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The present study investigated the effects of oleuropein-enriched extract(\u63d0\u53d6\u7269) from Jasminum grandiflorum L. flowers (OLE-JGF) in high-fat diet(\u996e\u98df) (HFD)-fed mice and oleic acid(\u9178) (OA)-treated AML-12 cells. Treatment(\u6cbb\u7597) of HFD-fed mice with 0.6% OLE-JGF for 8 weeks significantly reduced body and liver(\u809d) weights, as well as attenuating lipid dysmetabolism and hepatic steatosis. OLE-JGF administration(\u653f\u5e9c\u5f53\u5c40) prominently suppressed the mRNA expressions(\u8868\u8fbe) of monocyte chemoattractant protein(\u86cb\u767d)-1 (MCP-1) and cluster of differentiation 68 (CD68), and it also downregulated acetyl-CoA carboxylase (ACC) and fatty(\u8102\u80aa) acid(\u9178) synthase (FAS) as well as sterol-regulatory-element(\u5143\u7d20)-binding protein(\u86cb\u767d) (SREBP-1c) in the liver(\u809d). Meanwhile, mitochondrial DNA and uncoupling protein(\u86cb\u767d) 2 (UCP2) were upregulated along with the increased expression(\u8868\u8fbe) of mitochondrial biogenic promoters including liver(\u809d) kinase B1 (LKB1), peroxisome proliferator\u2013activated receptor-\u03b3 coactivator-1\u03b1 (PGC-1\u03b1), nuclear(\u6838) factor(\u56e0\u5b50)-erythroid-derived 2-like 2 (Nrf2), and mitochondrial transcription factor(\u56e0\u5b50) A (Tfam), but did not change AMP-activated protein(\u86cb\u767d) kinase (AMPK) in liver(\u809d). The lipid droplets were decreased significantly after treatment(\u6cbb\u7597) with 80 \u03bcM oleuropein for 24 h in OA-induced AML-12 cells. Furthermore, oleuropein significantly inhibited ACC mRNA expression(\u8868\u8fbe) and upregulated LKB1, PGC-1\u03b1, and Tfam mRNA levels, as well as increasing the binding level of LKB1 to PGC-1\u03b1 promoter in OA-induced cells. These findings indicate(\u8868\u660e) that OLE-JGF reduces hepatic lipid deposition in HFD-fed mice, as well as the fact that OA-induced liver(\u809d) cells may be partly(\u90e8\u5206) attributed to upregulation of the LKB1-PGC-1\u03b1 axis, which mediates hepatic lipogenesis and mitochondrial biogenesis. Our study provides a scientific(\u79d1\u5b66) basis(\u57fa\u7840) for the benefits and potential(\u6f5c\u5728) use(\u4f7f\u7528) of the J. grandiflorum flower as a food supplement(\u8865\u5145) for the prevention(\u9884\u9632) and treatment(\u6cbb\u7597) of metabolic disease(\u75be\u75c5).<\/jats:p>","DOI":"10.3390\/nu16010058","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T20:48:37Z","timestamp":1703450917000},"page":"58","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oleuropein-Rich Jasminum Grandiflorum Flower Extract Regulates the LKB1-PGC-1\u03b1 Axis Related to the Attenuation of Hepatocellular Lipid Dysmetabolism"],"prefix":"10.3390","volume":"16","author":[{"given":"Yajun","family":"Hou","sequence":"first","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"},{"name":"International Healthcare Innovation Institute (Jiangmen), Jiangmen 529040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapeng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-2803","authenticated-orcid":false,"given":"Xiu","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"},{"name":"International Healthcare Innovation Institute (Jiangmen), Jiangmen 529040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiming","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-2304","authenticated-orcid":false,"given":"Dongli","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"},{"name":"International Healthcare Innovation Institute (Jiangmen), Jiangmen 529040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishe","family":"Gan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"},{"name":"International Healthcare Innovation Institute (Jiangmen), Jiangmen 529040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5395-1166","authenticated-orcid":false,"given":"Rihui","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"},{"name":"International Healthcare Innovation Institute (Jiangmen), Jiangmen 529040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1002\/oby.23472","article-title":"Health consequences of obesity and projected future obesity health burden in China","volume":"30","author":"Sun","year":"2022","journal-title":"Obesity"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s42255-021-00493-6","article-title":"Lipolysis: Cellular mechanisms for lipid mobilization from fat stores","volume":"3","author":"Grabner","year":"2021","journal-title":"Nat. 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