{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:59:26Z","timestamp":1783090766215,"version":"3.54.6"},"reference-count":181,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"WHO"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D deficiency is a global public health concern with significant implications for bone health and chronic disease prevention. Our aim was to summarize the evidence from Cochrane and other systematic reviews evaluating the benefits or harms of vitamin D fortification of staple foods for household use. In April 2023, we systematically searched Ovid MEDLINE, Embase, Epistemonikos and the Cochrane Database of Systematic Reviews for systematic reviews investigating the effects of vitamin D fortification of food in general populations of any age. We used Cochrane methodology and assessed the methodological quality of included studies using AMSTAR (A MeaSurement Tool to Assess Systematic Reviews). We assessed the degree of overlap among reviews. All outcomes included in systematic reviews were assessed. The protocol is registered in PROSPERO (registration number: CRD42023420991). We included 27 systematic reviews out of 5028 records for analysis. Overall, 11 out of 12 systematic reviews calculating pooled estimates reported a significant increase in serum 25(OH)D concentrations. The mean change in serum 25(OH)D concentrations per additional 100 units of vitamin D ranged from 0.7 to 10.8 nmol\/L. Fortification of food with vitamin D showed a reduction in the prevalence of vitamin D deficiency based on high-certainty evidence. Parathormone (PTH) levels were described to decrease, bone mineral density to increase, while the effects on other bone turnover markers were inconsistent. Fortification did not significantly impact most anthropometric parameters, but it seemed to positively influence lipid profiles. In summary, fortification of food with vitamin D results in a reduction of vitamin D deficiency and might increase serum 25(OH)D concentrations, to varying extents depending on the fortified vehicle and population characteristics. Additionally, fortification may have a positive impact on bone turnover and lipid metabolism but may only have a limited effect on anthropometric parameters.<\/jats:p>","DOI":"10.3390\/nu15173742","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:45:42Z","timestamp":1693194342000},"page":"3742","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Fortification of Staple Foods for Household Use with Vitamin D: An Overview of Systematic Reviews"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8132-6886","authenticated-orcid":false,"given":"Patrick Nyamemba","family":"Nyakundi","sequence":"first","affiliation":[{"name":"Department of Public Health Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Doctoral School of Health Sciences, Faculty of Health Sciences, University of P\u00e9cs, 7621 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"N\u00e9methn\u00e9 Kont\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Cochrane Hungary, Clinical Center of the University of P\u00e9cs, Medical School, University of P\u00e9cs, 7623 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1471-8182","authenticated-orcid":false,"given":"Luca","family":"J\u00e1romi","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Zand","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-4802","authenticated-orcid":false,"given":"Szimonetta","family":"Lohner","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Medical School, University of P\u00e9cs, 7624 P\u00e9cs, Hungary"},{"name":"Cochrane Hungary, Clinical Center of the University of P\u00e9cs, Medical School, University of P\u00e9cs, 7623 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1080S","DOI":"10.1093\/ajcn\/87.4.1080S","article-title":"Vitamin D deficiency: A worldwide problem with health consequences","volume":"87","author":"Holick","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jcot.2019.07.004","article-title":"Vitamin D for skeletal and non-skeletal health: What we should know","volume":"10","author":"Charoenngam","year":"2019","journal-title":"J. Clin. Orthop. Trauma"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Charoenngam, N., and Holick, M.F. (2020). Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients, 12.","DOI":"10.3390\/nu12072097"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0004-27302010000200014","article-title":"Nutritional aspects of the prevention and treatment of osteoporosis","volume":"54","author":"Peters","year":"2010","journal-title":"Arq. Bras. De Endocrinol. Metabol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1689S","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/nyas.12443","article-title":"Diet, sun, and lifestyle as determinants of vitamin D status","volume":"1317","author":"Lips","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3945\/ajcn.115.120873","article-title":"Vitamin D deficiency in Europe: Pandemic?","volume":"103","author":"Cashman","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4161\/derm.24494","article-title":"Sunlight and Vitamin D: A global perspective for health","volume":"5","author":"Wacker","year":"2013","journal-title":"Derm. -Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00198-009-0954-6","article-title":"Global vitamin D status and determinants of hypovitaminosis D","volume":"20","author":"Mithal","year":"2009","journal-title":"Osteoporos. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline","volume":"96","author":"Holick","year":"2011","journal-title":"Med. J. Clin. Endocrinol. Metab."},{"key":"ref_11","unstructured":"Del Valle, H., Yaktine, A., Taylor, C., and Ross, A. (2011). Dietary Reference Intakes for Calcium and Vitamin D, The National Academics Press."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/nyas.13968","article-title":"Global prevalence and disease burden of vitamin D deficiency: A roadmap for action in low- and middle-income countries","volume":"1430","author":"Roth","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e04547","DOI":"10.2903\/j.efsa.2016.4547","article-title":"Dietary Reference Values for Vitamin D","volume":"14","author":"Bresson","year":"2016","journal-title":"EFSA J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1210\/jc.2015-2175","article-title":"Global Consensus Recommendations on Prevention and Management of Nutritional Rickets","volume":"101","author":"Munns","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_15","unstructured":"Allen, L., De Benoist, B., Dary, O., and Hurrell, R. (2006). Guidelines on Food Fortification with Micronutrients, WHO."