{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T18:39:52Z","timestamp":1788719992074,"version":"build-2803163510"},"reference-count":73,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ulla og Mogens Folmer Andersen\u2019s Legat"},{"name":"Marie Pedersen og Jensine Heiberg\u2019s Legat"},{"name":"Niels Jensens Forskningslegat"},{"name":"Region Nordjyllands Sundhedsvidenskabelige Forskningsfond"},{"name":"Torben og Alice Frimodt\u2019s Legat"},{"name":"Aase og Ejnar Danielsen\u2019s Legat"},{"name":"Lilly og Herbert Hansen\u2019s Legat"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Postmenopausal women are at risk of developing an overactive bladder (OAB). Conventional vaginal estrogen has shown promise for symptom relief. Isoflavones have proven effective as an alternative to estrogen treatment against menopause-related symptoms. However, its effect on OAB symptoms has not been studied. This study investigates if fermented red clover isoflavones reduce OAB symptoms in postmenopausal women. In this randomized, double-blinded, placebo-controlled trial, women were administered red clover extract (RCE) or a placebo twice daily for three months. Women filled out the International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) and Urinary Incontinence Short Form (ICIQ-UI-SF), together with a fluid intake and voiding diary. A total of 33 women (16 in the RCE group and 17 in the placebo group) were included in the analysis. Baseline demographics and OAB characteristics were comparable across groups. Intake of RCE did not lead to significant relief in most urinary bladder symptom measures, although a significant reduction in the bother of urinary urgency (p = 0.033) and a tendency towards a decreased ICIQ-OAB score were observed (p = 0.056). In contrast, the placebo exhibited a significant decrease in the ICIQ-OAB score (p = 0.021) and in some diary outcomes. We found that an intake of isoflavones did not relieve OAB symptoms in postmenopausal women.<\/jats:p>","DOI":"10.3390\/nu15194165","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T03:49:14Z","timestamp":1695786554000},"page":"4165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Use of Fermented Red Clover Isoflavones in the Treatment of Overactive Bladder in Postmenopausal Women: A Randomized, Double-Blinded, Placebo-Controlled Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-2900","authenticated-orcid":false,"given":"Annemarie B.","family":"Villadsen","sequence":"first","affiliation":[{"name":"Centre for Clinical Research, North Denmark Regional Hospital, 9800 Hjoerring, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie N.","family":"Holm-Jacobsen","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, North Denmark Regional Hospital, 9800 Hjoerring, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-3113","authenticated-orcid":false,"given":"Bala K.","family":"Prabhala","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2700-2378","authenticated-orcid":false,"given":"Caspar","family":"Bundgaard-Nielsen","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, North Denmark Regional Hospital, 9800 Hjoerring, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7861-9821","authenticated-orcid":false,"given":"Pam","family":"Huntjens","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, North Denmark Regional Hospital, 9800 Hjoerring, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette B.","family":"Kornum","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Glavind","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Aalborg University Hospital, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D. C.","family":"Leutscher","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, North Denmark Regional Hospital, 9800 Hjoerring, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5035-9201","authenticated-orcid":false,"given":"Lars P.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-7554","authenticated-orcid":false,"given":"Per B.","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus University Hospital, 8200 Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4201-1168","authenticated-orcid":false,"given":"Suzette","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, North Denmark Regional Hospital, 9800 Hjoerring, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark"},{"name":"Steno Diabetes Center North Denmark, 9000 Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise T. S.","family":"Arenholt","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, North Denmark Regional Hospital, 9800 Hjoerring, Denmark"},{"name":"Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark"},{"name":"Department of Obstetrics and Gynecology, North Denmark Regional Hospital, 9800 Hjoerring, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1111\/j.1464-410X.2008.07601.x","article-title":"The Impact of Overactive Bladder, Incontinence and Other Lower Urinary Tract Symptoms on Quality of Life, Work Productivity, Sexuality and Emotional Well-Being in Men and Women: Results from the EPIC Study","volume":"101","author":"Coyne","year":"2008","journal-title":"BJU Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/nau.20798","article-title":"An International Urogynecological Association (IUGA)\/International Continence Society (ICS) Joint Report on the Terminology for Female Pelvic Floor Dysfunction","volume":"29","author":"Haylen","year":"2010","journal-title":"Neurourol. 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