{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:09:15Z","timestamp":1789268955059,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objective: This study aimed to (1) characterize cardiometabolic factors in self-reported hip and knee osteoarthritis (OAD) across four body composition phenotypes defined by muscle mass and adiposity, and (2) associate risk factors with diabetes and hypertension (HTN). Methods: A cross-sectional analysis of the Chilean National Health Survey 2016\u201317 (n = 4996) stratified participants into four groups: low skeletal muscle mass\/high waist circumference (Low-SMM\/High-WC), low SMM\/low WC (Low-SMM\/Low-WC), high SMM\/high WC (High-SMM\/High-WC), and high SMM\/low WC (reference group). Each group was further divided into subgroups with or without diagnosed hip or knee OAD. The main outcomes were fasting plasma glucose, systolic (SBP)\/diastolic (DBP) blood pressure (continuous outcomes), and other secondary factors such as cardiovascular risk (CVR). Results: In the hip OAD subgroup, the Low-SMM\/High-WC groups had significantly higher SBP versus the reference value (145 vs. 127 mmHg, p &lt; 0.0001, diff +18 mmHg). In the knee OAD subgroup, the Low-SMM\/High-WC groups had significantly higher SBP versus the reference value (141 vs. 134 mmHg, p &lt; 0.0001, diff +7 mmHg). The SBP showed a significant interaction between the group and OAD diagnosis (p = 0.007 hip OAD; p &lt; 0.0001 knee OAD). Conclusions: Hip and knee OAD associates with elevated SBP\/DBP in older adults. OAD groups showed an OR above 2 for diabetes, 2.7 for HTN, 4.5 for metabolic syndrome, and over 2 for moderate-to-high cardiovascular risk. OAD interacts substantially with cardiometabolic factors, especially in low muscle mass\/high adiposity phenotypes. Lifestyle optimization of physical activity and nutrition to preserve muscle mass and mitigate adiposity is essential for cardiometabolic health promotion in OAD patients.<\/jats:p>","DOI":"10.3390\/nu15194263","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T09:14:22Z","timestamp":1696497262000},"page":"4263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Higher Skeletal Muscle Mass and Lower Adiposity Phenotype Is Associated with Better Cardiometabolic Control in Adults with Hip and Knee Osteoarthritis: Results from the Chilean National Health Survey 2016\u20132017"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-1396","authenticated-orcid":false,"given":"Francisco","family":"Guede-Rojas","sequence":"first","affiliation":[{"name":"Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Ibacache-Saavedra","sequence":"additional","affiliation":[{"name":"Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda In\u00e9s","family":"Leal","sequence":"additional","affiliation":[{"name":"Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-7520","authenticated-orcid":false,"given":"Marcelo","family":"Tuesta","sequence":"additional","affiliation":[{"name":"Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3937-1939","authenticated-orcid":false,"given":"Crist\u00f3bal","family":"Dur\u00e1n-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Physical Therapy, Faculty of Rehabilitation Sciences Carrera de Kinesiolog\u00eda, Universidad Andres Bello, Concepci\u00f3n 4260000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4836-3519","authenticated-orcid":false,"given":"Fernanda","family":"Carrasco-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Centro de Vida Saludable, Universidad de Concepci\u00f3n, Concepci\u00f3n 4030000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0418-8787","authenticated-orcid":false,"given":"Igor","family":"Cigarroa","sequence":"additional","affiliation":[{"name":"Escuela de Kinesiolog\u00eda, Facultad de Salud, Universidad Santo Tom\u00e1s, Los \u00c1ngeles 4440000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4783-9981","authenticated-orcid":false,"given":"Cristian","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-4272","authenticated-orcid":false,"given":"Mikel","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad P\u00fablica de Navarra (UPNA), IdiSNA, 31006 Pamplona, Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, 28220 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9952-993X","authenticated-orcid":false,"given":"Pedro","family":"Delgado-Floody","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Sports and Recreation, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/art.42089","article-title":"Prevalence trends of site-specific osteoarthritis from 1990 to 2019: Findings from the Global Burden of Disease Study 2019","volume":"74","author":"Long","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.joca.2021.04.020","article-title":"Epidemiology of osteoarthritis","volume":"30","author":"Allen","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Dell\u2019Isola, A., Allan, R., Smith, S., Marreiros, S., and Steultjens, M. (2016). Identification of clinical phenotypes in knee osteoarthritis: A systematic review of the literature. BMC Musculoskelet Disord., 17.","DOI":"10.1186\/s12891-016-1286-2"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Pegreffi, F., Balestra, A., De Lucia, O., Smith, L., Barbagallo, M., and Veronese, N. (2023). Prevalence of sarcopenia in knee osteoarthritis: A systematic review and meta-analysis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12041532"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Lee, S.Y., Ro, H.J., Chung, S.G., Kang, S.H., Seo, K.M., and Kim, D.-K. (2016). Low skeletal muscle mass in the lower limbs is independently associated to knee osteoarthritis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166385"},{"key":"ref_6","first-page":"293","article-title":"Osteoarthritis: Pathology, diagnosis, and treatment options","volume":"104","author":"Abramoff","year":"2020","journal-title":"Med. Clin."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41569-023-00847-5","article-title":"Obesity and the risk of cardiometabolic diseases","volume":"20","author":"Valenzuela","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jbspin.2019.06.013","article-title":"Cardiovascular profile in osteoarthritis: A meta-analysis of cardiovascular events and risk factors","volume":"86","author":"Mathieu","year":"2019","journal-title":"Jt. Bone Spine Rev. Du Rhum."