{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:37:19Z","timestamp":1774582639920,"version":"3.50.1"},"reference-count":210,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T00:00:00Z","timestamp":1695600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This review article aims to summarize the literature findings regarding the role of micronutrients in children with lung disease. The nutritional and respiratory statuses of critically ill children are interrelated, and malnutrition is commonly associated with respiratory failure. The most recent nutrition support guidelines for critically ill children have recommended an adequate macronutrient intake in the first week of admission due to its association with good outcomes. In children with lung disease, it is important not to exceed the proportion of carbohydrates in the diet to avoid increased carbon dioxide production and increased work of breathing, which potentially could delay the weaning of the ventilator. Indirect calorimetry can guide the process of estimating adequate caloric intake and adjusting the proportion of carbohydrates in the diet based on the results of the respiratory quotient. Micronutrients, including vitamins, trace elements, and others, have been shown to play a role in the structure and function of the immune system, antioxidant properties, and the production of antimicrobial proteins supporting the defense mechanisms against infections. Sufficient levels of micronutrients and adequate supplementation have been associated with better outcomes in children with lung diseases, including pneumonia, cystic fibrosis, asthma, bronchiolitis, and acute respiratory failure.<\/jats:p>","DOI":"10.3390\/nu15194142","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T02:31:29Z","timestamp":1695695489000},"page":"4142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Macronutrient and Micronutrient Intake in Children with Lung Disease"],"prefix":"10.3390","volume":"15","author":[{"given":"Nicole","family":"Knebusch","sequence":"first","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Texas Children\u2019s Hospital, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Mansour","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Texas Children\u2019s Hospital, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Texas Children\u2019s Hospital, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3852-0704","authenticated-orcid":false,"given":"Jorge A.","family":"Coss-Bu","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Texas Children\u2019s Hospital, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"128S","DOI":"10.1177\/0884533616687501","article-title":"Protein Requirements of the Critically Ill Pediatric Patient","volume":"32","author":"Patel","year":"2017","journal-title":"Nutr. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/ajcn\/74.5.664","article-title":"Energy metabolism, nitrogen balance, and substrate utilization in critically ill children","volume":"74","author":"Klish","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1378\/chest.123.6.2050","article-title":"Dead space ventilation in critically ill children with lung injury","volume":"123","author":"Walding","year":"2003","journal-title":"Chest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00134-009-1703-1","article-title":"Organ dysfunction is associated with hyperglycemia in critically ill children","volume":"36","author":"Kyle","year":"2010","journal-title":"Intensive Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.jand.2012.07.038","article-title":"Nutrition support in critically ill children: Underdelivery of energy and protein compared with current recommendations","volume":"112","author":"Kyle","year":"2012","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jand.2016.01.005","article-title":"Implementation of Nutrition Support Guidelines May Affect Energy and Protein Intake in the Pediatric Intensive Care Unit","volume":"116","author":"Kyle","year":"2016","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/0884533614555234","article-title":"Growth failure and nutrition considerations in chronic childhood wasting diseases","volume":"30","author":"Kyle","year":"2015","journal-title":"Nutr. Clin. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.healun.2013.06.002","article-title":"Changes in body composition after lung transplantation in children","volume":"32","author":"Kyle","year":"2013","journal-title":"J. Heart Lung Transplant."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/0148607109333114","article-title":"Clinical Guidelines: Nutrition support of the critically ill child","volume":"33","author":"Mehta","year":"2009","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.pcl.2009.06.007","article-title":"Nutritional deficiencies during critical illness","volume":"56","author":"Mehta","year":"2009","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/PCC.0000000000001134","article-title":"Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition","volume":"18","author":"Mehta","year":"2017","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1056\/NEJM197608122950703","article-title":"Clinical semi-starvation: Depression of hypoxic ventilatory response","volume":"295","author":"Doekel","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"ref_13","first-page":"5","article-title":"Respiratory muscle strength and maximal voluntary ventilation in undernourished patients","volume":"126","author":"Arora","year":"1982","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_14","first-page":"644","article-title":"Changes in connective tissue composition of the lung in starvation and refeeding","volume":"128","author":"Sahebjami","year":"1983","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/ajcn\/34.1.68","article-title":"Development of impaired cell-mediated immunity in mild and moderate malnutrition","volume":"34","author":"McMurray","year":"1981","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"568","DOI":"10.2215\/CJN.05790612","article-title":"Nutrition support among critically ill children with AKI","volume":"8","author":"Kyle","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.jrn.2016.09.009","article-title":"Protein Feeding in Pediatric Acute Kidney Injury Is Not Associated With a Delay in Renal Recovery","volume":"27","author":"Kyle","year":"2017","journal-title":"J. Ren. