{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:02:41Z","timestamp":1782964961035,"version":"3.54.5"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"VITECH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>7-MEGATM is a food product made from purified Alaska pollack fish oil containing palmitoleic acid (16:1), commonly referred to as omega-7. We sought to quantitatively evaluate whether this substance inhibits skin aging. A total of 101 middle-aged females were randomly allocated to the intervention (N = 50) or placebo group (N = 51). Each participant was advised to take either 500 mg of 7-MEGATM or a placebo twice daily for 12 weeks. The primary outcomes were the degree of improvement in wrinkles and the degree of moisture filling after consumption for 12 weeks compared to baseline. The secondary outcomes were improvement in skin wrinkles; moisture changes at 4 and 8 weeks from baseline; changes in transdermal water loss, skin elasticity, the melanin index, the erythema index, and the Global Photo Damage Score. We found a significant improvement in skin wrinkles and elasticity at 12 weeks in the 7-MEGATM-consuming group compared to that in the placebo group; skin moisture, elasticity, and the melanin index were also improved. No supplement-related adverse reactions were observed and 7-MEGATM was identified as safe. 7-MEGATM was effective for human skin function in terms of wrinkles, moisture, elasticity, and melanin production and may be useful as a skin nutritional supplement.<\/jats:p>","DOI":"10.3390\/nu16020212","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:38:51Z","timestamp":1704775131000},"page":"212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anti-Wrinkle and Skin Moisture Efficacy of 7-MEGATM: A Randomized, Double-Blind, Placebo Comparative Clinical Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-1707","authenticated-orcid":false,"given":"Hyun Kyung","family":"Sung","sequence":"first","affiliation":[{"name":"Global Cosmeceutical Center, Semyung University, Cheongju 28161, Republic of Korea"},{"name":"Department of Pediatrics, College of Korean Medicine, Semyung University, Jecheon 27136, Republic of Korea"},{"name":"Department of Education, Graduate School, Dongguk University, Seoul 04620, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6070-5642","authenticated-orcid":false,"given":"Tae Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Semyung University Chungju Korean Medicine Hospital, Chungju 27429, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8685-4589","authenticated-orcid":false,"given":"Hyung Mook","family":"Kim","sequence":"additional","affiliation":[{"name":"Global Cosmeceutical Center, Semyung University, Cheongju 28161, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2592-7043","authenticated-orcid":false,"given":"Sang Jun","family":"Youn","sequence":"additional","affiliation":[{"name":"RnBS Corporation, Seoul 06032, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Choi","sequence":"additional","affiliation":[{"name":"RnBS Corporation, Seoul 06032, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Young","family":"Lee","sequence":"additional","affiliation":[{"name":"R&D Team, Food & Supplement Health Claims, Vitech, Wanju 55365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jeong","family":"Oh","sequence":"additional","affiliation":[{"name":"R&D Team, Food & Supplement Health Claims, Vitech, Wanju 55365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuck Se","family":"Kwon","sequence":"additional","affiliation":[{"name":"R&D Team, Food & Supplement Health Claims, Vitech, Wanju 55365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1660-2973","authenticated-orcid":false,"given":"Seon Mi","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Korean Medicine, Semyung University, Jecheon 27136, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3389\/fphys.2017.00902","article-title":"Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications","volume":"8","author":"Carta","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_2","first-page":"484","article-title":"The Omega 7 as a Health Strategy for the Skin and Mucous Membranes","volume":"14","year":"2019","journal-title":"EC Nutr."},{"key":"ref_3","unstructured":"Heather, A.E., Benson, H.A.E., and Watkinson, A.C. (2012). Topical and Transdermal Drug Delivery, John Wiley & Sons, Inc."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Walters, K.A. (2002). Dermatological and Transdermal Formulations, CRC Press.","DOI":"10.1201\/9780824743239"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Riviere, J.E., and Monteiro-Riviere, N. (2005). Dermal Absorption Models in Toxicology and Pharmacology, CRC Press.","DOI":"10.1201\/9780203020821"},{"key":"ref_6","first-page":"515","article-title":"Skin Aging","volume":"49","author":"Situm","year":"2010","journal-title":"Acta Clin. Croat."},{"key":"ref_7","first-page":"47","article-title":"Skin Aging","volume":"17","year":"2008","journal-title":"Acta Dermatovenerol. Alp. Panon. Adriat."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.3109\/09546639709160948","article-title":"The Importance of Skin Barrier Function","volume":"8","author":"Cork","year":"1997","journal-title":"J. Dermatolog. Treat."