{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:59Z","timestamp":1787029199786,"version":"build-2736575974"},"reference-count":59,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Fatigue and musculoskeletal pain are also frequent in patients with psoriasis (PsO) without arthritis (PsA). The current study aimed to assess the impact of an intervention program based on aerobic training to reduce fatigue and musculoskeletal pain in patients with PsO without PsA. A total of 118 male patients with PsO volunteered in the current interventional study and were randomly allocated to the experimental (n = 59) or control group (n = 59). The intervention consisted of a 16-week aerobic training program on a treadmill, three sessions per week, consisting of a warm-up, 35\u201350 min treadmill exercise (increasing 5 min\/4 weeks) at a work intensity of 50\u201365% of peak heart-rate (increasing 5%\/4 weeks), and cooling-down. The functional assessment of chronic illness therapy fatigue scale (FACIT-Fatigue), health assessment questionnaire disability index (HAQ-DI), and visual analog scale (VAS) were compared pre and post intervention. Nutritional intake, maximal aerobic power, lipid profile, serum markers of muscle damage, and body composition were also assessed. When compared to baseline, FACIT-Fatigue, HAQ-DI, and VAS scores were significantly improved without increasing markers of muscle damage. Fat mass percentage, lipid profile, and maximal oxygen consumption were also improved. In conclusion, a 16-week aerobic training program at moderate intensity was safe, well tolerated, and effective in psoriatic patients without PsA. Long-term follow-up studies are required to examine whether these promising results may improve clinical outcomes.<\/jats:p>","DOI":"10.3390\/nu15214563","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T09:56:36Z","timestamp":1698400596000},"page":"4563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Regular Exercise Improved Fatigue and Musculoskeletal Pain in Young Adult Psoriatic Patients without Psoriatic Arthritis"],"prefix":"10.3390","volume":"15","author":[{"given":"Antonio J.","family":"Diaz","sequence":"first","affiliation":[{"name":"School of Nursing and Physiotherapy, University of Cadiz, Ana Viya Avenue, 52, 11009 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5050-0594","authenticated-orcid":false,"given":"Miguel A.","family":"Rosety","sequence":"additional","affiliation":[{"name":"School of Sports Sciences, University of Cadiz, Rep. Saharahui Avenue, 12, 11519 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C.","family":"Armario","sequence":"additional","affiliation":[{"name":"Dermatology Unit, School of Medicine, University of Cadiz, Fragela Square s\/n, 11003 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel J.","family":"Bandez","sequence":"additional","affiliation":[{"name":"Biomedicine Department, School of Medicine, University of Cadiz, Fragela Square s\/n, 11003 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Garcia-Gomez","sequence":"additional","affiliation":[{"name":"Histology and Pathology Department, School of Medicine, University of Cadiz, Fragela Square s\/n, 11003 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Sanchez-Sanchez","sequence":"additional","affiliation":[{"name":"School of Nursing, Punta de Europa Hospital, Algeciras, 11207 C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jara","family":"Diaz","sequence":"additional","affiliation":[{"name":"School of Sports Sciences, University of Cadiz, Rep. Saharahui Avenue, 12, 11519 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4571-5582","authenticated-orcid":false,"given":"Cristina","family":"Castejon-Riber","sequence":"additional","affiliation":[{"name":"School of Education Sciences, University of Cordoba, C\/San Alberto Magno s\/n, 14071 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1593-475X","authenticated-orcid":false,"given":"Marco","family":"Bernardi","sequence":"additional","affiliation":[{"name":"School of Sports Medicine, University La Sapienza, Ple. Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rosety-Rodriguez M","sequence":"additional","affiliation":[{"name":"School of Sports Medicine, University of Cadiz, Virgen del Carmen s\/n, 11100 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-503X","authenticated-orcid":false,"given":"Francisco J.","family":"Ordonez","sequence":"additional","affiliation":[{"name":"School of Sports Medicine, University of Cadiz, Virgen del Carmen s\/n, 11100 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Rosety","sequence":"additional","affiliation":[{"name":"Human Anatomy Department, School of Medicine, University of Cadiz, Fragela Square s\/n, 11003 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"m1590","DOI":"10.1136\/bmj.m1590","article-title":"National, regional, and worldwide epidemiology of psoriasis: Systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"adv00553","DOI":"10.2340\/00015555-3906","article-title":"Musculoskeletal Pain in Patients with Psoriasis and its Influence on Health-related Quality of Life: Results from a Danish Population-based Survey","volume":"101","author":"Felbo","year":"2021","journal-title":"Acta Derm. 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