{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:14:23Z","timestamp":1788545663287,"version":"build-2803163510"},"reference-count":58,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82103831"],"award-info":[{"award-number":["82103831"]}]},{"name":"National Natural Science Foundation of China","award":["2019M662549"],"award-info":[{"award-number":["2019M662549"]}]},{"name":"China Postdoctoral Science Foundation","award":["82103831"],"award-info":[{"award-number":["82103831"]}]},{"name":"China Postdoctoral Science Foundation","award":["2019M662549"],"award-info":[{"award-number":["2019M662549"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Type 2 diabetic osteoporosis (T2DOP) is a common complication in diabetic patients that seriously affects their health and quality of life. The pathogenesis of T2DOP is complex, and there are no targeted governance means in modern medicine. Citri Reticulatae Pericarpium (CRP) is a traditional Chinese medicine that has a long history and has been used in the treatment of osteoporosis diseases. However, the molecular mechanism for the CRP treatment of T2DOP is not clear. Therefore, this study aimed to explore the underlying mechanisms of CRP for the treatment of T2DOP by using network pharmacology and molecular modeling techniques. By retrieving multiple databases, we obtained 5 bioactive compounds and 63 common targets of bioactive compounds with T2DOP, and identified AKT 1, TP 53, JUN, BCL 2, MAPK 1, NFKB 1, and ESR 1 as the core targets of their PPI network. Enrichment analysis revealed that these targets were mainly enriched in the estrogen signaling pathway, TNF signaling pathway, and AGE-RAGE signaling pathway in diabetics, which were mainly related to oxidative stress and hormonal regulation. Molecular docking and molecular dynamics simulations have shown the excellent binding effect of the bioactive compounds of CRP and the core targets. These findings reveal that CRP may ameliorate T2DOP through multiple multicomponent and multitarget pathways.<\/jats:p>","DOI":"10.3390\/nu16020220","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T05:47:21Z","timestamp":1704865641000},"page":"220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Network Pharmacology and Molecular Modeling Techniques in Unraveling the Underlying Mechanism of Citri Reticulatae Pericarpium aganist Type 2 Diabetic Osteoporosis"],"prefix":"10.3390","volume":"16","author":[{"given":"Jiangtao","family":"Li","sequence":"first","affiliation":[{"name":"Centre for Nutritional Ecology and Centre for Sport Nutrition and Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for Nutritional Ecology and Centre for Sport Nutrition and Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Ullah","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Centre for Nutritional Ecology and Centre for Sport Nutrition and Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuge","family":"Sun","sequence":"additional","affiliation":[{"name":"Centre for Nutritional Ecology and Centre for Sport Nutrition and Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjie","family":"Li","sequence":"additional","affiliation":[{"name":"Centre for Nutritional Ecology and Centre for Sport Nutrition and Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangning","family":"Kou","sequence":"additional","affiliation":[{"name":"Centre for Nutritional Ecology and Centre for Sport Nutrition and Health, Zhengzhou University, Zhengzhou 450001, China"},{"name":"Department of Nutrition and Food Hygiene, School of Public Health, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1228045","DOI":"10.3389\/fendo.2023.1228045","article-title":"The role of autophagy in the treatment of type II diabetes and its complications: A review","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tem.2022.11.003","article-title":"Contributors to impaired bone health in type 2 diabetes","volume":"34","author":"Sheu","year":"2023","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Papaioannou, I., Pantazidou, G., Kokkalis, Z., Georgopoulos, N., and Jelastopulu, E. (2021). Systematic Review: Are the Elderly With Diabetes Mellitus Type 2 Prone to Fragility Fractures?. Cureus J. Med. Sci., 13.","DOI":"10.7759\/cureus.14514"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nrendo.2016.153","article-title":"Mechanisms of diabetes mellitus-induced bone