{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:26:54Z","timestamp":1791998814300,"version":"4.4.0"},"reference-count":53,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060597"],"award-info":[{"award-number":["82060597"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021BEG03031"],"award-info":[{"award-number":["2021BEG03031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023AAC02041"],"award-info":[{"award-number":["2023AAC02041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Research Project of Ningxia","award":["82060597"],"award-info":[{"award-number":["82060597"]}]},{"name":"Key Research Project of Ningxia","award":["2021BEG03031"],"award-info":[{"award-number":["2021BEG03031"]}]},{"name":"Key Research Project of Ningxia","award":["2023AAC02041"],"award-info":[{"award-number":["2023AAC02041"]}]},{"name":"Ningxia Natural Science Foundation of China","award":["82060597"],"award-info":[{"award-number":["82060597"]}]},{"name":"Ningxia Natural Science Foundation of China","award":["2021BEG03031"],"award-info":[{"award-number":["2021BEG03031"]}]},{"name":"Ningxia Natural Science Foundation of China","award":["2023AAC02041"],"award-info":[{"award-number":["2023AAC02041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Lycium barbarum polysaccharides (LBPs) have been shown to exert an antiglycemic effect. Emerging evidence suggests that patients with hyperglycemia have a hypercontractility of duodenum, and targeting duodenal contraction of duodenum can be beneficial to glucose metabolism. However, it is unknown whether LBPs can improve glucose metabolism by regulating the hypercontractility of the duodenum. Our aim was to explore the effect of LBPs on duodenal contraction in prediabetic mice and also preliminarily investigate the mechanism. The results showed that LBPs improved glucose homeostasis by decreasing the duodenal amplitude of contraction rather than frequency. Moreover, LBPs ameliorated the gut microbiota composition and the levels of short-chain fatty acids, especially acetic acid, which might bind to the receptor on neurons to regulate the contraction of the duodenum. Acetic acid was hypothesized to play a key role in the above process. Then, acetic acid was determined to exert an antiglycemic effect as expected. In conclusion, LBPs may rely on acetic acid to regulate duodenal contraction to ameliorate glucose metabolism in prediabetic mice, which provides a new therapeutic strategy to treat dysglycemia.<\/jats:p>","DOI":"10.3390\/nu15204437","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T07:15:36Z","timestamp":1697699736000},"page":"4437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lycium barbarum Polysaccharides Improved Glucose Metabolism in Prediabetic Mice by Regulating Duodenal Contraction"],"prefix":"10.3390","volume":"15","author":[{"given":"Doudou","family":"Li","sequence":"first","affiliation":[{"name":"School of Public Health, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, Ningxia Medical University, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanna","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Public Health, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Tao","sequence":"additional","affiliation":[{"name":"School of Public Health, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health, Ningxia Medical University, Yinchuan 750004, China"},{"name":"Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan 750004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"ref_1","unstructured":"International Diabetes Federation (2021). IDF Diabetes Atlas, International Diabetes Federation. [10th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1001\/jama.2021.22208","article-title":"Prevalence and Treatment of Diabetes in China, 2013\u20132018","volume":"326","author":"Wang","year":"2021","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/S0140-6736(12)60283-9","article-title":"Prediabetes: A high-risk state for diabetes development","volume":"379","author":"Tabak","year":"2012","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2018.09.004","article-title":"Prediabetes and cardiovascular disease risk: A nested case-control study","volume":"278","author":"Hu","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/MCO.0b013e328302c9b0","article-title":"Gut-brain axis","volume":"11","author":"Romijn","year":"2008","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s12276-021-00677-w","article-title":"Role of the gut-brain axis in energy and glucose metabolism","volume":"54","author":"Wachsmuth","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"G645","DOI":"10.1152\/ajpgi.00015.2016","article-title":"Glucosensing in the gastrointestinal tract: Impact on glucose metabolism","volume":"310","author":"Fournel","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1365-2982.2007.01023.x","article-title":"Diabetes and the enteric nervous system","volume":"19","author":"Chandrasekharan","year":"2007","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/gutjnl-2015-310230","article-title":"Apelin targets gut contraction to control glucose metabolism via the