{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:21:53Z","timestamp":1774671713900,"version":"3.50.1"},"reference-count":113,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shire Investigator Initiated Research Program","award":["IIR-DE-002562"],"award-info":[{"award-number":["IIR-DE-002562"]}]},{"name":"Shire Investigator Initiated Research Program","award":["130208"],"award-info":[{"award-number":["130208"]}]},{"name":"Zealand Pharma Denmark","award":["IIR-DE-002562"],"award-info":[{"award-number":["IIR-DE-002562"]}]},{"name":"Zealand Pharma Denmark","award":["130208"],"award-info":[{"award-number":["130208"]}]},{"name":"Forschungsf\u00f6rderung of the Charit\u00e9","award":["IIR-DE-002562"],"award-info":[{"award-number":["IIR-DE-002562"]}]},{"name":"Forschungsf\u00f6rderung of the Charit\u00e9","award":["130208"],"award-info":[{"award-number":["130208"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: The human intestinal tract reacts to extensive resection with spontaneous intestinal adaptation. We analyzed whether gene expression analyses or intestinal permeability (IP) testing could provide biomarkers to describe regulation mechanisms in the intestinal barrier in short bowel syndrome (SBS) patients during adaptive response or treatment with the glucagon-like peptide-2 analog teduglutide. Methods: Relevant regions of the GLP-2 receptor gene were sequenced. Gene expression analyses and immunohistochemistry were performed from mucosal biopsies. IP was assessed using a carbohydrate oral ingestion test. Results: The study includes 59 SBS patients and 19 controls. Increases in gene expression with teduglutide were received for sucrase-isomaltase, sodium\/glucose cotransporter 1, and calcium\/calmodulin serine protein kinase. Mannitol recovery was decreased in SBS but elevated with teduglutide (\u0394 40%), showed a positive correlation with remnant small bowel and an inverse correlation with parenteral support. Conclusions: Biomarkers predicting clinical and functional features in human SBS are very limited. Altered specific gene expression was shown for genes involved in nutrient transport but not for genes controlling tight junctions. However, mannitol recovery proved useful in describing the absorptive capacity of the gut during adaptation and treatment with teduglutide.<\/jats:p>","DOI":"10.3390\/nu15194220","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:28:08Z","timestamp":1696220888000},"page":"4220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictive Potential of Biomarkers of Intestinal Barrier Function for Therapeutic Management with Teduglutide in Patients with Short Bowel Syndrome"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4719-9718","authenticated-orcid":false,"given":"Janine","family":"B\u00fcttner","sequence":"first","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, Department of Hepatology and Gastroenterology, Campus Charit\u00e9 Mitte and Campus Virchow Klinikum, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7008-8795","authenticated-orcid":false,"given":"Elisabeth","family":"Bl\u00fcthner","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, Department of Hepatology and Gastroenterology, Campus Charit\u00e9 Mitte and Campus Virchow Klinikum, 10117 Berlin, Germany"},{"name":"Berlin Institute of Health (BIH), 10178 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1315-8766","authenticated-orcid":false,"given":"Sophie","family":"Greif","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, Department of Hepatology and Gastroenterology, Campus Charit\u00e9 Mitte and Campus Virchow Klinikum, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2293-5387","authenticated-orcid":false,"given":"Anja","family":"K\u00fchl","sequence":"additional","affiliation":[{"name":"iPATH.Berlin, Core Unit der Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt, Campus Benjamin Franklin, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sefer","family":"Elezkurtaj","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, Department of Pathology, Campus Mitte, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, Asklepios Klinik St. Georg, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Maasberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, Asklepios Klinik St. Georg, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Jochum","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, Department of Hepatology and Gastroenterology, Campus Charit\u00e9 Mitte and Campus Virchow Klinikum, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-0226","authenticated-orcid":false,"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, Department of Hepatology and Gastroenterology, Campus Charit\u00e9 Mitte and Campus Virchow Klinikum, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-8348","authenticated-orcid":false,"given":"Ulrich-Frank","family":"Pape","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, Department of Hepatology and Gastroenterology, Campus Charit\u00e9 Mitte and Campus Virchow Klinikum, 10117 Berlin, Germany"},{"name":"Department of Internal Medicine and Gastroenterology, Asklepios Klinik St. Georg, 20099 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1177\/0148607114520994","article-title":"Spectrum of short bowel syndrome in adults: Intestinal insufficiency to intestinal failure","volume":"38","author":"Jeppesen","year":"2014","journal-title":"JPEN J. 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