{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:19:52Z","timestamp":1790605192980,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Danone Nutricia Research"},{"name":"Danone subsidiaries"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>ESPEN guidelines recommend a minimum protein intake of 1.0 g\/kg body weight (BW) per day to maintain or restore lean body mass in patients with cancer. During anti-cancer treatment, optimal protein intake is difficult to achieve. We investigated whether a high-protein, low-volume oral nutritional supplement (ONS) supports patients in meeting recommendations. A multi-centre, randomised, controlled, open-label, parallel-group study was carried out in nine hospitals (five countries) between January 2019 and July 2021 in colorectal and lung cancer patients undergoing first-line systemic treatment with chemo(radio-) or immunotherapy. Subjects were randomised (2:1) to receive Fortimel Compact Protein\u00ae or standard care. Protein intake was assessed with a 3-day food diary (primary outcome). BW was a secondary outcome. Due to challenges in recruitment, the study was terminated prematurely with 42 patients randomised (intervention group (IG) 28; control group (CG) 14). At T1 and T2, protein intake was statistically significantly higher in the IG compared to the CG (1.40 vs. 1.07 g\/kg\/day at T1, p = 0.008; 1.32 vs. 0.94 g\/kg\/day at T2, p = 0.002). At baseline, only 65% (IG) and 45% (CG) of patients met ESPEN minimum protein intake recommendations. However, at T1 and T2 in the IG, a higher proportion of patients met recommendations than in the CG (88% vs. 55% and 40%). No statistically significant difference between study groups was observed for BW. Mean compliance to the ONS was 73.4%. A high-protein, low-volume ONS consumed twice daily enables the majority of patients to reach minimal ESPEN protein recommendations.<\/jats:p>","DOI":"10.3390\/nu15245030","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T10:45:33Z","timestamp":1701945933000},"page":"5030","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["High Protein Oral Nutritional Supplements Enable the Majority of Cancer Patients to Meet Protein Intake Recommendations during Systemic Anti-Cancer Treatment: A Randomised Controlled Parallel-Group Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Anne-Marie","family":"Dingemans","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Erasmus Medical Center Cancer Institute, 3015 CN Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"van Walree","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, Amphia Hospital, 4818 CK Breda, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Schramel","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdolen Youssef-El","family":"Soud","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Diseases, M\u00e1xima Medisch Centrum, 5504 DB Veldhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5089-9136","authenticated-orcid":false,"given":"Edita","family":"Baltru\u0161kevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, National Cancer Institute, 08406 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"Lybaert","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, VITAZ, 9100 Sint-Niklaas, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margriet","family":"Veldhorst","sequence":"additional","affiliation":[{"name":"Nutricia Research, 3584 CT Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia. A.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Nutricia Research, 3584 CT Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein","family":"Kaasa","sequence":"additional","affiliation":[{"name":"Department of Oncology, Oslo University Hospital, 0379 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.clnu.2020.08.004","article-title":"The GLIM criteria as an effective tool for nutrition assessment and survival prediction in older adult cancer patients","volume":"40","author":"Zhang","year":"2021","journal-title":"Clin. 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