brain","volume":"66","author":"Fournel","year":"2017","journal-title":"Gut"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.molmet.2018.01.020","article-title":"Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons","volume":"10","author":"Abot","year":"2018","journal-title":"Mol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrgastro.2012.32","article-title":"The enteric nervous system and neurogastroenterology","volume":"9","author":"Furness","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.17235\/reed.2016.4058\/2015","article-title":"Mechanisms responsible for neuromuscular relaxation in the gastrointestinal tract","volume":"108","author":"Gallego","year":"2016","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4448048","DOI":"10.1155\/2021\/4448048","article-title":"Kudzu Resistant Starch: An Effective Regulator of Type 2 Diabetes Mellitus","volume":"2021","author":"Song","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111408","DOI":"10.1016\/j.foodres.2022.111408","article-title":"Mechanism of glycometabolism regulation by bioactive compounds from the fruits of Lycium barbarum: A review","volume":"159","author":"Liu","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.foodchem.2018.01.176","article-title":"Lycium barbarum polysaccharides: Extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review","volume":"254","author":"Masci","year":"2018","journal-title":"Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/pca.3024","article-title":"Determination of monosaccharides in Lycium barbarum fruit polysaccharide by an efficient UHPLC-QTRAP-MS\/MS method","volume":"32","author":"Xu","year":"2021","journal-title":"Phytochem. Anal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1038\/srep05587","article-title":"Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model","volume":"4","author":"Xiao","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ijbiomac.2006.11.002","article-title":"Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats","volume":"40","author":"Li","year":"2007","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Rahman, M.M., Islam, M.R., Shohag, S., Ahasan, M.T., Sarkar, N., Khan, H., Hasan, A.M., Cavalu, S., and Rauf, A. (2022). Microbiome in cancer: Role in carcinogenesis and impact in therapeutic strategies. Biomed. Pharmacother., 149.","DOI":"10.1016\/j.biopha.2022.112898"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s13238-020-00814-7","article-title":"The role of the gut microbiome and its metabolites in metabolic diseases","volume":"12","author":"Wu","year":"2021","journal-title":"Protein Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.ijbiomac.2021.05.066","article-title":"Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation","volume":"183","author":"Gao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1113\/JP271441","article-title":"Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon","volume":"594","author":"Kaji","year":"2016","journal-title":"J. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"636803","DOI":"10.3389\/fimmu.2021.636803","article-title":"Depletion of Gut Microbiota Impairs Gut Barrier Function and Antiviral Immune Defense in the Liver","volume":"12","author":"Guo","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Portincasa, P., Bonfrate, L., Vacca, M., De Angelis, M., Farella, I., Lanza, E., Khalil, M., Wang, D.Q., Sperandio, M., and Di Ciaula, A. (2022). Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031105"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1001\/jama.2023.4063","article-title":"Diagnosis and Management of Prediabetes: A Review","volume":"329","author":"Perreault","year":"2023","journal-title":"JAMA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S2213-8587(19)30093-2","article-title":"Morbidity and mortality after lifestyle intervention for people with impaired glucose tolerance: 30-year results of the Da Qing Diabetes Prevention Outcome Study","volume":"7","author":"Gong","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s40265-015-0416-8","article-title":"Therapeutic Use of Metformin in Prediabetes and Diabetes Prevention","volume":"75","author":"Hostalek","year":"2015","journal-title":"Drugs"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.2337\/dc19-2221","article-title":"Metformin Should Not Be Used to Treat Prediabetes","volume":"43","author":"Davidson","year":"2020","journal-title":"Diabetes Care"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Rahman, M.M., Islam, M.R., Shohag, S., Hossain, M.E., Rahaman, M.S., Islam, F., Ahmed, M., Mitra, S., Khandaker, M.U., and Idris, A.M. (2022). The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review. Molecules, 27.","DOI":"10.3390\/molecules27051713"},{"key":"ref_30","first-page":"618","article-title":"The Effect of Lycium Barbarum Polysaccharide on the Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis","volume":"41","author":"Zhou","year":"2022","journal-title":"J. Am. Nutr. Assoc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2174\/1573406410666141110153858","article-title":"Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes","volume":"11","author":"Cai","year":"2015","journal-title":"Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s11684-019-0729-1","article-title":"Oxidative stress and diabetes: Antioxidative strategies","volume":"14","author":"Zhang","year":"2020","journal-title":"Front. Med."