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00223-019-00559-4","article-title":"Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing","volume":"106","author":"Cashman","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3945\/ajcn.114.103689","article-title":"Standardizing 25-hydroxyvitamin D values from the Canadian Health Measures Survey","volume":"102","author":"Sarafin","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3945\/jn.115.227728","article-title":"National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite Concentrations Measured by Liquid Chromatography\u2013Tandem Mass Spectrometry in the US Population during 2007\u20132010","volume":"146","author":"Schleicher","year":"2016","journal-title":"J. Nutr."},{"key":"ref_19","first-page":"59","article-title":"The burden of vitamin D deficiency in a mediterranean country without a policy of food fortification","volume":"86","author":"Lippi","year":"2015","journal-title":"Acta Bio-Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: An update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2340\/00015555-0980","article-title":"Factors Influencing Vitamin D Status","volume":"91","author":"Tsiaras","year":"2011","journal-title":"Acta Derm. Venereol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/bjd.12518","article-title":"Lifestyle factors including less cutaneous sun exposure contribute to starkly lower vitamin D levels in U.K. South Asians compared with the white population","volume":"169","author":"Kift","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_23","first-page":"3589","article-title":"Vitamin D Status and Dietary Habits Of Children with Adolescent Idiopathic Scoliosis in Varna","volume":"27","author":"Marinov","year":"2021","journal-title":"J. IMAB\u2014Annu. Proceeding Sci. Pap."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1017\/S0007114522001702","article-title":"Association between food intake patterns and serum vitamin D concentrations in US adults","volume":"129","author":"Ganji","year":"2023","journal-title":"Br. J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jsbmb.2013.11.003","article-title":"Is vitamin D deficiency a major global public health problem?","volume":"144","author":"Palacios","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.3945\/ajcn.114.089284","article-title":"Processed foods: Contributions to nutrition","volume":"99","author":"Weaver","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"P23","DOI":"10.1530\/EJE-18-0736","article-title":"Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: A position statement of the European Calcified Tissue Society","volume":"180","author":"Lips","year":"2019","journal-title":"Eur. J. Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10654-022-00867-4","article-title":"Vitamin D food fortification in European countries: The underused potential to prevent cancer deaths","volume":"37","author":"Niedermaier","year":"2022","journal-title":"Eur. J. Epidemiol."},{"key":"ref_29","unstructured":"Higgins, J., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M., and Welch, V. (2022). Cochrane Handbook for Systematic Reviews of Interventions, Cochrane."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e070849","DOI":"10.1136\/bmj-2022-070849","article-title":"Reporting guideline for overviews of reviews of healthcare interventions: Development of the PRIOR statement","volume":"378","author":"Gates","year":"2022","journal-title":"BMJ"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Moher, D., Liberati, A., Tetzlaff, J., and Altman, D.G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"599","DOI":"10.5195\/jmla.2021.1219","article-title":"Translation and validation of PubMed and Embase search filters for identification of systematic reviews, intervention studies, and observational studies in the field of first aid","volume":"109","author":"Avau","year":"2021","journal-title":"J. Med. Libr. Assoc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/bmj.38336.804167.47","article-title":"Optimal search strategies for retrieving systematic reviews from Medline: Analytical survey","volume":"330","author":"Montori","year":"2005","journal-title":"BMJ"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jclinepi.2008.10.009","article-title":"AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews","volume":"62","author":"Shea","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"ref_35","first-page":"1","article-title":"Effectiveness and Safety of Vitamin D in Relation to Bone Health","volume":"158","author":"Cranney","year":"2007","journal-title":"Evid. Rep. Technol. Assess."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.3390\/nu7042311","article-title":"Moderate Amounts of Vitamin D3 in Supplements are Effective in Raising Serum 25-Hydroxyvitamin D from Low Baseline Levels in Adults: A Systematic Review","volume":"7","author":"Whiting","year":"2015","journal-title":"Nutrients"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1080\/10408398.2018.1558172","article-title":"Efficacy of vitamin D fortified foods on bone mineral density and serum bone biomarkers: A systematic review and meta-analysis of interventional studies","volume":"60","author":"Tangestani","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"131325","DOI":"10.1016\/j.foodchem.2021.131325","article-title":"Vitamin d-fortified bread: Systematic review of fortification approaches and clinical studies","volume":"372","author":"Souza","year":"2022","journal-title":"Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"S251","DOI":"10.1093\/advances\/nmz001","article-title":"Role of Functional For-tified Dairy Products in Cardiometabolic Health: A Systematic Review and Meta-Analyses of Randomized Clinical Trials","volume":"10","author":"Gil","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3390\/nu3121023","article-title":"The Potential Role of Vitamin D Enhanced Foods in Improving Vitamin D Status","volume":"3","author":"OMahony","year":"2011","journal-title":"Nutrients"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.3945\/ajcn.2008.26415","article-title":"Efficacy of food fortification on serum 25-hydroxyvitamin D concentrations: Systematic review","volume":"88","author":"Cranney","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1017\/S0007114521002816","article-title":"The effects of vitamin D-fortified foods on circulating 25(OH)D concentrations in adults: A systematic review and meta-analysis","volume":"127","author":"Nikooyeh","year":"2021","journal-title":"Br. J. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.29252\/nfsr.5.4.1","article-title":"Efficacy of Food Fortification with Vitamin D in Iranian Adults: A Systematic Review and Meta-Analysis","volume":"5","author":"Nikooyeh","year":"2018","journal-title":"Nutr. Food Sci. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1097\/MPG.0000000000003300","article-title":"How Much Does Serum 25(OH)D Improve by Vitamin D Supplement and Fortified Food in Children? A Systematic Review and Meta-Analysis","volume":"74","author":"Nikooyeh","year":"2021","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Niedermaier, T., Gredner, T., Kuznia, S., Sch\u00f6ttker, B., Mons, U., and Brenner, H. (2021). Potential of Vitamin D Food Fortification in Prevention of Cancer Deaths\u2014A Modeling Study. Nutrients, 13.","DOI":"10.3390\/nu13113986"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jamda.2016.03.010","article-title":"Micronutrient Food Fortification for Residential Care: A Scoping Review of Current Interventions","volume":"17","author":"Lam","year":"2016","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8587","DOI":"10.3168\/jds.2018-16046","article-title":"Is vitamin D-fortified yogurt a value-added strategy for improving human health? A systematic review and meta-analysis of randomized trials","volume":"102","author":"Gasparri","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/nutrit\/nuab055","article-title":"Role of Food Fortification with Vitamin D and Calcium in the Bone Remodeling Process in Postmenopausal Women: A Systematic Review of Randomized Controlled Trials","volume":"80","author":"Santos","year":"2021","journal-title":"Nutr. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/biof.1632","article-title":"A systematic review and meta-analysis of the effect of Vitamin D-fortified food on glycemic indices","volume":"46","author":"Emadzadeh","year":"2020","journal-title":"BioFactors"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101242","DOI":"10.1016\/j.ctcp.2020.101242","article-title":"The effect of vitamin D fortified products on anthropometric indices: A systematic review and meta-analysis","volume":"41","author":"Emadzadeh","year":"2020","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_51","first-page":"278","article-title":"The Effects of Vitamin D Fortified Products on Bone Biomarkers: A Systematic Review and Meta-Analysis","volume":"51","author":"Emadzadeh","year":"2022","journal-title":"Iran. J. Public Health"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1093\/jn\/nxab180","article-title":"Vitamin D Food Fortification and Biofortification In-creases Serum 25-Hydroxyvitamin D Concentrations in Adults and Children: An Updated and Extended Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"151","author":"Dunlop","year":"2021","journal-title":"J. Nutr."},{"key":"ref_53","first-page":"2","article-title":"Micronutrient fortification of food and its impact on woman and child health: A systematic review","volume":"23","author":"Das","year":"2013","journal-title":"Syst. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00394-020-02298-x","article-title":"Individual participant data (IPD)-level meta-analysis of randomised controlled trials with vitamin D-fortified foods to estimate Dietary Reference Values for vitamin D","volume":"60","author":"Cashman","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"513S","DOI":"10.1093\/ajcn\/88.2.513S","article-title":"Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health","volume":"88","author":"Cranney","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Brooker, P.G., Rebuli, M.A., Williams, G., and Muhlhausler, B.S. (2022). Effect of Fortified Formula on Growth and Nutritional Status in Young Children: A Systematic Review and Meta-Analysis. Nutrients, 14.","DOI":"10.3390\/nu14235060"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/advances\/nmy012","article-title":"Effect of Vitamin D Supplementation, Food Fortification, or Bolus Injection on Vitamin D Status in Children Aged 2\u201318 Years: A Meta-Analysis","volume":"9","author":"Brett","year":"2018","journal-title":"Adv. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Brand\u00e3o-Lima, P.N., Santos, B., da, C., Aguilera, C.M., Freire, A.R.S., Martins-Filho, P.R.S., and Pires, L.V. (2019). Vitamin D Food Fortifi-cation and Nutritional Status in Children: A Systematic Review of Randomized Controlled Trials. Nutrients, 11.","DOI":"10.3390\/nu11112766"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3945\/jn.112.158014","article-title":"An Updated Systematic Review and Meta-Analysis of the Efficacy of Vitamin D Food Fortification","volume":"142","author":"Black","year":"2012","journal-title":"J. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13643-020-01360-3","article-title":"The impact of vitamin D food fortification and health outcomes in children: A systematic review and meta-regression","volume":"9","author":"Alsheikh","year":"2020","journal-title":"Syst. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/eurpub\/ckw270","article-title":"Preventing vitamin D deficiency (VDD): A systematic review of economic evaluations","volume":"27","author":"Aguiar","year":"2017","journal-title":"Eur. J. Public Health"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3945\/ajcn.116.136143","article-title":"A Micronutrient-Fortified Young-Child Formula Improves the Iron and Vitamin D Status of Healthy Young European Children: A Randomized, Double-Blind Controlled Trial","volume":"105","author":"Akkermans","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1139\/apnm-2018-0368","article-title":"Effect of multiple micronutrient fortified milk consumption on vitamin D status among school-aged children in rural region of Morocco","volume":"44","author":"Benjeddou","year":"2019","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3945\/ajcn.115.115956","article-title":"Dietary vitamin D dose-response in healthy children 2 to 8 y of age: A 12-wk randomized controlled trial using fortified foods","volume":"103","author":"Brett","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/ajcn\/nqx062","article-title":"Vitamin D status and functional health outcomes in children aged 2\u20138 y: A 6-mo vitamin D randomized controlled trial","volume":"107","author":"Brett","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jand.2013.07.027","article-title":"Multinutrient-Fortified Juices Improve Vitamin D and Vitamin E Status in Children: A Randomized Controlled Trial","volume":"114","author":"Economos","year":"2014","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1017\/S1368980008004357","article-title":"Vitamin D status of Year 3 children and supplementation through schools with fortified milk","volume":"12","author":"Graham","year":"2008","journal-title":"Public Health Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.3945\/jn.111.145052","article-title":"Vitamin D-Fortified Milk Achieves the Targeted Serum 25-Hydroxyvitamin D Concentration without Affecting That of Parathyroid Hormone in New Zealand Toddlers","volume":"141","author":"Houghton","year":"2011","journal-title":"J. