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Recent studies have highlighted the potential role of selenium in ND pathogenesis, as it plays a vital role in maintaining cellular homeostasis and preventing oxidative damage. However, a comprehensive analysis of the association between selenium and NDs is still lacking. Method: Five public databases, namely PubMed, Web of Science, EMBASE, Cochrane and Clinical Trials, were searched in our research. Random model effects were chosen, and Higgins inconsistency analyses (I2), Cochrane\u2019s Q test and Tau2 were calculated to evaluate the heterogeneity. Result: The association of selenium in ND patients with Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington\u2019s disease (HD) was studied. A statistically significant relationship was only found for AD patients (SMD = \u22120.41, 95% CI (\u22120.64, \u22120.17), p &lt; 0.001), especially for erythrocytes. However, no significant relationship was observed in the analysis of the other four diseases. Conclusion: Generally, this meta-analysis indicated that AD patients are strongly associated with lower selenium concentrations compared with healthy people, which may provide a clinical reference in the future. However, more studies are urgently needed for further study and treatment of neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/nu15173706","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:23:40Z","timestamp":1692872620000},"page":"3706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Association of Selenium Levels with Neurodegenerative Disease: A Systemic Review and Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-3466","authenticated-orcid":false,"given":"Jiaxin","family":"Zhou","sequence":"first","affiliation":[{"name":"International School, Jinan University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine and Public Health, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Cao","sequence":"additional","affiliation":[{"name":"Center for Data Science, New York University, New York, NY 10011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyan","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"He","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8322-3290","authenticated-orcid":false,"given":"Chaoqun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Medicine, Jinan University, Guangzhou 510632, China"},{"name":"Disease Control and Prevention Institute, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1242\/dmm.030205","article-title":"Neurodegenerative disease: Models, mechanisms, and a new hope","volume":"10","author":"Gitler","year":"2017","journal-title":"Dis. 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