{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:56:33Z","timestamp":1774479393410,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center of Excellence for the Oceans","award":["111J13801-61"],"award-info":[{"award-number":["111J13801-61"]}]},{"name":"National Taiwan Ocean University","award":["111J13801-61"],"award-info":[{"award-number":["111J13801-61"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study investigates the impact of various zinc supplementation methods on anemia in rats induced by phenylhydrazine (PHZ) and in 5\/6-nephrectomized anemic rats. We compare oral zinc sulfate (ZnSO4) supplementation, oyster Crassostrea gigas supplementation, and hard clam Meretrix lusoria supplementation on red blood cell (RBC) levels. Oral zinc-rich oyster supplementation (2.70 mg Zn (30 g oyster)\/day\/rat) effectively corrects anemia in both experimental groups. Rats orally fed oysters for four days exhibit similar effectiveness as those receiving a single ZnSO4 injection (0.95 mg Zn (4.18 mg ZnSO4\u22c57H2O)\/rat). In contrast, oral ZnSO4 supplementation (2.70 mg Zn (11.88 mg ZnSO4\u22c57H2O)\/day\/rat) does not significantly increase RBC levels, suggesting better zinc absorption from oysters. A placebo group of anemic rats supplemented with hard clams, similar in composition to oysters but much lower in zinc, did not change RBC counts. This supports oysters\u2019 high zinc content as the key to correcting anemia. Oysters also contain high iron levels, offering a potential solution for iron-deficiency anemia while supporting bone marrow erythropoiesis. In summary, oral oyster supplementation emerges as an effective strategy to correct anemia in rats with added zinc and iron support for erythropoiesis.<\/jats:p>","DOI":"10.3390\/nu15214675","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T14:51:01Z","timestamp":1699109461000},"page":"4675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral Zinc-Rich Oyster Supplementation Corrects Anemia in Rats"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3576-1371","authenticated-orcid":false,"given":"Yen-Hua","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Food Safety and Risk Management, College of Life Sciences, National Taiwan Ocean University, Keelung 20224, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Lin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Food Science, College of Life Sciences, National Taiwan Ocean University, Keelung 20224, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Cheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Food Science, College of Life Sciences, National Taiwan Ocean University, Keelung 20224, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-8381","authenticated-orcid":false,"given":"Sen-Shyong","family":"Jeng","sequence":"additional","affiliation":[{"name":"Department of Food Science, College of Life Sciences, National Taiwan Ocean University, Keelung 20224, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.hoc.2015.11.002","article-title":"The Global Burden of Anemia","volume":"30","author":"Kassebaum","year":"2016","journal-title":"Hematol. 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