{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:41:51Z","timestamp":1790012511422,"version":"4.0.1"},"reference-count":59,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sao Paulo Research Foundation (FAPESP)","award":["#2012\/15165-2"],"award-info":[{"award-number":["#2012\/15165-2"]}]},{"name":"Sao Paulo Research Foundation (FAPESP)","award":["#308434\/2022-6"],"award-info":[{"award-number":["#308434\/2022-6"]}]},{"name":"Sao Paulo Research Foundation (FAPESP)","award":["#2019\/05739-0"],"award-info":[{"award-number":["#2019\/05739-0"]}]},{"name":"Sao Paulo Research Foundation (FAPESP)","award":["#2019\/11244-4"],"award-info":[{"award-number":["#2019\/11244-4"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#2012\/15165-2"],"award-info":[{"award-number":["#2012\/15165-2"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#308434\/2022-6"],"award-info":[{"award-number":["#308434\/2022-6"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#2019\/05739-0"],"award-info":[{"award-number":["#2019\/05739-0"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#2019\/11244-4"],"award-info":[{"award-number":["#2019\/11244-4"]}]},{"name":"FAPESP","award":["#2012\/15165-2"],"award-info":[{"award-number":["#2012\/15165-2"]}]},{"name":"FAPESP","award":["#308434\/2022-6"],"award-info":[{"award-number":["#308434\/2022-6"]}]},{"name":"FAPESP","award":["#2019\/05739-0"],"award-info":[{"award-number":["#2019\/05739-0"]}]},{"name":"FAPESP","award":["#2019\/11244-4"],"award-info":[{"award-number":["#2019\/11244-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the overproduction of white blood cells, leading to symptoms such as fatigue, infections, and other complications. CML patients must take measures to prevent infections to mitigate the exacerbation of cancer cell proliferation and comorbidities. Methods: This study investigated whether vitamin C can suppress the hyperinflammatory activation of K-562 cells induced by lipopolysaccharide (LPS) and whether purinergic signaling (ATP and P2X7 receptor) and autophagy play a role in it. Two different doses of vitamin C (5 \u00b5g\/mL and 10 \u00b5g\/mL) were employed, along with the lysosome inhibitor chloroquine (CQ; 100 \u00b5M), administered 2 h prior to LPS stimulation (10 ng\/mL) for a duration of 22 h in K-562 cells (3 \u00d7 105 cells\/mL\/well). Results: Both doses of vitamin C reduced the release of interleukin-6 (IL-6) (5 \u00b5g\/mL, p &lt; 0.01 and 10 \u00b5g\/mL, p &lt; 0.01) and tumor necrosis factor (TNF) (5 \u00b5g\/mL, p &lt; 0.01 and 10 \u00b5g\/mL, p &lt; 0.01) induced by LPS. Furthermore, in LPS + CQ-stimulated cells, vitamin C at a concentration of 10 \u00b5g\/mL inhibited the expression of LC3-II (p &lt; 0.05). Conversely, both doses of vitamin C led to the release of the anti-inflammatory cytokine interleukin-10 (IL-10) (5 \u00b5g\/mL, p &lt; 0.01 and 10 \u00b5g\/mL, p &lt; 0.01), while only the 10 \u00b5g\/mL dose of vitamin C induced the release of Klotho (10 \u00b5g\/mL, p &lt; 0.01). In addition, both doses of vitamin C reduced the accumulation of ATP (5 \u00b5g\/mL, p &lt; 0.01 and 10 \u00b5g\/mL, p &lt; 0.01) and decreased the expression of the P2X7 receptor at the mRNA level. Conclusions: Vitamin C inhibits the hyperinflammatory state induced by LPS in K-562 cells, primarily by inhibiting the ATP accumulation, P2X7 receptor expression, and autophagy signaling.<\/jats:p>","DOI":"10.3390\/nu16030383","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:54:03Z","timestamp":1706518443000},"page":"383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin C Inhibits Lipopolysaccharide-Induced Hyperinflammatory State of Chronic Myeloid Leukemia Cells through Purinergic Signaling and Autophagy"],"prefix":"10.3390","volume":"16","author":[{"given":"Daniela A.","family":"Pires","sequence":"first","affiliation":[{"name":"Post-Graduation Program in Bioengineering, Universidade Brasil, Rua Carolina Fonseca 235, S\u00e3o Paulo 08230-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-8695","authenticated-orcid":false,"given":"Maysa A. R.","family":"Brand\u00e3o-Rangel","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Science of Human Movement and Rehabilitation, Federal University of S\u00e3o Paulo (UNIFESP), Avenida Ana Costa 95, Santos 11060-001, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamei","family":"Silva-Reis","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Science of Human Movement and Rehabilitation, Federal University of S\u00e3o Paulo (UNIFESP), Avenida Ana Costa 95, Santos 11060-001, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana R. S.","family":"Ol\u00edmpio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Postgraduate Program in Translational Medicine, Federal University of S\u00e3o Paulo (UNIFESP), Rua Pedro de Toledo 720, Vila Clementino, S\u00e3o Paulo 04039-002, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4290-541X","authenticated-orcid":false,"given":"Flavio","family":"Aimbire","sequence":"additional","affiliation":[{"name":"Department of Medicine, Postgraduate Program in Translational Medicine, Federal University of S\u00e3o Paulo (UNIFESP), Rua Pedro de Toledo 720, Vila Clementino, S\u00e3o Paulo 04039-002, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-2850","authenticated-orcid":false,"given":"Carlos R.