Catholic University of Sacred Heart, 00168 Rome, Italy"},{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy"},{"name":"Department of Clinical and Experimental Medicine, University of Messina, 98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/fampra\/cmab076","article-title":"Post-acute and Long COVID-19 symptoms in patients with mild diseases: A systematic review","volume":"39","author":"Lucassen","year":"2022","journal-title":"Fam. 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