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s00431-013-2092-6","article-title":"Vitamin D fortification of growing up milk prevents decrease of serum 25-hydroxyvitamin D concentrations during winter: A clinical intervention study in Germany","volume":"172","author":"Hower","year":"2013","journal-title":"Eur. J. Pediatr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s00198-013-2306-9","article-title":"Impact of vitamin D fortified milk supplementation on vitamin D status of healthy school children aged 10\u201314 years","volume":"24","author":"Khadgawat","year":"2013","journal-title":"Osteoporos. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.clnu.2015.02.001","article-title":"V The Effects of Regular Consumption of a Multiple Micronutrient Fortified Milk Beverage on the Micronutrient Status of School Children and on Their Mental and Physical Performance","volume":"35","author":"Kuriyan","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3945\/ajcn.113.059469","article-title":"Randomized Controlled Trial of the Effects of Vitamin D\u2013Fortified Milk and Bread on Serum 25-Hydroxyvitamin D Concentrations in Families in Denmark during Winter: The VitmaD Study","volume":"98","author":"Madsen","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/jhn.12191","article-title":"Calcium-vitamin D-fortified milk is as effective on circulating bone biomarkers as fortified juice and supplement but has less acceptance: A randomised controlled school-based trial","volume":"27","author":"Neyestani","year":"2014","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3945\/ajcn.116.147108","article-title":"Increased vitamin D intake differentiated according to skin color is needed to meet requirements in young Swedish children during winter: A double-blind randomized clinical trial","volume":"106","author":"Lind","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12937-016-0185-6","article-title":"Fortified breakfast cereal consumed daily for 12 wk leads to a significant improvement in micronutrient intake and micronutrient status in adolescent girls: A randomised controlled trial","volume":"15","author":"Powers","year":"2015","journal-title":"Nutr. J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3945\/ajcn.110.008771","article-title":"Randomized trial of fortified milk and supplements to raise 25-hydroxyvitamin D concentrations in schoolchildren in Mongolia","volume":"94","author":"Ganmaa","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Wang, X., Hui, Z., Dai, X., Terry, P., Zhang, Y., Ma, M., Wang, M., Deng, F., Gu, W., and Lei, S. (2017). Micronutrient Fortified Milk and Academic Performance among Chinese Middle School Students: A Cluster Randomized Controlled Trial. Nutrients, 9.","DOI":"10.3390\/nu9030226"},{"key":"ref_78","first-page":"917.1","article-title":"Effect of Vitamin D For-tified Cheese on Oral Glucose Tolerance in Individuals Exhibiting Marginal Vitamin D Status and an Increased Risk for De-veloping Type 2 Diabetes: A Double-Blind, Randomized Placebo-Controlled Clinical Trial","volume":"30","author":"Duncan","year":"2016","journal-title":"FASEB J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00394-008-0759-y","article-title":"Short-Term Effect of Bedtime Consumption of Fermented Milk Supplemented with Calcium, Inulin-Type Fructans and Caseinphosphopeptides on Bone Metabolism in Healthy, Postmenopausal Women","volume":"48","author":"Adolphi","year":"2008","journal-title":"Eur. J. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"105378","DOI":"10.1016\/j.jsbmb.2019.105378","article-title":"Effects of different vitamin D supplementation strategies in reversing metabolic syndrome and its component risk factors in adolescents","volume":"191","author":"Amer","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.nut.2005.07.012","article-title":"Effect of Micronutrient Supplement on Health and Nutritional Status of Schoolchildren: Biochemical Status","volume":"22","author":"Sivakumar","year":"2006","journal-title":"Nutrition"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3945\/ajcn.2009.27972","article-title":"Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults","volume":"91","author":"Biancuzzo","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1172\/JCI119287","article-title":"Calcium-enriched foods and bone mass growth in prepubertal girls: A randomized, double-blind, placebo-controlled trial","volume":"99","author":"Bonjour","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1017\/S0007114509371743","article-title":"Inhibition of markers of bone resorption by consumption of vitamin D and calcium-fortified soft plain cheese by institutionalised elderly women","volume":"102","author":"Bonjour","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s12603-011-0003-y","article-title":"Nutritional approach for inhibiting bone resorption in institutionalized elderly women with vitamin D insufficiency and high prevalence of fracture","volume":"15","author":"Bonjour","year":"2011","journal-title":"J. Nutr. Health Aging"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3945\/jn.111.153692","article-title":"Consumption of Vitamin D-and Calcium-Fortified Soft White Cheese Lowers the Biochemical Marker of Bone Resorption TRAP 5b in Postmenopausal Women at Moderate Risk of Osteoporosis Fracture","volume":"142","author":"Bonjour","year":"2012","journal-title":"J. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1210\/jc.2013-1274","article-title":"Consumption of Yogurts Fortified in Vitamin D and Calcium Reduces Serum Parathyroid Hormone and Markers of Bone Resorption: A Double-Blind Randomized Controlled Trial in Institutionalized El-derly Women","volume":"98","author":"Bonjour","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s12603-015-0498-8","article-title":"Fortification of yogurts with vitamin D and calcium enhances the inhibition of serum parathyroid hormone and bone resorption markers: A double blind randomized controlled trial in women over 60 living in a community dwelling home","volume":"19","author":"Bonjour","year":"2015","journal-title":"J. Nutr. Health Aging"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/07315724.2017.1355761","article-title":"Evolution of Serum 25OHD in Response to Vitamin D3\u2013Fortified Yogurts Consumed by Healthy Menopausal Women: A 6-Month Randomized Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status, and Seasonality","volume":"37","author":"Bonjour","year":"2017","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1007\/s00198-003-1448-6","article-title":"The effect of milk supplementation on bone mineral density in postmenopausal Chinese women in Malaysia","volume":"14","author":"Chee","year":"2003","journal-title":"Osteoporos. Int."