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In independently living older adults with oropharyngeal dysphagia (OD), we assessed: (1) the rheological properties of TUGE; (2) its therapeutic effect at four viscosity levels (achieved by 5 g, 10 g, 20 g and 30 g of TUGE in water + Omnipaque X-ray contrast) versus thin liquid; and (3) the effect on hydration status and gastrointestinal tolerance after fourteen days. Shear viscosity of TUGE was measured in SI units (mPa\u00b7s at 50 s\u22121). The Penetration Aspiration Scale (PAS) score and the swallow response at each viscosity level was assessed with videofluoroscopy (VFS), and in the 14-day study we assessed fluid intake, hydration, and tolerance. Thickened fluids with TUGE were unaffected (\u22120.3%) by \u03b1-salivary amylase (\u03b1-SA). The shear viscosity values with VFS were 49.41 \u00b1 2.38, 154.83 \u00b1 10.22, 439.33 \u00b1 11.72 and 672.5 \u00b1 35.62 mPa\u00b7s. We studied 60 independently living adults (70 \u00b1 11.4 years) with mild OD (PAS 4.1 \u00b1 2.2, 25% aspirations). TUGE caused a shear-viscosity-dependent improvement in PAS at 150\u2013670 mPa\u00b7s and in safety of swallow, slightly increased oral residue, did not affect pharyngeal residue and reduced time to laryngeal vestibule closure (\u221227%) at 670 mPa\u00b7s. Fluid intake with TUGE (1488 mL\/day) was well tolerated, and hydration status improved. In conclusion, TUGE was unaffected by \u03b1-SA and strongly improved safety of swallow in a viscosity-dependent manner without affecting pharyngeal residue. Fourteen-day treatment of thickened fluids with TUGE is safe and well tolerated and improves hydration status in older adults with dysphagia.<\/jats:p>","DOI":"10.3390\/nu15214621","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:48:31Z","timestamp":1698756511000},"page":"4621","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Therapeutic Effect on Swallowing Function and on Hydration Status of a New Liquid Gum-Based Thickener in Independently-Living Older Patients with Oropharyngeal Dysphagia"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-7948","authenticated-orcid":false,"given":"Noem\u00ed","family":"Tomsen","sequence":"first","affiliation":[{"name":"Gastrointestinal Physiology Lab, Hospital de Matar\u00f3, Consorci Sanitari del Maresme, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-1150","authenticated-orcid":false,"given":"Mireia","family":"Bol\u00edvar-Prados","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Lab, Hospital de Matar\u00f3, Consorci Sanitari del Maresme, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6178-3748","authenticated-orcid":false,"given":"Omar","family":"Ortega","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Lab, Hospital de Matar\u00f3, Consorci Sanitari del Maresme, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-8560","authenticated-orcid":false,"given":"Pere","family":"Clav\u00e9","sequence":"additional","affiliation":[{"name":"Gastrointestinal Physiology Lab, Hospital de Matar\u00f3, Consorci Sanitari del Maresme, 08304 Matar\u00f3, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Hep\u00e1ticas y Digestivas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrgastro.2015.199","article-title":"Oropharyngeal Dysphagia: Manifestations and Diagnosis","volume":"13","author":"Rommel","year":"2016","journal-title":"Nat. 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