{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:01:11Z","timestamp":1787029271213,"version":"build-2736575974"},"reference-count":26,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MCIN\/AEI\/10.13039\/501100011033\/ and FEDER, \u201cA Way of Making Europe\u201d","award":["SAF2017-82369-R"],"award-info":[{"award-number":["SAF2017-82369-R"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033\/ and FEDER, \u201cA Way of Making Europe\u201d","award":["PID2020-112870RB-I00"],"award-info":[{"award-number":["PID2020-112870RB-I00"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011033\/ and FEDER, \u201cA Way of Making Europe\u201d","award":["2021SGR-00345"],"award-info":[{"award-number":["2021SGR-00345"]}]},{"DOI":"10.13039\/501100004837","name":"MCIN\/AEI\/10.13039\/501100011033\/","doi-asserted-by":"publisher","award":["SAF2017-82369-R"],"award-info":[{"award-number":["SAF2017-82369-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"MCIN\/AEI\/10.13039\/501100011033\/","doi-asserted-by":"publisher","award":["PID2020-112870RB-I00"],"award-info":[{"award-number":["PID2020-112870RB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"MCIN\/AEI\/10.13039\/501100011033\/","doi-asserted-by":"publisher","award":["2021SGR-00345"],"award-info":[{"award-number":["2021SGR-00345"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Generalitat de Catalunya","award":["SAF2017-82369-R"],"award-info":[{"award-number":["SAF2017-82369-R"]}]},{"name":"Generalitat de Catalunya","award":["PID2020-112870RB-I00"],"award-info":[{"award-number":["PID2020-112870RB-I00"]}]},{"name":"Generalitat de Catalunya","award":["2021SGR-00345"],"award-info":[{"award-number":["2021SGR-00345"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Non-alcoholic fatty liver disease is a sexual dimorphic disease, with adipose tissue playing an essential role. Our previous work showed that female rats fed a high-fat high-fructose diet devoid of cholesterol (HFHFr) developed simple hepatic steatosis dissociated from obesity. This study assessed the impact of the HFHFr diet on the male rat metabolism compared with data obtained for female rats. A total of 16 Sprague Dawley (SD) male rats were fed either a control (standard rodent chow and water) or HFHFr (high-fat diet devoid of cholesterol, plus 10% fructose in drinking water) diet for 3 months. Unlike female rats, and despite similar increases in energy consumption, HFHFr males showed increased adiposity and hyperleptinemia. The expression of hormone-sensitive lipase in the subcutaneous white adipose tissue was enhanced, leading to high free fatty acid and glycerol serum levels. HFHFr males presented hypertriglyceridemia, but not hepatic steatosis, partially due to enhanced liver PPAR\u03b1-related fatty acid \u03b2-oxidation and the VLDL-promoting effect of leptin. In conclusion, the SD rats showed a sex-related dimorphic response to the HFHFr diet. Contrary to previous results for HFHFr female rats, the male rats were able to expand the adipose tissue, increase fatty acid catabolism, or export it as VLDL, avoiding liver lipid deposition.<\/jats:p>","DOI":"10.3390\/nu15183909","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T07:57:17Z","timestamp":1694159837000},"page":"3909","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Adipose Tissue Protects against Hepatic Steatosis in Male Rats Fed a High-Fat Diet plus Liquid Fructose: Sex-Related Differences"],"prefix":"10.3390","volume":"15","author":[{"given":"Roger","family":"Bentanachs","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Montesinos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5038-2794","authenticated-orcid":false,"given":"Aleix","family":"Sala-Vila","sequence":"additional","affiliation":[{"name":"IMIM-Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain"},{"name":"Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"IMIM-Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain"},{"name":"Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-9983","authenticated-orcid":false,"given":"Jose","family":"Rodr\u00edguez-Morat\u00f3","sequence":"additional","affiliation":[{"name":"Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain"},{"name":"Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7082-0704","authenticated-orcid":false,"given":"Juan Carlos","family":"Laguna","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-021X","authenticated-orcid":false,"given":"N\u00faria","family":"Roglans","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5652-8651","authenticated-orcid":false,"given":"Marta","family":"Alegret","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Therapeutic Chemistry, School of Pharmacy and Food Science, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1111\/liv.14943","article-title":"Clinical impact of sexual dimorphism in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)","volume":"41","author":"Burra","year":"2021","journal-title":"Liver Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/hep.24097","article-title":"Gender-specific differences in adipose distribution and adipocytokines influence adolescent 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