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0272-5231(21)00622-5","article-title":"Clinical and physiologic evaluation of respiratory muscle function","volume":"10","author":"Celli","year":"1989","journal-title":"Clin. Chest Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/nyas.13145","article-title":"Nutrition meets the microbiome: Micronutrients and the microbiota","volume":"1372","author":"Biesalski","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gombart, A.F., Pierre, A., and Maggini, S. (2020). A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients, 12.","DOI":"10.3390\/nu12010236"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1186\/cc13790","article-title":"Vitamin D status and its association with season, hospital and sepsis mortality in critical illness","volume":"18","author":"Amrein","year":"2014","journal-title":"Crit. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/carcin\/17.6.1389","article-title":"Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor","volume":"17","author":"Clairmont","year":"1996","journal-title":"Carcinogenesis"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1017\/S0029665111003351","article-title":"Vitamin D and respiratory infection in adults","volume":"71","author":"Laaksi","year":"2012","journal-title":"Proc. Nutr. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lin, P.H., Sermersheim, M., Li, H., Lee, P.H.U., Steinberg, S.M., and Ma, J. (2017). Zinc in Wound Healing Modulation. Nutrients, 10.","DOI":"10.3390\/nu10010016"},{"key":"ref_25","first-page":"1","article-title":"Feeding the immune system: The role of micronutrients in restoring resistance to infections","volume":"3","author":"Maggini","year":"2010","journal-title":"Cab. Rev. Perspect. Agric. Vet. Sci. Nutr. Nat. Resour."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0272-5231(21)00324-5","article-title":"The effects of undernutrition on the respiratory muscles","volume":"7","author":"Kelsen","year":"1986","journal-title":"Clin. Chest Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0272-5231(21)00509-8","article-title":"Nutrition and the respiratory muscles","volume":"9","author":"Lewis","year":"1988","journal-title":"Clin. Chest Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0272-5231(21)00323-3","article-title":"Malnutrition and the respiratory muscles","volume":"7","author":"Rochester","year":"1986","journal-title":"Clin. Chest Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1183\/09031936.02.00063102","article-title":"Effects of mechanical ventilation on diaphragm function and biology","volume":"20","author":"Decramer","year":"2002","journal-title":"Eur. Respir. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/ACO.0b013e3283440185","article-title":"Diaphragmatic dysfunction in mechanical ventilation","volume":"24","author":"Haitsma","year":"2011","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/cc10023","article-title":"Clinical review: Ventilator-induced diaphragmatic dysfunction--human studies confirm animal model findings!","volume":"15","author":"Jaber","year":"2011","journal-title":"Crit. Care"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s13054-021-03647-w","article-title":"Evolution of inspiratory muscle function in children during mechanical ventilation","volume":"25","author":"Crulli","year":"2021","journal-title":"Crit. Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"520","DOI":"10.20344\/amp.10830","article-title":"Ultrasound Assessment of Ventilator-induced Diaphragmatic Dysfunction in Paediatrics","volume":"32","author":"Dionisio","year":"2019","journal-title":"Acta Med. Port."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/PCC.0000000000001485","article-title":"Progressive Diaphragm Atrophy in Pediatric Acute Respiratory Failure","volume":"19","author":"Glau","year":"2018","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Johnson, R.W., Ng, K.W.P., Dietz, A.R., Hartman, M.E., Baty, J.D., Hasan, N., Zaidman, C.M., and Shoykhet, M. (2018). Muscle atrophy in mechanically-ventilated critically ill children. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0207720"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1002\/ppul.25076","article-title":"Diaphragmatic atrophy and dysfunction in critically ill mechanically ventilated children","volume":"55","author":"Mistri","year":"2020","journal-title":"Pediatr. Pulmonol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/mus.26327","article-title":"Reliability of bedside ultrasound of limb and diaphragm muscle thickness in critically ill children","volume":"59","author":"Ng","year":"2019","journal-title":"Muscle Nerve"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00134-016-4524-z","article-title":"Assessment of diaphragmatic dysfunction in the critically ill patient with ultrasound: A systematic review","volume":"43","author":"Zambon","year":"2017","journal-title":"Intensive Care Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3945\/ajcn.114.104893","article-title":"Adequate enteral protein intake is inversely associated with 60-d mortality in critically ill children: A multicenter, prospective, cohort study","volume":"102","author":"Mehta","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.resp.2007.08.008","article-title":"Effects of different nutritional support on lung mechanics and remodelling in undernourished rats","volume":"160","author":"Dias","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1152\/japplphysiol.00091.2004","article-title":"Effects of undernutrition on respiratory mechanics and lung parenchyma remodeling","volume":"97","author":"Dias","year":"2004","journal-title":"J. Appl. Physiol. (1985)"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1152\/jappl.1985.58.4.1354","article-title":"Effects of prolonged undernutrition on structure and function of the diaphragm","volume":"58","author":"Kelsen","year":"1985","journal-title":"J. Appl. Physiol. (1985)"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/hrt.64.1.20","article-title":"Ultrasound in the diagnosis of diaphragmatic paralysis after operation for congenital heart disease","volume":"64","author":"Balaji","year":"1990","journal-title":"Br. Heart J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1177\/0148607115575033","article-title":"An Analysis of Reliability and Accuracy of Muscle Thickness Ultrasonography in Critically Ill Children and Adults","volume":"40","author":"Fivez","year":"2016","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/j.1651-2227.1991.tb11929.x","article-title":"Quantitation of muscles and fat by ultrasonography: A useful method in the assessment of malnutrition in children","volume":"80","author":"Koskelo","year":"1991","journal-title":"Acta Paediatr. Scand."