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Gap Biotech Laboratory of Biotechnology and Bioinformatics, Rua Comendador Remo Cesaroni 223, S\u00e3o Jos\u00e9 dos Campos 12243-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6067-1442","authenticated-orcid":false,"given":"Jos\u00e9 R.","family":"Mateus-Silva","sequence":"additional","affiliation":[{"name":"Gap Biotech Laboratory of Biotechnology and Bioinformatics, Rua Comendador Remo Cesaroni 223, S\u00e3o Jos\u00e9 dos Campos 12243-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-431X","authenticated-orcid":false,"given":"Lucas S.","family":"Zamarioli","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), Rua Tr\u00eas de Maio 100, S\u00e3o Paulo 04044-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-1416","authenticated-orcid":false,"given":"Andr\u00e9 L. L.","family":"Bachi","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Health Science, Santo Amaro University, Rua Prof. En\u00e9as de Siqueira Neto 340, S\u00e3o Paulo 04829-300, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanesko F.","family":"Bella","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Science of Human Movement and Rehabilitation, Federal University of S\u00e3o Paulo (UNIFESP), Avenida Ana Costa 95, Santos 11060-001, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0527-0723","authenticated-orcid":false,"given":"Juliana M. B.","family":"Santos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Science of Human Movement and Rehabilitation, Federal University of S\u00e3o Paulo (UNIFESP), Avenida Ana Costa 95, Santos 11060-001, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6666-3673","authenticated-orcid":false,"given":"Claudia","family":"Bincoletto","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Federal University of S\u00e3o Paulo (UNIFESP), Rua Tr\u00eas de Maio 100, S\u00e3o Paulo 04044-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Antonio Herbert","family":"Lancha","sequence":"additional","affiliation":[{"name":"Experimental Surgery (LIM 26), Laboratory of Clinical Investigation, School of Medicine, University of Sao Paulo, Avenida Doutor Arnaldo 455, S\u00e3o Paulo 05508-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-1143","authenticated-orcid":false,"given":"Rodolfo P.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Post-Graduation Program in Bioengineering, Universidade Brasil, Rua Carolina Fonseca 235, S\u00e3o Paulo 08230-030, SP, Brazil"},{"name":"Postgraduate Program in Science of Human Movement and Rehabilitation, Federal University of S\u00e3o Paulo (UNIFESP), Avenida Ana Costa 95, Santos 11060-001, SP, Brazil"},{"name":"Gap Biotech Laboratory of Biotechnology and Bioinformatics, Rua Comendador Remo Cesaroni 223, S\u00e3o Jos\u00e9 dos Campos 12243-020, SP, Brazil"},{"name":"Postgraduate Program in Human Movement and Rehabilitation and in Pharmaceutical Sciences, Evangelical University of Goi\u00e1s (Unievang\u00e9lica), Avenida Universit\u00e1ria Km 3,5, An\u00e1polis 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12032-021-01462-5","article-title":"Combating TKI resistance in CML by inhibiting the PI3K\/Akt\/mTOR pathway in combination with TKIs: A review","volume":"38","author":"Singh","year":"2021","journal-title":"Med. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1002\/cncr.26679","article-title":"Estimations of the increasing prevalence and plateau prevalence of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy","volume":"118","author":"Huang","year":"2012","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2147\/JBM.S382090","article-title":"Chronic Myeloid Leukemia, from Pathophysiology to Treatment-Free Remission: A Narrative Literature Review","volume":"14","author":"Rinaldi","year":"2023","journal-title":"J. Blood Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Aldapt, M.B., Al-Mashdali, A.F., Obeidat, K., Chandra, P., and Yassin, M. (2023). Viral Infections and Incidence of Reactivations in Chronic Myeloid Leukemia Patients. Oncology, Online ahead of print.","DOI":"10.1159\/000534266"},{"key":"ref_5","first-page":"45","article-title":"Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. Experience of the French Severe Chronic Neutropenia Study Group","volume":"90","author":"Donadieu","year":"2005","journal-title":"Haematologica"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"106221","DOI":"10.1016\/j.leukres.2019.106221","article-title":"The dynamic of TNF and IL6 gene expression in chronic myeloid leukemia patients reveals early responders to imatinib","volume":"86","author":"Bestach","year":"2019","journal-title":"Leuk. Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"\u0106ojba\u0161i\u0107, I., Golubovi\u0107, I., and \u0106ojba\u0161i\u0107, \u017d. (2023). Clinical Outcomes of Patients with Chronic Myeloid Leukemia and COVID-19 Infection\u2014A Single Center Survey. Medicina, 59.","DOI":"10.3390\/medicina59091564"},{"key":"ref_8","first-page":"93","article-title":"Tyrosine Kinase Inhibitors for Pediatric Leukemia: History and Current Status","volume":"33","author":"Sun","year":"2022","journal-title":"Discov. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11302-019-09686-x","article-title":"Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line","volume":"16","author":"Willig","year":"2020","journal-title":"Purinergic Signal."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bella, Y.F., Oliveira, C.R., Mateus-Silva, J.R., Brandao-Rangel, M.A.R., Silva-Reis, A., Santos, J.d.M.B., Albertini, R., Lopes-Martins, R.A.B., de Oliveira, L.V.F., and Vieira, R.P. (2023). A phytotherapic blend immunity-6\u2122 inhibits myeloid leukemic cells 2 activation involving purinergic signaling. Biomed. Pharmacother., 159.","DOI":"10.1016\/j.biopha.2023.114263"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1172\/JCI35660","article-title":"Targeting autophagy potentiates tyrosine kinase inhibitor\u2013induced cell death in Philadelphia chromosome\u2013positive cells, including primary CML stem cells","volume":"119","author":"Bellodi","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ajh.21914","article-title":"Autophagy induction by Bcr-Abl-expressing cells facilitates their recovery from a targeted or nontargeted treatment","volume":"86","author":"Crowley","year":"2010","journal-title":"Am. J. Hematol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1038\/leu.2017.108","article-title":"A novel AHI-1\u2013BCR-ABL\u2013DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy","volume":"31","author":"Liu","year":"2017","journal-title":"Leukemia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/leu.2012.65","article-title":"Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells","volume":"26","author":"Yu","year":"2012","journal-title":"Leukemia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1038\/cddis.2012.111","article-title":"Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence","volume":"3","author":"Drullion","year":"2012","journal-title":"Cell Death Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature23876","article-title":"Ascorbate regulates haematopoietic stem cell function and leukaemogenesis","volume":"549","author":"Agathocleous","year":"2017","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semcancer.2017.11.001","article-title":"Vitamin C\u2014A new player in regulation of the cancer epigenome","volume":"51","author":"Gillberg","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.cell.2017.07.032","article-title":"Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression","volume":"170","author":"Cimmino","year":"2017","journal-title":"Cell"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Foster, M.N., Carr, A.C., Antony, A., Peng, S., and Fitzpatrick, M.G. (2018). Intravenous Vitamin C Administration Improved Blood Cell Counts and Health-Related Quality of Life of Patient with History of Relapsed Acute Myeloid Leukaemia. Antioxidants, 7.","DOI":"10.3390\/antiox7070092"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.freeradbiomed.2020.11.039","article-title":"Activation of adenosine A3 receptors regulates vitamin C transport and redox balance in neurons","volume":"163","author":"Portugal","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biochi.2017.08.004","article-title":"Effect and proposed mechanism of vitamin C modulating amino acid regulation of autophagic proteolysis","volume":"142","author":"Karim","year":"2017","journal-title":"Biochimie"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Rothe, K., Porter, V., and Jiang, X. (2019). Current Outlook on Autophagy in Human Leukemia: Foe in Cancer Stem Cells and Drug Resistance, Friend in New Therapeutic Interventions. