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Fund","award":["PI16\/01407"],"award-info":[{"award-number":["PI16\/01407"]}]},{"name":"RETIC program of ISCIII-European Regional Development Fund","award":["CAS079P17"],"award-info":[{"award-number":["CAS079P17"]}]},{"name":"RETIC program of ISCIII-European Regional Development Fund","award":["GRS1879\/A\/18"],"award-info":[{"award-number":["GRS1879\/A\/18"]}]},{"name":"RETIC program of ISCIII-European Regional Development Fund","award":["RD21\/0017\/0006"],"award-info":[{"award-number":["RD21\/0017\/0006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Graft-versus-host disease (GvHD) is a common and severe complication following allogeneic hematopoietic stem cell transplantation (HSCT). Its prevention and treatment is a major challenge. Ferulic acid (FA) has anti-inflammatory and antioxidant properties that could be attractive in this setting. Our aim was to evaluate a bioactive ingredient derived from wheat bran (WB), selected for its high concentration of FA, in a murine model of GvHD. The ingredient was obtained via a bioprocess involving hydrolysis and spray-drying. GvHD was induced via HSCT between MHC-mismatched mouse strains. FA treatment was administered orally. Survival and disease scores (weight loss, hunching, activity, fur texture, and skin integrity, each scored between 0 and 2 depending on disease severity) were recorded daily, histological evaluation was performed at the end of the experiment, and serum inflammatory cytokines were analyzed on days 9 and 28. Treatment with FA did not protect GvHD mice from death, nor did it diminish GvHD scores. However, histological analysis showed that ulcers with large areas of inflammatory cells, vessels, and keratin were less common in skin samples from FA-treated mice. Areas of intense inflammatory response were also seen in fewer small intestine samples from treated mice. In addition, a slight decrease in INF-\u03b3 and TNF-\u03b1 expression was observed in the serum of treated mice on day 28. The results showed some local effect of the ingredient intervention, but that the dose used may not be sufficient to control or reduce the inflammatory response at the systemic level in mice with GvHD. Higher dosages of FA may have an impact when evaluating the immunomodulatory capabilities of the hydrolyzed WB ingredient. Thus, further experiments and the use of technological strategies that enrich the ingredients in soluble ferulic acid to improve its efficacy in this setting are warranted.<\/jats:p>","DOI":"10.3390\/nu15214582","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:27:28Z","timestamp":1698658048000},"page":"4582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Dietary Supplementation with a Ferulic Acid-Rich Bioactive Component of Wheat Bran in a Murine Model of Graft-Versus-Host Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7811-4679","authenticated-orcid":false,"given":"Silvia","family":"Preciado","sequence":"first","affiliation":[{"name":"Cell Therapy Unit, Hematology Department, University Hospital of Salamanca, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain"},{"name":"RICORS TERAV, ISCIII, 28029 Madrid, Spain"},{"name":"Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y Le\u00f3n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1155-6464","authenticated-orcid":false,"given":"Cristina","family":"Mart\u00ednez-Villaluenga","sequence":"additional","affiliation":[{"name":"Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Jos\u00e9 Antonio Novais 10, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-3033","authenticated-orcid":false,"given":"Daniel","family":"Rico","sequence":"additional","affiliation":[{"name":"Agrarian Technological Institute of Castilla and Leon (ITACyL), Ctra. Burgos Km 119, Finca Zamadue\u00f1as, 47071 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Munti\u00f3n","sequence":"additional","affiliation":[{"name":"Cell Therapy Unit, Hematology Department, University Hospital of Salamanca, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain"},{"name":"RICORS TERAV, ISCIII, 28029 Madrid, Spain"},{"name":"Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y Le\u00f3n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Carmen","family":"Garc\u00eda-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Research Center, University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-5666","authenticated-orcid":false,"given":"Almudena","family":"Navarro-Bail\u00f3n","sequence":"additional","affiliation":[{"name":"Cell Therapy Unit, Hematology Department, University Hospital of Salamanca, Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain"},{"name":"RICORS TERAV, ISCIII, 28029 Madrid, Spain"},{"name":"Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y Le\u00f3n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5014-9848","authenticated-orcid":false,"given":"Ana Bel\u00e9n","family":"Mart\u00edn-Diana","sequence":"additional","affiliation":[{"name":"Agrarian Technological Institute of Castilla and Leon (ITACyL), Ctra. 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