{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:01:11Z","timestamp":1787029271927,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","award":["HHSN275200800013C"],"award-info":[{"award-number":["HHSN275200800013C"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","award":["HHSN275200800002I"],"award-info":[{"award-number":["HHSN275200800002I"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","award":["HHSN27500006"],"award-info":[{"award-number":["HHSN27500006"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","award":["HHSN275200800003IC"],"award-info":[{"award-number":["HHSN275200800003IC"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","award":["HHSN275200800014C"],"award-info":[{"award-number":["HHSN275200800014C"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","award":["HHSN275200800012C"],"award-info":[{"award-number":["HHSN275200800012C"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","award":["HHSN275200800028C"],"award-info":[{"award-number":["HHSN275200800028C"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","award":["HHSN275201000009C"],"award-info":[{"award-number":["HHSN275201000009C"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","award":["HHSN275201000001Z"],"award-info":[{"award-number":["HHSN275201000001Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Objective: the aim of this study was to identify plasma metabolomic markers of Dietary Approaches to Stop Hypertension (DASH) dietary patterns in pregnant women. Methods: This study included 186 women who had both dietary intake and metabolome measured from a nested case-control study within the NICHD Fetal Growth Studies\u2013Singletons cohort (FGS). Dietary intakes were ascertained at 8\u201313 gestational weeks (GW) using the Food Frequency Questionnaire (FFQ) and DASH scores were calculated based on eight food and nutrient components. Fasting plasma samples were collected at 15\u201326 GW and untargeted metabolomic profiling was performed. Multivariable linear regression models were used to examine the association of individual metabolites with the DASH score. Least absolute shrinkage and selection operator (LASSO) regression was used to select a panel of metabolites jointly associated with the DASH score. Results: Of the total 460 known metabolites, 92 were individually associated with DASH score in linear regressions, 25 were selected as a panel by LASSO regressions, and 18 were identified by both methods. Among the top 18 metabolites, there were 11 lipids and lipid-like molecules (i.e., TG (49:1), TG (52:2), PC (31:0), PC (35:3), PC (36:4) C, PC (36:5) B, PC (38:4) B, PC (42:6), SM (d32:0), gamma-tocopherol, and dodecanoic acid), 5 organic acids and derivatives (i.e., asparagine, beta-alanine, glycine, taurine, and hydroxycarbamate), 1 organic oxygen compound (i.e., xylitol), and 1 organoheterocyclic compound (i.e., maleimide). Conclusions: our study identified plasma metabolomic markers for DASH dietary patterns in pregnant women, with most of being lipids and lipid-like molecules.<\/jats:p>","DOI":"10.3390\/nu16040492","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T09:00:02Z","timestamp":1707382802000},"page":"492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Metabolomic Biomarkers of Dietary Approaches to Stop Hypertension (DASH) Dietary Patterns in Pregnant Women"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8458-5661","authenticated-orcid":false,"given":"Liwei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-746X","authenticated-orcid":false,"given":"Jin","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqi","family":"Yu","sequence":"additional","affiliation":[{"name":"Global Center for Asian Women\u2019s Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"},{"name":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"},{"name":"Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5938-7022","authenticated-orcid":false,"given":"Wei Wei","family":"Pang","sequence":"additional","affiliation":[{"name":"Global Center for Asian Women\u2019s Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"},{"name":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"},{"name":"Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad L.","family":"Rahman","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-1674","authenticated-orcid":false,"given":"Xinyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-8928","authenticated-orcid":false,"given":"Oliver","family":"Fiehn","sequence":"additional","affiliation":[{"name":"West Coast Metabolomics Center, UC Davis Genome Center, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-6954","authenticated-orcid":false,"given":"Claire","family":"Guivarch","sequence":"additional","affiliation":[{"name":"Global Center for Asian Women\u2019s Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"},{"name":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"},{"name":"Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuilin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Global Center for Asian Women\u2019s Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"},{"name":"Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"},{"name":"Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1056\/NEJM199704173361601","article-title":"A clinical trial of the effects of dietary patterns on blood pressure. 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