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030461"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejphar.2006.06.004","article-title":"Biphosphinic palladacycle complex mediates lysosomal-membrane permeabilization and cell death in K562 leukaemia cells","volume":"542","author":"Barbosa","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/eji.201847657","article-title":"Creatine supplementation impairs airway inflammation in an experimental model of asthma involving P2 \u00d7 7 receptor","volume":"49","author":"Garcia","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF02100994","article-title":"Buckingham. Comparison of three actin-coding sequences in the mouse; evolutionary relationships between the actin genes of warm-blooded vertebrates","volume":"23","author":"Alonso","year":"1986","journal-title":"J. Mol. Evol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-5793(00)02306-1","article-title":"P2 purinergic receptors of human eosinophils: Characterization and coupling to oxygen radical production","volume":"486","author":"Ferrari","year":"2000","journal-title":"FEBS Lett."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Silva, L.M.G., da Silva, C.A.A., da Silva, A., Vieira, R.P., Mesquita-Ferrari, R.A., Cogo, J.C., and Zamuner, S.R. (2016). Photobiomodulation Protects and Promotes Differentiation of C2C12 Myoblast Cells Exposed to Snake Venom. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0152890"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1158\/1078-0432.CCR-13-2442","article-title":"Inflammatory Markers and Development of Symptom Burden in Patients with Multiple Myeloma during Autologous Stem Cell Transplantation","volume":"20","author":"Wang","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12935-020-1152-z","article-title":"Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor \u03ba B-reactive oxygen species signaling axis","volume":"20","author":"Wang","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pharmthera.2013.09.004","article-title":"Targeting interleukin-6 in inflammatory autoimmune diseases and cancers","volume":"141","author":"Yao","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"F1000","DOI":"10.12688\/f1000research.17023.1","article-title":"Tumour necrosis factor signalling in health and disease","volume":"8","author":"Holbrook","year":"2019","journal-title":"F1000Research"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ajem.2018.05.040","article-title":"Interleukin-6 as a diagnostic marker for infection in critically ill patients: A systematic review and meta-analysis","volume":"37","author":"Iwase","year":"2018","journal-title":"Am. J. Emerg. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Thompson, D.K., Huffman, K.M., Kraus, W.E., and Kraus, V.B. (2012). Critical Appraisal of Four IL-6 Immunoassays. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030659"},{"key":"ref_34","first-page":"986","article-title":"Differences between adult and pediatric septic shock","volume":"77","author":"Aneja","year":"2011","journal-title":"Minerva Anestesiol."},{"key":"ref_35","first-page":"CD011811","article-title":"Plasma interleukin-6 concentration for the diagnosis of sepsis in critically ill adults","volume":"4","author":"Franco","year":"2019","journal-title":"Emergencias"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zhang, L., Zhang, J., He, H., Ling, X., Li, F., Yang, Z., Zhao, J., Li, H., Yang, T., and Zhao, S. (2022). Increased Cytokine Levels Assist in the Diagnosis of Respiratory Bacterial Infections or Concurrent Bacteremia in Patients With Non-Hodgkin\u2019s Lymphoma. Front. Cell Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.860526"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13045-023-01440-6","article-title":"Elevated plasma levels of IL-6 and MCP-1 selectively identify CML patients who better sustain molecular remission after TKI withdrawal","volume":"16","author":"Pavlovsky","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.2147\/OTT.S197535","article-title":"Tumor necrosis factor \u03b1 knockout impaired tumorigenesis in chronic myeloid leukemia cells partly by metabolism modification and miRNA regulation","volume":"12","author":"Shen","year":"2019","journal-title":"OncoTargets Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrc2628","article-title":"Tumour necrosis factor and cancer","volume":"9","author":"Balkwill","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: The master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"key":"ref_41","first-page":"237","article-title":"Aerobic Exercise Reduces Asthma Phenotype by Modulation of the Leukotriene Pathway","volume":"7","author":"Greiffo","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1249\/MSS.0000000000000927","article-title":"Dendritic Cells Are Involved in the Effects of Exercise in a Model of