{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:26:05Z","timestamp":1790958365369,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"APHP"},{"name":"Fujirebio"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Short bowel syndrome (SBS) is a rare but serious condition that may lead to chronic intestinal failure. Citrulline concentrations are currently used to reflect the residual intestinal mass in patients with SBS, although this method has several limitations. In a cohort of patients with SBS, we quantified apolipoprotein B-48 (ApoB-48), which is exclusively synthesized by enterocytes and secreted associated with dietary lipids and investigated the relationship between ApoB-48 and clinical and biological data as well as PN dependence. A total of 51 adult patients were included, 36 of whom were PN-dependent. We found a robust positive correlation between circulating ApoB-48 and residual small bowel length, which was also found in the subgroup of patients with jejunocolic anastomosis. Fasting ApoB-48 levels were significantly lower in PN-dependent patients than in PN-weaned patients and negatively correlated with parenteral nutrition dependence. Our results suggest that ApoB-48 could be proposed as a marker of intestinal absorptive function and could be an interesting follow-up marker in patients with SBS.<\/jats:p>","DOI":"10.3390\/nu15183982","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T03:50:10Z","timestamp":1694749810000},"page":"3982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Circulating Apolipoprotein B-48 as a Biomarker of Parenteral Nutrition Dependence in Adult Patients with Short Bowel Syndrome"],"prefix":"10.3390","volume":"15","author":[{"given":"Salma","family":"Fourati","sequence":"first","affiliation":[{"name":"Service de Biochimie Endocrinienne et Oncologique, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, UMR-S 1149 Centre de Recherche sur l\u2019Inflammation Inserm, Paris Cit\u00e9 University, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Hamon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, IBD and Nutrition Support, CRMR MarDi, Beaujon Hospital, Assistance Publique-H\u00f4pitaux de Paris, 92110 Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Daclat","sequence":"additional","affiliation":[{"name":"UMR_S1166, Research Institute of Cardiovascular Disease, Metabolism and Nutrition Inserm, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Sorbonne University, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0331-3307","authenticated-orcid":false,"given":"Joe-Elie","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Investigation Centre (CIC-1901), Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Sorbonne University, INSERM, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-1243","authenticated-orcid":false,"given":"Katell","family":"Peoc\u2019h","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, CRI INSERM UMR1149, HUPNVS, Assistance Publique-H\u00f4pitaux de Paris, Paris Cit\u00e9 University, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne","family":"Le Beyec","sequence":"additional","affiliation":[{"name":"Service de Biochimie Endocrinienne et Oncologique, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, UMR-S 1149 Centre de Recherche sur l\u2019Inflammation Inserm, Sorbonne University, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Joly","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, IBD and Nutrition Support, CRMR MarDi, Beaujon Hospital, Assistance Publique-H\u00f4pitaux de Paris, 92110 Clichy, UMR-S 1149 Centre de Recherche sur l\u2019Inflammation Inserm, Universit\u00e9 Paris Cit\u00e9, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Lacorte","sequence":"additional","affiliation":[{"name":"Service de Biochimie Endocrinienne et Oncologique, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique-H\u00f4pitaux de Paris, Research Unit on Cardiovascular and Metabolic Disease, UMR ICAN, Sorbonne University, Inserm, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.clnu.2018.07.036","article-title":"Intestinal failure in adults: Recommendations from the ESPEN expert groups","volume":"37","author":"Pironi","year":"2018","journal-title":"Clin. Nutr. Edinb. Scotl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1016\/j.clnu.2021.07.002","article-title":"ESPEN practical guideline: Clinical nutrition in chronic intestinal failure","volume":"40","author":"Cuerda","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Bielawska, B., and Allard, J.P. (2017). Parenteral Nutrition and Intestinal Failure. Nutrients, 9.","DOI":"10.3390\/nu9050466"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.clnu.2017.06.016","article-title":"Five-year survival and causes of death in patients on home parenteral nutrition for severe chronic and benign intestinal failure","volume":"37","author":"Joly","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.clnu.2014.08.017","article-title":"ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults","volume":"34","author":"Pironi","year":"2015","journal-title":"Clin. Nutr. Edinb. Scotl."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3748\/wjg.v7.i6.741","article-title":"Management of patients with a short bowel","volume":"7","author":"Nightingale","year":"2001","journal-title":"World J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-nutr-011720-122203","article-title":"Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition?","volume":"40","author":"Billiauws","year":"2020","journal-title":"Annu. Rev. