{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:02:29Z","timestamp":1783648949455,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nutrition Research Collaborative, and Dietetics and Food Services Department, Royal Brisbane and Womens\u2019 Hospital, Australia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Potassium dysregulation can be life-threatening. Dietary potassium modification is a management strategy for hyperkalaemia. However, a 2017 review for clinical guidelines found no trials evaluating dietary restriction for managing hyperkalaemia in chronic kidney disease (CKD). Evidence regarding dietary hyperkalaemia management was reviewed and practice recommendations disseminated. A literature search using terms for potassium, hyperkalaemia, and CKD was undertaken from 2018 to October 2022. Researchers extracted data, discussed findings, and formulated practice recommendations. A consumer resource, a clinician education webinar, and workplace education sessions were developed. Eighteen studies were included. Observational studies found no association between dietary and serum potassium in CKD populations. In two studies, 40\u201360 mmol increases in dietary\/supplemental potassium increased serum potassium by 0.2\u20130.4 mmol\/L. No studies examined lowering dietary potassium as a therapeutic treatment for hyperkalaemia. Healthy dietary patterns were associated with improved outcomes and may predict lower serum potassium, as dietary co-factors may support potassium shifts intracellularly, and increase excretion through the bowel. The resource recommended limiting potassium additives, large servings of meat and milk, and including high-fibre foods: wholegrains, fruits, and vegetables. In seven months, the resource received &gt; 3300 views and the webinar &gt; 290 views. This review highlights the need for prompt review of consumer resources, hospital diets, and health professionals\u2019 knowledge.<\/jats:p>","DOI":"10.3390\/nu16010003","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T04:18:37Z","timestamp":1702959517000},"page":"3","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Re-Thinking Hyperkalaemia Management in Chronic Kidney Disease\u2014Beyond Food Tables and Nutrition Myths: An Evidence-Based Practice Review"],"prefix":"10.3390","volume":"16","author":[{"given":"Helen L.","family":"MacLaughlin","sequence":"first","affiliation":[{"name":"Nutrition Research Collaborative, Department of Dietetics and Foodservices, Royal Brisbane and Women\u2019s Hospital, Herston, QLD 4029, Australia"},{"name":"School of Exercise & Nutrition Sciences, Queensland University of Technology, Brisbane, QLD 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9645-248X","authenticated-orcid":false,"given":"Erynn","family":"McAuley","sequence":"additional","affiliation":[{"name":"Nutrition Research Collaborative, Department of Dietetics and Foodservices, Royal Brisbane and Women\u2019s Hospital, Herston, QLD 4029, Australia"},{"name":"School of Exercise & Nutrition Sciences, Queensland University of Technology, Brisbane, QLD 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Fry","sequence":"additional","affiliation":[{"name":"Nutrition Research Collaborative, Department of Dietetics and Foodservices, Royal Brisbane and Women\u2019s Hospital, Herston, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Nutrition Research Collaborative, Department of Dietetics and Foodservices, Royal Brisbane and Women\u2019s Hospital, Herston, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Moran","sequence":"additional","affiliation":[{"name":"Nutrition Research Collaborative, Department of Dietetics and Foodservices, Royal Brisbane and Women\u2019s Hospital, Herston, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Morgan","sequence":"additional","affiliation":[{"name":"Nutrition Research Collaborative, Department of Dietetics and Foodservices, Royal Brisbane and Women\u2019s Hospital, Herston, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"McGuire","sequence":"additional","affiliation":[{"name":"Nutrition Research Collaborative, Department of Dietetics and Foodservices, Royal Brisbane and Women\u2019s Hospital, Herston, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-0932","authenticated-orcid":false,"given":"Marguerite","family":"Conley","sequence":"additional","affiliation":[{"name":"School of Exercise & Nutrition Sciences, Queensland University of Technology, Brisbane, QLD 4059, Australia"},{"name":"Nutrition and Dietetics Department, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-3460","authenticated-orcid":false,"given":"David