{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:02:11Z","timestamp":1787871731834,"version":"build-2784847793"},"reference-count":49,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Low serum magnesium (sMg) is associated with cardiovascular risk factors and atherosclerotic disease. Objective: To evaluate the association between sMg levels on admission and clinical outcomes in hospitalized non-ST-elevation myocardial infarction (NSTEMI) patients. Methods: A retrospective analysis of all patients admitted to a single tertiary center with a primary diagnosis of NSTEMI. Patients with advanced chronic kidney disease were excluded. Clinical data were collected and compared between lower sMg quartile patients (Q1; sMg &lt; 1.9 mg\/dL) and all other patients (Q2\u2013Q4; sMg \u2265 1.9 mg\/dL). Results: The study cohort included 4552 patients (70% male, median age 69 [IQR 59\u201379]) who were followed for a median of 4.4 (IQR 2.4\u20136.6) years. The median sMg level in the low sMg group was 1.7 (1.6\u20131.8) and 2.0 (2.0\u20132.2) mg\/dL in the normal\/high sMg group. The low sMg group was older (mean of 72 vs. 67 years), less likely to be male (64% vs. 72%), and had higher rates of comorbidities, including diabetes, hypertension, and atrial fibrillation (59% vs. 29%, 92% vs. 85%, and 6% vs. 5%; p &lt; 0.05 for all). Kaplan\u2013Meier survival analysis demonstrated significantly higher cumulative death probability at 4 years in the low sMg group (34% vs. 22%; p log rank &lt;0.001). In a multivariable analysis model adjusted for sex, significant comorbidities, coronary interventions during the hospitalization, and renal function, the low sMg group exhibited an independent 24% increased risk of death during follow up (95% CI 1.11\u20131.39; p &lt; 0.001). Conclusions: Low sMg is independently associated with higher risk of long-term mortality among patients recovering from an NSTEMI event.<\/jats:p>","DOI":"10.3390\/nu15194299","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T07:37:50Z","timestamp":1696837070000},"page":"4299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum Magnesium Is Associated with Long-Term Survival of Non-ST-Elevation Myocardial Infarction Patients"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-7543","authenticated-orcid":false,"given":"Amitai","family":"Segev","sequence":"first","affiliation":[{"name":"The Leviev Cardiothoracic & Vascular Center, Sheba Medical Center, Ramat Gan 5262504, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4193-9917","authenticated-orcid":false,"given":"Michael","family":"Shechter","sequence":"additional","affiliation":[{"name":"The Leviev Cardiothoracic & Vascular Center, Sheba Medical Center, Ramat Gan 5262504, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1564-6395","authenticated-orcid":false,"given":"Avishai","family":"Tsur","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Medicine, Sheba Medical Center, Ramat Gan 5262504, Israel"},{"name":"Israel Defense Forces, Medical Corps, Ramat Gan 5262504, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Belkin","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hofit","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"The Bert W. Strassburger Lipid Center, Sheba Medical Center, Ramat Gan 5262504, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Sharon","sequence":"additional","affiliation":[{"name":"The Leviev Cardiothoracic & Vascular Center, Sheba Medical Center, Ramat Gan 5262504, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-752X","authenticated-orcid":false,"given":"Nira","family":"Morag","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehud","family":"Grossman","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Department of Medicine, Sheba Medical Center, Ramat Gan 5262504, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5087-0464","authenticated-orcid":false,"given":"Elad","family":"Maor","sequence":"additional","affiliation":[{"name":"The Leviev Cardiothoracic & Vascular Center, Sheba Medical Center, Ramat Gan 5262504, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/07315724.1994.10718432","article-title":"Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications (a review)","volume":"13","author":"Seelig","year":"1994","journal-title":"J. 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