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Union","award":["MOH-CSAINV19nov-0002"],"award-info":[{"award-number":["MOH-CSAINV19nov-0002"]}]},{"name":"European Union","award":["MC_UU_12011\/4"],"award-info":[{"award-number":["MC_UU_12011\/4"]}]},{"name":"European Union","award":["NF-SI-0515-10042"],"award-info":[{"award-number":["NF-SI-0515-10042"]}]},{"name":"European Union","award":["598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP"],"award-info":[{"award-number":["598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Dysregulated transplacental lipid transfer and fetal\u2013placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with singleton pregnancies recruited into the GUSTO mother\u2013offspring cohort were selected from across the glycemic range based on a mid-gestation 75 g oral glucose tolerance test, excluding pre-existing diabetes. Cord plasma samples collected at term delivery were analyzed using targeted liquid-chromatography tandem mass-spectrometry to determine the concentrations of 404 lipid species across 17 lipid classes. The birthweights were standardized for sex and gestational age by local references, and regression analyses were adjusted for the maternal age, BMI, parity, mode of delivery, insulin treatment, and fasting\/2 h glucose, with a false discovery-corrected p &lt; 0.05 considered significant. Ten lysophosphatidylcholines (LPCs) and two lysophosphatidylethanolamines were positively associated with the birthweight percentiles, while twenty-four triacylglycerols were negatively associated with the birthweight percentiles. The topmost associated lipid was LPC 20:2 [21.28 (95%CI 12.70, 29.87) percentile increase in the standardized birthweight with each SD-unit increase in log10-transformed concentration]. Within these same regression models, maternal glycemia did not significantly associate with the birthweight percentiles. Specific fetal circulating lysophospholipids and triacylglycerols associate with birthweight independently of maternal glycemia, but a causal relationship remains to be established.<\/jats:p>","DOI":"10.3390\/nu16020274","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T04:16:56Z","timestamp":1705465016000},"page":"274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles"],"prefix":"10.3390","volume":"16","author":[{"given":"Gerard","family":"Wong","sequence":"first","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kothandaraman","family":"Narasimhan","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Fun","family":"Cheong","sequence":"additional","affiliation":[{"name":"Singapore Lipidomics Incubator, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Ng","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore"},{"name":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izzuddin M.","family":"Aris","sequence":"additional","affiliation":[{"name":"Division of Chronic Disease Research across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See Ling","family":"Loy","sequence":"additional","affiliation":[{"name":"KK Women\u2019s and Children\u2019s Hospital (KKH), Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8198-6104","authenticated-orcid":false,"given":"Anne K.","family":"Bendt","sequence":"additional","affiliation":[{"name":"Singapore Lipidomics Incubator, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1945-0266","authenticated-orcid":false,"given":"Kok Hian","family":"Tan","sequence":"additional","affiliation":[{"name":"KK Women\u2019s and Children\u2019s Hospital (KKH), Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-7958","authenticated-orcid":false,"given":"Fabian K. P.","family":"Yap","sequence":"additional","affiliation":[{"name":"KK Women\u2019s and Children\u2019s Hospital (KKH), Singapore 229899, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9064-8983","authenticated-orcid":false,"given":"Lynette P.","family":"Shek","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore"},{"name":"Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yap Seng","family":"Chong","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore"},{"name":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Gluckman","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4643-0618","authenticated-orcid":false,"given":"Keith M.","family":"Godfrey","sequence":"additional","affiliation":[{"name":"MRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK"},{"name":"NIHR Southampton Biomedical Research Centre, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Seng","family":"Lee","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore"},{"name":"Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus R.","family":"Wenk","sequence":"additional","affiliation":[{"name":"Singapore Lipidomics Incubator, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neerja","family":"Karnani","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3530-3023","authenticated-orcid":false,"given":"Shiao-Yng","family":"Chan","sequence":"additional","affiliation":[{"name":"Singapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore"},{"name":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","article-title":"Hyperglycemia and adverse pregnancy outcomes","volume":"358","author":"Group","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000371628","article-title":"Gestational diabetes mellitus and macrosomia: A literature review","volume":"66","author":"Kc","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ladfors, L., Shaat, N., Wiberg, N., Katasarou, A., Berntorp, K., and Kristensen, K. (2017). Fetal overgrowth in women with type 1 and type 2 diabetes mellitus. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187917"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.2337\/dc08-0039","article-title":"Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus","volume":"31","author":"Graf","year":"2008","journal-title":"Diabetes Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11892-018-0978-4","article-title":"Implications of Lipids in Neonatal Body Weight and Fat Mass in Gestational Diabetic Mothers and Non-Diabetic Controls","volume":"18","author":"Herrera","year":"2018","journal-title":"Curr. Diab. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nature08147","article-title":"Emerging roles for lipids in shaping membrane-protein function","volume":"459","author":"Phillips","year":"2009","journal-title":"Nature"},{"key":"ref_7","first-page":"394","article-title":"A potential role for lysophosphatidylcholine in the delivery of long chain polyunsaturated fatty acids to the fetal circulation","volume":"1864","author":"Kramer","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1194\/jlr.P072355","article-title":"The influence of placental metabolism on fatty acid transfer to the fetus","volume":"58","author":"Perazzolo","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"787848","DOI":"10.3389\/fphys.2021.787848","article-title":"Maternal Fatty Acid Metabolism in Pregnancy and Its Consequences in the Feto-Placental Development","volume":"12","author":"Duttaroy","year":"2021","journal-title":"Front Physiol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/ije\/dyt125","article-title":"Cohort profile: Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study","volume":"43","author":"Soh","year":"2014","journal-title":"Int. J. Epidemiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41398-021-01208-x","article-title":"The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring","volume":"11","author":"Wong","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/S0140-6736(11)60364-4","article-title":"A global reference for fetal-weight and birthweight percentiles","volume":"377","author":"Mikolajczyk","year":"2011","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B (Methodol.)"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"14209","DOI":"10.1038\/s41598-020-71081-z","article-title":"Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight","volume":"10","author":"LaBarre","year":"2020","journal-title":"Sci Rep"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jpeds.2018.07.056","article-title":"Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia","volume":"203","author":"Kadakia","year":"2018","journal-title":"J Pediatr"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000453001","article-title":"Cord Blood Metabolome Is Highly Associated with Birth Weight, but Less Predictive for Later Weight Development","volume":"10","author":"Hellmuth","year":"2017","journal-title":"Obes. Facts"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1159\/000487118","article-title":"Cord Blood Lysophosphatidylcholine 16: 1 is Positively Associated with Birth Weight","volume":"45","author":"Lu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E28","DOI":"10.1152\/ajpendo.90897.2008","article-title":"Biochemical and physiological function of stearoyl-CoA desaturase","volume":"297","author":"Paton","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11010-006-9280-x","article-title":"Lysophosphatidylcholine induces inflammatory activation of human coronary artery smooth muscle cells","volume":"295","author":"Aiyar","year":"2007","journal-title":"Mol. Cell Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbalip.2012.07.019","article-title":"Lysoglycerophospholipids in chronic inflammatory disorders: The PLA(2)\/LPC and ATX\/LPA axes","volume":"1831","author":"Sevastou","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Sugasini, D., Yalagala, P.C.R., Goggin, A., Tai, L.M., and Subbaiah, P.V. (2019). Enrichment of brain docosahexaenoic acid (DHA) is highly dependent upon the molecular carrier of dietary DHA: Lysophosphatidylcholine is more efficient than either phosphatidylcholine or triacylglycerol. J. Nutr. Biochem., 74.","DOI":"10.1016\/j.jnutbio.2019.108231"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"33833","DOI":"10.1074\/jbc.M109.024869","article-title":"Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes","volume":"284","author":"Yea","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Geraghty, A.A., Alberdi, G., O\u2019Sullivan, E.J., O\u2019Brien, E.C., Crosbie, B., Twomey, P.J., and McAuliffe, F.M. (2016). Maternal Blood Lipid Profile during Pregnancy and Associations with Child Adiposity: Findings from the ROLO Study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161206"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"44845","DOI":"10.1038\/srep44845","article-title":"Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance","volume":"7","author":"Jenkins","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev.nu.11.070191.001245","article-title":"Lipoprotein lipase","volume":"11","author":"Bensadoun","year":"1991","journal-title":"Annu. Rev. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0022-2275(20)41537-8","article-title":"Structure and evolution of the lipase superfamily","volume":"33","author":"Hide","year":"1992","journal-title":"J. Lipid Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1038\/sj.ijo.0801506","article-title":"The role of lipoprotein lipase in adipose tissue development and metabolism","volume":"24","author":"Zechner","year":"2000","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3233\/NPM-15814099","article-title":"Hypertriglyceridemia in extremely low birth weight infants receiving lipid emulsions","volume":"8","author":"Holtrop","year":"2015","journal-title":"J. Neonatal. Perinatal. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"902","DOI":"10.2337\/dc16-2452","article-title":"Maternal BMI and Glycemia Impact the Fetal Metabolome","volume":"40","author":"Lowe","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1210\/jc.2017-00876","article-title":"Cord Metabolic Profiles in Obese Pregnant Women: Insights Into Offspring Growth and Body Composition","volume":"103","author":"Patel","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Rico, J.E., Saed Samii, S., Mathews, A.T., Lovett, J., Haughey, N.J., and McFadden, J.W. (2017). Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176787"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.2337\/dc17-1318","article-title":"Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis","volume":"41","author":"Apostolopoulou","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tips.2017.04.004","article-title":"Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance","volume":"38","author":"Petersen","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"de Seymour, J., Chia, A., Colega, M., Jones, B., McKenzie, E., Shirong, C., Godfrey, K., Kwek, K., Saw, S.M., and Conlon, C. (2016). Maternal Dietary Patterns and Gestational Diabetes Mellitus in a Multi-Ethnic Asian Cohort: The GUSTO Study. Nutrients, 8.","DOI":"10.3390\/nu8090574"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Wang, W., Xie, X., Yuan, T., Wang, Y., Zhao, F., Zhou, Z., and Zhang, H. (2021). Epidemiological trends of maternal hypertensive disorders of pregnancy at the global, regional, and national levels: A population-based study. 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