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The Warburg hypothesis states that cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to target cancers metabolically by depriving them of glucose. In addition to dietary and lifestyle modifications which work on tumors metabolically, there are a panoply of nutritional supplements and repurposed drugs associated with cancer prevention and better treatment outcomes. These interventions and their evidentiary basis are covered in the latter half of this review to guide future cancer treatment.<\/jats:p>","DOI":"10.3390\/nu15194245","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:28:08Z","timestamp":1696220888000},"page":"4245","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Cancer Metabolism as a Therapeutic Target and Review of Interventions"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2487-0636","authenticated-orcid":false,"given":"Matthew","family":"Halma","sequence":"first","affiliation":[{"name":"Department of Physics and Astronomy, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands"},{"name":"EbMC Squared CIC, Bath BA2 4BL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-0429","authenticated-orcid":false,"given":"Jack","family":"Tuszynski","sequence":"additional","affiliation":[{"name":"Department of Physics, University of Alberta, 11335 Saskatchewan Dr NW, Edmonton, AB T6G 2M9, Canada"},{"name":"Department of Data Science and Engineering, The Silesian University of Technology, 44-100 Gliwice, Poland"},{"name":"DIMEAS, Politecnico di Torino, Corso Duca degli Abruzzi 24, I-1029 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Marik","sequence":"additional","affiliation":[{"name":"Frontline COVID-19 Critical Care Alliance, Washington, DC 20036, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.7150\/jca.14274","article-title":"Warburg effect-a consequence or the cause of carcinogenesis?","volume":"7","author":"Devic","year":"2016","journal-title":"J. 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