{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:32:31Z","timestamp":1791844351368,"version":"4.3.4"},"reference-count":50,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study aimed to assess the prevalence of dry eye syndrome among Korean women aged 40 and above and explore the correlation between the syndrome and daily dietary nutrient intake. We analyzed data from 92,888 female participants (mean age: 63.35 \u00b1 8.86 years) from the 8th Korea National Health and Nutrition Examination Survey (KNHANES 2019). Dietary intake was evaluated using a personalized 24 h recall method for 21 nutrients, including macronutrients, macro- and micro-minerals, and both water- and fat-soluble vitamins. Associations between nutrient intake and dry eye syndrome were determined using odds ratios from multivariate logistic regression. We found a 7.7% prevalence of dry eye syndrome in the population studied. Intake of dietary fiber (adjusted OR: 0.72), protein (adjusted OR: 0.84), omega-3 fatty acids (adjusted OR: 0.90), water (adjusted OR: 0.76), calcium (adjusted OR: 0.82), phosphate (adjusted OR: 0.87), potassium (adjusted OR: 0.88), magnesium (adjusted OR: 0.87), vitamin A (adjusted OR: 0.78), vitamin C (adjusted OR: 0.73), and vitamin E (adjusted OR: 0.86) was inversely associated with dry eye syndrome prevalence (p &lt; 0.0001 for all). Conversely, a higher intake of carbohydrates (adjusted OR: 1.23), sugar (adjusted OR: 1.30), fat (adjusted OR: 1.25), cholesterol (adjusted OR: 1.32), sodium (adjusted OR: 1.18), iron (adjusted OR: 1.28), and zinc (adjusted OR: 1.26) correlated with an increased risk (p &lt; 0.0001 for all). No significant associations were found between the prevalence of dry eye syndrome and the intake of omega-6 fatty acids and vitamin D. Our study identified significant associations between specific dietary nutrients and the risk of dry eye syndrome among Korean women aged 40 and above. These findings suggest that dietary choices could influence the likelihood of developing dry eye syndrome, indicating a potential role for dietary intervention in its management. However, it is important to note that these observations are preliminary, and further research is necessary to confirm these relationships and explore their implications for dietary recommendations in dry eye syndrome prevention and management.<\/jats:p>","DOI":"10.3390\/nu16030372","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T10:54:27Z","timestamp":1706266467000},"page":"372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Impact of Dietary Nutrients on the Prevalence of Dry Eye Syndrome among Korean Women Aged 40 and above: Evidence from the Korea National Health and Nutrition Examination Survey"],"prefix":"10.3390","volume":"16","author":[{"given":"Jeong-Mee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Visual Optics, Far East University, Eumseong 27601, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4613-2098","authenticated-orcid":false,"given":"Yean-Jung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Sahmyook University, 815, Hwarang-ro, Nowon-gu, Seoul 01795, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"International Dry Eye WorkShop (2007). The definition and classification of dry eye disease: Report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop. Ocul. Surf., 5, 75\u201392.","DOI":"10.1016\/S1542-0124(12)70081-2"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/978-1-4615-5359-5_111","article-title":"Epidemiology and classification of dry eye","volume":"438","author":"Lemp","year":"1998","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jtos.2017.04.001","article-title":"TFOS DEWS II sex, gender, and hormones report","volume":"15","author":"Sullivan","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ajo.2006.11.060","article-title":"Impact of dry eye syndrome on vision-related quality of life","volume":"143","author":"Dana","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"ref_6","unstructured":"(2023, August 27). HIRA Bigdata Open Portal: Health Insurance Review & Assessment Service. Available online: http:\/\/opendata.hira.or.kr\/op\/opc\/olapMfrnIntrsIlnsInfo.do."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1089\/jwh.2018.7041","article-title":"Dry eye disease: Consideration for women\u2019s health","volume":"28","author":"Matossian","year":"2019","journal-title":"J. Womens Health"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Schaumberg, D.A., Uchino, M., Christen, W.G., Semba, R.D., Buring, J.E., and Li, J.Z. (2013). Patient-reported differences in dry eye disease between men and women: Impact, management, and patient satisfaction. