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China","award":["No. 2022-YF05-01444-SN"],"award-info":[{"award-number":["No. 2022-YF05-01444-SN"]}]},{"name":"National Key Research and Development Program of China","award":["No. 2023YFS0031"],"award-info":[{"award-number":["No. 2023YFS0031"]}]},{"name":"National Key Research and Development Program of China","award":["No. 2022YFC2502600"],"award-info":[{"award-number":["No. 2022YFC2502600"]}]},{"name":"National Key Research and Development Program of China","award":["2022YFC2502603"],"award-info":[{"award-number":["2022YFC2502603"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objective: Although several studies have found dietary intake is related to multiple myeloma (MM) and its precursor status risks, the role of one\u2019s nutritional status has been ignored and its role in plasma cell neoplasm development is still unclear. This study aimed to explore the relationship between various clinical indices of nutritional status and the risk of monoclonal gammopathy of undetermined significance (MGUS) in the population. Methods: We selected 9520 participants from the NHANES III and NHANES 1999\u20132004 studies. Controlling nutritional status index (CONUT), prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI) and body mass index (BMI) were calculated as indices of nutritional status of the participants. Associations between nutritional indices and MGUS were investigated using multiple logistic regression, subgroup analysis, and an RCS model. Results: In our study, 266 participants had MGUS, with a prevalence of 2.79%. This study found that CONUT and PNI identified populations with poor nutritional status and had a significant positive correlation with the risk of MGUS. In multivariate logistic regression, compared with the lower CONUT score (&lt;3) group, the OR for the group with higher scores (\u22653) was 1.805 (95%CI: 1.271, 2.564). Compared with the lowest quartile group, the highest quartile PNI score group had an OR of 0.509 (95%CI: 0.290, 0.896). GNRI had no significant correlation with the risk of MGUS, with an OR of 0.737 (95%CI: 0.443, 1.227). Conclusion: This study found that older adults with CONUT and PNI scores indicating poorer nutrition had a higher risk of MGUS.<\/jats:p>","DOI":"10.3390\/nu15194210","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T05:48:13Z","timestamp":1695966493000},"page":"4210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nutritional Status Indices and Monoclonal Gammopathy of Undetermined Significance Risk in the Elderly Population: Findings from the National Health and Nutrition Examination Survey"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2975-3713","authenticated-orcid":false,"given":"Linfeng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengrui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1580-1014","authenticated-orcid":false,"given":"Ting","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1056\/NEJMoa054494","article-title":"Prevalence of Monoclonal Gammopathy of Undetermined Significance","volume":"354","author":"Kyle","year":"2006","journal-title":"N. 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