{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:40:39Z","timestamp":1780598439244,"version":"3.54.1"},"reference-count":43,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SAPIENZA UNIVERSITA\u2019 DI ROMA","award":["2021\u20132022"],"award-info":[{"award-number":["2021\u20132022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Corpus Atrophic Gastritis (CAG) is characterised by iron malabsorption leading to iron deficiency anaemia (IDA), which rarely responds to oral therapy. Ferric carboxymaltose (FCM), shown to be a safe and effective intravenous iron therapy in other diseases, has not been investigated yet in CAG. Thus, we aimed to assess the safety and efficacy of FCM in CAG-related IDA. A retrospective study on 91 patients identified CAG as the only cause of IDA treated with FCM. Twenty-three were excluded for incomplete follow-up. Sixty-eight were evaluated for safety and efficacy, while three were evaluated for safety only due to infusion interruption for side effects. Haemoglobin and iron storage were evaluated pre-infusion (T0), at 4 weeks (T4) and 12 weeks (T12) after infusion. An eventual IDA relapse was analysed. Two cases reported mild side effects. Haemoglobin significantly increased at T4, and T12, reaching +3.1 g\/dL. Ferritin increased at T4, decreasing at T12, while transferrin saturation increased progressively until reaching a plateau. IDA relapsed in 55.4% of patients at a mean of 24.6 months. The only factor associated with relapse was female gender [OR (95% CI): 6.6 (1.5\u201328.6)]. FCM proved to be safe and effective in treating CAG-related IDA, ensuring quick and long-lasting recovery.<\/jats:p>","DOI":"10.3390\/nu15194199","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:48:13Z","timestamp":1695966493000},"page":"4199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and Safety of Intravenous Ferric Carboxymaltose Treatment of Iron Deficiency Anaemia in Patients with Corpus Atrophic Gastritis: A Retrospective Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Ludovica","family":"Dottori","sequence":"first","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniil","family":"Corleone Tsar'kov","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9070-7733","authenticated-orcid":false,"given":"Emanuele","family":"Dilaghi","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pivetta","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Scalamonti","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Ligato","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2242-5048","authenticated-orcid":false,"given":"Gianluca","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9120-5957","authenticated-orcid":false,"given":"Bruno","family":"Annibale","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-8639","authenticated-orcid":false,"given":"Edith","family":"Lahner","sequence":"additional","affiliation":[{"name":"Department of Medical-Surgical Sciences and Translational Medicine, Sant\u2019Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.dld.2019.09.016","article-title":"Chronic atrophic gastritis: Natural history, diagnosis and therapeutic management. A position paper by the Italian Society of Hospital Gastroenterologists and Digestive Endoscopists [AIGO], the Italian Society of Digestive Endoscopy [SIED], the Italian Society of Gastroenterology [SIGE], and the Italian Society of Internal Medicine [SIMI]","volume":"51","author":"Lahner","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1182\/blood-2005-09-3534","article-title":"Variable hematologic presentation of autoimmune gastritis: Age-related progression from iron deficiency to cobalamin depletion","volume":"107","author":"Hershko","year":"2006","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17040","DOI":"10.1038\/nrdp.2017.40","article-title":"Vitamin B12 deficiency","volume":"3","author":"Green","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Esposito, G., Dottori, L., Pivetta, G., Ligato, I., Dilaghi, E., and Lahner, E. (2022). Pernicious Anemia: The Hematological Presentation of a Multifaceted Disorder Caused by Cobalamin Deficiency. Nutrients, 14.","DOI":"10.3390\/nu14081672"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Lenti, M.V., Lahner, E., Bergamaschi, G., Miceli, E., Conti, L., Massironi, S., Cococcia, S., Zilli, A., Caprioli, F., and Vecchi, M. (2019). Cell Blood Count Alterations and Patterns of Anaemia in Autoimmune Atrophic Gastritis at Diagnosis: A Multicentre Study. J. Clin. Med., 8.","DOI":"10.3390\/jcm8111992"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1182\/blood-2018-05-815944","article-title":"Iron deficiency","volume":"133","author":"Camaschella","year":"2019","journal-title":"Blood"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCULATIONAHA.118.030099","article-title":"Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies","volume":"138","author":"Anand","year":"2018","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000496966","article-title":"Safety of Oral and Intravenous Iron","volume":"142","author":"DeLoughery","year":"2019","journal-title":"Acta Haematol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0002-9343(01)00883-X","article-title":"Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms","volume":"111","author":"Annibale","year":"2001","journal-title":"Am. J. Med."