fragility","volume":"13","author":"Napoli","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1011561","DOI":"10.3389\/fphar.2022.1011561","article-title":"Identification of kaempferol as an OSX upregulator by network pharmacology-based analysis of qianggu Capsule for osteoporosis","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Chen, J., Wu, X., and Yu, R. (2023). Unraveling the Therapeutic Mechanism of Saussurea involucrata against Rheumatoid Arthritis: A Network Pharmacology and Molecular Modeling-Based Investigation. Nutrients, 15.","DOI":"10.3390\/nu15194294"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wang, Y., Zhang, X., Zhou, C., Khan, H., Fu, M., and Cheang, W.S. (2022). Citri Reticulatae Pericarpium (Chenpi) Protects against Endothelial Dysfunction and Vascular Inflammation in Diabetic Rats. Nutrients, 14.","DOI":"10.3390\/nu14245221"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jep.2018.03.031","article-title":"Citri Reticulatae Pericarpium (Chenpi): Botany, ethnopharmacology, phytochemistry, and pharmacology of a frequently used traditional Chinese medicine","volume":"220","author":"Yu","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zou, J., Wang, J., Ye, W., Lu, J., Li, C., Zhang, D., Ye, W., Xu, S., Chen, C., and Liu, P. (2022). Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases. Biomed. Pharmacother., 154.","DOI":"10.1016\/j.biopha.2022.113626"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s00394-019-02105-2","article-title":"The effect of hesperidin supplementation on metabolic profiles in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled clinical trial","volume":"59","author":"Yari","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1210\/jc.2015-3767","article-title":"Effect of Hesperidin With and Without a Calcium (Calcilock) Supplement on Bone Health in Postmenopausal Women","volume":"101","author":"Martin","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Shi, T., Liu, T., Kou, Y., Rong, X., Meng, L., Cui, Y., Gao, R., Hu, S., and Li, M. (2023). The Synergistic Effect of Zuogui Pill and Eldecalcitol on Improving Bone Mass and Osteogenesis in Type 2 Diabetic Osteoporosis. Med.-Lith., 59.","DOI":"10.3390\/medicina59081414"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wang, J.F., Shao, L.H., Wu, X.Y., Liu, C., Ni, S., Dai, T., Liu, H.W., and Zhao, H.B. (2023). Electrospun sandwich mesh structures loaded with naringenin and vitamin K2 polycaprolactone\/gelatin nanofibers synergistically promote bone regeneration. Mater. Today Bio, 23.","DOI":"10.1016\/j.mtbio.2023.100794"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Muhamad, M.L.N., Ekeuku, S.O., Wong, S.K., and Chin, K.Y. (2022). A Scoping Review of the Skeletal Effects of Naringenin. Nutrients, 14.","DOI":"10.3390\/nu14224851"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/biof.5520300305","article-title":"Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA\/1J mice: Possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation","volume":"30","author":"Murakami","year":"2007","journal-title":"Biofactors"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ortiz, A.d.C., Moura Fideles, S.O., Bertoni Reis, C.H., Bellini, M.Z., Bastos Mazuqueli Pereira, E.d.S., Pilon, J.P.G., de Marchi, M.A., Penteado Detregiachi, C.R., Prync Flato, U.A., and de Moraes Trazzi, B.F. (2022). Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health. Biomolecules, 12.","DOI":"10.3390\/biom12050626"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1021\/jf902680n","article-title":"Molecular Mechanism of Hesperetin-7-O-glucuronide, the Main Circulating Metabolite of Hesperidin, Involved in Osteoblast Differentiation","volume":"58","author":"Trzeciakiewicz","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: Theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Batool, S., Javed, M.R., Aslam, S., Noor, F., Javed, H.M.F., Seemab, R., Rehman, A., Aslam, M.F., Paray, B.A., and Gulnaz, A. (2022). Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target Pharmacological Mechanism of Fumaria indica in the Treatment of Liver Cancer. Pharmaceuticals, 15.","DOI":"10.3390\/ph15060654"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115540","DOI":"10.1016\/j.jep.2022.115540","article-title":"Systemic pharmacological verification of Guizhi Fuling decoction in treating endometriosis-associated pain","volume":"297","author":"Gao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Chin, C.-H., Chen, S.