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1051\/medsci\/2021110","article-title":"Le syndrome de gr\u00eale court chez l\u2019adulte-De l\u2019insuffisance intestinale \u00e0 l\u2019adaptation intestinale","volume":"37","author":"Fourati","year":"2021","journal-title":"M\u00e9decine\/Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1177\/0148607113512678","article-title":"Short bowel syndrome: Highlights of patient management, quality of life, and survival","volume":"38","author":"Kelly","year":"2014","journal-title":"JPEN J. Parenter Enteral Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1136\/gut.46.5.701","article-title":"Intestinal failure defined by measurements of intestinal energy and wet weight absorption","volume":"46","author":"Jeppesen","year":"2000","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/oby.22965","article-title":"Procedures for Measuring Excreted and Ingested Calories to Assess Nutrient Absorption Using Bomb Calorimetry","volume":"28","author":"Basolo","year":"2020","journal-title":"Obesity"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"23S","DOI":"10.1177\/0148607114525210","article-title":"Intestinal Adaptation Following Resection","volume":"38","author":"Tappenden","year":"2014","journal-title":"J. Parenter Enter. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/S0016-5085(03)00170-7","article-title":"Plasma citrulline: A marker of enterocyte mass in villous atrophy-associated small bowel disease","volume":"124","author":"Crenn","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.clnu.2019.11.001","article-title":"Citrulline correlations in short bowel syndrome\u2013intestinal failure by patient stratification: Analysis of 24 weeks of teduglutide treatment from a randomized controlled study","volume":"39","author":"Jeppesen","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jcmgh.2018.10.015","article-title":"Regulation of Chylomicron Secretion: Focus on Post-Assembly Mechanisms","volume":"7","author":"Xiao","year":"2019","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/B978-0-12-800263-6.00003-3","article-title":"Apolipoprotein B-48: A unique marker of chylomicron metabolism","volume":"64","author":"Nakajima","year":"2014","journal-title":"Adv. Clin. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/S0022-2275(20)37199-6","article-title":"A single copy of apolipoprotein B-48 is present on the human chylomicron remnant","volume":"38","author":"Phillips","year":"1997","journal-title":"J. Lipid Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1194\/jlr.M086264","article-title":"Plasma PCSK9 correlates with apoB-48-containing triglyceride-rich lipoprotein production in men with insulin resistance","volume":"59","author":"Tremblay","year":"2018","journal-title":"J. Lipid Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"31646","DOI":"10.1074\/jbc.M200544200","article-title":"Fasting and Postprandial Overproduction of Intestinally Derived Lipoproteins in an Animal Model of Insulin Resistance: Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and apob48-containing lipoprotein overproduction","volume":"277","author":"Haidari","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1053\/gast.2003.50057","article-title":"Low-dose growth hormone in adult home parenteral nutrition\u2013dependent short bowel syndrome patients: A positive study","volume":"124","author":"Seguy","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/j.1365-2036.2008.03678.x","article-title":"The citrulline generation test: Proposal for a new enterocyte function test","volume":"27","author":"Peters","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00384-011-1255-z","article-title":"Plasma citrulline as surrogate marker of intestinal inflammation in pediatric and adolescent with Crohn\u2019s disease: Preliminary report","volume":"26","author":"Diamanti","year":"2011","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/014860710703100101","article-title":"Are Plasma Citrulline and Glutamine Biomarkers of Intestinal Absorptive Function in Patients with Short Bowel Syndrome?","volume":"31","author":"Luo","year":"2007","journal-title":"J. Parenter Enter. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1111\/j.1572-0241.2007.01513.x","article-title":"Poor Diagnostic Accuracy of a Single Fasting Plasma Citrulline Concentration to Assess Intestinal Energy Absorption Capacity","volume":"102","author":"Peters","year":"2007","journal-title":"Off. J. Am. Coll. Gastroenterol. ACG"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/2050640617737632","article-title":"Citrulline as a marker of intestinal function and absorption in clinical settings: A systematic review and meta-analysis","volume":"6","author":"Fragkos","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_26","unstructured":"Terjung, R. (2018). Comprehensive Physiology, Wiley. [1st ed.]."