W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Kidney and Transplant Services, Division of Medicine, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia"},{"name":"Centre for Health Services Research, The University of Queensland, St. Lucia, QLD 4067, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad K.","family":"Ratanjee","sequence":"additional","affiliation":[{"name":"Kidney Health Service, Royal Brisbane and Women\u2019s Hospital, Herston, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Mason","sequence":"additional","affiliation":[{"name":"Nutrition Research Collaborative, Department of Dietetics and Foodservices, Royal Brisbane and Women\u2019s Hospital, Herston, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.2215\/CJN.01730215","article-title":"Association between Serum Potassium and Outcomes in Patients with Reduced Kidney Function","volume":"11","author":"Luo","year":"2016","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1172\/JCI101204","article-title":"The Toxicity of Orally Administered Potassium Salts in Renal Insufficiency","volume":"20","author":"Winkler","year":"1941","journal-title":"J. Clin. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1172\/JCI101860","article-title":"The Tolerance for Potassium in Severe Renal in-Sufficiency: A Study of Ten Cases","volume":"26","author":"Keith","year":"1947","journal-title":"J. Clin. Investig."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1111\/j.1747-0080.2006.00100.x","article-title":"Evidence based practice guidelines for the nutritional management of chronic kidney disease","volume":"63","author":"Ash","year":"2006","journal-title":"Nutr. Diet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"ii45","DOI":"10.1093\/ndt\/gfm020","article-title":"EBPG guideline on nutrition","volume":"22","author":"Fouque","year":"2007","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1755-6686.2003.tb00270.x","article-title":"European Guidelines for the Nutritional Care of Adult Renal Patients","volume":"29","author":"James","year":"2003","journal-title":"EDTNA-ERCA J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2020.05.006","article-title":"KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update","volume":"76","author":"Ikizler","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.kint.2019.09.018","article-title":"Potassium homeostasis and management of dyskalemia in kidney diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"97","author":"Clase","year":"2020","journal-title":"Kidney Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1053\/j.jrn.2020.07.001","article-title":"Handouts for Low-Potassium Diets Disproportionately Restrict Fruits and Vegetables","volume":"31","author":"Picard","year":"2021","journal-title":"J. Ren. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1053\/j.ajkd.2020.04.019","article-title":"Adherence to Healthy Dietary Patterns and Risk of CKD Progression and All-Cause Mortality: Findings From the CRIC (Chronic Renal Insufficiency Cohort) Study","volume":"77","author":"Hu","year":"2021","journal-title":"Am. J. Kidney Dis."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Caldiroli, L., Molinari, P., Abinti, M., Rusconi, C., Castellano, G., and Vettoretti, S. (2022). Can Mediterranean Diet Have a Positive Impact on Kidney Health? A Pending Answer to a Long-Time Question. Nutrients, 14.","DOI":"10.3390\/nu14204366"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/ndt\/gfx085","article-title":"Mediterranean diet as the diet of choice for patients with chronic kidney disease","volume":"33","author":"Chauveau","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2215\/CJN.08580718","article-title":"Fruit and Vegetable Intake and Mortality in Adults undergoing Maintenance Hemodialysis","volume":"14","author":"Saglimbene","year":"2019","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1080\/09637480701690519","article-title":"An investigation into the bioaccessibility of potassium in unprocessed fruits and vegetables","volume":"59","author":"Naismith","year":"2008","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.jrn.2016.02.005","article-title":"Nutrient Non-equivalence: Does Restricting High-Potassium Plant Foods Help to Prevent Hyperkalemia in Hemodialysis Patients?","volume":"26","author":"Goldfarb","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00424-022-02718-3","article-title":"Potassium homeostasis: Sensors, mediators, and targets","volume":"474","author":"McDonough","year":"2022","journal-title":"Pflug. Arch."