{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:44:26Z","timestamp":1760150666777,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2013\/07607-8","2018\/25088-1"],"award-info":[{"award-number":["2013\/07607-8","2018\/25088-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The consumption of large amounts of dietary fats and pregnancy are independent factors that can promote changes in gut permeability and the gut microbiome landscape. However, there is limited evidence regarding the impact of pregnancy on the regulation of such parameters in females fed a high-fat diet. Here, gut permeability and microbiome landscape were evaluated in a mouse model of diet-induced obesity in pregnancy. The results show that pregnancy protected against the harmful effects of the consumption of a high-fat diet as a disruptor of gut permeability; thus, there was a two-fold reduction in FITC\u2013dextran passage to the bloodstream compared to non-pregnant mice fed a high-fat diet (p &lt; 0.01). This was accompanied by an increased expression of gut barrier-related transcripts, particularly in the ileum. In addition, the beneficial effect of pregnancy on female mice fed the high-fat diet was accompanied by a reduced presence of bacteria belonging to the genus Clostridia, and by increased Lactobacillus murinus in the gut (p &lt; 0.05). Thus, this study advances the understanding of how pregnancy can act during a short window of time, protecting against the harmful effects of the consumption of a high-fat diet by promoting an increased expression of transcripts encoding proteins involved in the regulation of gut permeability, particularly in the ileum, and promoting changes in the gut microbiome.<\/jats:p>","DOI":"10.3390\/nu15245041","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T03:03:33Z","timestamp":1702004613000},"page":"5041","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnancy Protects against Abnormal Gut Permeability Promoted via the Consumption of a High-Fat Diet in Mice"],"prefix":"10.3390","volume":"15","author":[{"given":"Caio F.","family":"Biolcatti","sequence":"first","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil"},{"name":"School of Medical Sciences, University of Campinas, Campinas 13083-894, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa C.","family":"Bobbo","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil"},{"name":"School of Nursing, University of Campinas, Campinas 13083-887, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Solon","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseane","family":"Morari","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Haddad-Tovolli","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil"},{"name":"Neuronal Control of Metabolism (NeuCoMe) Laboratory, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana P.","family":"Araujo","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil"},{"name":"School of Nursing, University of Campinas, Campinas 13083-887, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela R.","family":"Simoes","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licio A.","family":"Velloso","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas, Campinas 13083-864, Brazil"},{"name":"School of Medical Sciences, University of Campinas, Campinas 13083-894, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S2213-8587(16)30107-3","article-title":"Influence of Maternal Obesity on the Long-Term Health of Offspring","volume":"5","author":"Godfrey","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/bmj.1.4607.702","article-title":"Maternal Obesity, Large Babies, and Diabetes","volume":"1","author":"Gilbert","year":"1949","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Heslehurst, N., Vieira, R., Akhter, Z., Bailey, H., Slack, E., Ngongalah, L., Pemu, A., and Rankin, J. 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