{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:17:37Z","timestamp":1790821057960,"version":"4.1.0"},"reference-count":91,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JEG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D deficiency, prevalent worldwide, is linked to muscle weakness, sarcopenia, and falls. Muscle regeneration is a vital process that allows for skeletal muscle tissue maintenance and repair after injury. PubMed and Web of Science were used to search for studies published prior to May 2023. We assessed eligible studies that discussed the relationship between vitamin D, muscle regeneration in this review. Overall, the literature reports strong associations between vitamin D and skeletal myocyte size, and muscle regeneration. In vitro studies in skeletal muscle cells derived from mice and humans showed vitamin D played a role in regulating myoblast growth, size, and gene expression. Animal studies, primarily in mice, demonstrate vitamin D\u2019s positive effects on skeletal muscle function, such as improved grip strength and endurance. These studies encompass vitamin D diet research, genetically modified models, and disease-related mouse models. Relatively few studies looked at muscle function after injury, but these also support a role for vitamin D in muscle recovery. The human studies have also reported that vitamin D deficiency decreases muscle grip strength and gait speed, especially in the elderly population. Finally, human studies reported the benefits of vitamin D supplementation and achieving optimal serum vitamin D levels in muscle recovery after eccentric exercise and surgery. However, there were no benefits in rotator cuff injury studies, suggesting that repair mechanisms for muscle\/ligament tears may be less reliant on vitamin D. In summary, vitamin D plays a crucial role in skeletal muscle function, structural integrity, and regeneration, potentially offering therapeutic benefits to patients with musculoskeletal diseases and in post-operative recovery.<\/jats:p>","DOI":"10.3390\/nu15204377","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:43:49Z","timestamp":1697435029000},"page":"4377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["The Role of Vitamin D in Skeletal Muscle Repair and Regeneration in Animal Models and Humans: A Systematic Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Miguel","family":"Agoncillo","sequence":"first","affiliation":[{"name":"Centre for Diabetes, Obesity and Endocrinology (CDOE), The Westmead Institute for Medical Research, The University of Sydney, Sydney 2145, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4615-5257","authenticated-orcid":false,"given":"Josephine","family":"Yu","sequence":"additional","affiliation":[{"name":"Centre for Diabetes, Obesity and Endocrinology (CDOE), The Westmead Institute for Medical Research, The University of Sydney, Sydney 2145, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-9773","authenticated-orcid":false,"given":"Jenny E.","family":"Gunton","sequence":"additional","affiliation":[{"name":"Centre for Diabetes, Obesity and Endocrinology (CDOE), The Westmead Institute for Medical Research, The University of Sydney, Sydney 2145, Australia"},{"name":"Faculty of Medicine and Health, The University of Sydney, Sydney 2145, Australia"},{"name":"Department of Diabetes and Endocrinology, Westmead Hospital, Sydney 2145, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-L\u00e1zaro, D., Garrosa, E., Seco-Calvo, J., and Garrosa, M. (2022). Potential Satellite Cell-Linked Biomarkers in Aging Skeletal Muscle Tissue: Proteomics and Proteogenomics to Monitor Sarcopenia. Proteomes, 10.","DOI":"10.3390\/proteomes10030029"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/jcsm.12460","article-title":"Mice with myocyte deletion of vitamin D receptor have sarcopenia and impaired muscle function","volume":"10","author":"Girgis","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s00223-015-0054-x","article-title":"Vitamin D Receptor Ablation and Vitamin D Deficiency Result in Reduced Grip Strength, Altered Muscle Fibers, and Increased Myostatin in Mice","volume":"97","author":"Girgis","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1210\/jc.2010-2704","article-title":"The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: What clinicians need to know","volume":"96","author":"Ross","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","unstructured":"Feingold, K.R., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., Dungan, K., and Hofland, J. (2000). Endotext, MDText.com, Inc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.chembiol.2013.12.016","article-title":"Vitamin D metabolism, mechanism of action, and clinical applications","volume":"21","author":"Bikle","year":"2014","journal-title":"Chem. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1210\/er.2012-1012","article-title":"The roles of vitamin D in skeletal muscle: Form, function, and metabolism","volume":"34","author":"Girgis","year":"2013","journal-title":"Endocr. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1210\/en.2013-1205","article-title":"Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells","volume":"155","author":"Girgis","year":"2014","journal-title":"Endocrinology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1210\/en.2003-0502","article-title":"Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors","volume":"144","author":"Endo","year":"2003","journal-title":"Endocrinology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bbr.2004.07.008","article-title":"Behavioural characterization of vitamin D receptor knockout mice","volume":"157","author":"Burne","year":"2005","journal-title":"Behav. Brain Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1002\/jcsm.13102","article-title":"Influence of vitamin D on sarcopenia pathophysiology: A longitudinal study in humans and basic research in knockout mice","volume":"13","author":"Mizuno","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1113\/JP280652","article-title":"The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo","volume":"599","author":"Bass","year":"2021","journal-title":"J. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1530\/EC-17-0008","article-title":"Vitamin D induces myogenic differentiation in skeletal muscle derived stem cells","volume":"6","author":"Braga","year":"2017","journal-title":"Endocr. Connect."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Agostini, D., Gervasi, M., Ferrini, F., Bartolacci, A., Stranieri, A., Piccoli, G., Barbieri, E., Sestili, P., Patti, A., and Stocchi, V. (2023). An Integrated Approach to Skeletal Muscle Health in Aging. Nutrients, 15.","DOI":"10.3390\/nu15081802"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.arr.2015.12.004","article-title":"Skeletal muscle regeneration and impact of aging and nutrition","volume":"26","author":"Vasson","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Forcina, L., Cosentino, M., and Musar\u00f2, A. (2020). Mechanisms Regulating Muscle Regeneration: Insights into the Interrelated and Time-Dependent Phases of Tissue Healing. Cells, 9.","DOI":"10.3390\/cells9051297"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.9.2.493","article-title":"Satellite cell of skeletal muscle fibers","volume":"9","author":"Mauro","year":"1961","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cell.2005.05.010","article-title":"Stem cell function, self-renewal, and behavioral heterogeneity of cells from the adult muscle satellite cell niche","volume":"122","author":"Collins","year":"2005","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1242\/dev.067595","article-title":"An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration","volume":"138","author":"Lepper","year":"2011","journal-title":"Development"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(00)00066-0","article-title":"Pax7 is required for the specification of myogenic satellite cells","volume":"102","author":"Seale","year":"2000","journal-title":"Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13287-023-03363-y","article-title":"Insight into muscle stem cell regeneration and mechanobiology","volume":"14","author":"Pang","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"12242","DOI":"10.1038\/s41598-020-69021-y","article-title":"Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice","volume":"10","author":"Nakamura","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/jcsm.12497","article-title":"Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis-associated cachexia","volume":"11","author":"Cheung","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"14175","DOI":"10.1038\/s41598-020-70190-z","article-title":"Vitamin D ameliorates adipose browning in chronic kidney disease cachexia","volume":"10","author":"Cheung","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"21778","DOI":"10.18632\/oncotarget.15583","article-title":"Vitamin D and VDR in cancer cachexia and muscle regeneration","volume":"8","author":"Camperi","year":"2017","journal-title":"Oncotarget"},{"key":"ref_28","first-page":"12638","article-title":"1,25-Dihydroxyvitamin D deficiency induces sarcopenia by inducing skeletal muscle cell senescence","volume":"13","author":"Yu","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1152\/japplphysiol.01018.2015","article-title":"Effects of intramuscular administration of 1\u03b1,25(OH)2D3 during skeletal muscle regeneration on regenerative capacity, muscular fibrosis, and angiogenesis","volume":"120","author":"Srikuea","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1743-7075-11-47","article-title":"Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old wistar rats","volume":"11","author":"Chanet","year":"2014","journal-title":"Nutr. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ajpath.2012.11.006","article-title":"Vitamin D increases cellular turnover and functionally restores the skeletal muscle after crush injury in rats","volume":"182","author":"Stratos","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/03635465221145711","article-title":"Serum Vitamin D Level Correlations With Tissue Vitamin D Level and Muscle Performance Before and After Rotator Cuff Repair","volume":"51","author":"Rhee","year":"2023","journal-title":"Am. J. Sports Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jsbmb.2017.01.022","article-title":"Skeletal muscle vitamin D in patients with end stage osteoarthritis of the knee","volume":"173","author":"Mor","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s00198-020-05809-y","article-title":"A longitudinal histologic evaluation of vitamin D receptor expression in the skeletal muscles of patients with a distal radius fracture","volume":"32","author":"Shim","year":"2021","journal-title":"Osteoporos. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.arthro.2018.09.032","article-title":"Perioperative Serum 25-Hydroxyvitamin D Levels Affect Revision Surgery Rates After Arthroscopic Rotator Cuff Repair","volume":"35","author":"Cancienne","year":"2019","journal-title":"Arthroscopy"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1177\/03635465231184392","article-title":"Influence of Vitamin D Deficiency on the Expression of Genes and Proteins in Patients With Medium Rotator Cuff Tears","volume":"51","author":"Kim","year":"2023","journal-title":"Am. J. Sports Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12937-019-0504-9","article-title":"Effect of vitamin D fortified foods on bone markers and muscle strength in women of Pakistani and Danish origin living in Denmark: A randomised controlled trial","volume":"18","author":"Tetens","year":"2019","journal-title":"Nutr. J."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Hosoyama, T., Iida, H., Kawai-Takaishi, M., and Watanabe, K. (2020). Vitamin D Inhibits Myogenic Cell Fusion and Expression of Fusogenic Genes. Nutrients, 12.","DOI":"10.3390\/nu12082192"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsbmb.2012.09.004","article-title":"1,25(OH)2vitamin D3 enhances myogenic differentiation by modulating the expression of key angiogenic growth factors and angiogenic inhibitors in C2C12 skeletal muscle cells","volume":"133","author":"Garcia","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3177\/jnsv.68.65","article-title":"Vitamin D Activates Various Gene Expressions, Including Lipid Metabolism, in C2C12 Cells","volume":"68","author":"Mizutani","year":"2022","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jnutbio.2018.11.002","article-title":"Vitamin D produces a perilipin 2-dependent increase in mitochondrial function in C2C12 myotubes","volume":"65","author":"Schnell","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"C396","DOI":"10.1152\/ajpcell.00014.2012","article-title":"VDR and CYP27B1 are expressed in C2C12 cells and regenerating skeletal muscle: Potential role in suppression of myoblast proliferation","volume":"303","author":"Srikuea","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101059","DOI":"10.1016\/j.molmet.2020.101059","article-title":"Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy","volume":"42","author":"Bass","year":"2020","journal-title":"Mol. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.spinee.2018.01.007","article-title":"Relationships between vitamin D and paraspinal muscle: Human data and experimental rat model analysis","volume":"18","author":"Bang","year":"2018","journal-title":"Spine J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"E1019","DOI":"10.1152\/ajpendo.00375.2015","article-title":"A systems-based investigation into vitamin D and skeletal muscle repair, regeneration, and hypertrophy","volume":"309","author":"Owens","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/en.2010-1109","article-title":"Is the Vitamin D Receptor Found in Muscle?","volume":"152","author":"Wang","year":"2011","journal-title":"Endocrinology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1210\/en.2014-1016","article-title":"The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers","volume":"155","author":"Girgis","year":"2014","journal-title":"Endocrinology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s00223-014-9932-x","article-title":"Effects of 1,25-dihydroxyvitamin D3 and vitamin D3 on the expression of the vitamin d receptor in human skeletal muscle cells","volume":"96","author":"Pojednic","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/jcb.10191","article-title":"1,25(OH)2-vitamin D3 induces translocation of the vitamin D receptor (VDR) to the plasma membrane in skeletal muscle cells","volume":"86","author":"Capiati","year":"2002","journal-title":"J. Cell. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8239","DOI":"10.1038\/s41598-020-65067-0","article-title":"Regulation of vitamin D system in skeletal muscle and resident myogenic stem cell during development, maturation, and ageing","volume":"10","author":"Srikuea","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jos.2016.12.005","article-title":"A vitamin D analogue, eldecalcitol, enhances expression of fast myosin heavy chain subtypes in differentiated C2C12 myoblasts","volume":"22","author":"Saito","year":"2017","journal-title":"J. Orthop. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1042\/CBI20100782","article-title":"1\u03b1,25-dihydroxyvitamin D\u2083 enhances fast-myosin heavy chain expression in differentiated C2C12 myoblasts","volume":"36","author":"Okuno","year":"2012","journal-title":"Cell Biol. Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1530\/JME-14-0102","article-title":"Actions of 1,25(OH)2-vitamin D3 on the cellular cycle depend on VDR and p38 MAPK in skeletal muscle cells","volume":"53","author":"Irazoqui","year":"2014","journal-title":"J. Mol. Endocrinol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1210\/en.2011-0159","article-title":"1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells","volume":"152","author":"Garcia","year":"2011","journal-title":"Endocrinology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1002\/mnfr.201300074","article-title":"1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt\/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes","volume":"57","author":"Salles","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/jcb.23444","article-title":"1\u03b1,25(OH)2D3-dependent modulation of Akt in proliferating and differentiating C2C12 skeletal muscle cells","volume":"113","author":"Buitrago","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1002\/jcp.25388","article-title":"Effects of 1,25(OH)2 D3 and 25(OH)D3 on C2C12 Myoblast Proliferation, Differentiation, and Myotube Hypertrophy","volume":"231","author":"Bravenboer","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"C536","DOI":"10.1152\/ajpcell.00568.2019","article-title":"The vitamin D receptor regulates mitochondrial function in C2C12 myoblasts","volume":"318","author":"Ashcroft","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1113\/expphysiol.2012.064592","article-title":"Preferential utilization of perilipin 2-associated intramuscular triglycerides during 1 h of moderate-intensity endurance-type exercise","volume":"97","author":"Shepherd","year":"2012","journal-title":"Exp. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.2337\/db11-1402","article-title":"Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels","volume":"61","author":"Bosma","year":"2012","journal-title":"Diabetes"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1210\/en.2015-1685","article-title":"Evidence for Vitamin D Receptor Expression and Direct Effects of 1\u03b1,25(OH)2D3 in Human Skeletal Muscle Precursor Cells","volume":"157","author":"Olsson","year":"2016","journal-title":"Endocrinology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1074\/jbc.M115.684399","article-title":"1\u03b1,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells","volume":"291","author":"Ryan","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Romeu Montenegro, K., Carlessi, R., Cruzat, V., and Newsholme, P. (2019). Effects of vitamin D on primary human skeletal muscle cell proliferation, differentiation, protein synthesis and bioenergetics. J. Steroid Biochem. Mol. Biol., 193.","DOI":"10.1016\/j.jsbmb.2019.105423"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2220\/biomedres.36.71","article-title":"1\u03b1,25(OH)2D3 downregulates gene expression levels of muscle ubiquitin ligases MAFbx and MuRF1 in human myotubes","volume":"36","author":"Hayakawa","year":"2015","journal-title":"Biomed. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/physrev.90100.2007","article-title":"Muscle as an endocrine organ: Focus on muscle-derived interleukin-6","volume":"88","author":"Pedersen","year":"2008","journal-title":"Physiol. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"7498","DOI":"10.1073\/pnas.131029498","article-title":"Targeted ablation of the 25-hydroxyvitamin D 1\u03b1-hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction","volume":"98","author":"Panda","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1210\/en.2013-1369","article-title":"Vitamin D deficiency-induced muscle wasting occurs through the ubiquitin proteasome pathway and is partially corrected by calcium in male rats","volume":"154","author":"Bhat","year":"2013","journal-title":"Endocrinology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3390\/nu5041253","article-title":"Higher serum 25-hydroxyvitamin D concentrations associate with a faster recovery of skeletal muscle strength after muscular injury","volume":"5","author":"Barker","year":"2013","journal-title":"Nutrients"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1743-7075-10-69","article-title":"Supplemental vitamin D enhances the recovery in peak isometric force shortly after intense exercise","volume":"10","author":"Barker","year":"2013","journal-title":"Nutr. Metab."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1177\/0363546515578101","article-title":"Low Serum Vitamin D Is Not Correlated With the Severity of a Rotator Cuff Tear or Retear After Arthroscopic Repair","volume":"43","author":"Ryu","year":"2015","journal-title":"Am. J. Sports Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1177\/0884533616629628","article-title":"Effect of Calcium \u03b2-Hydroxy-\u03b2-Methylbutyrate (CaHMB), Vitamin D, and Protein Supplementation on Postoperative Immobilization in Malnourished Older Adult Patients With Hip Fracture: A Randomized Controlled Study","volume":"31","author":"Ekinci","year":"2016","journal-title":"Nutr. Clin. Pract."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/j.jrn.2007.06.001","article-title":"Relationship between vitamin D and muscle size and strength in patients on hemodialysis","volume":"17","author":"Gordon","year":"2007","journal-title":"J. Ren. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00223-019-00558-5","article-title":"Vitamin D in Relation to Incident Sarcopenia and Changes in Muscle Parameters Among Older Adults: The KORA-Age Study","volume":"105","author":"Conzade","year":"2019","journal-title":"Calcif. Tissue Int."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00421-017-3755-1","article-title":"Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain","volume":"118","author":"Dzik","year":"2018","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"6835341","DOI":"10.1155\/2019\/6835341","article-title":"Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain","volume":"2019","author":"Dzik","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1365-2265.2010.03858.x","article-title":"A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adults","volume":"73","author":"Scott","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s00198-005-1860-1","article-title":"Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women","volume":"16","author":"Gerdhem","year":"2005","journal-title":"Osteoporos. Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"E1927","DOI":"10.1210\/jc.2013-2820","article-title":"A randomized study on the effect of vitamin D\u2083 supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women","volume":"98","author":"Ceglia","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Michalczyk, M.M., Go\u0142a\u015b, A., Maszczyk, A., Kaczka, P., and Zaj\u0105c, A. (2020). Influence of Sunlight and Oral D3 Supplementation on Serum 25(OH)D Concentration and Exercise Performance in Elite Soccer Players. Nutrients, 12.","DOI":"10.3390\/nu12051311"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.exger.2006.05.001","article-title":"Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects","volume":"41","author":"Bunout","year":"2006","journal-title":"Exp. Gerontol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1519\/JSC.0000000000001337","article-title":"Effect of Vitamin D Supplementation on Training Adaptation in Well-Trained Soccer Players","volume":"30","author":"Kaczmarczyk","year":"2016","journal-title":"J. Strength Cond. Res."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Bezuglov, E., Tikhonova, A., Zueva, A., Khaitin, V., Wa\u015bkiewicz, Z., Gerasimuk, D., \u017bebrowska, A., Rosemann, T., Nikolaidis, P., and Knechtle, B. (2019). Prevalence and Treatment of Vitamin D Deficiency in Young Male Russian Soccer Players in Winter. Nutrients, 11.","DOI":"10.3390\/nu11102405"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.ajcnut.2023.04.021","article-title":"Vitamin D Supplementation and Muscle Power, Strength and Physical Performance in Older Adults: A Randomized Controlled Trial","volume":"117","author":"Houston","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/s41598-022-05783-x","article-title":"Single bout of exercise triggers the increase of vitamin D blood concentration in adolescent trained boys: A pilot study","volume":"12","author":"Dzik","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Alfaqih, M.S., Tarawan, V.M., Sylviana, N., Goenawan, H., Lesmana, R., and Susianti, S. (2022). Effects of Vitamin D on Satellite Cells: A Systematic Review of In Vivo Studies. Nutrients, 14.","DOI":"10.3390\/nu14214558"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1172\/JCI117731","article-title":"Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle","volume":"95","author":"Biolo","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/mnfr.201100695","article-title":"Leucine induces myofibrillar protein accretion in cultured skeletal muscle through mTOR dependent and -independent control of myosin heavy chain mRNA levels","volume":"56","author":"Haegens","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"660498","DOI":"10.3389\/fphys.2021.660498","article-title":"Vitamin D Promotes Skeletal Muscle Regeneration and Mitochondrial Health","volume":"12","author":"Latham","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1242\/dev.064162","article-title":"Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration","volume":"138","author":"Murphy","year":"2011","journal-title":"Development"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Ha\u00df, U., Kochlik, B., Herpich, C., Rudloff, S., and Norman, K. (2022). Effects of an Omega-3 Supplemented, High-Protein Diet in Combination with Vibration and Resistance Exercise on Muscle Power and Inflammation in Old Adults: A Pilot Randomized Controlled Trial. Nutrients, 14.","DOI":"10.3390\/nu14204274"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Jannas-Vela, S., Espinosa, A., Candia, A.A., Flores-Opazo, M., Pe\u00f1ailillo, L., and Valenzuela, R. (2023). The Role of Omega-3 Polyunsaturated Fatty Acids and Their Lipid Mediators on Skeletal Muscle Regeneration: A Narrative Review. Nutrients, 15.","DOI":"10.3390\/nu15040871"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/20\/4377\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:07:32Z","timestamp":1760130452000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/20\/4377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":91,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["nu15204377"],"URL":"https:\/\/doi.org\/10.3390\/nu15204377","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,16]]}}}