},{"key":"ref_10","first-page":"585","article-title":"Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia","volume":"90","author":"Hershko","year":"2005","journal-title":"Haematologica"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1136\/gutjnl-2021-325210","article-title":"British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults","volume":"70","author":"Snook","year":"2021","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/pharmaceutics3010012","article-title":"The pharmacokinetics and pharmacodynamics of iron preparations","volume":"3","author":"Geisser","year":"2011","journal-title":"Pharmaceutics"},{"key":"ref_13","first-page":"11","article-title":"The pharmacology and safety profile of ferric carboxymaltose (Ferinject\u00ae): Structure\/reactivity relationships of iron preparations","volume":"23","author":"Geisser","year":"2009","journal-title":"Port. J. Nephrol. Hypert."},{"key":"ref_14","first-page":"345","article-title":"The new generation of intravenous iron: Chemistry, pharmacology, and toxicology of ferric carboxymaltose","volume":"60","author":"Funk","year":"2010","journal-title":"Arzneimittelforschung"},{"key":"ref_15","unstructured":"Vifor Pharma UK Limited (2018, February 09). Ferinject (Ferric Carboxymaltose): UK Summary of Product Characteristics. Available online: http:\/\/www.medicines.org.uk."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2165\/00003495-200969060-00007","article-title":"Ferric carboxymaltose: A review of its use in iron-deficiency anaemia","volume":"69","author":"Keating","year":"2009","journal-title":"Drugs"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1053\/j.gastro.2011.06.005","article-title":"FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease","volume":"141","author":"Evstatiev","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1572-0241.2007.01744.x","article-title":"A novel intravenous iron formulation for treatment of anemia in inflammatory bowel disease: The ferric carboxymaltose (FERINJECT_) randomized controlled trial","volume":"103","author":"Kulnigg","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cgh.2012.10.013","article-title":"Ferric carboxymaltose prevents recurrence of anemia in patients with inflammatory bowel disease","volume":"11","author":"Evstatiev","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3109\/00365521.2013.819442","article-title":"Anemia and iron deficiency in inflammatory bowel disease: An open, prospective, observational study on diagnosis, treatment with ferric carboxymaltose and quality of life","volume":"48","author":"Befrits","year":"2013","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_21","first-page":"S77","article-title":"Improvement in hematological status and symptoms in IBD patients using ferric carboxymaltose (Ferinject_): A German multicenter non-interventional study (abstract no. P157)","volume":"5","author":"Stein","year":"2011","journal-title":"J. Crohns Colitis"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/ecco-jcc\/jjy042","article-title":"Safety and Efficacy of Ferric Carboxymaltose in the Treatment of Iron Deficiency Anaemia in Patients with Inflammatory Bowel Disease, in Routine Daily Practice","volume":"12","author":"Stein","year":"2018","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1053\/j.gastro.2021.06.078","article-title":"AGA clinical practice update on the diagnosis and management of atrophic gastritis: Expert review","volume":"161","author":"Shah","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/a-0859-1883","article-title":"Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019","volume":"51","author":"Areia","year":"2019","journal-title":"Endoscopy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.dld.2020.10.038","article-title":"Endoscopic surveillance at 3 years after diagnosis, according to European guidelines, seems safe in patients with atrophic gastritis in a low-risk region","volume":"53","author":"Esposito","year":"2021","journal-title":"Dig. Liver Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","article-title":"Classification and Grading of Gastritis. The updated Sydney System. In-ternational Workshop on the Histopathology of Gastritis, Houston 1994","volume":"20","author":"Dixon","year":"1996","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_27","unstructured":"World Health Organization (2011). Vitamin and Mineral Nutrition Information System, World Health Organization. Available online: http:\/\/www.who.int\/vmnis\/indicators\/haemoglobin.pdf."