{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:59:17Z","timestamp":1791802757902,"version":"4.3.4"},"reference-count":150,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Modern Agro-industry Technology Research System of China","award":["CARS-34"],"award-info":[{"award-number":["CARS-34"]}]},{"name":"Modern Agro-industry Technology Research System of China","award":["22IRTSTHN022"],"award-info":[{"award-number":["22IRTSTHN022"]}]},{"name":"Science and Technology Innovation Team of Henan Province High Quality Forage and Animal Health","award":["CARS-34"],"award-info":[{"award-number":["CARS-34"]}]},{"name":"Science and Technology Innovation Team of Henan Province High Quality Forage and Animal Health","award":["22IRTSTHN022"],"award-info":[{"award-number":["22IRTSTHN022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>With the increasing prevalence of energy metabolism disorders such as diabetes, cardiovascular disease, obesity, and anorexia, the regulation of feeding has become the focus of global attention. The gastrointestinal tract is not only the site of food digestion and absorption but also contains a variety of appetite-regulating signals such as gut-brain peptides, short-chain fatty acids (SCFAs), bile acids (BAs), bacterial proteins, and cellular components produced by gut microbes. While the central nervous system (CNS), as the core of appetite regulation, can receive and integrate these appetite signals and send instructions to downstream effector organs to promote or inhibit the body\u2019s feeding behaviour. This review will focus on the gut-brain axis mechanism of feeding behaviour, discussing how the peripheral appetite signal is sensed by the CNS via the gut-brain axis and the role of the central \u201cfirst order neural nuclei\u201d in the process of appetite regulation. Here, elucidation of the gut-brain axis mechanism of feeding regulation may provide new strategies for future production practises and the treatment of diseases such as anorexia and obesity.<\/jats:p>","DOI":"10.3390\/nu15173728","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:33:09Z","timestamp":1692952389000},"page":"3728","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["The Mechanism of the Gut-Brain Axis in Regulating Food Intake"],"prefix":"10.3390","volume":"15","author":[{"given":"Shouren","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixi","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boshuai","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China"},{"name":"Henan Key Laboratory of Innovation and Utilization of Grassland Resources, Zhengzhou 450002, China"},{"name":"Henan Forage Engineering Technology Research Center, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defeng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China"},{"name":"Henan Key Laboratory of Innovation and Utilization of Grassland Resources, Zhengzhou 450002, China"},{"name":"Henan Forage Engineering Technology Research Center, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China"},{"name":"Henan Key Laboratory of Innovation and Utilization of Grassland Resources, Zhengzhou 450002, China"},{"name":"Henan Forage Engineering Technology Research Center, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China"},{"name":"Henan Key Laboratory of Innovation and Utilization of Grassland Resources, Zhengzhou 450002, China"},{"name":"Henan Forage Engineering Technology Research Center, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalei","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China"},{"name":"Henan Key Laboratory of Innovation and Utilization of Grassland Resources, Zhengzhou 450002, China"},{"name":"Henan Forage Engineering Technology Research Center, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450002, China"},{"name":"Henan Key Laboratory of Innovation and Utilization of Grassland Resources, Zhengzhou 450002, China"},{"name":"Henan Forage Engineering Technology Research Center, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.psyneuen.2014.05.016","article-title":"Chronic Variable Stress Improves Glucose Tolerance in Rats with Sucrose-Induced Prediabetes","volume":"47","author":"Packard","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.beem.2014.03.004","article-title":"Crosstalk between Gastrointestinal Neurons and the Brain in the Control of Food Intake","volume":"28","author":"Mithieux","year":"2014","journal-title":"Best Pract. 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