{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:58:55Z","timestamp":1784638735633,"version":"3.55.0"},"reference-count":39,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Czech Ministry of Health","award":["MH CZ-DRO-VFN64165"],"award-info":[{"award-number":["MH CZ-DRO-VFN64165"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Objectives: Intestinal failure in home parenteral nutrition patients (HPNPs) results in oxidative stress and liver damage. This study investigated how a high dose of fish oil (FO) added to various lipid emulsions influences antioxidant status and liver function markers in HPNPs. (2) Methods: Twelve HPNPs receiving Smoflipid for at least 3 months were given FO (Omegaven) for a further 4 weeks. Then, the patients were randomized to subsequently receive Lipoplus and ClinOleic for 6 weeks or vice versa plus 4 weeks of Omegaven after each cycle in a crossover design. Twelve age- and sex-matched healthy controls (HCs) were included. (3) Results: Superoxide dismutase (SOD1) activity and oxidized-low-density lipoprotein concentration were higher in all baseline HPN regimens compared to HCs. The Omegaven lowered SOD1 compared to baseline regimens and thus normalized it toward HCs. Lower paraoxonase 1 activity and fibroblast growth factor 19 (FGF19) concentration and, on the converse, higher alkaline phosphatase activity and cholesten concentration were observed in all baseline regimens compared to HCs. A close correlation was observed between FGF19 and SOD1 in baseline regimens. (4) Conclusions: An escalated dose of FO normalized SOD1 activity in HPNPs toward that of HCs. Bile acid metabolism was altered in HPNPs without signs of significant cholestasis and not affected by Omegaven.<\/jats:p>","DOI":"10.3390\/nu16040485","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T03:36:17Z","timestamp":1707363377000},"page":"485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High Dose Fish Oil Added to Various Lipid Emulsions Normalizes Superoxide Dismutase 1 Activity in Home Parenteral Nutrition Patients"],"prefix":"10.3390","volume":"16","author":[{"given":"Stanislav","family":"Sevela","sequence":"first","affiliation":[{"name":"4th Department of Internal Medicine, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Meisnerova","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-1817","authenticated-orcid":false,"given":"Marek","family":"Vecka","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Vavrova","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Rychlikova","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-3488","authenticated-orcid":false,"given":"Martin","family":"Lenicek","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5318-0151","authenticated-orcid":false,"given":"Libor","family":"Vitek","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic"},{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Novakova","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Science, Charles University, 128 00 Prague, Czech Republic"},{"name":"Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5582-3977","authenticated-orcid":false,"given":"Frantisek","family":"Novak","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, 1st Faculty of Medicine and General University Hospital, Charles University, 128 08 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1016\/j.clnu.2021.07.002","article-title":"ESPEN practical guideline: Clinical nutrition in chronic intestinal failure","volume":"40","author":"Cuerda","year":"2021","journal-title":"Clin. 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