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","article-title":"Glucagon-like peptide 1 (GLP-1)","volume":"30","author":"Finan","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"G670","DOI":"10.1152\/ajpgi.00293.2002","article-title":"Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection","volume":"284","author":"Dahly","year":"2003","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"28345","DOI":"10.1038\/srep28345","article-title":"Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome","volume":"6","author":"Gillard","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1053\/j.gastro.2014.08.037","article-title":"Glucagon-Like Peptide-2 Regulates Release of Chylomicrons From the Intestine","volume":"147","author":"Dash","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.atherosclerosis.2010.05.028","article-title":"Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus","volume":"212","author":"Schwartz","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1161\/ATVBAHA.118.310990","article-title":"Liraglutide Reduces Postprandial Hyperlipidemia by Increasing ApoB48 (Apolipoprotein B48) Catabolism and by Reducing ApoB48 Production in Patients with Type 2 Diabetes Mellitus","volume":"38","author":"Duvillard","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.2047-6310.2012.00116.x","article-title":"Elevated remnant lipoproteins may increase subclinical CVD risk in pre-pubertal children with obesity: A case-control study","volume":"8","author":"Wang","year":"2013","journal-title":"Pediatr. Obes."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5538","DOI":"10.1016\/j.clnu.2021.09.004","article-title":"Postprandial dyslipidemia after a standardized high-fat meal in BMI-matched healthy individuals, and in subjects with prediabetes or type 2 diabetes","volume":"40","author":"Lim","year":"2021","journal-title":"Clin. Nutr. Edinb. Scotl."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/j.1365-2362.2012.02687.x","article-title":"Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence","volume":"42","author":"Masuda","year":"2012","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0009-8981(90)90154-K","article-title":"Early alterations of plasma free amino acids in chronic renal failure","volume":"188","author":"Ceballos","year":"1990","journal-title":"Clin. Chim. Acta"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1194\/jlr.M300090-JLR200","article-title":"Measurement of fasting serum apoB-48 levels in normolipidemic and hyperlipidemic subjects by ELISA1","volume":"44","author":"Sakai","year":"2003","journal-title":"J. Lipid Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.metabol.2009.04.040","article-title":"Fasting and postprandial apolipoprotein B-48 levels in healthy, obese, and hyperlipidemic subjects","volume":"58","author":"Otokozawa","year":"2009","journal-title":"Metabolism"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1194\/jlr.M600548-JLR200","article-title":"Evidence of increased secretion of apolipoprotein B-48-containing lipoproteins in subjects with type 2 diabetes","volume":"48","author":"Hogue","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.atherosclerosis.2012.02.001","article-title":"Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity","volume":"222","author":"Adiels","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1161\/CIRCULATIONAHA.107.739888","article-title":"Both Intestinal and Hepatic Lipoprotein Production Are Stimulated by an Acute Elevation of Plasma Free Fatty Acids in Humans","volume":"117","author":"Duez","year":"2008","journal-title":"Circulation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"580","DOI":"10.2337\/db09-1297","article-title":"Insulin Acutely Inhibits Intestinal Lipoprotein Secretion in Humans in Part by Suppressing Plasma Free Fatty Acids","volume":"59","author":"Pavlic","year":"2010","journal-title":"Diabetes"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Tejero, M.D., Virgili, N., Targarona, J., Ruiz, J., Garc\u00eda, N., Or\u00f3, D., Garc\u00eda-Villoria, J., Creus, G., and Pita, A.M. (2016). Apo AIV and Citrulline Plasma Concentrations in Short Bowel Syndrome Patients: The Influence of Short Bowel Anatomy. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163762"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7326\/0003-4819-132-7-200004040-00003","article-title":"Prevalence of Liver Disease and Contributing Factors in Patients Receiving Home Parenteral Nutrition for Permanent Intestinal Failure","volume":"132","author":"Cavicchi","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.clnu.2016.01.020","article-title":"ESPEN guidelines on chronic intestinal failure in adults","volume":"35","author":"Pironi","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.dld.2019.11.013","article-title":"Understanding short bowel syndrome: Current status and future perspectives","volume":"52","author":"Massironi","year":"2020","journal-title":"Dig. Liver Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000515057","article-title":"Management of Home Parenteral Nutrition: Complications and Survival","volume":"11","author":"Reber","year":"2021","journal-title":"Ann. Nutr. Metab."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/18\/3982\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:51:11Z","timestamp":1760129471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/18\/3982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,14]]},"references-count":47,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["nu15183982"],"URL":"https:\/\/doi.org\/10.3390\/nu15183982","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,14]]}}}