{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:10:52Z","timestamp":1792609852648,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The combination of resistance exercise and creatine supplementation has been shown to decrease body fat percentage in adults \u2265 50 years of age. However, the effect on adults &lt; 50 years of age is currently unknown. To address this limitation, we systematically reviewed the literature and performed several meta-analyses comparing studies that included resistance exercise and creatine supplementation to resistance exercise and placebo on fat mass and body fat percentage Twelve studies were included, involving 266 participants. Adults (&lt;50 years of age) who supplemented with creatine and performed resistance exercise experienced a very small, yet significant reduction in body fat percentage (\u22121.19%, p = 0.006); however, no difference was found in absolute fat mass (\u22120.18 kg, p = 0.76). Collectively, in adults &lt; 50 years of age, the combination of resistance exercise and creatine supplementation produces a very small reduction in body fat percentage without a corresponding decrease in absolute fat mass.<\/jats:p>","DOI":"10.3390\/nu15204343","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:14:32Z","timestamp":1697080472000},"page":"4343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Resistance Exercise and Creatine Supplementation on Fat Mass in Adults &lt; 50 Years of Age: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"given":"Darren G.","family":"Candow","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-9388","authenticated-orcid":false,"given":"Konstantinos","family":"Prokopidis","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal and Ageing Science, University of Liverpool, Liverpool L69 3BX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6896-5552","authenticated-orcid":false,"given":"Scott C.","family":"Forbes","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Faculty of Education, Brandon University, Brandon, MB R7A 6A9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Rusterholz","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-3871","authenticated-orcid":false,"given":"Bill I.","family":"Campbell","sequence":"additional","affiliation":[{"name":"College of Education, University of South Florida, Tampa, FL 33620, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7270-2541","authenticated-orcid":false,"given":"Sergej M.","family":"Ostojic","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Public Health, University of Agder, 4630 Kristiansand, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Souza, N.A.B., Rimes-Dias, K.A., Costa, J.C., and Canella, D.S. 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