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1089\/jmf.2012.0210","article-title":"Vitamin D Fortified Bread Improves Pain and Physical Function Domains of Quality of Life in Nursing Home Residents","volume":"17","author":"Costan","year":"2014","journal-title":"J. Med. Food"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.bone.2006.04.003","article-title":"Long-term effects of calcium\u2013vitamin-D3-fortified milk on bone geometry and strength in older men","volume":"39","author":"Daly","year":"2006","journal-title":"Bone"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1359\/JBMR.051206","article-title":"Calcium- and Vitamin D3-Fortified Milk Reduces Bone Loss at Clinically Relevant Skeletal Sites in Older Men: A 2-Year Randomized Controlled Trial","volume":"21","author":"Daly","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/ajcn\/87.3.771","article-title":"The skeletal benefits of calcium- and vitamin D3\u2013fortified milk are sustained in older men after withdrawal of supplementation: An 18-mo follow-up study","volume":"87","author":"Daly","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/ejcn.2008.79","article-title":"Long-Term Effect of Calcium-Vitamin D3 Fortified Milk on Blood Pressure and Serum Lipid Concentrations in Healthy Older Men","volume":"63","author":"Daly","year":"2009","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1093\/jn\/129.11.2028","article-title":"Functional Biochemical and Nutrient Indices in Frail Elderly People Are Partly Affected by Dietary Supplements but Not by Exercise","volume":"129","author":"Paw","year":"1999","journal-title":"J. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.3945\/jn.111.156166","article-title":"Fortified Malted Milk Drinks Containing Low-Dose Ergocalciferol and Cholecalciferol Do Not Differ in Their Capacity to Raise Serum 25-Hydroxyvitamin D Concentrations in Healthy Men and Women Not Exposed to UV-B","volume":"142","author":"Fisk","year":"2012","journal-title":"J. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bone.2014.08.002","article-title":"Calcium and vitamin D supplementation maintains parathyroid hormone and improves bone density during initial military training: A randomized, double-blind, placebo controlled trial","volume":"68","author":"Lutz","year":"2014","journal-title":"Bone"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bone.2019.03.021","article-title":"Calcium and vitamin D supplementation and bone health in Marine recruits: Effect of season","volume":"123","author":"Nakayama","year":"2019","journal-title":"Bone"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Ganmaa, D., Stuart, J.J., Sumberzul, N., Ninjin, B., Giovannucci, E., Kleinman, K., Holick, M.F., Willett, W.C., Frazier, L.A., and Rich-Edwards, J.W. (2017). Vitamin D supplementation and growth in urban Mongol school children: Results from two randomized clinical trials. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0175237"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12937-019-0504-9","article-title":"Effect of Vitamin D Fortified Foods on Bone Markers and Muscle Strength in Women of Pakistani and Danish Origin Living in Denmark: A Randomised Controlled Trial","volume":"18","author":"Tetens","year":"2019","journal-title":"Nutr. J."},{"key":"ref_102","first-page":"741","article-title":"Vitamin D-fortified foods improve wintertime vitamin D status in women of Danish and Pakistani origin living in Denmark: A randomized controlled trial","volume":"59","author":"Tetens","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3945\/ajcn.116.132530","article-title":"Vitamin D\u2013enhanced eggs are protective of wintertime serum 25-hydroxyvitamin D in a randomized controlled trial of adults","volume":"104","author":"Hayes","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1017\/S0007114515004766","article-title":"Consumption of a Calcium and Vitamin D-Fortified Food Product Does Not Affect Iron Status during Initial Military Training: A Randomised, Double-Blind, Placebo-Controlled Trial","volume":"115","author":"Hennigar","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/07315724.2013.767659","article-title":"Regular Consumption of Both Vitamin D\u2013 and Calcium- and Vitamin D\u2013Fortified Yogurt Drink Is Equally Accompanied by Lowered Blood Lipoprotein (a) and Elevated Apoprotein A1 in Subjects with Type 2 Diabetes: A Randomized Clinical Trial","volume":"32","author":"Heravifard","year":"2013","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1515\/jpem.2010.094","article-title":"Long-term cereal-based nutritional supplementation improved the total spine bone mineral density amongst Sri Lankan preschool children: A randomized controlled study","volume":"23","author":"Hettiarachchi","year":"2010","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s00198-005-1963-8","article-title":"A Prospective Study of the Effects of 1-Year Calcium-Fortified Soy Milk Supplementation on Dietary Calcium Intake and Bone Health in Chinese Adolescent Girls Aged 14 to 16","volume":"16","author":"Ho","year":"2005","journal-title":"Osteoporos. Int."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1017\/S0007114516000192","article-title":"Effects of Vitamin D2-Fortified Breadv. Supplementation with Vitamin D2 or D3 on Serum 25-Hydroxyvitamin D Metabolites: An 8-Week Randomised-Controlled Trial in Young Adult Finnish Women","volume":"115","author":"Itkonen","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.3945\/ajcn.116.151415","article-title":"The positive impact of general vitamin D food fortification policy on vitamin D status in a representative adult Finnish population: Evidence from an 11-y follow-up based on standardized 25-hydroxyvitamin D data","volume":"105","author":"Itkonen","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.clnu.2015.02.014","article-title":"Effects of vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women: A randomised controlled clinical trial","volume":"35","author":"Jafari","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.foodchem.2013.10.043","article-title":"Stability of vitamin D in foodstuffs during cooking","volume":"148","author":"Jakobsen","year":"2014","journal-title":"Food Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.3168\/jds.S0022-0302(05)72907-6","article-title":"Bioavailability of Vitamin D from Fortified Process Cheese and Effects on Vitamin D Status in the Elderly","volume":"88","author":"Johnson","year":"2005","journal-title":"J. Dairy Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00223-012-9571-z","article-title":"Changes in Parameters of Bone Metabolism in Postmenopausal Women Following a 12-Month Intervention Period Using Dairy Products Enriched with Calcium, Vitamin D, and Phylloquinone (Vitamin K1) or Menaquinone-7 (Vitamin K2): The Postmenopausal Health Study II","volume":"90","author":"Kanellakis","year":"2012","journal-title":"Calcif. Tissue Int."