{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:40:39Z","timestamp":1785314439945,"version":"3.55.0"},"reference-count":32,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Indian Council of Medical Research Senior Research Fellowship","award":["3\/1\/2\/241\/2021-Nut"],"award-info":[{"award-number":["3\/1\/2\/241\/2021-Nut"]}]},{"name":"Indian Council of Medical Research Senior Research Fellowship","award":["SR\/FIST\/LS-1\/2019\/502"],"award-info":[{"award-number":["SR\/FIST\/LS-1\/2019\/502"]}]},{"name":"Indian Council of Medical Research Senior Research Fellowship","award":["SR\/PURSE\/2021\/77"],"award-info":[{"award-number":["SR\/PURSE\/2021\/77"]}]},{"name":"DST-FIST","award":["3\/1\/2\/241\/2021-Nut"],"award-info":[{"award-number":["3\/1\/2\/241\/2021-Nut"]}]},{"name":"DST-FIST","award":["SR\/FIST\/LS-1\/2019\/502"],"award-info":[{"award-number":["SR\/FIST\/LS-1\/2019\/502"]}]},{"name":"DST-FIST","award":["SR\/PURSE\/2021\/77"],"award-info":[{"award-number":["SR\/PURSE\/2021\/77"]}]},{"name":"DST-PURSE","award":["3\/1\/2\/241\/2021-Nut"],"award-info":[{"award-number":["3\/1\/2\/241\/2021-Nut"]}]},{"name":"DST-PURSE","award":["SR\/FIST\/LS-1\/2019\/502"],"award-info":[{"award-number":["SR\/FIST\/LS-1\/2019\/502"]}]},{"name":"DST-PURSE","award":["SR\/PURSE\/2021\/77"],"award-info":[{"award-number":["SR\/PURSE\/2021\/77"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Severe acute malnutrition (SAM) is a significant public health problem in developing countries, including India, where a significant proportion of children suffer from malnutrition. Objective: This research aims to investigate the factors contributing to severe acute malnutrition (SAM). Additionally, the study seeks to explore the relationship between micronutrient levels and pro-inflammatory cytokines in SAM children with and without clinical complications. Furthermore, the effectiveness of antibiotic treatment in SAM children without complications is evaluated. Methods: The study involved three groups comprising 66 subjects each: a healthy control group, SAM children with complications, and SAM children without complications. Blood samples were collected, and various analyses were conducted, including biochemical, hematological, micronutrient, and pro-inflammatory marker quantification. The data were analyzed using SPSS version 22.0. Results: The results indicate that the levels of IL-6, CRP, and TNF-\u03b1 were significantly higher in the SAM group with complications compared to both the control group and the SAM group without complications. Zinc and copper levels were significantly lower in both SAM groups compared to the control group, and a negative correlation was observed between zinc levels and inflammatory markers. The study also assessed the efficacy of antibiotic treatment in SAM children without complications by comparing their weight, height, weight-for-height, and weight-for-age at baseline and after a 15-day follow-up period. Significant improvements in these parameters were observed in both the group receiving antibiotic treatment and the group not receiving antibiotic treatment. Conclusion: The findings suggest that a combination of antibiotic treatment and nutritional support can lead to significant clinical improvements in SAM children without complications. This study has important implications for the management and treatment of SAM in India and other developing countries.<\/jats:p>","DOI":"10.3390\/nu15234865","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:54:37Z","timestamp":1700625277000},"page":"4865","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Micronutrients and Pro-Inflammatory Cytokines Levels in Nutritionally Deprived Children\u2014A Tertiary Care Hospital-Based Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Malvika","family":"Mishra","sequence":"first","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2161-0604","authenticated-orcid":false,"given":"Alok","family":"Raghav","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur 208002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashwant Kumar","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur 208002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2967-8838","authenticated-orcid":false,"given":"Desh Deepak","family":"Singh","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"ref_1","unstructured":"(2023, October 19). 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