{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:14:45Z","timestamp":1777673685135,"version":"3.51.4"},"reference-count":80,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universit\u00e9 de Bourgogne (France)"},{"name":"Moulay Ismail University of Meknes"},{"name":"ABASIM (Association Bourguignonne pour les Applications des Sciences de l\u2019Information en M\u00e9decine)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Thymus atlanticus (Lamiaceae) is a plant endemic to the Mediterranean basin that is found in significant quantities in the arid regions of Morocco. Thymus atlanticus is used in traditional medicine to treat infectious and non-infectious diseases. It is also used for the isolation of essential oils and for the seasoning of many dishes in the Mediterranean diet. The major constituents of Thymus atlanticus are saponins, flavonoids, tannins, alkaloids, various simple and hydroxycinnamic phenolic compounds, and terpene compounds. Several of these compounds act on signaling pathways of oxidative stress, inflammation, and blood sugar, which are parameters often dysregulated during aging. Due to its physiochemical characteristics and biological activities, Thymus atlanticus could be used for the prevention and\/or treatment of age-related diseases. These different aspects are treated in the present review, and we focused on phytochemistry and major age-related diseases: dyslipidemia, cardiovascular diseases, and type 2 diabetes.<\/jats:p>","DOI":"10.3390\/nu15184077","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T04:53:05Z","timestamp":1695271985000},"page":"4077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Thymus atlanticus: A Source of Nutrients with Numerous Health Benefits and Important Therapeutic Potential for Age-Related Diseases"],"prefix":"10.3390","volume":"15","author":[{"given":"Adil","family":"El Midaoui","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada"},{"name":"Department of Biology, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail University of Meknes, Meknes 50050, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid","family":"Khallouki","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail University of Meknes, Meknes 50050, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9jean","family":"Couture","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-672X","authenticated-orcid":false,"given":"Florina","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Research Center of CHU Sainte Justine, Faculty of Dentistry, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud Ali","family":"Ismael","sequence":"additional","affiliation":[{"name":"Northgate Centre 2074-9499 137 Ave NW, Edmonton, AB T5E 5R8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brice","family":"Ongali","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, QC H3C 3J7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Yvonne","family":"Akoume","sequence":"additional","affiliation":[{"name":"Research Center of CHU Sainte Justine, Faculty of Dentistry, Universit\u00e9 de Montr\u00e9al, Montreal, QC H3T 1J4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chakib","family":"Alem","sequence":"additional","affiliation":[{"name":"Research Team in Biochemistry and Natural Resources, Faculty of Sciences and Techniques, Moulay Ismail University of Meknes, Meknes 20250, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ait Boughrous","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail University of Meknes, Meknes 50050, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Zennouhi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences and Techniques, Errachidia, Moulay Ismail University of Meknes, Meknes 50050, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mhammed Chaoui","family":"Roqai","sequence":"additional","affiliation":[{"name":"Ecole des Hautes Etudes de Biotechnologie et de Sant\u00e9 (EHEB), 183 Bd de la R\u00e9sistance, Casablanca 20250, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-8991","authenticated-orcid":false,"given":"Lhoussain","family":"Hajji","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactives and Environmental Health, Faculty of Sciences, Moulay Ismail University, Meknes 50050, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-9445","authenticated-orcid":false,"given":"Imen","family":"Ghzaiel","sequence":"additional","affiliation":[{"name":"Laboratory \u201cBiochemistry of the Peroxisome, Inflammation and Lipid Metabolism\u201d, Bio-peroxIL\/EA7270, Universit\u00e9 de Bourgogne\/Inserm, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-9680","authenticated-orcid":false,"given":"Anne","family":"Vejux","sequence":"additional","affiliation":[{"name":"Laboratory \u201cBiochemistry of the Peroxisome, Inflammation and Lipid Metabolism\u201d, Bio-peroxIL\/EA7270, Universit\u00e9 de Bourgogne\/Inserm, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-0172","authenticated-orcid":false,"given":"G\u00e9rard","family":"Lizard","sequence":"additional","affiliation":[{"name":"Laboratory \u201cBiochemistry of the Peroxisome, Inflammation and Lipid Metabolism\u201d, Bio-peroxIL\/EA7270, Universit\u00e9 de Bourgogne\/Inserm, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/J157v04n01_07","article-title":"Thyme (Thymus vulgaris L.), thymol","volume":"4","author":"Basch","year":"2004","journal-title":"J. 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