{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:10:51Z","timestamp":1790345451863,"version":"4.1.0"},"reference-count":109,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nephrolithiasis affects around 10% of the population and is frequently associated with impaired dietary factors. The first one is insufficient fluid intake inducing reduced urine volume, urine supersaturation, and subsequently urinary lithiasis. Kidneys regulate 24 h urine volume, which, under physiological conditions, approximately reflects daily fluid intake. The aim of this study is to synthesize and highlight the role of hydration in the treatment of nephrolithiasis. Increasing fluid intake has a preventive effect on the risk of developing a first kidney stone (primary prevention) and also decreases the risk of stone recurrence (secondary prevention). Current guidelines recommend increasing fluid intake to at least at 2.5 L\/day to prevent stone formation, and even to 3.5\u20134 L in some severe forms of nephrolithiasis (primary or enteric hyperoxaluria or cystinuria). Fluid intake must also be balanced between day and night, to avoid urinary supersaturation during the night. Patients should be informed and supported in this difficult process of increasing urine dilution, with practical ways and daily routines to increase their fluid intake. The liquid of choice is water, which should be chosen depending on its composition (such as calcium, bicarbonate, or magnesium content). Finally, some additional advice has to be given to avoid certain beverages such as those containing fructose or phosphoric acid, which are susceptible to increase the risk of nephrolithiasis.<\/jats:p>","DOI":"10.3390\/nu15234885","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T03:45:18Z","timestamp":1700711118000},"page":"4885","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hydration for Adult Patients with Nephrolithiasis: Specificities and Current Recommendations"],"prefix":"10.3390","volume":"15","author":[{"given":"Marie","family":"Courbebaisse","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"},{"name":"Institut Necker Enfants Malades, Inserm U1151, F-75015 Paris, France"},{"name":"Physiology\u2014Functional Explorations Department, Georges Pompidou European Hospital, AP-HP, F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l\u2019Enfant et de l\u2019Adulte (MARHEA), F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares du Calcium et du Phosphate, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Travers","sequence":"additional","affiliation":[{"name":"\u00c9quipe Biologie, Lip(Sys)2, EA7357, UFR de Pharmacie, Universit\u00e9 Paris-Saclay, F-91400 Orsay, France"},{"name":"Clinical Chemistry Department, Georges Pompidou European Hospital, AP-HP, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Bouderlique","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"},{"name":"Physiology\u2014Functional Explorations Department, Georges Pompidou European Hospital, AP-HP, F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l\u2019Enfant et de l\u2019Adulte (MARHEA), F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares du Calcium et du Phosphate, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Michon-Colin","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"},{"name":"Physiology\u2014Functional Explorations Department, Georges Pompidou European Hospital, AP-HP, F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l\u2019Enfant et de l\u2019Adulte (MARHEA), F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares du Calcium et du Phosphate, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Daudon","sequence":"additional","affiliation":[{"name":"Department of Multidisciplinary Functional Explorations, Tenon Hospital, AP-HP, F-75019 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"De Mul","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares du Calcium et du Phosphate, Fili\u00e8re Maladies Rares OSCAR, H\u00f4pital Femme M\u00e8re Enfant, Hospices Civils de Lyon, F-69500 Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Poli","sequence":"additional","affiliation":[{"name":"Physiology\u2014Functional Explorations Department, Georges Pompidou European Hospital, AP-HP, F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l\u2019Enfant et de l\u2019Adulte (MARHEA), F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares du Calcium et du Phosphate, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0375-6968","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Baron","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"},{"name":"Physiology\u2014Functional Explorations Department, Georges Pompidou European Hospital, AP-HP, F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l\u2019Enfant et de l\u2019Adulte (MARHEA), F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares du Calcium et du Phosphate, F-75015 Paris, France"},{"name":"Centre de Recherche des Cordeliers, INSERM, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"},{"name":"CNRS ERL 8228\u2014Laboratoire de Physiologie R\u00e9nale et Tubulopathies, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Prot-Bertoye","sequence":"additional","affiliation":[{"name":"Physiology\u2014Functional Explorations Department, Georges Pompidou European Hospital, AP-HP, F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales H\u00e9r\u00e9ditaires de l\u2019Enfant et de l\u2019Adulte (MARHEA), F-75015 Paris, France"},{"name":"Centre de R\u00e9f\u00e9rence des Maladies Rares du Calcium et du Phosphate, F-75015 Paris, France"},{"name":"Centre de Recherche des Cordeliers, INSERM, Sorbonne Universit\u00e9, Universit\u00e9 Paris Cit\u00e9, F-75006 Paris, France"},{"name":"CNRS ERL 8228\u2014Laboratoire de Physiologie R\u00e9nale et Tubulopathies, F-75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/j.ackd.2015.04.004","article-title":"The new epidemiology of nephrolithiasis","volume":"22","author":"Shoag","year":"2015","journal-title":"Adv. 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