Asthma","volume":"48","author":"Mackenzie","year":"2016","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1182\/bloodadvances.2021005522","article-title":"Decreased IL-10 accelerates B-cell leukemia\/lymphoma in a mouse model of pediatric lymphoid leukemia","volume":"6","author":"Fitch","year":"2022","journal-title":"Blood Adv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.cyto.2012.12.023","article-title":"Cytokine profiles in acute myeloid leukemia patients at diagnosis: Survival is inversely correlated with IL-6 and directly correlated with IL-10 levels","volume":"61","author":"Bergua","year":"2013","journal-title":"Cytokine"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Sachdeva, A., Gouge, J., Kontovounisios, C., Nikolaou, S., Ashworth, A., Lim, K., and Chong, I. (2020). Klotho and the Treatment of Human Malignancies. Cancers, 12.","DOI":"10.3390\/cancers12061665"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Zou, D., Wu, W., He, Y., Ma, S., and Gao, J. (2018). The role of klotho in chronic kidney disease. BMC Nephrol., 19.","DOI":"10.1186\/s12882-018-1094-z"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"102854","DOI":"10.1016\/j.dsx.2023.102854","article-title":"Emerging role of \u03b1-Klotho in energy metabolism and cardiometabolic diseases","volume":"17","author":"Liu","year":"2023","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"931331","DOI":"10.3389\/fragi.2022.931331","article-title":"Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations","volume":"3","author":"Kurt","year":"2022","journal-title":"Front. Aging"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.3892\/mmr.2017.6172","article-title":"Reduced Klotho expression contributes to poor survival rates in human patients with ovarian cancer, and overexpression of Klotho inhibits the progression of ovarian cancer partly via the inhibition of systemic inflammation in nude mice","volume":"15","author":"Yan","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_50","first-page":"50","article-title":"Effects of aerobic exercise on molecular aspects of asthma: Involvement of SOCS-JAK-STAT","volume":"25","author":"Abbasi","year":"2019","journal-title":"Exerc. Immunol. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nature13085","article-title":"Nucleotide signalling during inflammation","volume":"509","author":"Idzko","year":"2014","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.lungcan.2015.10.005","article-title":"Altered purinergic signaling in the tumor associated immunologic microenvironment in metastasized non-small-cell lung cancer","volume":"90","author":"Schmid","year":"2015","journal-title":"Lung Cancer"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11302-021-09776-9","article-title":"Antagonism of the ATP-gated P2X7 receptor: A potential therapeutic strategy for cancer","volume":"17","author":"Drill","year":"2021","journal-title":"Purinergic Signal."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/glia.22628","article-title":"P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-\u03b1 in cultured mouse microglia","volume":"62","author":"Shieh","year":"2014","journal-title":"Glia"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s11302-020-09746-7","article-title":"P2X7 receptor deletion attenuates oxidative stress and liver damage in sepsis","volume":"16","author":"Tamura","year":"2020","journal-title":"Purinergic Signal."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"eaah7107","DOI":"10.1126\/scisignal.aah7107","article-title":"ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors","volume":"10","author":"Vargas","year":"2017","journal-title":"Sci. Signal."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.exphem.2004.01.007","article-title":"Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line","volume":"32","author":"Tarumoto","year":"2004","journal-title":"Exp. Hematol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/1871525720666220819123639","article-title":"The mRNA Expression of PTEN, LEF1, JAK3, LC3 and p62\/SQSTM1 Genes in Patients with Chronic Myeloid Leukemia","volume":"21","author":"Sharifzadeh","year":"2023","journal-title":"Cardiovasc. Hematol. Agents Med. Chem."},{"key":"ref_59","first-page":"583","article-title":"Dual role of autophagy in chronic myeloid leukemia","volume":"23","author":"Li","year":"2015","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/3\/383\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:50:53Z","timestamp":1760104253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/16\/3\/383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":59,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["nu16030383"],"URL":"https:\/\/doi.org\/10.3390\/nu16030383","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]}}}