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1177\/0148607116683143","article-title":"Skeletal Muscle Ultrasonography in Nutrition and Functional Outcome Assessment of Critically Ill Children: Experience and Insights From Pediatric Disease and Adult Critical Care Studies [Formula: See text]","volume":"41","author":"Ong","year":"2017","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1747-0803.2010.00431.x","article-title":"Diagnosis of abnormal diaphragm motion after cardiothoracic surgery: Ultrasound performed by a cardiac intensivist vs. fluoroscopy","volume":"5","author":"Munoz","year":"2010","journal-title":"Congenit. Heart Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1007\/BF02012733","article-title":"Diaphragmatic paralysis in children: Diagnosis by TM-mode ultrasound","volume":"24","author":"Urvoas","year":"1994","journal-title":"Pediatr. Radiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1007\/s00431-023-05024-x","article-title":"Diaphragm thickness by ultrasound in pediatric patients with primary malnutrition","volume":"182","year":"2023","journal-title":"Eur. J. Pediatr."},{"key":"ref_50","first-page":"130","article-title":"Nutritional state and lung disease in cystic fibrosis","volume":"41","author":"Bakker","year":"1992","journal-title":"J. Med."},{"key":"ref_51","first-page":"457","article-title":"The interrelationship of nutrition and pulmonary function in patients with cystic fibrosis","volume":"2","author":"Borowitz","year":"1996","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1164\/ajrccm.154.5.8912731","article-title":"Cystic fibrosis","volume":"154","author":"Davis","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0022-3476(80)80180-6","article-title":"Improved growth and clinical, nutritional, and respiratory changes in response to nutritional therapy in cystic fibrosis","volume":"97","author":"Shepherd","year":"1980","journal-title":"J. Pediatr."},{"key":"ref_54","first-page":"350","article-title":"Nutritional growth retardation is associated with defective lung growth in cystic fibrosis: A preventable determinant of progressive pulmonary dysfunction","volume":"11","author":"Thomson","year":"1995","journal-title":"Nutrition"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1203\/00006450-199610000-00011","article-title":"Prospective evaluation of resting energy expenditure, nutritional status, pulmonary function, and genotype in children with cystic fibrosis","volume":"40","author":"Zemel","year":"1996","journal-title":"Pediatr. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1067\/mpd.2000.107891","article-title":"Longitudinal relationship among growth, nutritional status, and pulmonary function in children with cystic fibrosis: Analysis of the Cystic Fibrosis Foundation National CF Patient Registry","volume":"137","author":"Zemel","year":"2000","journal-title":"J. Pediatr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1067\/mpd.2003.152","article-title":"Growth and nutritional indexes in early life predict pulmonary function in cystic fibrosis","volume":"142","author":"Konstan","year":"2003","journal-title":"J. Pediatr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/ajcn\/80.5.1201","article-title":"Nutritional status is an important predictor of diaphragm strength in young patients with cystic fibrosis","volume":"80","author":"Hart","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_59","first-page":"8","article-title":"Association of nutritional status with lung function and morbidity in children and adolescents with cystic fibrosis: A 36-month cohort study","volume":"36","author":"Hauschild","year":"2018","journal-title":"Rev. Paul. Pediatr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1136\/thoraxjnl-2016-209061","article-title":"Growing large and fast: Is infant growth relevant for the early origins of childhood asthma?","volume":"71","author":"Duijts","year":"2016","journal-title":"Thorax"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.3390\/ijerph8041174","article-title":"Malnutrition and gastrointestinal and respiratory infections in children: A public health problem","volume":"8","author":"Cervantes","year":"2011","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10654-013-9761-7","article-title":"Obstructive pulmonary disease in old age among individuals born preterm","volume":"28","author":"Akre","year":"2013","journal-title":"Eur. J. Epidemiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1017\/S1368980013001262","article-title":"Nutritional status and childhood wheezing in rural Bangladesh","volume":"17","author":"Hawlader","year":"2014","journal-title":"Public Health Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1017\/S1368980019004853","article-title":"Early childhood malnutrition trajectory and lung function at preadolescence","volume":"24","author":"Ferdous","year":"2021","journal-title":"Public Health Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/thoraxjnl-2017-211216","article-title":"The effect of early growth patterns and lung function on the development of childhood asthma: A population based study","volume":"73","author":"Casas","year":"2018","journal-title":"Thorax"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.jaci.2015.08.050","article-title":"Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children","volume":"137","author":"Arshad","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S2213-2600(21)00355-6","article-title":"The role of growth and nutrition in the early origins of spirometric restriction in adult life: A longitudinal, multicohort, population-based study","volume":"10","author":"Voraphani","year":"2022","journal-title":"Lancet Respir. Med."},{"key":"ref_68","first-page":"5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield","year":"1985","journal-title":"Hum. Nutr. Clin. Nutr."},{"key":"ref_69","first-page":"503","article-title":"Energy Metabolism","volume":"Volume 2","author":"Caballero","year":"2016","journal-title":"The Encyclopedia of Food and Health"},{"key":"ref_70","unstructured":"Goday, P.S., and Mehta, N.M. (2015). Pediatric Critical Care Nutrition, McGraw-Hill Education Medical. [1st ed.]."},{"key":"ref_71","unstructured":"Watson, R.S., and Thompson, A.E. (2017). Pediatric Intensive Care, Oxford University Press."},{"key":"ref_72","unstructured":"Stockwell, J.A., and Preissig, C.M. (2012). Comprehensive Critical Care: Pediatric, Society of Critical Care Medicine."