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1346-8138.2004.tb00565.x","article-title":"Skin Aging and Dry Skin","volume":"31","author":"Hashizume","year":"2004","journal-title":"J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/1523-1747.ep12259203","article-title":"Changes with Age in the Moisture Content of Human Skin","volume":"82","author":"Potts","year":"1984","journal-title":"J. Investig. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1046\/j.0022-202x.2001.01577.x","article-title":"Skin Melanin, Hemoglobin, and Light Scattering Properties Can Be Quantitatively Assessed in vivo Using Diffuse Reflectance Spectroscopy","volume":"117","author":"Zonios","year":"2001","journal-title":"J. Investig. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Lee, A.-Y. (2021). Skin Pigmentation Abnormalities and Their Possible Relationship with Skin Aging. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073727"},{"key":"ref_13","first-page":"1213","article-title":"Aging of Skin","volume":"Volume 1","author":"Goldsmith","year":"1999","journal-title":"Fitzpatrick\u2019s Dermatology in General Medicine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1195272","DOI":"10.3389\/fphys.2023.1195272","article-title":"Skin Aging from Mechanisms to Interventions: Focusing on Dermal Aging","volume":"14","author":"Shin","year":"2023","journal-title":"Front. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1001\/jama.1990.03440220081034","article-title":"Treatment of Photoaged Skin with Topical Tretinoin Increases Epidermal-Dermal Anchoring Fibrils. A Preliminary Report","volume":"263","author":"Woodley","year":"1990","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1111\/jocd.13493","article-title":"Evaluation of Safety and Efficacy of Booster Injections of Hyaluronic Acid in Improving the Facial Skin Quality","volume":"19","author":"Ayatollahi","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_17","first-page":"e2022018","article-title":"Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Field of Dermatology and Cosmetics","volume":"12","year":"2022","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"843469","DOI":"10.3389\/fphar.2022.843469","article-title":"Anti-Wrinkle Efficacy of Edible Bird\u2019s Nest Extract: A Randomized, Double-Blind, Placebo-Controlled, Comparative Study","volume":"13","author":"Kim","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lee, S.-W., Sin, H.-S., Hurh, J., and Kim, S.-Y. (2022). Anti-Wrinkle Effect of BB-1000: A Double-Blind, Randomized Controlled Study. Cosmetics, 9.","DOI":"10.3390\/cosmetics9030050"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1089\/rej.2015.1660","article-title":"Efficacy and Safety of Enzyme-Modified Panax Ginseng for Anti-Wrinkle Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study","volume":"18","author":"Hwang","year":"2015","journal-title":"Rejuvenation Res."},{"key":"ref_21","unstructured":"Shinde, S., Kale, A., Kulaga, T., Licamele, J.D., and Tonkovich, A.L. (2012). Omega 7 Rich Compositions and Methods of Isolating Omega 7 Fatty Acids. (20130129775 A1), U.S. Patent."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biortech.2015.06.048","article-title":"New Yeast-Based Approaches in Production of Palmitoleic Acid","volume":"192","author":"Sigler","year":"2015","journal-title":"Bioresour. Technol."},{"key":"ref_23","unstructured":"Eldridge, G. (2005). Control of Biofilm with a Biofilm Inhibitor. (20060228384 A1), U.S. Patent."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s13765-018-0377-1","article-title":"Omega-7 Inhibits Inflammation and Promotes Collagen Synthesis through SIRT1 Activation","volume":"61","author":"Song","year":"2018","journal-title":"Appl. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e16711","DOI":"10.1016\/j.heliyon.2023.e16711","article-title":"Efficacy and Safety of Oral Palmitoleic Acid Supplementation for Skin Barrier Improvement: A 12-Week, Randomized, Double-Blinded, Placebo-Controlled Study","volume":"9","author":"Koh","year":"2023","journal-title":"Heliyon"},{"key":"ref_26","unstructured":"Sabnis, N., Mathew, E., Dossou, A., Zheng, A., Nagarajan, B., Fudala, R., and Lacko, A.G. (2021). Overcoming Drug Resistance in Gynecologic Cancers, Elsevier."},{"key":"ref_27","unstructured":"Herbst, M.C. (2015). Fact Sheet on Palmitoleic Acid (Omega-7), Cancer Association of South Africa (CANSA)."},{"key":"ref_28","unstructured":"(2023, December 14). Notice to US Food and Drug Administration of the Conclusion that the Intended Uses of AlaskOmega\u00ae Omega-7 500 & 700 Are Generally Recognized as Safe. GRAS Notice (GRN) No. 819, Available online: http:\/\/www.accessdata.fda.gov\/scripts\/fdcc\/?set=GRASNotices."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/2\/212\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:42:54Z","timestamp":1760103774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/2\/212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,9]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["nu16020212"],"URL":"https:\/\/doi.org\/10.3390\/nu16020212","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,9]]}}}