{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:27:40Z","timestamp":1790810860408,"version":"4.1.0"},"reference-count":53,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006013","name":"Zayed bin Sultan Al Nahyan Center for Health Sciences, United Arab Emirates University (UAEU)","doi-asserted-by":"publisher","award":["31R138"],"award-info":[{"award-number":["31R138"]}],"id":[{"id":"10.13039\/501100006013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006013","name":"Zayed bin Sultan Al Nahyan Center for Health Sciences, United Arab Emirates University (UAEU)","doi-asserted-by":"publisher","award":["12S136"],"award-info":[{"award-number":["12S136"]}],"id":[{"id":"10.13039\/501100006013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006013","name":"UAEU-National Faculty Research Program","doi-asserted-by":"publisher","award":["31R138"],"award-info":[{"award-number":["31R138"]}],"id":[{"id":"10.13039\/501100006013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006013","name":"UAEU-National Faculty Research Program","doi-asserted-by":"publisher","award":["12S136"],"award-info":[{"award-number":["12S136"]}],"id":[{"id":"10.13039\/501100006013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D (VD) deficiency can result from insufficiency of either light exposure or VD intake. We investigated the biological effects of VD deficiency for 7 months on the mouse gastric glands. Varying degrees of VD deficiency were induced in C57BL\/6 mice by keeping them on standard diet with constant-dark conditions (SDD) or VD deficient diet with constant-dark conditions (VDD). Samples of serum, glandular stomach, and gastric contents were collected for LCMS\/MS, RT-PCR, immunohistochemistry, and acid content measurements. Both SDD and VDD mice had a significant decline in 25OHVD metabolite, gastric epithelial cell proliferation, and mucin 6 gene expression. These effects were enhanced with the severity of VD deficiency from SDD to VDD. Besides and compared to the control group, SDD mice only displayed a significant increase in the number of zymogenic cells (p \u2264 0.0001) and high expression of the adiponectin (p \u2264 0.05), gastrin (p \u2264 0.0001), mucin 5AC (*** p \u2264 0.001) and the Cyclin-dependent kinase inhibitor 1A (**** p \u2264 0.0001). These phenotypes were unique to SDD gastric samples and not seen in the VDD or control groups. This study suggests that the body reacts differently to diverse VD deficiency sources, light or diet.<\/jats:p>","DOI":"10.3390\/nu15214648","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T09:28:13Z","timestamp":1698917293000},"page":"4648","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Seven-Month Vitamin D Deficiency Inhibits Gastric Epithelial Cell Proliferation, Stimulates Acid Secretion, and Differentially Alters Cell Lineages in the Gastric Glands"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6357-4787","authenticated-orcid":false,"given":"Shaima","family":"Sirajudeen","sequence":"first","affiliation":[{"name":"Department of Biology, College of Science, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-6083","authenticated-orcid":false,"given":"Iltaf","family":"Shah","sequence":"additional","affiliation":[{"name":"Zayed bin Sultan Al Nahyan Center for Health Sciences, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates"},{"name":"Department of Chemistry, College of Science, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8590-3975","authenticated-orcid":false,"given":"Sherif M.","family":"Karam","sequence":"additional","affiliation":[{"name":"Zayed bin Sultan Al Nahyan Center for Health Sciences, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates"},{"name":"Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-561X","authenticated-orcid":false,"given":"Asma","family":"Al Menhali","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates"},{"name":"Zayed bin Sultan Al Nahyan Center for Health Sciences, United Arab Emirates University (UAEU), Al Ain 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: An update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur. 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