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0899-9007(98)00050-1","article-title":"Resting energy expenditure and nitrogen balance in critically ill pediatric patients on mechanical ventilation","volume":"14","author":"Jefferson","year":"1998","journal-title":"Nutrition"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/jpen.1018","article-title":"Feasibility of Enteral Protein Supplementation in Critically Ill Children","volume":"42","author":"Moreno","year":"2018","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"48S","DOI":"10.1177\/0884533617691244","article-title":"Variation in Protein Origin and Utilization: Research and Clinical Application","volume":"32","author":"Morris","year":"2017","journal-title":"Nutr. Clin. Pract."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/chd.12064","article-title":"Perioperative nutritional support and malnutrition in infants and children with congenital heart disease","volume":"9","author":"Toole","year":"2014","journal-title":"Congenit. Heart Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1097\/CCM.0b013e3182257410","article-title":"Current recommended parenteral protein intakes do not support protein synthesis in critically ill septic, insulin-resistant adolescents with tight glucose control","volume":"39","author":"Verbruggen","year":"2011","journal-title":"Crit. Care Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.clnu.2011.02.001","article-title":"Albumin synthesis rates in post-surgical infants and septic adolescents; influence of amino acids, energy, and insulin","volume":"30","author":"Verbruggen","year":"2011","journal-title":"Clin. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fped.2016.00108","article-title":"Nutrition: A Primary Therapy in Pediatric Acute Respiratory Distress Syndrome","volume":"4","author":"Wilson","year":"2016","journal-title":"Front. Pediatr."},{"key":"ref_80","first-page":"596","article-title":"Respiratory distress secondary to a high carbohydrate load: A case report","volume":"87","author":"Askanazi","year":"1980","journal-title":"Surgery"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/00000542-198105000-00005","article-title":"Nutrition for the patient with respiratory failure: Glucose vs. fat","volume":"54","author":"Askanazi","year":"1981","journal-title":"Anesthesiology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1001\/jama.1980.03300400028023","article-title":"Respiratory changes induced by the large glucose loads of total parenteral nutrition","volume":"243","author":"Askanazi","year":"1980","journal-title":"JAMA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00003246-198802000-00018","article-title":"Intravenous fat emulsions and lung function: A review","volume":"16","author":"Skeie","year":"1988","journal-title":"Crit. Care Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/00003246-198805000-00001","article-title":"Changes in respiratory control induced by amino acid infusions","volume":"16","author":"Takala","year":"1988","journal-title":"Crit. Care Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1093\/ajcn\/67.1.74","article-title":"Resting energy expenditure in children in a pediatric intensive care unit: Comparison of Harris-Benedict and Talbot predictions with indirect calorimetry values","volume":"67","author":"Jefferson","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/01.mco.0000222107.15548.f5","article-title":"Indirect calorimetry: Methodology, instruments and clinical application","volume":"9","author":"Alves","year":"2006","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/0148607111415108","article-title":"Is indirect calorimetry a necessity or a luxury in the pediatric intensive care unit?","volume":"36","author":"Kyle","year":"2012","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ccc.2010.08.001","article-title":"Indirect calorimetry measurements in the ventilated critically ill patient: Facts and controversies--the heat is on","volume":"26","author":"Lev","year":"2010","journal-title":"Crit. Care Clin."},{"key":"ref_89","first-page":"430","article-title":"Energy expenditure: Components and evaluation methods","volume":"26","author":"Esteves","year":"2011","journal-title":"Nutr. Hosp."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.nut.2013.03.013","article-title":"Indirect calorimetry: A guide for optimizing nutritional support in the critically ill child","volume":"29","author":"Cohen","year":"2013","journal-title":"Nutrition"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/0148607113511990","article-title":"Indirect calorimetry reveals that better monitoring of nutrition therapy in pediatric intensive care is needed","volume":"39","author":"Dokken","year":"2015","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.nut.2004.05.020","article-title":"Adequate feeding and the usefulness of the respiratory quotient in critically ill children","volume":"21","author":"Hulst","year":"2005","journal-title":"Nutrition"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/MPG.0000000000001197","article-title":"Use of Indirect Calorimetry to Detect Overfeeding in Critically Ill Children: Finding the Appropriate Definition","volume":"63","author":"Kerklaan","year":"2016","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_94","first-page":"655","article-title":"The respiratory quotient has little value in evaluating the state of feeding in burn patients","volume":"29","author":"Palmieri","year":"2008","journal-title":"J. Burn Care Res. Off. Publ. Am. Burn. Assoc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/014860710302700121","article-title":"Clinical use of the respiratory quotient obtained from indirect calorimetry","volume":"27","author":"McClave","year":"2003","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1177\/0148607108325249","article-title":"Cumulative energy imbalance in the pediatric intensive care unit: Role of targeted indirect calorimetry","volume":"33","author":"Mehta","year":"2009","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.jcf.2020.12.008","article-title":"Vitamin D supplementation in patients with cystic fibrosis: A systematic review and meta-analysis","volume":"20","author":"Varannai","year":"2021","journal-title":"J. Cyst. Fibros."