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1159\/000213341","article-title":"Vitamin-D-Fortified Liquid Milk\u2014A Highly Effective Method of Vitamin D Administration for House-Bound and Institutionalised Elderly","volume":"38","author":"Keane","year":"1992","journal-title":"Gerontology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s002239900435","article-title":"Vitamin D-Fortified Liquid Milk: Benefits for the Elderly Com-munity-Based Population","volume":"62","author":"Keane","year":"1998","journal-title":"Calcif. Tissue Int."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.nut.2006.08.008","article-title":"Effect of Calcium Fortified Milk Supplementation with or without Vitamin K on Biochemical Markers of Bone Turnover in Premenopausal Women","volume":"22","author":"Kruger","year":"2006","journal-title":"Nutrition"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bone.2009.10.036","article-title":"The effect of a fortified milk drink on vitamin D status and bone turnover in post-menopausal women from South East Asia","volume":"46","author":"Kruger","year":"2010","journal-title":"Bone"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1007\/s00394-017-1544-6","article-title":"Calcium and vitamin D fortified milk reduces bone turnover and improves bone density in postmenopausal women over 1 year","volume":"57","author":"Kruger","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/ejcn.2012.54","article-title":"High-Calcium, Vitamin D Fortified Milk Is Effective in Improving Bone Turnover Markers and Vitamin D Status in Healthy Postmenopausal Chinese Women","volume":"66","author":"Kruger","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1089\/biores.2018.0027","article-title":"Fortified Milk Supplementation Improves Vitamin D Status, Grip Strength, and Maintains Bone Density in Chinese Premenopausal Women Living in Malaysia","volume":"8","author":"Kruger","year":"2019","journal-title":"BioResearch Open Access"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1152\/japplphysiol.00392.2009","article-title":"Effects of resistance exercise and fortified milk on skeletal muscle mass, muscle size, and functional performance in middle-aged and older men: An 18-mo randomized controlled trial","volume":"107","author":"Kukuljan","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s00198-008-0776-y","article-title":"Effects of a Multi-Component Exercise Program and Calcium\u2013Vitamin-D3-Fortified Milk on Bone Mineral Density in Older Men: A Randomised Controlled Trial","volume":"20","author":"Kukuljan","year":"2008","journal-title":"Osteoporos. Int."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1210\/jc.2010-2284","article-title":"Independent and Combined Effects of Calcium-Vitamin D3 and Exercise on Bone Structure and Strength in Older Men: An 18-Month Factorial Design Randomized Controlled Trial","volume":"96","author":"Kukuljan","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1359\/jbmr.2001.16.9.1704","article-title":"Milk Supplementation of the Diet of Postmenopausal Chinese Women on a Low Calcium Intake Retards Bone Loss","volume":"16","author":"Lau","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1017\/S0007114508894469","article-title":"Prospective study on food fortification with vitamin D among adolescent females in Finland: Minor effects","volume":"100","author":"Leino","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000447433","article-title":"Vitamin D3-Supplemented Yogurt Drink Improves Insulin Resistance and Lipid Profiles in Women with Gestational Diabetes Mellitus: A Randomized Double Blinded Clinical Trial","volume":"68","author":"Li","year":"2016","journal-title":"Ann. Nutr. Metab."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1093\/jn\/nxy167","article-title":"Compared with Cow Milk, a Growing-Up Milk Increases Vitamin D and Iron Status in Healthy Children at 2 Years of Age: The Growing-Up Milk\u2013Lite (GUMLi) Randomized Controlled Trial","volume":"148","author":"Lovell","year":"2018","journal-title":"J. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1007\/s00198-019-05105-4","article-title":"Effects of milk powder intervention on bone mineral density and indicators related to bone metabolism in Chinese adolescents","volume":"30","author":"Lu","year":"2019","journal-title":"Osteoporos. Int."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/ajcn\/86.3.781","article-title":"Changes in biochemical indexes of bone metabolism and bone mineral density after a 12-mo dietary intervention program: The Postmenopausal Health Study","volume":"86","author":"Manios","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1365-277X.2008.00934.x","article-title":"Changes in biochemical indices of bone metabolism in post-menopausal women following a dietary intervention with fortified dairy products","volume":"22","author":"Manios","year":"2009","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/ejcn.2010.270","article-title":"Seasonal variations of vitamin D status in Greek postmenopausal women receiving enriched dairy products for 30 months: The Postmenopausal Health Study","volume":"65","author":"Manios","year":"2011","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1007\/s00394-016-1277-y","article-title":"Reduced-Fat Gouda-Type Cheese Enriched with Vitamin D3 Effectively Prevents Vitamin D Deficiency during Winter Months in Post-menopausal Women in Greece","volume":"56","author":"Manios","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3945\/ajcn.2008.26890","article-title":"Long-Term Effects of Giving Nursing Home Residents Bread Fortified with 125 \u03bcg (5000 IU) Vitamin D3 per Daily Serving","volume":"89","author":"Mocanu","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1475-2891-12-137","article-title":"Three-Year Follow-up of Serum 25-Hydroxyvitamin D, Parathyroid Hormone, and Bone Mineral Density in Nursing Home Residents Who Had Received 12 Months of Daily Bread Fortification with 125 \u03bcg of Vitamin D3","volume":"12","author":"Mocanu","year":"2013","journal-title":"Nutr. J."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.numecd.2018.03.001","article-title":"The effect of daily fortified yogurt consumption on weight loss in adults with metabolic syndrome: A 10-week randomized controlled trial","volume":"28","author":"Bellissimo","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_136","first-page":"133","article-title":"Effect of vitamin D supplementation on oral glucose tolerance in individuals with low vitamin D status and increased risk for developing type 2 diabetes (EVIDENCE): A double-blind, randomized, placebo-controlled clinical trial","volume":"19","author":"Duncan","year":"2016","journal-title":"Diabetes Obes. Metab."