-H., Wu, H.-H., Ho, C.-W., Ko, M.-T., and Lin, C.-Y. (2014). cytoHubba: Identifying hub objects and sub-networks from complex interactome. Bmc Syst. Biol., 8.","DOI":"10.1186\/1752-0509-8-S4-S11"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gkaa1113","article-title":"The Gene Ontology resource: Enriching a GOld mine","volume":"49","author":"Carbon","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/wcms.1121","article-title":"An overview of the Amber biomolecular simulation package","volume":"3","author":"Case","year":"2013","journal-title":"Wiley Interdiscip. Rev.-Comput. Mol. Sci."},{"key":"ref_25","first-page":"U403","article-title":"Antechamber: An accessory software package for molecular mechanical calculations","volume":"222","author":"Wang","year":"2001","journal-title":"Abstr. Pap. Am. Chem. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","article-title":"Development and testing of a general amber force field","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theory Comput."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9954","DOI":"10.1021\/jp003020w","article-title":"Structure and dynamics of the TIP3P, SPC, and SPC\/E water models at 298 K","volume":"105","author":"Mark","year":"2001","journal-title":"J. Phys. Chem. A"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.biophys.28.1.155","article-title":"Molecular dynamics simulations of biomolecules: Long-range electrostatic effects","volume":"28","author":"Sagui","year":"1999","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/1096-987X(20010415)22:5<501::AID-JCC1021>3.0.CO;2-V","article-title":"A fast SHAKE: Algorithm to solve distance constraint equations for small molecules in molecular dynamics simulations","volume":"22","year":"2001","journal-title":"J. Comput. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"104101","DOI":"10.1063\/1.2464095","article-title":"Langevin stabilization of molecular-dynamics simulations of polymers by means of quasisymplectic algorithms","volume":"126","author":"Larini","year":"2007","journal-title":"J. Chem. Phys."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1039\/D0CP00831A","article-title":"The application of the MM\/GBSA method in the binding pose prediction of FGFR inhibitors","volume":"22","author":"Chen","year":"2020","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ci100275a","article-title":"Assessing the Performance of the MM\/PBSA and MM\/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations","volume":"51","author":"Hou","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities","volume":"10","author":"Genheden","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/jcc.21372","article-title":"Fast and Accurate Predictions of Binding Free Energies Using MM-PBSA and MM-GBSA","volume":"31","author":"Rastelli","year":"2010","journal-title":"J. Comput. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1021\/ct3010485","article-title":"Improved Generalized Born Solvent Model Parameters for Protein Simulations","volume":"9","author":"Nguyen","year":"2013","journal-title":"J. Chem. Theory Comput."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/(SICI)1096-987X(19990130)20:2<217::AID-JCC4>3.0.CO;2-A","article-title":"Approximate atomic surfaces from linear combinations of pairwise overlaps (LCPO)","volume":"20","author":"Weiser","year":"1999","journal-title":"J. Comput. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrendo.2011.233","article-title":"Bone, sweet bone-osteoporotic fractures in diabetes mellitus","volume":"8","author":"Hamann","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Ji, C., Wang, Y.-N., Liu, S., Wang, M., Xu, X., and Zhang, D. (2022). Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis. Cells, 11.","DOI":"10.3390\/cells11162560"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.1064987","article-title":"A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules","volume":"295","author":"Tong","year":"2002","journal-title":"Science"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cellsig.2011.05.004","article-title":"Akt signalling in health and disease","volume":"23","author":"Hers","year":"2011","journal-title":"Cell. Signal."