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1513\/AnnalsATS.201306-171BC","article-title":"Vitamin D status in children with cystic fibrosis. Associations with inflammation and bacterial colonization","volume":"11","author":"Simoneau","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/ajcn\/nqy291","article-title":"Vitamin D for the Immune System in Cystic Fibrosis (DISC): A double-blind, multicenter, randomized, placebo-controlled clinical trial","volume":"109","author":"Tangpricha","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.clnu.2015.04.010","article-title":"Vitamin A intake and serum retinol levels in children and adolescents with cystic fibrosis","volume":"35","author":"Woestenenk","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3945\/ajcn.2010.29350","article-title":"Suboptimal vitamin K status despite supplementation in children and young adults with cystic fibrosis","volume":"92","author":"Dougherty","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1017\/S0007114515000215","article-title":"Vitamin E intake, \u03b1-tocopherol levels and pulmonary function in children and adolescents with cystic fibrosis","volume":"113","author":"Woestenenk","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Ahmad, S., Arora, S., Khan, S., Mohsin, M., Mohan, A., Manda, K., and Syed, M.A. (2021). Vitamin D and its therapeutic relevance in pulmonary diseases. J. Nutr. Biochem., 90.","DOI":"10.1016\/j.jnutbio.2020.108571"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/B978-0-12-386960-9.00009-5","article-title":"Vitamin D effects on lung immunity and respiratory diseases","volume":"86","author":"Hansdottir","year":"2011","journal-title":"Vitam. Horm."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ped4.12270","article-title":"Association of vitamin A status with lung function in children and adolescents with cystic fibrosis","volume":"5","author":"Loukou","year":"2021","journal-title":"Pediatr. Investig."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Timoneda, J., Rodr\u00edguez-Fern\u00e1ndez, L., Zaragoz\u00e1, R., Mar\u00edn, M.P., Cabezuelo, M.T., Torres, L., Vi\u00f1a, J.R., and Barber, T. (2018). Vitamin A Deficiency and the Lung. Nutrients, 10.","DOI":"10.3390\/nu10091132"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1164\/rccm.2206019","article-title":"Vitamin E as an antioxidant of the lung: Mechanisms of vitamin E delivery to alveolar type II cells","volume":"166","author":"Kolleck","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"10471","DOI":"10.1021\/jf902403p","article-title":"High dose vitamin C supplementation increases the Th1\/Th2 cytokine secretion ratio, but decreases eosinophilic infiltration in bronchoalveolar lavage fluid of ovalbumin-sensitized and challenged mice","volume":"57","author":"Chang","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1177\/014107680710001109","article-title":"Vitamin C may affect lung infections","volume":"100","author":"Louhiala","year":"2007","journal-title":"J. R. Soc. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1096\/fj.00-0085com","article-title":"Extracellular glutathione peroxidase induction in asthmatic lungs: Evidence for redox regulation of expression in human airway epithelial cells","volume":"15","author":"Comhair","year":"2001","journal-title":"FASEB J."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Liu, X., Ali, M.K., Dua, K., and Xu, R. (2022). The Role of Zinc in the Pathogenesis of Lung Disease. Nutrients, 14.","DOI":"10.3390\/nu14102115"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Wessels, I., Maywald, M., and Rink, L. (2017). Zinc as a Gatekeeper of Immune Function. Nutrients, 9.","DOI":"10.3390\/nu9121286"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejphar.2015.11.001","article-title":"DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation","volume":"785","author":"Duvall","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1017\/S000711452000330X","article-title":"Nutritional status of micronutrients as a possible and modifiable risk factor for COVID-19: A UK perspective","volume":"125","author":"Richardson","year":"2021","journal-title":"Br. J. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1111\/j.1398-9995.2010.02378.x","article-title":"Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults","volume":"65","author":"Thuesen","year":"2010","journal-title":"Allergy"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jmv.27277","article-title":"Evaluation of the relationship between serum levels of zinc, vitamin B12, vitamin D, and clinical outcomes in patients with COVID-19","volume":"94","author":"Shakeri","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1159\/000107673","article-title":"Contribution of selected vitamins and trace elements to immune function","volume":"51","author":"Wintergerst","year":"2007","journal-title":"Ann. Nutr. Metab."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"100078","DOI":"10.1016\/j.cdnut.2023.100078","article-title":"Quantification of the Relationship of Pyridoxine and Spirometry Measurements in the United States Population","volume":"7","author":"Huang","year":"2023","journal-title":"Curr. Dev. Nutr."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1021\/bi401618y","article-title":"Thiamin function, metabolism, uptake, and transport","volume":"53","author":"Manzetti","year":"2014","journal-title":"Biochemistry"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"111267","DOI":"10.1016\/j.nut.2021.111267","article-title":"Potential role of folate status on pulmonary function in pediatric asthma","volume":"90","author":"Papamichael","year":"2021","journal-title":"Nutrition"},{"key":"ref_122","first-page":"L679","article-title":"Perinatal hypocuprosis affects synthesis and composition of neonatal lung collagen, elastin, and surfactant","volume":"267","author":"Welti","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1019153","DOI":"10.3389\/fonc.2022.1019153","article-title":"Relationship between copper and immunity: The potential role of copper in tumor immunity","volume":"12","author":"Cheng","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Peterson, C.T., Rodionov, D.A., Osterman, A.L., and Peterson, S.N. (2020). B Vitamins and Their Role in Immune Regulation and Cancer. Nutrients, 12.","DOI":"10.3390\/nu12113380"},{"key":"ref_125","unstructured":"National Academies of Sciences, Engineering, and Medicine (2019). Dietary Reference Intakes for Sodium and Potassium, The National Academies Press."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e007411","DOI":"10.1136\/bmjgh-2021-007411","article-title":"The impact of childhood malnutrition on mortality from pneumonia: A systematic review and network meta-analysis","volume":"6","author":"Kirolos","year":"2021","journal-title":"BMJ Glob. Health"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Hemil\u00e4, H. (2017). Vitamin C and Infections. Nutrients, 9.","DOI":"10.3390\/nu9040339"},{"key":"ref_128","first-page":"Cd000980","article-title":"Vitamin C for preventing and treating the common cold","volume":"2013","author":"Chalker","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_129","first-page":"Cd005532","article-title":"Vitamin C for preventing and treating pneumonia","volume":"8","author":"Louhiala","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_130","first-page":"Cd013134","article-title":"Vitamin C supplementation for prevention and treatment of pneumonia","volume":"11","author":"Padhani","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1442-200X.2010.03224.x","article-title":"Serum vitamin D concentrations and associated severity of acute lower respiratory tract infections in Japanese hospitalized children","volume":"53","author":"Inamo","year":"2011","journal-title":"Pediatr. Int."