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1017\/BJN20061977","article-title":"Skeletal site-dependent response of bone mineral density and quantitative ultrasound parameters following a 12-month dietary intervention using dairy products fortified with calcium and vitamin D: The Postmenopausal Health Study","volume":"96","author":"Moschonis","year":"2006","journal-title":"Br. J. Nutr."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1017\/S000711451000019X","article-title":"The effects of a 30-month dietary intervention on bone mineral density: The Postmenopausal Health Study","volume":"104","author":"Moschonis","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00774-010-0256-2","article-title":"Possible Site-Specific Effect of an Intervention Combining Nutrition and Lifestyle Counselling with Consumption of Fortified Dairy Products on Bone Mass: The Postmenopausal Health Study II","volume":"29","author":"Moschonis","year":"2011","journal-title":"J. Bone Miner. Metab."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jff.2018.01.001","article-title":"Fortified Yogurt with Vitamin D as a Cost-Effective Food to Prevent Diabetes: A Randomized Double-Blind Clinical Trial","volume":"42","author":"Mostafai","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/jn\/136.1.123","article-title":"Bread Fortified with Cholecalciferol Increases the Serum 25-HydroxyvitaminD Concentration in Women as Effectively as a Cholecalciferol Supplement","volume":"136","author":"Natri","year":"2006","journal-title":"J. Nutr."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1210\/jc.2011-3465","article-title":"Improvement of Vitamin D Status via Daily Intake of Fortified Yogurt Drink Either with or without Extra Calcium Ameliorates Systemic Inflammatory Biomarkers, Including Adipokines, in the Subjects with Type 2 Diabetes","volume":"97","author":"Neyestani","year":"2012","journal-title":"J. Clin. En-docrinol. Metab."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1024\/0300-9831\/a000227","article-title":"A Vitamin D-Calcium-Fortified Yogurt Drink De-creased Serum PTH but Did Not Affect Osteocalcin in Subjects with Type 2 Diabetes","volume":"85","author":"Neyestani","year":"2015","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3945\/ajcn.110.007336","article-title":"Daily consumption of vitamin D\u2013 or vitamin D + calcium\u2013fortified yogurt drink improved glycemic control in patients with type 2 diabetes: A randomized clinical trial","volume":"93","author":"Nikooyeh","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1210\/jc.2016-1631","article-title":"Vitamin D-Fortified Bread Is as Effective as Supplement in Improving Vitamin D Status: A Randomized Clinical Trial","volume":"101","author":"Nikooyeh","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s12263-014-0413-7","article-title":"Real-life use of vitamin D3-fortified bread and milk during a winter season: The effects of CYP2R1 and GC genes on 25-hydroxyvitamin D concentrations in Danish families, the VitmaD study","volume":"9","author":"Nissen","year":"2014","journal-title":"Genes Nutr."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1007\/s00394-019-02103-4","article-title":"Vitamin D-fortified cooking oil is an effective way to improve vitamin D status: An institutional efficacy trial","volume":"59","author":"Nikooyeh","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00042192-200512010-00012","article-title":"Changes in bone turnover markers after calcium-enriched milk supplementation in healthy postmenopausal women: A randomized, double-blind, prospective clinical trial","volume":"12","author":"Palacios","year":"2005","journal-title":"Menopause"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0271-5317(03)00113-1","article-title":"Diet can increase 25-hydroxyvitamin-D3 plasma levels in the elderly: A dietary intervention trial","volume":"23","author":"Panunzio","year":"2003","journal-title":"Nutr. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/ajcn\/41.2.254","article-title":"The effect of milk supplements on calcium metabolism, bone metabolism and calcium balance","volume":"41","author":"Recker","year":"1985","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3945\/ajcn.111.019489","article-title":"Calcium and Vitamin D Supplementation Is Associated with De-creased Abdominal Visceral Adipose Tissue in Overweight and Obese Adults","volume":"95","author":"Rosenblum","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/s41430-017-0062-1","article-title":"Vitamin D3-fortified milk did not affect glycemic control, lipid profile, and anthropometric measures in patients with type 2 diabetes, a triple-blind randomized clinical trial","volume":"72","author":"Salehi","year":"2018","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1017\/S1368980015003171","article-title":"Economic Evaluation of Vitamin D and Calcium Food Fortification for Fracture Prevention in Germany","volume":"20","author":"Sandmann","year":"2015","journal-title":"Public Health Nutr."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Shab-Bidar, S., Neyestani, T.R., Djazayery, A., Eshraghian, M.-R., Houshiarrad, A., Gharavi, A., Kalayi, A., Shariatzadeh, N., Zahedirad, M., and Khalaji, N. (2011). Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: A randomized double-blind clinical trial. BMC Med., 9.","DOI":"10.1186\/1741-7015-9-125"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Shab-Bidar, S., Neyestani, T.R., and Djazayery, A. (2011). Efficacy of Vitamin D3-Fortified-Yogurt Drink on Anthropometric, Metabolic, Inflammatory and Oxidative Stress Biomarkers According to Vitamin D Receptor Gene Polymorphisms in Type 2 Diabetic Patients: A Study Protocol for a Randomized Controlled Clinical Trial. BMC Endocr. Disord., 11.","DOI":"10.1186\/1472-6823-11-12"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1017\/S0007114515003049","article-title":"Vitamin D receptor Cdx-2-dependent response of central obesity to vitamin D intake in the subjects with type 2 diabetes: A randomised clinical trial","volume":"114","author":"Neyestani","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s11657-014-0188-x","article-title":"Milk fortified with vitamin D could reduce the prevalence of vitamin D deficiency among Japanese female college students","volume":"9","author":"Suzuki","year":"2014","journal-title":"Arch. Osteoporos."