{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:30:52Z","timestamp":1793298652410,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Non-alcoholic fatty liver disease (NAFLD) is associated with visceral adiposity. We assessed the effectiveness of time-restricted fasting (TRF) for 16 h daily without calorie restrictions compared to standard care (SC; diet and lifestyle advice) in improving visceral adiposity and steatosis via controlled attenuation parameter (CAP). Methods: In a prospective single-blind randomized controlled trial, 32 participants with NAFLD were randomly assigned to TRF or SC for 12 weeks. The secondary endpoints were changes in liver stiffness, anthropometry, blood pressure, and other metabolic factors. Results: Twenty-eight participants completed the first arm of the study (TRF = 14, SC = 14), with 23 completing the crossover arm (TRF = 10, SC = 13). The baseline demographics were similar between the groups. Intermittent fasting caused a significant decrease in hepatic steatosis (p = 0.038), weight (p = 0.005), waist circumference (p = 0.001), and BMI (p = 0.005) compared to standard care. Intermittent fasting also resulted in additional within-group changes that were not seen in the standard care intervention. Conclusion: TRF offers superior improvements in patients with NAFLD, improving steatosis, weight, and waist circumference despite a lack of change in overall caloric intake. Time-restricted fasting should be considered as a primary weight loss intervention in the context of NAFLD. Trial registration: ACTRN12613000935730.<\/jats:p>","DOI":"10.3390\/nu15234870","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T03:54:37Z","timestamp":1700625277000},"page":"4870","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Time-Restricted Fasting Improves Liver Steatosis in Non-Alcoholic Fatty Liver Disease\u2014A Single Blinded Crossover Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9627-1299","authenticated-orcid":false,"given":"Jack","family":"Feehan","sequence":"first","affiliation":[{"name":"Institute for Health and Sport, Victoria University, Melbourne 3011, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Mack","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, Monash University, Melbourne 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Tuck","sequence":"additional","affiliation":[{"name":"Department of Nursing and Allied Health, Swinburne University of Technology, Hawthorn 3122, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Tchongue","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Unit, Monash Health, Melbourne 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7752-6279","authenticated-orcid":false,"given":"Darcy Q.","family":"Holt","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Unit, Monash Health, Melbourne 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7829-0974","authenticated-orcid":false,"given":"William","family":"Sievert","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, Monash University, Melbourne 3168, Australia"},{"name":"Gastroenterology and Hepatology Unit, Monash Health, Melbourne 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-8858","authenticated-orcid":false,"given":"Gregory T.","family":"Moore","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, Monash University, Melbourne 3168, Australia"},{"name":"Gastroenterology and Hepatology Unit, Monash Health, Melbourne 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8760-2511","authenticated-orcid":false,"given":"Barbora","family":"de Courten","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Sciences, RMIT, Bundoora 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6680-2303","authenticated-orcid":false,"given":"Alexander","family":"Hodge","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences, Monash University, Melbourne 3168, Australia"},{"name":"Gastroenterology and Hepatology Unit, Monash Health, Melbourne 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1016\/j.cgh.2021.12.002","article-title":"2019 Global NAFLD Prevalence: A Systematic Review and Meta-analysis","volume":"20","author":"Le","year":"2022","journal-title":"Clin. 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