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e9060","DOI":"10.1097\/MD.0000000000009060","article-title":"Association between serum 25-hydroxyvitamin D concentration and pulmonary infection in children","volume":"97","author":"Li","year":"2018","journal-title":"Medicine"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/ppul.21089","article-title":"Vitamin D deficiency in young children with severe acute lower respiratory infection","volume":"44","author":"McNally","year":"2009","journal-title":"Pediatr. Pulmonol."},{"key":"ref_134","first-page":"373","article-title":"Relationship between vitamin D levels and outcome of pneumonia in children","volume":"29","author":"Oduwole","year":"2010","journal-title":"West. Afr. J. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jpeds.2018.07.097","article-title":"Vitamin D Status at the Time of Hospitalization for Bronchiolitis and Its Association with Disease Severity","volume":"203","author":"Vo","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_136","first-page":"Cd011597","article-title":"Vitamin D as an adjunct to antibiotics for the treatment of acute childhood pneumonia","volume":"1","author":"Das","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3945\/ajcn.2009.29094","article-title":"Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren","volume":"91","author":"Urashima","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e561","DOI":"10.1542\/peds.2011-3029","article-title":"Randomized trial of vitamin D supplementation and risk of acute respiratory infection in Mongolia","volume":"130","author":"Camargo","year":"2012","journal-title":"Pediatrics"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"e12987","DOI":"10.1111\/mcn.12987","article-title":"Association of vitamin D supplementation with respiratory tract infection in infants","volume":"16","author":"Hong","year":"2020","journal-title":"Matern. Child. Nutr."},{"key":"ref_140","first-page":"Cd008524","article-title":"Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age","volume":"3","author":"Imdad","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e13211","DOI":"10.1111\/ijcp.13211","article-title":"Low serum zinc level: The relationship with severe pneumonia and survival in critically ill children","volume":"72","author":"Saleh","year":"2018","journal-title":"Int. J. Clin. Pract."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3389\/fped.2019.00431","article-title":"Zinc Supplementation Promotes a Th1 Response and Improves Clinical Symptoms in Fewer Hours in Children With Pneumonia Younger Than 5 Years Old. A Randomized Controlled Clinical Trial","volume":"7","year":"2019","journal-title":"Front. Pediatr."},{"key":"ref_143","first-page":"e4475","article-title":"Therapeutic Role of Zinc Supplementation in Children Hospitalized with Pneumonia","volume":"11","author":"Laghari","year":"2019","journal-title":"Cureus"},{"key":"ref_144","first-page":"Cd005978","article-title":"Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months","volume":"12","author":"Lassi","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4103\/lungindia.lungindia_589_20","article-title":"Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center","volume":"38","author":"Aziz","year":"2021","journal-title":"Lung India"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0007114518003021","article-title":"Vitamin D intake, serum 25-hydroxy vitamin D and pulmonary function in paediatric patients with cystic fibrosis: A longitudinal approach","volume":"121","author":"Timmers","year":"2019","journal-title":"Br. J. Nutr."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/jclinpath-2013-201787","article-title":"Fat-soluble vitamin deficiency in children and adolescents with cystic fibrosis","volume":"67","author":"Rana","year":"2014","journal-title":"J. Clin. Pathol."},{"key":"ref_148","unstructured":"Andropoulos, D.B. (2012). Gregory\u2019s Pediatric Anesthesia, Wiley-Blackwell."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1513\/AnnalsATS.201208-068OC","article-title":"Vitamin D deficiency is associated with pulmonary exacerbations in children with cystic fibrosis","volume":"11","author":"McCauley","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Escobedo-Monge, M.F., Barrado, E., Alonso Vicente, C., Escobedo-Monge, M.A., Torres-Hinojal, M.C., Marug\u00e1n-Miguelsanz, J.M., and Redondo Del R\u00edo, M.P. (2020). Copper and Copper\/Zinc Ratio in a Series of Cystic Fibrosis Patients. Nutrients, 12.","DOI":"10.3390\/nu12113344"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/crj.12335","article-title":"Serum zinc concentration in cystic fibrosis patients with CFTR I1234V mutation associated with pancreatic sufficiency","volume":"11","author":"AbdulWahab","year":"2017","journal-title":"Clin. Respir. J."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/ppul.20771","article-title":"Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis","volume":"43","author":"Abdulhamid","year":"2008","journal-title":"Pediatr. Pulmonol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4187\/respcare.04038","article-title":"Zinc Supplementation for One Year Among Children with Cystic Fibrosis Does Not Decrease Pulmonary Infection","volume":"61","author":"Sharma","year":"2016","journal-title":"Respir. Care"},{"key":"ref_154","first-page":"Cd002201","article-title":"Omega-3 fatty acid supplementation for cystic fibrosis","volume":"4","author":"Watson","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_155","first-page":"Cd007020","article-title":"Antioxidant supplementation for lung disease in cystic fibrosis","volume":"10","author":"Ciofu","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/ppul.25287","article-title":"Vitamin-D supplementation as an adjunct to standard treatment of asthma in children: A randomized controlled trial (ViDASTA Trial)","volume":"56","author":"Thakur","year":"2021","journal-title":"Pediatr. Pulmonol."