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1053\/j.gastro.2020.06.046","article-title":"AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia","volume":"159","author":"Ko","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.3748\/wjg.15.4638","article-title":"A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases","volume":"15","author":"Bermejo","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/2040620714521127","article-title":"Experience with intravenous ferric carboxymaltose in patients with iron deficiency anemia","volume":"5","author":"Bregman","year":"2014","journal-title":"Ther. Adv. Hematol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s40265-014-0332-3","article-title":"Ferric carboxymaltose: A review of its use in iron deficiency","volume":"75","author":"Keating","year":"2015","journal-title":"Drugs"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s40265-018-0885-7","article-title":"Ferric carboxymaltose: A review in iron deficiency","volume":"78","author":"Scott","year":"2018","journal-title":"Drugs"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.clinthera.2019.12.010","article-title":"Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Ferric Carboxymaltose in Chinese Patients with Iron-deficiency Anemia","volume":"42","author":"Ding","year":"2020","journal-title":"Clin. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/ndt\/gft251","article-title":"Ferric carboxymaltose in patients with iron-deficiency anemia and impaired renal function: The REPAIR-IDA trial","volume":"29","author":"Onken","year":"2014","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"172104","DOI":"10.1155\/2012\/172104","article-title":"Safety and efficacy of intravenous ferric carboxymaltose (750 mg) in the treatment of iron deficiency anemia: Two randomized, controlled trials","volume":"2012","author":"Barish","year":"2012","journal-title":"Anemia"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/trf.12289","article-title":"A multicenter, randomized, active-controlled study to investigate the efficacy and safety of intravenous ferric carboxymaltose in patients with iron deficiency anemia","volume":"54","author":"Onken","year":"2013","journal-title":"Transfusion"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s11695-013-0939-6","article-title":"Comparative review of the safety and efficacy of ferric carboxymaltose versus standard medical care for the treatment of iron deficiency anemia in bariatric and gastric surgery patients","volume":"23","author":"Malone","year":"2013","journal-title":"Obes. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/ajh.25060","article-title":"Comparative safety of intravenous ferumoxytol versus ferric carboxymaltose in iron deficiency anemia: A randomized trial","volume":"93","author":"Adkinson","year":"2018","journal-title":"Am. J. Hematol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/bjh.18979","article-title":"Incidence and predictors of hypophosphataemia after ferric carboxymaltose use\u2014A 3-year experience from a single institution in Singapore","volume":"202","author":"Chu","year":"2023","journal-title":"Br. J. Haematol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.iac.2014.04.013","article-title":"Hypersensitivity from Intravenous Iron Products","volume":"34","author":"Bircher","year":"2014","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_41","first-page":"301","article-title":"Eisen-Dextran intraven\u00f6s: Therapeutische und experimentelle M\u00f6glichkeiten [Intravenous iron-dextran: Therapeutic and experimental possibilities]","volume":"100","author":"Ganzoni","year":"1970","journal-title":"Schweiz. Med. Wochenschr."},{"key":"ref_42","first-page":"176","article-title":"Intravenous ferric carboxymaltose is effective and safe in patients with inflammatory rheumatic diseases","volume":"18","author":"Salvadori","year":"2020","journal-title":"Blood Transfus."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2022.04.006","article-title":"Gender-sex differences in autoimmune atrophic gastritis","volume":"248","author":"Lahner","year":"2022","journal-title":"Transl. Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/19\/4199\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:01:19Z","timestamp":1760130079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/19\/4199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":43,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["nu15194199"],"URL":"https:\/\/doi.org\/10.3390\/nu15194199","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]}}}