{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:12Z","timestamp":1787029212921,"version":"build-2736575974"},"reference-count":63,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federal University of Health Sciences of Porto Alegre","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Obesity has been linked to cognitive decline and adverse effects on brain health. Zinc (Zn) is a mineral with important metabolic functions that can modulate obesity-related neurological impairment. Thus, the present study aimed to evaluate the effects of 12 weeks of Zn supplementation on the inflammatory profile, cognitive function, and mood of overweight or obese women through a double-blind, placebo-controlled study. The study included 42 women aged between 40 and 60, randomly divided into two groups: Zn supplementation (30 mg\/day) or placebo for 12 weeks. Data regarding sociodemographic, anthropometric, dietary, and physical activity were collected. Mini-mental state examination (MMSE), verbal fluency test, clock drawing test, and Stroop test were performed. Anxiety and depression symptoms were assessed using the Beck anxiety inventory and the BDI-II, respectively. Saliva samples were collected to evaluate IL-1\u03b2, IL-6, TNF-\u03b1, insulin, nitrite, and Zn levels. Of the 42 participants (mean age 49.58 \u00b1 6.46 years), 32 were included in the study analyses. Changes in body weight and macronutrient consumption were not different between placebo and Zn supplementation groups. Cognitive scores on the MMSE and Stroop tests were higher in the Zn supplementation group than in the placebo group. Salivary levels of IL-1b and Zn increased in the Zn group compared to placebo. There was no significant change in the adjusted means of the BDI-II and BECK scores between the zinc vs. placebo groups. Twelve weeks of Zn supplementation was able to partially improve the cognitive scores assessed in overweight or obese women, regardless of weight loss. These findings suggest that Zn supplementation can be considered an adjunct strategy to enhance cognitive health in overweight or obese women.<\/jats:p>","DOI":"10.3390\/nu15204396","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:10:19Z","timestamp":1697530219000},"page":"4396","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Zinc Supplementation on Inflammatory and Cognitive Parameters in Middle-Aged Women with Overweight or Obesity"],"prefix":"10.3390","volume":"15","author":[{"given":"Liziane da Silva","family":"de Vargas","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioci\u00eancias, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre 90050-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-1308","authenticated-orcid":false,"given":"Jeferson","family":"Jantsch","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioci\u00eancias, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre 90050-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Ribeiro","family":"Fontoura","sequence":"additional","affiliation":[{"name":"Gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre 90050-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-3204","authenticated-orcid":false,"given":"Gilson Pires","family":"Dorneles","sequence":"additional","affiliation":[{"name":"Hospital Moinhos de Vento, Rua Ramiro Barcelos, 910, Porto Alegre 90035-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Peres","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioci\u00eancias, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre 90050-170, Brazil"},{"name":"Gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre 90050-170, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre 90050-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Padilha","family":"Guedes","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Bioci\u00eancias, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre 90050-170, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Rua Sarmento Leite, 245, Porto Alegre 90050-170, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12576-017-0521-4","article-title":"Physiological roles of zinc transporters: Molecular and genetic importance in zinc homeostasis","volume":"67","author":"Hara","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Vashum, K.P., McEvoy, M., Milton, A.H., Islam, M.R., Hancock, S., and Attia, J. (2014). Is Serum Zinc Associated with Pancreatic Beta Cell Function and Insulin Sensitivity in Pre-Diabetic and Normal Individuals? Findings from the Hunter Community Study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0083944"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zhang, C., Dischler, A., Glover, K., and Qin, Y. (2022). Neuronal signalling of zinc: From detection and modulation to function. Open Biol., 12.","DOI":"10.1098\/rsob.220188"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Maares, M., and Haase, H. (2020). A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models. Nutrients, 12.","DOI":"10.3390\/nu12030762"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Wang, B., Fang, T., and