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.47197\/retos.v50.99716","article-title":"Pacientes hipertensos muestran una mayor respuesta de la frecuencia card\u00edaca durante el ejercicio progre-sivo en relaci\u00f3n con pares adultos normotensos: PROYECTO VASCU-HEALTH (Hypertensive patients show higher heart rate response during incremental exercise and elevated arterial age estimation than normotensive adult peers: VASCU-HEALTH PROJECT)","volume":"50","author":"Alvarez","year":"2023","journal-title":"Retos"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1590\/0034-7167-2017-0121","article-title":"Calf circumference: Clinical validation for evaluation of muscle mass in the elderly","volume":"71","author":"Pagotto","year":"2018","journal-title":"Rev. Bras. De Enferm."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pie\u0144kowska, J., Brzeska, B., Kaszubowski, M., Kozak, O., Jankowska, A., and Szurowska, E. (2020). The correlation between the MRI-evaluated ectopic fat accumulation and the incidence of diabetes mellitus and hypertension depends on body mass index and waist circumference ratio. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0226889"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12370","DOI":"10.1038\/s41598-017-10775-3","article-title":"The association between education and cardiovascular disease incidence is mediated by hypertension, diabetes, and body mass index","volume":"7","author":"Marrugat","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_13","first-page":"267","article-title":"Mechanistic links underlying the impact of C-reactive protein on muscle mass in elderly","volume":"44","author":"Wilkinson","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.47197\/retos.v44i0.89359","article-title":"Caracter\u00edsticas de la adherencia y motivos del abandono de las intervenciones basadas en el ejercicio f\u00edsico en adultos mayores en Am\u00e9rica Latina: Una revisi\u00f3n de alcance (Adherence characteristics and reasons for abandonment of physical exercise-based in: Una revisi\u00f3n de alcance","volume":"44","author":"Cigarroa","year":"2022","journal-title":"Retos"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1046\/j.1532-5415.2003.51362.x","article-title":"Sarcopenia, calf circumference, and physical function of elderly women: A cross-sectional study","volume":"51","author":"Rolland","year":"2003","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_16","first-page":"400","article-title":"Lifestyle and cardiometabolic risk factors in the ethnic and non-ethnic population> 15 years of age: Results from the National Chilean Health Survey 2016\u20132017","volume":"40","author":"Lepin","year":"2023","journal-title":"Nutr. Hosp."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/HYP.0000000000000066","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"996","DOI":"10.4067\/s0034-98872017000800996","article-title":"Risk factors associated with hypertension. Analysis of the 2009\u20132010 Chilean health survey","volume":"145","author":"Petermann","year":"2017","journal-title":"Rev. Medica Chile"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"NCEP (2002). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation, 106, 3143.","DOI":"10.1161\/circ.106.25.3143"},{"key":"ref_20","first-page":"28","article-title":"Niveles de actividad f\u00edsica y tiempo sedente en personas mayores con fragilidad: Resultados de la Encuesta Nacional de Salud 2016\u20132017","volume":"40","year":"2023","journal-title":"Nutr. Hosp."},{"key":"ref_21","unstructured":"WHO (2000). Obesity: Preventing and Managing the Global Epidemic, WHO."},{"key":"ref_22","unstructured":"MINSAL (2018). Informe de Encuesta Nacional de Salud 2016\u20132017, Riesgo Cardiovascular Santiago de Chile."},{"key":"ref_23","first-page":"12","article-title":"Association between hypertension and osteoarthritis: A systematic review and meta-analysis of observational studies","volume":"32","author":"Lo","year":"2022","journal-title":"J. Orthop. Transl."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1097\/HJH.0b013e3283379120","article-title":"Exercise training normalizes skeletal muscle vascular endothelial growth factor levels in patients with essential hypertension","volume":"28","author":"Hansen","year":"2010","journal-title":"J. Hypertens."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1172\/JCI110399","article-title":"Synergistic interaction between exercise and insulin on peripheral glucose uptake","volume":"68","author":"DeFronzo","year":"1981","journal-title":"J. Clin. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rubio-Ruiz, M.E., Guarner-Lans, V., P\u00e9rez-Torres, I., and Soto, M.E. (2019). Mechanisms underlying metabolic syndrome-related sarcopenia and possible therapeutic measures. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030647"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/art.40087","article-title":"Metabolic syndrome, its components, and knee osteoarthritis: The Framingham Osteoarthritis Study","volume":"69","author":"Niu","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1089\/rej.2017.1917","article-title":"Knee osteoarthritis and risk of hypertension: A longitudinal cohort study","volume":"21","author":"Veronese","year":"2018","journal-title":"Rejuvenation Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.4067\/s0034-98872018001201405","article-title":"Asociaci\u00f3n de un \u00edndice de estilos de vida saludable con factores de riesgo cardiovascular en poblaci\u00f3n chilena","volume":"146","author":"Leiva","year":"2018","journal-title":"Rev. Medica De Chile"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"762","DOI":"10.47197\/retos.v49.98939","article-title":"Efectos del ejercicio f\u00edsico sobre los biomarcadores hep\u00e1ticos en adultos: Revisi\u00f3n sistem\u00e1tica y metan\u00e1lisis (Effects of Physical Exercise on Hepatic Biomarkers in Adult Individuals: A Systematic Review and Meta-Analysis)","volume":"49","year":"2023","journal-title":"Retos"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1210\/jc.2014-1043","article-title":"Association between metabolic syndrome, radiographic knee osteoarthritis, and intensity of knee pain: Results of a national survey","volume":"99","author":"Shin","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/19\/4263\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:01:34Z","timestamp":1760130094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/19\/4263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,5]]},"references-count":31,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["nu15194263"],"URL":"https:\/\/doi.org\/10.3390\/nu15194263","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,5]]}}}