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1152\/physrev.00044.2018","article-title":"Regulation of the Renal NaCl Cotransporter and Its Role in Potassium Homeostasis","volume":"100","author":"Hoorn","year":"2020","journal-title":"Physiol. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1152\/physiol.00022.2016","article-title":"Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits","volume":"32","author":"McDonough","year":"2017","journal-title":"Physiology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1681\/ASN.2008020166","article-title":"Mechanisms in hyperkalemic renal tubular acidosis","volume":"20","author":"Karet","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1056\/NEJM198002213020803","article-title":"Adrenergic modulation of extrarenal potassium disposal","volume":"302","author":"Rosa","year":"1980","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/ki.2014.83","article-title":"Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rate","volume":"86","author":"Goraya","year":"2014","journal-title":"Kidney Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2215\/CJN.02430312","article-title":"A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate","volume":"8","author":"Goraya","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1085\/jgp.201511407","article-title":"Na,K-ATPase \u03b12 activity in mammalian skeletal muscle T-tubules is acutely stimulated by extracellular K+","volume":"146","author":"DiFranco","year":"2015","journal-title":"J. Gen. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00421-020-04546-8","article-title":"Regulation of muscle potassium: Exercise performance, fatigue and health implications","volume":"121","author":"Lindinger","year":"2021","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1053\/j.jrn.2021.07.001","article-title":"CORRECTED ARTICLE: Effect of Dietary Potassium Restriction on Serum Potassium, Disease Progression, and Mortality in Chronic Kidney Disease: A Systematic Review and Meta-Analysis","volume":"32","author":"Morris","year":"2022","journal-title":"J. Ren. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1093\/advances\/nmaa027","article-title":"Dietary Potassium Intake and Risk of Chronic Kidney Disease Progression in Predialysis Patients with Chronic Kidney Disease: A Systematic Review","volume":"11","author":"Picard","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1093\/ndt\/gfaa232","article-title":"Does dietary potassium intake associate with hyperkalemia in patients with chronic kidney disease?","volume":"36","author":"Ramos","year":"2021","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.2215\/CJN.08360621","article-title":"Dietary Potassium Intake and All-Cause Mortality in Adults Treated with Hemodialysis","volume":"16","author":"Wong","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/ndt\/gfaa194","article-title":"Nutritional status, hyperkalaemia and attainment of energy\/protein intake targets in haemodialysis patients following plant-based diets: A longitudinal cohort study","volume":"36","author":"Xu","year":"2021","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1053\/j.jrn.2020.05.008","article-title":"Dietary Potassium Intake and Mortality in a Prospective Hemodialysis Cohort","volume":"31","author":"Narasaki","year":"2021","journal-title":"J. Ren. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Garagarza, C., Valente, A., Caetano, C., Ramos, I., Sebastiao, J., Pinto, M., Oliveira, T., Ferreira, A., and Sousa Guerreiro, C. (2022). Potassium Intake-(Un)Expected Non-Predictor of Higher Serum Potassium Levels in Hemodialysis DASH Diet Consumers. Nutrients, 14.","DOI":"10.3390\/nu14102071"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s00467-021-05365-5","article-title":"Potassium and fiber: A controversial couple in the nutritional management of children with chronic kidney disease","volume":"37","author":"Delva","year":"2022","journal-title":"Pediatr. Nephrol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1681\/ASN.2022020147","article-title":"Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD","volume":"33","author":"Gritter","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Turban, S., Juraschek, S.P., Miller, E.R., Anderson, C.A.M., White, K., Charleston, J., and Appel, L.J. (2021). Randomized Trial on the Effects of Dietary Potassium on Blood Pressure and Serum Potassium Levels in Adults with Chronic Kidney Disease. Nutrients, 13.","DOI":"10.3390\/nu13082678"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Pineda, M., Vercet, A., and Yag\u00fce-Ruiz, C. (2021). Are Food