},{"key":"ref_157","first-page":"103","article-title":"Zinc and vitamin C deficiencies associate with poor pulmonary function in children with persistent asthma","volume":"40","author":"Siripornpanich","year":"2022","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4103\/0970-2113.209227","article-title":"Vitamin D and asthma in children: A systematic review and meta-analysis of observational studies","volume":"34","author":"Jat","year":"2017","journal-title":"Lung India"},{"key":"ref_159","first-page":"60","article-title":"Does vitamin E prevent asthma or wheeze in children: A systematic review and meta-analysis","volume":"27","author":"Wu","year":"2018","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/ijaai.ijaai_8_20","article-title":"Severity of asthma and Vitamin D status in children: A case-control study in a tertiary care center","volume":"34","author":"Anand","year":"2020","journal-title":"Indian J. Allergy Asthma Immunol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00408-023-00605-x","article-title":"Association between serum Vitamin D levels and asthma severity and control in children and adolescents","volume":"201","author":"Malheiro","year":"2023","journal-title":"Lung"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1001\/jama.2020.12384","article-title":"Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial","volume":"324","author":"Forno","year":"2020","journal-title":"JAMA"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/tropej\/fmz078","article-title":"Serum Zinc, Selenium and Total Antioxidant Contents of Nigerian Children with Asthma: Association with Disease Severity and Symptoms Control","volume":"66","author":"Kuti","year":"2020","journal-title":"J. Trop. Pediatr."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00431-022-04656-9","article-title":"Association of serum zinc levels and symptom control of asthma in children and adolescents- a prospective observational study","volume":"182","author":"Rajkumar","year":"2023","journal-title":"Eur. J. Pediatr."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1900990","DOI":"10.1183\/13993003.00990-2019","article-title":"Dietary antioxidant intake in school age and lung function development up to adolescence","volume":"55","author":"Sdona","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cyto.2016.06.002","article-title":"Effects of omega-3 fatty acids on serum levels of T-helper cytokines in children with asthma","volume":"85","author":"Farjadian","year":"2016","journal-title":"Cytokine"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(05)71877-8","article-title":"WHO estimates of the causes of death in children","volume":"365","author":"Bryce","year":"2005","journal-title":"Lancet"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"408","DOI":"10.2471\/BLT.07.048769","article-title":"Epidemiology and etiology of childhood pneumonia","volume":"86","author":"Rudan","year":"2008","journal-title":"Bull. World Health Organ."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"fmab081","DOI":"10.1093\/tropej\/fmab081","article-title":"The Relationship between Bronchiolitis Severity and Vitamin D Status","volume":"67","author":"Tolunay","year":"2021","journal-title":"J. Trop. Pediatr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/sj.ejcn.1602946","article-title":"Vitamin D status is not associated with the risk of hospitalization for acute bronchiolitis in early childhood","volume":"63","author":"Roth","year":"2009","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/pai.12977","article-title":"Circulating 25-hydroxyvitamin D, nasopharyngeal microbiota, and bronchiolitis severity","volume":"29","author":"Toivonen","year":"2018","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Doumat, G., Mehta, G.D., Mansbach, J.M., Hasegawa, K., and Camargo, C.A. (2023). Association between Early Childhood Vitamin D Status and Age 6-Year Lung Function among Children with a History of Severe Bronchiolitis in Infancy. Nutrients, 15.","DOI":"10.3390\/nu15102379"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Khoshnevisasl, P., Sadeghzadeh, M., Kamali, K., and Ardalani, A. (2022). A randomized clinical trial to assess the effect of zinc and vitamin D supplementation in addition to hypertonic saline on treatment of acute bronchiolitis. BMC Infect. Dis., 22.","DOI":"10.1186\/s12879-022-07492-2"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.prrv.2012.01.004","article-title":"Short-term therapeutic role of zinc in children < 5 years of age hospitalised for severe acute lower respiratory tract infection","volume":"13","author":"Das","year":"2012","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"50","DOI":"10.18203\/2349-3259.ijct20201711","article-title":"Comparing the effect of zinc gluconate and placebo in the treatment of tachypnea, dyspnea and fever in children aged 2 to 23 months with acute bronchiolitis","volume":"7","author":"Ahadi","year":"2020","journal-title":"Int. J. Clin. Trials"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1385\/BTER:100:2:097","article-title":"Relationship among serum selenium levels, lipid peroxidation, and acute bronchiolitis in infancy","volume":"100","author":"Gurkan","year":"2004","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1097\/00003246-200208000-00018","article-title":"Oxidative stress in critically ill patients with systemic inflammatory response syndrome","volume":"30","author":"Serrano","year":"2002","journal-title":"Crit. Care Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s001340050813","article-title":"Antioxidant status in patients with acute respiratory distress syndrome","volume":"25","author":"Metnitz","year":"1999","journal-title":"Intensive Care Med."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"e455","DOI":"10.1097\/PCC.0000000000001626","article-title":"Multiple Micronutrient Plasma Level Changes Are Related to Oxidative Stress Intensity in Critically Ill Children","volume":"19","author":"Valla","year":"2018","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1742-4658.2006.05607.x","article-title":"Biosynthesis, recycling and degradation in mammals","volume":"274","author":"Linster","year":"2007","journal-title":"FEBS J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/s41390-021-01673-6","article-title":"Vitamin therapy in sepsis","volume":"91","author":"Wald","year":"2022","journal-title":"Pediatr. Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3945\/ajcn.2009.29078","article-title":"Low blood thiamine concentrations in children upon admission to the intensive care unit: Risk factors and prognostic significance","volume":"93","author":"Lima","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/PCC.0000000000002914","article-title":"Vitamin C Deficiency in Critically Ill Children: Prospective Observational Cohort Study","volume":"23","author":"Fathi","year":"2022","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.chest.2016.11.036","article-title":"Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study","volume":"151","author":"Marik","year":"2017","journal-title":"Chest"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1164\/rccm.201908-1543LE","article-title":"Hydrocortisone-Ascorbic Acid-Thiamine Use Associated with Lower Mortality in Pediatric Septic Shock","volume":"201","author":"Wald","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1007\/s00134-012-2718-6","article-title":"Vitamin D status in critically ill children","volume":"38","author":"Rippel","year":"2012","journal-title":"Intensive Care Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1542\/peds.2011-3328","article-title":"Vitamin D deficiency in critically ill children","volume":"130","author":"Madden","year":"2012","journal-title":"Pediatrics"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1542\/peds.2011-3059","article-title":"The association of vitamin D status with pediatric critical illness","volume":"130","author":"McNally","year":"2012","journal-title":"Pediatrics"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13054-017-1875-y","article-title":"Vitamin D deficiency in critically ill children: A systematic review and meta-analysis","volume":"21","author":"McNally","year":"2017","journal-title":"Crit. Care"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/s41430-018-0249-0","article-title":"Vitamin D deficiency and clinical outcomes related to septic shock in children with critical illness: A systematic review","volume":"73","author":"Wang","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12937-019-0507-6","article-title":"Association between micronutrient deficiency and acute respiratory infections in healthy adults: A systematic review of observational studies","volume":"18","author":"Wang","year":"2019","journal-title":"Nutr. J."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1016\/j.clnu.2021.03.001","article-title":"Vitamin D deficiency in critically ill COVID-19 ARDS patients","volume":"41","author":"Notz","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2008.02.043","article-title":"Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury","volume":"133","author":"Imai","year":"2008","journal-title":"Cell"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2020.06.008","article-title":"Mitochondria and microbiota dysfunction in COVID-19 pathogenesis","volume":"54","author":"Saleh","year":"2020","journal-title":"Mitochondrion"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.abb.2016.03.022","article-title":"Zinc and immunity: An essential interrelation","volume":"611","author":"Maares","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3945\/an.114.007575","article-title":"Dietary selenium in adjuvant therapy of viral and bacterial infections","volume":"6","author":"Steinbrenner","year":"2015","journal-title":"Adv. Nutr."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Gammoh, N.Z., and Rink, L. (2017). Zinc in Infection and Inflammation. Nutrients, 9.","DOI":"10.20944\/preprints201705.0176.v1"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/ajcn\/86.4.1167","article-title":"Serum zinc and pneumonia in nursing home elderly","volume":"86","author":"Meydani","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.abb.2012.02.015","article-title":"Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease","volume":"520","author":"Chou","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.antiviral.2017.11.001","article-title":"Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein","volume":"149","author":"Lei","year":"2018","journal-title":"Antivir. Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"e01697","DOI":"10.1128\/mBio.01697-15","article-title":"Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials","volume":"6","author":"Warnes","year":"2015","journal-title":"mBio"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"111047","DOI":"10.1016\/j.nut.2020.111047","article-title":"Potential roles of micronutrient deficiency and immune system dysfunction in the coronavirus disease 2019 (COVID-19) pandemic","volume":"82","author":"Gorji","year":"2021","journal-title":"Nutrition"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1097\/00003246-199809000-00021","article-title":"Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients","volume":"26","author":"Forceville","year":"1998","journal-title":"Crit. Care Med."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1097\/01.CCM.0000055371.27268.36","article-title":"Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome","volume":"31","author":"Motoyama","year":"2003","journal-title":"Crit. Care Med."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1096\/fasebj.12.12.1143","article-title":"Glutathione peroxidase protects mice from viral-induced myocarditis","volume":"12","author":"Beck","year":"1998","journal-title":"FASEB J."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"G71","DOI":"10.1152\/ajpgi.00379.2014","article-title":"Selenium and inflammatory bowel disease","volume":"309","author":"Kudva","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Guillin, O.M., Vindry, C., Ohlmann, T., and Chavatte, L. (2019). Selenium, Selenoproteins and Viral Infection. Nutrients, 11.","DOI":"10.3390\/nu11092101"},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Notz, Q., Herrmann, J., Schlesinger, T., Helmer, P., Sudowe, S., Sun, Q., Hackler, J., Roeder, D., Lotz, C., and Meybohm, P. (2021). Clinical Significance of Micronutrient Supplementation in Critically Ill COVID-19 Patients with Severe ARDS. Nutrients, 13.","DOI":"10.3390\/nu13062113"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/CMR.18.3.446-464.2005","article-title":"Effects of vitamin a supplementation on immune responses and correlation with clinical outcomes","volume":"18","author":"Villamor","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Tepasse, P.R., Vollenberg, R., Fobker, M., Kabar, I., Schmidt, H., Meier, J.A., Nowacki, T., and H\u00fcsing-Kabar, A. (2021). Vitamin A Plasma Levels in COVID-19 Patients: A Prospective Multicenter Study and Hypothesis. Nutrients, 13.","DOI":"10.3390\/nu13072173"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/19\/4142\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:57:55Z","timestamp":1760129875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/19\/4142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,25]]},"references-count":210,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["nu15194142"],"URL":"https:\/\/doi.org\/10.3390\/nu15194142","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,25]]}}}