{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T02:54:04Z","timestamp":1769568844757,"version":"3.49.0"},"reference-count":48,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,26]],"date-time":"2023-11-26T00:00:00Z","timestamp":1700956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Ciencia e Innovaci\u00f3n","award":["DI-17-096274"],"award-info":[{"award-number":["DI-17-096274"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n","award":["RTC2019-006806-1"],"award-info":[{"award-number":["RTC2019-006806-1"]}]},{"DOI":"10.13039\/501100011033","name":"Spanish State Investigation Agency and RETOS funds","doi-asserted-by":"publisher","award":["DI-17-096274"],"award-info":[{"award-number":["DI-17-096274"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Spanish State Investigation Agency and RETOS funds","doi-asserted-by":"publisher","award":["RTC2019-006806-1"],"award-info":[{"award-number":["RTC2019-006806-1"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>A large number of patients with celiac disease (CD) remain undiagnosed because they do not fulfill the criteria for entry into the conventional diagnostic workflow. This study evaluated the clinical utility of anti-tissue transglutaminase IgA antibody lateral flow immunoassays (anti-tTG-IgA LFIA) in the undiagnosed-CD-based pediatric population and the impact of a gluten-free diet (GFD) on screening-detected CD. A total of 576 volunteers were tested for anti-tTG-IgA. Gluten consumption habits, CD related symptoms, and risk factors for CD development were evaluated. Volunteers testing positive for anti-tTG-IgA were referred to the conventional CD diagnostic workflow, and the impact of the GFD on health-related quality of life (HR-QoL) was measured. Among them, 13 had a positive anti-tTG-IgA LFIA test result: 11 had confirmed CD (1.91%), one refused confirmatory tests, and another is undergoing diagnosis. Regarding the CD prevalence, no significant differences were observed among risk (1.89%) and symptomatic (2.65%) groups and the entire tested population (1.55%). Rapid anti-tTG-IgA LFIAs could be of clinical utility in primary care for the early identification of children with CD unidentified by the conventional diagnostic workflow. It could potentially reduce the costs of undiagnosed CD, avoiding unnecessary referrals to gastroenterologists, reducing diagnosis delays and long-term problems, and improving patients\u2019 HR-QoL.<\/jats:p>","DOI":"10.3390\/nu15234926","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:35:06Z","timestamp":1701056106000},"page":"4926","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rapid Anti-tTG-IgA Screening Test for Early Diagnosis of Celiac Disease in Pediatric Populations"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-7885","authenticated-orcid":false,"given":"Irati","family":"Mendia","sequence":"first","affiliation":[{"name":"Biomedal S.L., 41900 Seville, Spain"},{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-8979","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Segura","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-846X","authenticated-orcid":false,"given":"\u00c1ngela","family":"Ruiz-Carnicer","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-2027","authenticated-orcid":false,"given":"Laura","family":"Coto","sequence":"additional","affiliation":[{"name":"Biomedal S.L., 41900 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Negrete","sequence":"additional","affiliation":[{"name":"Biomedal S.L., 41900 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6476-2026","authenticated-orcid":false,"given":"Joshua C. D.","family":"Long","sequence":"additional","affiliation":[{"name":"Biomedal S.L., 41900 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-8813","authenticated-orcid":false,"given":"Joaquin","family":"Reyes","sequence":"additional","affiliation":[{"name":"Instituto Hispalense de Pediatr\u00eda, 41014 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benito","family":"Amil","sequence":"additional","affiliation":[{"name":"Instituto Hispalense de Pediatr\u00eda, 41014 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0561-9913","authenticated-orcid":false,"given":"Ignacio","family":"Salamanca","sequence":"additional","affiliation":[{"name":"Instituto Hispalense de Pediatr\u00eda, 41014 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4982-273X","authenticated-orcid":false,"given":"Isabel","family":"Comino","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-4522","authenticated-orcid":false,"given":"\u00c1ngel","family":"Cebolla","sequence":"additional","affiliation":[{"name":"Biomedal S.L., 41900 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-9496","authenticated-orcid":false,"given":"Carolina","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41572-018-0054-z","article-title":"Coeliac disease","volume":"5","author":"Lindfors","year":"2015","journal-title":"Nat. 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