Additives a Really Problematic Hidden Source of Potassium for Chronic Kidney Disease Patients?. Nutrients, 13.","DOI":"10.3390\/nu13103569"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/jhn.12846","article-title":"Potassium reduction in food by preparation technique for the dietetic management of patients with chronic kidney disease: A review","volume":"34","author":"Batista","year":"2021","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Cupisti, A., Kovesdy, C.P., D\u2019Alessandro, C., and Kalantar-Zadeh, K. (2018). Dietary Approach to Recurrent or Chronic Hyperkalaemia in Patients with Decreased Kidney Function. Nutrients, 10.","DOI":"10.3390\/nu10030261"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1053\/j.jrn.2018.10.003","article-title":"Potassium Additives and Bioavailability: Are We Missing Something in Hyperkalemia Management?","volume":"29","author":"Picard","year":"2019","journal-title":"J. Ren. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/j.jrn.2022.06.010","article-title":"Soaking to Reduce Potassium and Phosphorus Content of Foods","volume":"33","author":"Picard","year":"2023","journal-title":"J. Ren. Nutr."},{"key":"ref_40","first-page":"1015","article-title":"The feasibility of using the Dietary Approaches to Stop Hypertension (DASH) diet in people with chronic kidney disease and hypertension","volume":"3","author":"Hannah","year":"2018","journal-title":"J. Clin. Nephrol. Kidney Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/ckj\/sfw046","article-title":"Short-term effects of the DASH diet in adults with moderate chronic kidney disease: A pilot feeding study","volume":"9","author":"Tyson","year":"2016","journal-title":"Clin. Kidney J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.2215\/CJN.00670117","article-title":"Randomized, Controlled Trial of the Effect of Dietary Potassium Restriction on Nerve Function in CKD","volume":"12","author":"Arnold","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1051-2276(98)90034-6","article-title":"Safety and tolerance of medical nutritional products as sole sources of nutrition in people on hemodialysis","volume":"8","author":"Cockram","year":"1998","journal-title":"J. Ren. Nutr."},{"key":"ref_44","unstructured":"National Health and Medical Research Council (2013). Australian Dietary Guidelines, National Health and Medical Research Council."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1053\/j.ajkd.2022.08.013","article-title":"Risks and Benefits of Different Dietary Patterns in CKD","volume":"81","author":"Joshi","year":"2023","journal-title":"Am. J. Kidney Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"272","DOI":"10.2215\/CJN.06190616","article-title":"Healthy Dietary Patterns and Risk of Mortality and ESRD in CKD: A Meta-Analysis of Cohort Studies","volume":"12","author":"Kelly","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/jorc.12260","article-title":"How do patients and carers make sense of renal dietary advice? A qualitative exploration","volume":"44","author":"Lambert","year":"2018","journal-title":"J. Ren. Care"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1093\/nutrit\/nuac026","article-title":"Etiology-based dietary approach for managing hyperkalemia in people with chronic kidney disease","volume":"80","author":"Fouque","year":"2022","journal-title":"Nutr. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1159\/000500042","article-title":"Fruit and Vegetable Treatment of Chronic Kidney Disease-Related Metabolic Acidosis Reduces Cardiovascular Risk Better than Sodium Bicarbonate","volume":"49","author":"Goraya","year":"2019","journal-title":"Am. J. Nephrol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3945\/jn.114.205336","article-title":"The Dietary Patterns Methods Project: Synthesis of findings across cohorts and relevance to dietary guidance","volume":"145","author":"Liese","year":"2015","journal-title":"J. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ahj.2023.01.002","article-title":"Outcomes in patients with cardiometabolic disease who develop hyperkalemia while treated with a renin-angiotensin-aldosterone system inhibitor","volume":"258","author":"Johnson","year":"2023","journal-title":"Am. Heart J."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/1\/3\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:41:21Z","timestamp":1760132481000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/1\/3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["nu16010003"],"URL":"https:\/\/doi.org\/10.3390\/nu16010003","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,19]]}}}