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1093\/ajcn\/77.6.1478","article-title":"Fortification of orange juice with vitamin D: A novel approach for enhancing vitamin D nutritional health","volume":"77","author":"Tangpricha","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00394-010-0142-7","article-title":"Calcium and vitamin D supplementation through fortified dairy products counterbalances seasonal variations of bone metabolism indices: The Postmenopausal Health Study","volume":"50","author":"Tenta","year":"2010","journal-title":"Eur. J. Nutr."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.3390\/nu5124966","article-title":"Changes in Blood Pressure and Lipid Levels in Young Women Consuming a Vitamin D-Fortified Skimmed Milk: A Randomised Controlled Trial","volume":"5","author":"Toxqui","year":"2013","journal-title":"Nutrients"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/07315724.2013.826116","article-title":"Effects of an Iron or Iron and Vitamin D\u2013Fortified Flavored Skim Milk on Iron Metabolism: A Randomized Controlled Double-Blind Trial in Iron-Deficient Women","volume":"32","author":"Toxqui","year":"2013","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00394-013-0544-4","article-title":"Low iron status as a factor of increased bone resorption and effects of an iron and vitamin D-fortified skimmed milk on bone remodelling in young Spanish women","volume":"53","author":"Toxqui","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-13-6","article-title":"Effect of calcium phosphate and vitamin D3supplementation on bone remodelling and metabolism of calcium, phosphorus, magnesium and iron","volume":"13","author":"Trautvetter","year":"2014","journal-title":"Nutr. J."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3945\/ajcn.116.138693","article-title":"Daily Supplementation with 15 \u03bcg Vitamin D2 Compared with Vitamin D3 to Increase Wintertime 25-Hydroxyvitamin D Status in Healthy South Asian and White European Women: A 12-Wk Randomized, Placebo-Controlled Food-Fortification Trial","volume":"106","author":"Tripkovic","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/ejcn.2011.53","article-title":"Bioavailability of Vitamin D2 from UV-B-Irradiated Button Mush-rooms in Healthy Adults Deficient in Serum 25-Hydroxyvitamin D: A Randomized Controlled Trial","volume":"65","author":"Urbain","year":"2011","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/jn\/138.7.1365","article-title":"The Bioavailability of Vitamin D from Fortified Cheeses and Supplements Is Equivalent in Adults","volume":"138","author":"Wagner","year":"2008","journal-title":"J. Nutr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1089\/jwh.2006.0222","article-title":"Milk Supple-mentation and Bone Health in Young Adult Chinese Women","volume":"16","author":"Woo","year":"2007","journal-title":"J. Womens Health"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1079\/BJN20041118","article-title":"School-milk intervention trial enhances growth and bone mineral accretion in Chinese girls aged 10\u201312 years in Beijing","volume":"92","author":"Du","year":"2004","journal-title":"Br. J. Nutr."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/ajcn\/81.5.1168","article-title":"Effects of School Milk Intervention on Cortical Bone Accretion and Indicators Relevant to Bone Metabolism in Chinese Girls Aged 10\u201312 y in Beijing","volume":"81","author":"Zhu","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1017\/S0007114515003967","article-title":"The Effects of Different Levels of Calcium Supple-mentation on the Bone Mineral Status of Postpartum Lactating Chinese Women: A 12-Month Randomised, Double-Blinded, Controlled Trial","volume":"115","author":"Zhang","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_171","first-page":"147","article-title":"Effects of two years\u2019 milk supplementation on size-corrected bone mineral density of Chinese girls","volume":"17","author":"Zhu","year":"2008","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_172","first-page":"959","article-title":"Prospective Study on Effect of Calcium and Vitamin D Fortified Drinks on Bone Development in Children","volume":"37","author":"Sun","year":"2011","journal-title":"J. Jilin Univ. Med. Ed."},{"key":"ref_173","first-page":"895","article-title":"Safety and Efficacy of In-creasing Wintertime Vitamin D and Calcium Intake by Milk Fortification","volume":"88","author":"McKenna","year":"1995","journal-title":"QJM"},{"key":"ref_174","first-page":"195","article-title":"Milk Fortified with the Current Adequate Intake for Vitamin D (5\u03bcg) Increases Serum 25-Hydroxyvitamin D Compared to Control Milk but Is Not Sufficient to Prevent a Seasonal Decline in Young Women","volume":"19","author":"Green","year":"2010","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_175","first-page":"68","article-title":"Effects of Vitamin D Fortified Milk on Vitamin D Status in Mongolian School Age Children","volume":"17","author":"Ganmaa","year":"2008","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.3390\/nu6093601","article-title":"Fortification of Foods with Vitamin D in India","volume":"6","author":"Gupta","year":"2014","journal-title":"Nutrients"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fendo.2018.00373","article-title":"Rationale and Plan for Vitamin D Food Fortification: A Review and Guidance Paper","volume":"9","author":"Pilz","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1177\/15648265130342S110","article-title":"A Review of Vitamin D Fortification: Implications for Nutrition Programming in Southeast Asia","volume":"34","author":"Yang","year":"2013","journal-title":"Food Nutr. Bull."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Grant, W.B., and Boucher, B.J. (2019). A Review of the Potential Benefits of Increasing Vitamin D Status in Mongolian Adults through Food Fortification and Vitamin D Supplementation. Nutrients, 11.","DOI":"10.3390\/nu11102452"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Faggion, C.M. (2015). Critical appraisal of AMSTAR: Challenges, limitations, and potential solutions from the perspective of an assessor. BMC Med. Res. Methodol., 15.","DOI":"10.1186\/s12874-015-0062-6"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"105479","DOI":"10.1016\/j.jsbmb.2019.105479","article-title":"Exploration of strategic food vehicles for vitamin D fortification in low\/lower-middle income countries","volume":"195","author":"Cashman","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/17\/3742\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:39:44Z","timestamp":1760128784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/17\/3742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,26]]},"references-count":181,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["nu15173742"],"URL":"https:\/\/doi.org\/10.3390\/nu15173742","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,26]]}}}