{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:14:21Z","timestamp":1791400461095,"version":"4.3.3"},"reference-count":45,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Science and Technology Projects in Yunnan Province","award":["202102AE090050"],"award-info":[{"award-number":["202102AE090050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This research aimed to probe the potential alleviative effects of ethanol extracts of Chinese sumac (Rhus\u00a0chinesis Mill.) fruits against type 2 diabetes mellitus (T2DM) in C57BL\/6 mice induced by high-fat\/high-fructose diet (HFFD) and streptozotocin. The results showed that the ethanol extracts could significantly regulate blood glucose levels, glycosylated hemoglobin, blood lipids, insulin, and insulin resistance, while also restoring endogenous oxidative stress. Pathological and immunohistochemical analyses revealed that the extracts partially restored the physiological function of islet cells. Furthermore, Western blotting results suggested that the extracts could regulate the protein expression in IRS-1\/PI3K\/AKT signaling pathway, and immunofluorescence findings demonstrated their potential to promote the translocation of Nrf2 into the nucleus. This study elucidated a novel finding that ethanol extracts derived from Chinese sumac fruits have the potential to alleviate symptoms of T2DM in mice. Moreover, these findings could offer valuable scientific insights into the potential utilization of R. chinensis fruits as nutritional supplement and\/or functional food to prevent or ameliorate diabetes.<\/jats:p>","DOI":"10.3390\/nu15184080","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T04:53:05Z","timestamp":1695271985000},"page":"4080","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chinese Sumac Fruits (Rhus\u00a0chinesis Mill.) Alleviate Type 2 Diabetes in C57BL\/6 Mice through Repairing Islet Cell Functions, Regulating IRS-1\/PI3K\/AKT Pathways and Promoting the Entry of Nrf2 into the Nucleus"],"prefix":"10.3390","volume":"15","author":[{"given":"Xiaojing","family":"Liu","sequence":"first","affiliation":[{"name":"Faculty of Food Science and Engineering, Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 650500, China"},{"name":"State Key Lab of Food Science and Technology, Jiangnan University, Wuxi 214122, China"},{"name":"Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-5062","authenticated-orcid":false,"given":"Shengbao","family":"Cai","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Engineering, Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 650500, China"},{"name":"Yunnan Engineering Research Center for Fruit & Vegetable Products, Kunming 650500, China"},{"name":"Green Food Processing International Science and Technology R & D Center of Kunming City, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Yi","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Engineering, Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 650500, China"},{"name":"Yunnan Engineering Research Center for Fruit & Vegetable Products, Kunming 650500, China"},{"name":"Green Food Processing International Science and Technology R & D Center of Kunming City, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanqi","family":"Chu","sequence":"additional","affiliation":[{"name":"Faculty of Food Science and Engineering, Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming 650500, China"},{"name":"Yunnan Engineering Research Center for Fruit & Vegetable Products, Kunming 650500, China"},{"name":"Green Food Processing International Science and Technology R & D Center of Kunming City, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.12968\/bjon.2007.16.16.27079","article-title":"An epidemiological overview of diabetes across the world","volume":"16","author":"Meetoo","year":"2013","journal-title":"Br. 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