{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:31:47Z","timestamp":1790728307321,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Health-Instituto de Salud Carlos III (ISCIII)","award":["PI19\/00500"],"award-info":[{"award-number":["PI19\/00500"]}]},{"name":"Spanish Ministry of Health-Instituto de Salud Carlos III (ISCIII)","award":["PI22\/00327"],"award-info":[{"award-number":["PI22\/00327"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: The physiopathology of sarcopenia is still not completely understood. Aim: To assess the relationship between dehydration and skeletal muscle catabolism, muscle mass, and sarcopenia in an aged population. Methods: Observational cross-sectional study of community-dwelling subjects aged 70 years and older. Dehydration was assessed by plasma osmolarity; bioimpedance analysis (BIA) was used to assess body composition and water content; sarcopenia was established according to the EWGSOP-2 criteria; and 3-methyl-histidine (3MH) was used as an indicator of muscle catabolism. Results: 190 participants were recruited (77.4 years; 51.6% women). In total, 22.6% and 20.5% presented plasma osmolarity of 295\u2013300 mOsm\/L and &gt;300 mOsm\/L, respectively. Age was correlated with plasma osmolarity (rs = 0.439; p &lt; 0.001). Plasma osmolarity was correlated with 3MH (rs = 0.360; p &lt; 0.001) and showed an effect on 3MH levels, with an adjusted (by age, sex, and number of medications) beta of 0.283 (p &lt; 0.001). BIA water content indicators showed no correlation with 3MH. Lower in sarcopenic compared to non-sarcopenic subjects were the intracellular water percentage (60.3 vs. 61.2%; p = 0.004) and intracellular water\/free-fat mass ratio (44.3 vs. 45.0; p = 0.004). Conclusions: Dehydration is a highly prevalent clinical condition in aged populations, increases with age, and is associated with muscle catabolism but not sarcopenia.<\/jats:p>","DOI":"10.3390\/nu15224718","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T07:02:05Z","timestamp":1699426925000},"page":"4718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Relationship between Hydration Status and Muscle Catabolism in the Aged Population: A Cross-Sectional Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-9913","authenticated-orcid":false,"given":"Mateu","family":"Serra-Prat","sequence":"first","affiliation":[{"name":"Research Unit, Consorci Sanitari del Maresme, 08304 Matar\u00f3, Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28222 Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Information Management Unit, Consorci Sanitari del Maresme, 08304 Matar\u00f3, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Dietetics and Nutritional Unit, Consorci Sanitari del Maresme, 08304 Matar\u00f3, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Palomera","sequence":"additional","affiliation":[{"name":"Research Unit, Consorci Sanitari del Maresme, 08304 Matar\u00f3, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulogio","family":"Pleguezuelos","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Hospital of Matar\u00f3, Consorci Sanitari del Maresme, 08304 Matar\u00f3, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Tecnocampus Foundation, 08302 Matar\u00f3, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_2","first-page":"192","article-title":"Sarcopenia and physical frailty: Two sides of the same coin","volume":"28","author":"Cesari","year":"2014","journal-title":"Front. 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