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1128\/MCB.06361-11","article-title":"Selective Signaling by Akt1 Controls Osteoblast Differentiation and Osteoblast-Mediated Osteoclast Development","volume":"32","author":"Mukherjee","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e53509","DOI":"10.15252\/embr.202153509","article-title":"Myeloid-derived growth factor (MYDGF) protects bone mass through inhibiting osteoclastogenesis and promoting osteoblast differentiation","volume":"23","author":"Xu","year":"2022","journal-title":"Embo Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.intimp.2015.01.010","article-title":"Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-\u03baB and MAPK pathways","volume":"25","author":"Zhou","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.freeradbiomed.2022.12.102","article-title":"17\u03b2-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation","volume":"195","author":"Yang","year":"2023","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Pelusi, L., Mandatori, D., Di Pietrantonio, N., Del Pizzo, F., Di Tomo, P., Di Pietro, N., Buda, R., Genovese, S., Epifano, F., and Pandolfi, A. (2022). Estrogen Receptor 1 (ESR1) and the Wnt\/\u03b2-Catenin Pathway Mediate the Effect of the Coumarin Derivative Umbelliferon on Bone Mineralization. Nutrients, 14.","DOI":"10.3390\/nu14153209"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8054","DOI":"10.1038\/s41598-023-34965-4","article-title":"Pharmacological inhibition of BCL-2 with the FDA-approved drug venetoclax impairs longitudinal bone growth","volume":"13","author":"Velentza","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1038\/s12276-022-00875-0","article-title":"Lnc Tmem235 promotes repair of early steroid-induced osteonecrosis of the femoral head by inhibiting hypoxia-induced apoptosis of BMSCs","volume":"54","author":"Zhang","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"10473","DOI":"10.18632\/aging.103271","article-title":"p53 plays a central role in the development of osteoporosis","volume":"12","author":"Yu","year":"2020","journal-title":"Aging"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/cr.2010.159","article-title":"Role of NF-\u03baB in the skeleton","volume":"21","author":"Novack","year":"2011","journal-title":"Cell Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1186\/s12967-023-04449-0","article-title":"CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation through NF-?B signaling pathway in ankylosing spondylitis in vitro","volume":"21","author":"Feng","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.bone.2009.01.003","article-title":"Glutaredoxin 5 regulates osteoblast apoptosis by protecting against oxidative stress","volume":"44","author":"Linares","year":"2009","journal-title":"Bone"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.molmed.2009.08.004","article-title":"Oxidative stress in bone remodelling and disease","volume":"15","author":"Wauquier","year":"2009","journal-title":"Trends Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1089\/dna.2021.1165","article-title":"Association of Polymorphisms in Estrogen Receptor Genes (ESR1 and ESR2) with Osteoporosis and Fracture-Involvement of Comorbidities and Epistasis","volume":"41","year":"2022","journal-title":"DNA Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1210\/js.2019-00160","article-title":"Advanced Glycation End Products (AGEs), Receptor for AGEs, Diabetes, and Bone: Review of the Literature","volume":"3","author":"Asadipooya","year":"2019","journal-title":"J. Endocr. Soc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4239\/wjd.v4.i4.101","article-title":"Biomolecular basis of the role of diabetes mellitus in osteoporosis and bone fractures","volume":"4","author":"Roy","year":"2013","journal-title":"World J. Diabetes"},{"key":"ref_57","first-page":"7331","article-title":"HOXA1 binds RBCK1\/HOIL-1 and TRAF2 and modulates the TNF\/NF-\u03baB pathway in a transcription-independent manner","volume":"44","author":"Taminiau","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"18363","DOI":"10.1038\/s41598-023-45448-x","article-title":"Dual-target drugs against Leishmania donovani for potential novel therapeutics","volume":"13","author":"Bora","year":"2023","journal-title":"Sci. Rep."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/2\/220\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:43:39Z","timestamp":1760103819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/2\/220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["nu16020220"],"URL":"https:\/\/doi.org\/10.3390\/nu16020220","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]}}}