},{"key":"ref_33","first-page":"809","article-title":"Oxidative stress and inflammatory markers in prediabetes and diabetes","volume":"70","author":"Luc","year":"2019","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fphar.2020.00742","article-title":"Effects of Lycium barbarum Polysaccharide on Endoplasmic Reticulum Stress and Oxidative Stress in Obese Mice","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"145641","DOI":"10.1155\/2014\/145641","article-title":"Dietary Lycium barbarum polysaccharide induces Nrf2\/ARE pathway and ameliorates insulin resistance induced by high-fat via activation of PI3K\/AKT signaling","volume":"2014","author":"Yang","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1248\/yakushi.125.981","article-title":"Effect of Lycium barbarum polysaccharide on the improvement of insulin resistance in NIDDM rats","volume":"125","author":"Zhao","year":"2005","journal-title":"Yakugaku Zasshi"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1039\/C3FO60602C","article-title":"LBP-4a improves insulin resistance via translocation and activation of GLUT4 in OLETF rats","volume":"5","author":"Zhao","year":"2014","journal-title":"Food Funct."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.ijbiomac.2022.10.176","article-title":"Impact of Lycium barbarum polysaccharide on the expression of glucagon-like peptide 1 in vitro and in vivo","volume":"224","author":"Zhao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"119626","DOI":"10.1016\/j.carbpol.2022.119626","article-title":"The polysaccharides from the fruits of Lycium barbarum L. confer anti-diabetic effect by regulating gut microbiota and intestinal barrier","volume":"291","author":"Zhou","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/nrgastro.2015.204","article-title":"Neurogastroenterology: Improving glucose tolerance via the gut-brain axis","volume":"13","author":"Weber","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jnutbio.2018.10.003","article-title":"Gut microbiome and type 2 diabetes: Where we are and where to go?","volume":"63","author":"Sharma","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41588-019-0350-x","article-title":"Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases","volume":"51","author":"Sanna","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.chom.2020.06.004","article-title":"Arrhythmic Gut Microbiome Signatures Predict Risk of Type 2 Diabetes","volume":"28","author":"Reitmeier","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41564-021-00880-5","article-title":"Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice","volume":"6","author":"Yoon","year":"2021","journal-title":"Nat. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","article-title":"Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study","volume":"25","author":"Depommier","year":"2019","journal-title":"Nat. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1002\/imt2.58","article-title":"Metabolite profiling of human-originated Lachnospiraceae at the strain level","volume":"1","author":"Abdugheni","year":"2022","journal-title":"iMeta"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e4446","DOI":"10.7717\/peerj.4446","article-title":"Inulin-type fructan improves diabetic phenotype and gut microbiota profiles in rats","volume":"6","author":"Zhang","year":"2018","journal-title":"PeerJ"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnesp.2019.05.008","article-title":"Vinegar (acetic acid) intake on glucose metabolism: A narrative review","volume":"32","author":"Santos","year":"2019","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1007\/s00394-020-02214-3","article-title":"Safety and side effects of apple vinegar intake and its effect on metabolic parameters and body weight: A systematic review","volume":"59","author":"Launholt","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1038\/s41366-022-01137-9","article-title":"Gut microbiota accelerates obesity in peri-\/post-menopausal women via Bacteroides fragilis and acetic acid","volume":"46","author":"Shen","year":"2022","journal-title":"Int. J. Obes."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41574-019-0156-z","article-title":"Gut microbial metabolites in obesity, NAFLD and T2DM","volume":"15","author":"Canfora","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabres.2017.01.021","article-title":"Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials","volume":"127","author":"Shishehbor","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jff.2018.02.003","article-title":"Beneficial effects of apple cider vinegar on weight management, visceral adiposity index and lipid profile in overweight or obese subjects receiving restricted calorie diet: A randomized clinical trial","volume":"43","author":"Khezri","year":"2018","journal-title":"J. Funct. Foods"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/20\/4437\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:09:49Z","timestamp":1760130589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/15\/20\/4437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,19]]},"references-count":53,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["nu15204437"],"URL":"https:\/\/doi.org\/10.3390\/nu15204437","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,19]]}}}