Chen, H. (2023). Zinc and Central Nervous System Disorders. Nutrients, 15.","DOI":"10.3390\/nu15092140"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.soard.2011.09.015","article-title":"Micronutrient status in morbidly obese women before bariatric surgery","volume":"9","author":"Pacheco","year":"2013","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.csbj.2021.02.015","article-title":"COVID-19 pandemic: Can zinc supplementation provide an additional shield against the infection?","volume":"19","author":"Razzaque","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/ejcn.2015.60","article-title":"Zinc intake, status and indices of cognitive function in adults and children: A systematic review and meta-analysis","volume":"69","author":"Moran","year":"2015","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Fukunaka, A., and Fujitani, Y. (2018). Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020476"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1007\/s00394-018-1876-x","article-title":"The association between serum zinc level and overweight\/obesity: A meta-analysis","volume":"58","author":"Gu","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_11","first-page":"339","article-title":"Serum trace elements in obese women with or without diabetes","volume":"137","author":"Yerlikaya","year":"2013","journal-title":"Indian J. Med. Res."},{"key":"ref_12","first-page":"161","article-title":"Effects of zinc supplementation on the anthropometric measurements, lipid profiles and fasting blood glucose in the healthy obese adults","volume":"3","author":"Payahoo","year":"2013","journal-title":"Adv. Pharm. Bull."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/advances\/nmz084","article-title":"Zinc Supplementation and Body Weight: A Systematic Review and Dose\u2013Response Meta-analysis of Randomized Controlled Trials","volume":"11","author":"Abdollahi","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12576-017-0571-7","article-title":"Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism","volume":"68","author":"Olechnowicz","year":"2018","journal-title":"J. Physiol. Sci."},{"key":"ref_15","first-page":"231","article-title":"Review: The role of zinc in the endocrine system","volume":"32","author":"Baltaci","year":"2019","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.advms.2015.02.002","article-title":"Pro-inflammatory adipocytokines, oxidative stress, insulin, Zn and Cu: Interrelations with obesity in Egyptian non-diabetic obese children and adolescents","volume":"60","author":"Habib","year":"2015","journal-title":"Adv. Med. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"798995","DOI":"10.3389\/fnint.2022.798995","article-title":"The Obese Brain: Mechanisms of Systemic and Local Inflammation, and Interventions to Reverse the Cognitive Deficit","volume":"16","year":"2022","journal-title":"Front. Integr. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e220","DOI":"10.1212\/WNL.0000000000201367","article-title":"Association of Obesity With Cognitive Decline in Black and White Americans","volume":"100","author":"Quaye","year":"2023","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/pubmed\/fdy121","article-title":"The association between body mass index, waist circumference, waist\u2013hip ratio and cognitive disorder in older adults","volume":"41","author":"Liu","year":"2019","journal-title":"J. Public Health"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neubiorev.2021.08.028","article-title":"Relationship between Central Obesity and the incidence of Cognitive Impairment and Dementia from Cohort Studies Involving 5,060,687 Participants","volume":"130","author":"Tang","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"114163","DOI":"10.1016\/j.bbr.2022.114163","article-title":"Zinc supplement reverses short-term memory deficit in sodium benzoate-induced neurotoxicity in male Wistar rats by enhancing anti-oxidative capacity via Nrf 2 up-regulation","volume":"437","author":"Akintoye","year":"2023","journal-title":"Behav. Brain Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mohammadi, H., Talebi, S., Ghavami, A., Rafiei, M., Sharifi, S., Faghihimani, Z., Ranjbar, G., Miraghajani, M., and Askari, G. (2021). Effects of zinc supplementation on inflammatory biomarkers and oxidative stress in adults: A systematic review and meta-analysis of randomized controlled trials. J. Trace Elem. Med. Biol., 68.","DOI":"10.1016\/j.jtemb.2021.126857"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"You, Y.X., Shahar, S., Rajab, N.F., Haron, H., Yahya, H.M., Mohamad, M., Din, N.C., and Maskat, M.Y. (2021). Effects of 12 Weeks Cosmos caudatus Supplement among Older Adults with Mild Cognitive Impairment: A Randomized, Double-Blind and Placebo-Controlled Trial. Nutrients, 13.","DOI":"10.3390\/nu13020434"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cca.2007.04.011","article-title":"Saliva specimen: A new laboratory tool for diagnostic and basic