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This study aimed to examine whether administrating 800 IU of vitamin D3 orally would improve maternal serum 25OHD levels, lipid profile, and pregnancy outcomes compared to 400 IU. This was a two-arm, parallel, non-blinded randomised controlled trial involving 274 pregnant women recruited from KK Women\u2019s and Children\u2019s Hospital, with a body mass index of \u226525 kg\/m2 within 16 weeks gestation. The participants were randomly assigned to receive 800 IU\/day (intervention group) or 400 IU\/day (control group) of oral vitamin D3 supplements. The primary outcomes were maternal serum 25OHD and lipid levels at 24\u201328 weeks gestation. The secondary outcomes included maternal and birth outcomes. Compared with controls (n = 119), the intervention group (n = 112) exhibited higher 25OHD levels at 24\u201328 weeks gestation (adjusted mean difference 6.52 nmol\/L; 95% confidence interval 2.74, 10.31). More women in the intervention group achieved sufficient 25OHD levels (77.7% vs. 55.5%; p &lt; 0.001). No differences were observed in lipid profiles or maternal or birth outcomes between the groups. An additional 400 IU of oral vitamin D3 supplementation increased serum 25OHD levels but did not impact lipid profiles or pregnancy outcomes.<\/jats:p>","DOI":"10.3390\/nu16010146","type":"journal-article","created":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T10:01:06Z","timestamp":1704016866000},"page":"146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Effect of Vitamin D Supplementation in Pregnant Women with Overweight and Obesity: A Randomised Controlled Trial"],"prefix":"10.3390","volume":"16","author":[{"given":"Chee Wai","family":"Ku","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"},{"name":"Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4187-6430","authenticated-orcid":false,"given":"Angeline Jia Wen","family":"Lee","sequence":"additional","affiliation":[{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Experimental Medicine Building, Singapore 636921, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjarat","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7117-6006","authenticated-orcid":false,"given":"Celeste Hong Fei","family":"Lim","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore 117597, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore 117597, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-7958","authenticated-orcid":false,"given":"Fabian","family":"Yap","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore"},{"name":"Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Experimental Medicine Building, Singapore 636921, Singapore"},{"name":"Endocrinology Service, Department of Paediatrics, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry Kok Yen","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"},{"name":"Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See Ling","family":"Loy","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, KK Women\u2019s and Children\u2019s Hospital, 100 Bukit Timah Road, Singapore 229899, Singapore"},{"name":"Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.mayocp.2011.12.010","article-title":"A Dermatologist\u2019s Perspective on Vitamin D","volume":"87","author":"Vanchinathan","year":"2012","journal-title":"Mayo Clin. 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