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076121"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ajo.2013.12.023","article-title":"Dry eye in the Beaver Dam Offspring Study: Prevalence, risk factors, and health-related quality of life","volume":"157","author":"Paulsen","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0181-5512(07)89584-2","article-title":"A new approach for better comprehension of diseases of the ocular surface","volume":"30","author":"Baudouin","year":"2007","journal-title":"J. Fr. Ophtalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40135-013-0009-1","article-title":"Dry eye disease: Impact on quality of life and vision","volume":"1","author":"Uchino","year":"2013","journal-title":"Curr. Ophthalmol. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.clae.2015.01.007","article-title":"Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye","volume":"38","author":"Bhargava","year":"2015","journal-title":"Cont. Lens Anterior Eye"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/ajcn\/82.4.887","article-title":"Relation between dietary n\u22123 and n\u22126 fatty acids and clinically diagnosed dry eye syndrome in women","volume":"82","author":"Trivedi","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.clae.2017.09.007","article-title":"Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and\/or low serum vitamin D","volume":"41","author":"Yang","year":"2018","journal-title":"Cont. Lens Anterior Eye"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2147\/OPTH.S198349","article-title":"Effects of short-term oral vitamin A supplementation on the ocular tear film in patients with dry eye","volume":"13","author":"Alanazi","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/112067210901900302","article-title":"Antioxidants intake and dry eye syndrome: A crossover, placebo-controlled, randomized trial","volume":"19","author":"Bieuvelet","year":"2009","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.exger.2012.03.020","article-title":"Aging and dry eye disease","volume":"47","author":"Ding","year":"2012","journal-title":"Exp. Gerontol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1001\/jama.286.17.2114","article-title":"Hormone replacement therapy and dry eye syndrome","volume":"286","author":"Schaumberg","year":"2001","journal-title":"JAMA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/GME.0000000000000530","article-title":"Dry eye in postmenopausal women: A hormonal disorder","volume":"23","author":"Sriprasert","year":"2016","journal-title":"Menopause"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/PRS.0b013e318272a00e","article-title":"Pharmaceutical and herbal products that may contribute to dry eyes","volume":"131","author":"Askeroglu","year":"2013","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ajo.2005.06.031","article-title":"Dry eye (keratoconjunctivitis sicca), rheumatoid arthritis, and Sj\u00f6gren\u2019s syndrome","volume":"140","author":"Lemp","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ajo.2005.05.025","article-title":"Correlation between dry eye and rheumatoid arthritis activity","volume":"140","author":"Fujita","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1167\/iovs.05-1392","article-title":"Tear film, contact lens, and patient-related factors associated with contact lens\u2013related dry eye","volume":"47","author":"Nichols","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/S0161-6420(00)00388-2","article-title":"Effect of laser in situ keratomileusis on tear stability","volume":"107","author":"Yu","year":"2000","journal-title":"Ophthalmology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1600-0668.2006.00429.x","article-title":"The modern office environment desiccates the eye?","volume":"16","author":"Wolkoff","year":"2006","journal-title":"Indoor Air"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Courtin, R., Pereira, B., Naughton, G., Chamoux, A., Chiambaretta, F., Lanhers, C., and Dutheil, F. (2016). Prevalence of dry eye disease in visual display terminal workers: A systematic review and meta-analysis. BMJ Open, 6.","DOI":"10.1136\/bmjopen-2015-009675"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1001\/jama.2020.0878","article-title":"Trends in diet quality among youth in the United States, 1999\u20132016","volume":"323","author":"Liu","year":"2020","journal-title":"JAMA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11745-003-1068-y","article-title":"N-3 polyunsaturated fatty acids and inflammation: From molecular biology to the clinic","volume":"38","author":"Calder","year":"2003","journal-title":"Lipids"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1167\/iovs.12-9724","article-title":"Anti-inflammatory effects of alpha linolenic Acid on human corneal epithelial cells","volume":"53","author":"Erdinest","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/ICO.0000000000001884","article-title":"Efficacy of omega-3 fatty acid supplementation for treatment of dry eye disease: A meta-analysis of randomized clinical trials","volume":"38","author":"Giannaccare","year":"2019","journal-title":"Cornea"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S1542-0124(12)70214-8","article-title":"Essential fatty acids in the treatment of dry eye","volume":"8","author":"Rosenberg","year":"2010","journal-title":"Ocul. Surf."