investigation","volume":"383","author":"Chiappin","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/niox.2000.0319","article-title":"A Rapid, Simple Spectrophotometric Method for Simultaneous Detection of Nitrate and Nitrite","volume":"5","author":"Miranda","year":"2001","journal-title":"Nitric Oxide"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/oby.23024","article-title":"Zinc Supplementation Decreases Obesity-Related Neuroinflammation and Improves Metabolic Function and Memory in Rats","volume":"29","author":"Neto","year":"2021","journal-title":"Obesity"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1590\/S0004-282X1998000400014","article-title":"Mini exame dos estado mental e o diagn\u00f3stico de dem\u00eancia no Brasil","volume":"56","author":"Almeida","year":"1998","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/gps.930080606","article-title":"Clock-drawing and dementia in the community: A longitudinal study","volume":"8","author":"Shulman","year":"1993","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1590\/S0004-282X1997000100009","article-title":"Dados normativos para o teste de flu\u00eancia verbal categoria animais em nosso meio","volume":"55","author":"Brucki","year":"1997","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/h0054651","article-title":"Studies of interference in serial verbal reactions","volume":"18","author":"Stroop","year":"1935","journal-title":"J. Exp. Psychol."},{"key":"ref_31","unstructured":"Beck, A.T., Steer, R.A., and Brown, G.K. (1987). Beck Depression Inventory, Harcourt Brace Jovanovich."},{"key":"ref_32","unstructured":"Beck, A.T., Epstein, N., Brown, G., and Steer, R. (1993). Beck anxiety inventory. J. Consult. Clin. Psychol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"10227","DOI":"10.1038\/s41598-021-89297-y","article-title":"Comparing physiological responses during cognitive tests in virtual environments vs. in identical real-world environments","volume":"11","author":"Kalantari","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_34","first-page":"502","article-title":"Screening tools for virtual assessment of cognition","volume":"66","author":"Frank","year":"2020","journal-title":"Can. Fam. Physician"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s10787-017-0309-4","article-title":"Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF- j B signaling","volume":"25","author":"Jarosz","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnut.2014.00014","article-title":"Zinc is an antioxidant and anti-inflammatory agent: Its role in human health","volume":"1","author":"Prasad","year":"2014","journal-title":"Front. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1523\/JNEUROSCI.1980-20.2020","article-title":"Zinc Status Alters Alzheimer\u2019s Disease Progression through NLRP3-Dependent Inflammation","volume":"41","author":"Tapia","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1132907","DOI":"10.3389\/fnagi.2023.1132907","article-title":"Serum zinc deficiency could be associated with dementia conversion in Parkinson\u2019 s disease","volume":"15","author":"Lee","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuro.2020.07.003","article-title":"Multifunctional roles of zinc in Alzheimer\u2019s disease","volume":"80","author":"Xie","year":"2020","journal-title":"Nerotoxicology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"14612","DOI":"10.1038\/s41598-021-94124-5","article-title":"Zinc status in attention-deficit\/hyperactivity disorder: A systematic review and meta-analysis of observational studies","volume":"11","author":"Ghoreishy","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3389\/fphar.2017.00414","article-title":"The Emerging Role for Zinc in Depression and Psychosis","volume":"8","author":"Petrilli","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1007\/s11064-017-2353-2","article-title":"Differential Effects of Low- and High-dose Zinc Supplementation on Synaptic Plasticity and Neurogenesis in the Hippocampus of Control and High-fat Diet-fed Mice","volume":"42","author":"Nam","year":"2017","journal-title":"Neurochem. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00394-020-02454-3","article-title":"Neurobiology of zinc and its role in neurogenesis","volume":"60","author":"Kumar","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1038\/s41598-023-31781-8","article-title":"Ameliorative effects of zinc supplementation on cognitive function and hippocampal leptin signaling pathway in obese male and female rats","volume":"13","author":"Hafez","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1179\/1476830513Y.0000000105","article-title":"Zinc monotherapy increases serum brain-derived neurotrophic factor (BDNF) levels and decreases depressive symptoms in overweight or obese subjects: A double-blind, randomized, placebo-controlled trial","volume":"18","author":"Solati","year":"2015","journal-title":"Nutr. Neurosci."},{"key":"ref_46","unstructured":"World Health Organization (2023, March 02). Obesity an Overweight n.d. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5923862","DOI":"10.1155\/2017\/5923862","article-title":"Relationship between Obesity and Cognitive Function in Young Women: The Food, Mood and Mind Study","volume":"2017","author":"Cook","year":"2017","journal-title":"J. Obes."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/oby.21514","article-title":"Mild cognitive impairment is prevalent in persons with severe obesity","volume":"24","author":"Rochette","year":"2016","journal-title":"Obesity"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.bbadis.2008.09.004","article-title":"Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition","volume":"1792","author":"Kloppenborg","year":"2009","journal-title":"Biochim. Biophys. Acta-Mol. Basis Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1080\/17470218.2015.1099163","article-title":"Higher Body Mass Index is Associated with Episodic Memory Deficits in Young Adults","volume":"69","author":"Cheke","year":"2016","journal-title":"Q. J. Exp. Psychol."},{"key":"ref_51","first-page":"6613385","article-title":"Structural Brain Changes Associated with Overweight and Obesity","volume":"2021","year":"2021","journal-title":"J. Obes."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"fcad059","DOI":"10.1093\/braincomms\/fcad059","article-title":"Alteration in the number of neuronal and non-neuronal cells in mouse models of obesity","volume":"5","author":"Andrade","year":"2023","journal-title":"Brain Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tins.2017.02.005","article-title":"Obesity-Induced Neuroinflammation: Beyond the Hypothalamus","volume":"40","author":"Muccioli","year":"2017","journal-title":"Trends Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1212\/WNL.0b013e3182661f63","article-title":"Obesity phenotypes in midlife and cognition in early old age: The Whitehall II cohort study","volume":"79","author":"Czernichow","year":"2012","journal-title":"Neurology"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ch\u00e1vez-Manzanera, E., Ram\u00edrez-Flores, M., Duran, M., Torres, M., Ram\u00edrez, M., Kaufer-Horwitz, M., Stephano, S., Quiroz-Casian, L., Cant\u00fa-Brito, C., and Chiquete, E. (2022). Influence of Weight Loss on Cognitive Functions: A Pilot Study of a Multidisciplinary Intervention Program for Obesity Treatment. Brain Sci., 12.","DOI":"10.3390\/brainsci12040509"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13098-019-0497-8","article-title":"Zinc supplementation improves body weight management, inflammatory biomarkers and insulin resistance in individuals with obesity: A randomized, placebo-controlled, double-blind trial","volume":"11","author":"Khorsandi","year":"2019","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Te, L., Liu, J., Ma, J., and Wang, S. (2023). Correlation between serum zinc and testosterone: A systematic review. J. Trace Elem. Med. Biol., 76.","DOI":"10.1016\/j.jtemb.2022.127124"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/ajcn\/85.3.837","article-title":"Zinc supplementation decreases incidence of infections in the elderly: Effect of zinc on generation of cytokines and oxidative stress","volume":"85","author":"Prasad","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.4049\/jimmunol.156.3.1166","article-title":"A20 zinc finger protein inhibits TNF and IL-1 signaling","volume":"156","author":"Jaattela","year":"1996","journal-title":"J. Immunol."},{"key":"ref_60","first-page":"272","article-title":"Zinc regulates cytokine induction by superantigens and lipopolysaccharide","volume":"84","author":"Driessen","year":"1995","journal-title":"Immunology"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Squizani, S., Jantsch, J., Rodrigues, F.d.S., Braga, M.F., Eller, S., de Oliveira, T.F., Silveira, A.K., Moreira, J.C.F., Giovenardi, M., and Porawski, M. (2022). Zinc Supplementation Partially Decreases the Harmful Effects of a Cafeteria Diet in Rats but Does Not Prevent Intestinal Dysbiosis. Nutrients, 14.","DOI":"10.3390\/nu14193921"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1019296","DOI":"10.3389\/fnagi.2022.1019296","article-title":"Salivary inflammatory biomarkers are predictive of mild cognitive impairment and Alzheimer\u2019s disease in a feasibility study","volume":"14","author":"McNicholas","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zy\u015bk, B., Ostrowska, L., and Smarkusz-Zarzecka, J. (2021). Salivary Adipokine and Cytokine Levels as Potential Markers for the Development of Obesity and Metabolic Disorders. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111703"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/20\/4396\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:08:12Z","timestamp":1760130492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/20\/4396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,17]]},"references-count":63,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["nu15204396"],"URL":"https:\/\/doi.org\/10.3390\/nu15204396","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,17]]}}}