{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:14:36Z","timestamp":1776492876195,"version":"3.51.2"},"reference-count":43,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Authority of Sheba Medical Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The Mediterranean diet (MED) is highly recommended. Medical nutrition therapy is the cornerstone of diabetes treatment. The primary outcome was to evaluate the change in micronutrient intake of youth with type 1 diabetes before and after a 6-month MED intervention; we also assessed adherence and glycemic control. Twenty adolescents, median age 18 years (interquartile range: 15.5\u201321), median diabetes duration 9 years (7\u201314), using continuous glucose monitoring devices, received personalized diet regimes based on MED. At 6 months post-intervention, the caloric intake remained unchanged; however, the carbohydrate proportion was lower (p = 0.058), and the intakes of some monounsaturated fats increased (p = 0.049). Sodium intake exceeded the recommended daily allowance by 250% (p = 0.653), before and after the intervention. For blood glucose, the percent TIR (time-in-range, 70\u2013180 mg\/dL) improved from 52% (38\u201360) to 63% (47\u201371) (p = 0.047). The total insulin dose decreased marginally, from 0.76 u\/kg (0.64\u20130.97) to 0.72 u\/kg (0.61\u20130.89) (p = 0.067). BMI z-score and waist circumference did not change (p = 0.316 and p = 0.161, respectively). Diastolic blood pressure percentile decreased from 73% (68\u201388) to 69% (50\u201379) (p = 0.028), and LDL cholesterol from 114 mg\/dL (105\u2013134) to 104 mg\/dL (96\u2013124) (p = 0.059). The Israeli Mediterranean diet screener score increased, from 8 (7\u201311) to 13 points (12\u201314) (p &lt; 0.001). The MED-based intervention in youth with type 1 diabetes is feasible and leads to improvement in monounsaturated fat intake, TIR, and diastolic blood pressure. Other parameters show no change (caloric intake, BMI, and HbA1c).<\/jats:p>","DOI":"10.3390\/nu15214577","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:27:28Z","timestamp":1698658048000},"page":"4577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Mediterranean Diet for Adolescents with Type 1 Diabetes: A Prospective Interventional Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-3176","authenticated-orcid":false,"given":"Neriya","family":"Levran","sequence":"first","affiliation":[{"name":"Pediatric Endocrine and Diabetes Unit, Chaim Sheba Medical Center, Edmond and Lily Safra Children\u2019s Hospital, Ramat-Gan 5262000, Israel"},{"name":"National Juvenile Diabetes Center, Maccabi Health Care Services, Ra\u2019anana 4345020, Israel"},{"name":"The Institute of Biochemistry, Food Science and Nutrition, The Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 5290002, Israel"},{"name":"Division of Nutrition Unit, Chaim Sheba Medical Center, Ramat-Gan 5262000, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-8970","authenticated-orcid":false,"given":"Noah","family":"Levek","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine and Diabetes Unit, Chaim Sheba Medical Center, Edmond and Lily Safra Children\u2019s Hospital, Ramat-Gan 5262000, Israel"},{"name":"National Juvenile Diabetes Center, Maccabi Health Care Services, Ra\u2019anana 4345020, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruria","family":"Sher","sequence":"additional","affiliation":[{"name":"National Juvenile Diabetes Center, Maccabi Health Care Services, Ra\u2019anana 4345020, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elinor","family":"Mauda-Yitzhak","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine and Diabetes Unit, Chaim Sheba Medical Center, Edmond and Lily Safra Children\u2019s Hospital, Ramat-Gan 5262000, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-3250","authenticated-orcid":false,"given":"Noah","family":"Gruber","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine and Diabetes Unit, Chaim Sheba Medical Center, Edmond and Lily Safra Children\u2019s Hospital, Ramat-Gan 5262000, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8057-0622","authenticated-orcid":false,"given":"Arnon","family":"Afek","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"General Management, The Chaim Sheba Medical Center, Tel Hashomer, Ramat-Gan 5262000, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-5065","authenticated-orcid":false,"given":"Efrat","family":"Monsonego-Ornan","sequence":"additional","affiliation":[{"name":"The Institute of Biochemistry, Food Science and Nutrition, The Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 5290002, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8365-8091","authenticated-orcid":false,"given":"Orit","family":"Pinhas-Hamiel","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine and Diabetes Unit, Chaim Sheba Medical Center, Edmond and Lily Safra Children\u2019s Hospital, Ramat-Gan 5262000, Israel"},{"name":"National Juvenile Diabetes Center, Maccabi Health Care Services, Ra\u2019anana 4345020, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/S0140-6736(18)31320-5","article-title":"Type 1 Diabetes","volume":"391","author":"DiMeglio","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.2337\/dc12-1959","article-title":"Most Youth with Type 1 Diabetes in the T1D Exchange Clinic Registry Do Not Meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes Clinical Guidelines","volume":"36","author":"Wood","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2147\/DMSO.S304347","article-title":"Glycaemic Control in Youth and Young Adults: Challenges and Solutions","volume":"15","author":"Khadilkar","year":"2022","journal-title":"Diabetes Metab. 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