},{"key":"ref_32","first-page":"e677","article-title":"Efficacy of nutritional supplementation with omega-3 and omega-6 fatty acids in dry eye syndrome: A systematic review of randomized clinical trials","volume":"95","year":"2017","journal-title":"Acta Ophthalmol."},{"key":"ref_33","first-page":"811","article-title":"A randomized controlled trial of omega-3 fatty acids in dry eye syndrome","volume":"6","author":"Bhargava","year":"2013","journal-title":"Int. J. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jtos.2020.07.019","article-title":"Dry eye disease in children and adolescents in India","volume":"18","author":"Donthineni","year":"2020","journal-title":"Ocul. Surf."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0033-3506(99)00121-3","article-title":"Vitamin A intake and xerophthalmia among Indian children","volume":"113","author":"Khandait","year":"1999","journal-title":"Public Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.clindermatol.2015.11.009","article-title":"An eye on nutrition: The role of vitamins, essential fatty acids, and antioxidants in age-related macular degeneration, dry eye syndrome, and cataract","volume":"34","author":"McCusker","year":"2016","journal-title":"Clin. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jnutbio.2009.10.010","article-title":"\u03b1-Tocopherol is an effective Phase II enzyme inducer: Protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells","volume":"21","author":"Feng","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1463-5224.2004.00325.x","article-title":"The tear film and ocular mucins","volume":"7","author":"Davidson","year":"2004","journal-title":"Vet. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.2147\/CIA.S48955","article-title":"A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction","volume":"8","author":"Olenik","year":"2013","journal-title":"Clin. Interv. Aging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/00006324-199101000-00010","article-title":"Influence of diet on tear function","volume":"68","author":"Caffery","year":"1991","journal-title":"Optom. Vis. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ajo.2010.04.016","article-title":"Association of dyslipidemia in moderate to severe meibomian gland dysfunction","volume":"150","author":"Dao","year":"2010","journal-title":"Am. J. Ophthalmol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1167\/iovs.63.5.23","article-title":"High-fat nutritional challenge reshapes circadian signatures in murine extraorbital lacrimal glands","volume":"63","author":"Zou","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s11745-001-0812-7","article-title":"Polyunsaturated fatty acids, inflammation, and immunity","volume":"36","author":"Calder","year":"2001","journal-title":"Lipids"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e591","DOI":"10.1111\/j.1755-3768.2011.02196.x","article-title":"A multicentre, double-masked, randomized, controlled trial assessing the effect of oral supplementation of omega-3 and omega-6 fatty acids on a conjunctival inflammatory marker in dry eye patients","volume":"89","author":"Baudouin","year":"2011","journal-title":"Acta Ophthalmol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/nure.12145","article-title":"Efficacy of polyunsaturated fatty acids for dry eye syndrome: A meta-analysis of randomized controlled trials","volume":"72","author":"Zhu","year":"2014","journal-title":"Nutr. Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4103\/IJO.IJO_3174_22","article-title":"Vitamin D and eye: Current evidence and practice guidelines","volume":"71","author":"Gorimanipalli","year":"2023","journal-title":"Indian J. Ophthalmol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Rolando, M., and Barabino, S. (2023). Dry Eye Disease: What Is the Role of Vitamin D?. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021458"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/aos.14470","article-title":"Vitamin D deficiency is associated with dry eye syndrome: A systematic review and meta-analysis","volume":"98","author":"Liu","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.clae.2020.03.001","article-title":"Association between vitamin D and dry eye disease: A systematic review and meta-analysis of observational studies","volume":"43","author":"Askari","year":"2020","journal-title":"Cont. Lens Anterior Eye"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/ICO.0000000000001822","article-title":"Vitamin D enhances the efficacy of topical artificial tears in patients with dry eye disease","volume":"38","author":"Hwang","year":"2019","journal-title":"Cornea"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/3\/372\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:50:07Z","timestamp":1760104207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/3\/372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,26]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["nu16030372"],"URL":"https:\/\/doi.org\/10.3390\/nu16030372","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,26]]}}}